Flutamide – Uses, Dosage, Side Effects, Interaction

RxHarun

1 year ago

Flutamide is an Androgen Receptor Inhibitor. The mechanism of action of flutamide is as an Androgen Receptor Antagonist. Flutamide is a nonsteroidal antiandrogen that acts by binding to and blocking intracellular androgen receptors in target tissues including testes, prostate, skin, and hair follicles. Flutamide is frequently associated with minor serum aminotransferase elevations and has been linked to numerous cases of acute liver injury, which are frequently severe and can be fatal.

Flutamide is a monocarboxylic acid amide and a member of (trifluoromethyl)benzenes. It has a role as an androgen antagonist and an antineoplastic agent.

Flutamide is a nonsteroidal antiandrogen (NSAA) that is used primarily to treat prostate cancer. It is also used in the treatment of androgen-dependent conditions like acne, excessive hair growth, and high androgen levels in women.^[rx] It is taken by mouth, usually three times per day

Mechanism of Action

Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition, Flutamide is a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen.

Flutamide is a nonsteroidal antiandrogen. In animal studies, flutamide demonstrates potent antiandrogenic effects. It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting the nuclear binding of androgen in target tissues or both. Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g. castration. Elevations of plasma testosterone and estradiol levels have been noted following flutamide administration.

Indications

For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate
Flutamide is a nonsteroidal antiandrogen that acts by binding to and blocking intracellular androgen receptors in target tissues including testes, prostate, skin, and hair follicles.
Flutamide is approved to treat: Prostate cancer that may be locally advanced or has metastasized (spread to other parts of the body). It is used with a type of drug called a luteinizing hormone-releasing hormone agonist. Flutamide is also being studied in the treatment of other conditions and types of cancer.
Antineoplastic agents are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on the removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias
Flutamide has been used in case reports to decrease the frequency of spontaneous orgasms, for instance in men with post-orgasmic illness syndrome
Flutamide has been researched and used extensively in the treatment of androgen-dependent skin and hair conditions in women including acne, seborrhea, hirsutism, and scalp hair loss, as well as in hyperandrogenism (e.g., in polycystic ovary syndrome or congenital adrenal hyperplasia), and is effective in improving the symptoms of these conditions.
Flutamide has been found to be effective in the treatment of acne and seborrhea in women in a number of studies.^[rx]^[rx] In a long-term study of 230 women with acne, 211 of whom also had seborrhea, very-low-dose flutamide alone or in combination with an oral contraceptive caused a marked decrease in acne and seborrhea after 6 months of treatment, with maximal effect by 1 year of treatment and benefits maintained in the years thereafter
Flutamide has been found to be effective in the treatment of hirsutism (excessive body/facial hair growth) in numerous studies.^[rx]^[rx] It possesses moderate effectiveness for this indication, and the overall quality of the evidence is considered to be moderate
Flutamide has been found to be effective in the treatment of female pattern hair loss in a number of studies. In one study of 101 pre- and postmenopausal women, flutamide alone or in combination with an oral contraceptive produced a marked decrease in hair loss scores after 1 year of treatment, with maximum effect after 2 years of treatment and benefits maintained for another 2 years

Use in Cancer

Flutamide is approved to treat:

Prostate cancer that may be locally advanced or has metastasized (spread to other parts of the body). It is used with a type of drug called a luteinizing hormone-releasing hormone agonist.

Flutamide is also being studied in the treatment of other conditions and types of cancer.

Contraindications

glucose-6-phosphate dehydrogenase (G6PD) deficiency
deficiency of the blood enzyme cytochrome b5 reductase
methemoglobinemia, a type of blood disorder
liver failure
liver problems
severe liver disease
high amount of bilirubin in the blood
abnormal liver function tests
pregnancy
a patient who is producing milk and breastfeeding
anemia from pyruvate kinase and G6PD deficiencies

Dosage

Strengths: 125 mg, 250 mg

Prostate Cancer

250 mg orally every 8 hours
This drug may be taken with or without food.
Stage B2-C Prostatic Carcinoma: Treatment with this drug and the goserelin acetate implant starts 8 weeks prior to initiating radiation therapy and continues during radiation therapy.
Stage D2 Metastatic Carcinoma: This drug should be initiated with the LHRH-agonist and continued until progression.
Locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate

Side Effects

The Most Common

diarrhea
nausea
vomiting
loss of appetite
hot flashes
decrease in sexual ability or desire
breast enlargement in men
drowsiness
confusion
depression
anxiety
swelling of the hands, feet, ankles, or lower legs
blue-green or orange-colored urine
nausea, upper stomach pain, loss of appetite;
itching, tiredness, flu-like symptoms;
dark urine, clay-colored stools; or
jaundice (yellowing of the skin or eyes).
breast swelling or tenderness;
hot flashes;
vomiting, nausea, diarrhea; or
impotence, loss of interest in sex.

More common

Black, tarry stools
bloody or cloudy urine
continuing diarrhea
continuing stomach pain
difficult, burning, or painful urination
frequent urge to urinate
pale skin
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness
appetite changes
constipation
diarrhea
dizziness
drowsiness
headache
hot flashes
impotence
nausea
indigestion
nervousness
reduction in sexual desire
sleeping problems
swelling of breasts with pain or tenderness
vomiting

Rare

Blurred vision
chest pain
chills
cough
difficulty with breathing
dizziness
drowsiness
fever
headache
nervousness
pounding in the ears
shortness of breath
slow or fast heartbeat
sore throat
sores, ulcers, or white spots on the lips or in the mouth
swelling
swollen glands
Abdominal or stomach pain
clay-colored stools
dark urine
general tiredness and weakness
itching
light-colored stools
loss of appetite
nausea and vomiting
rash
tumor
unpleasant breath odor
upper right abdominal pain
vomiting of blood
yellow eyes and skin
Back, leg, or stomach pains
bleeding gums
blistering, peeling, or loosening of the skin
bluish-colored lips, fingernails, or palms
discoloration of the urine
dizziness or lightheadedness
flushing or redness of the skin
general body swelling
headache
itching
joint or muscle pain
nosebleeds
rapid heart rate
red irritated eyes
red skin lesions, often with a purple center
unusually warm skin

Drug interaction

DRUG	INTERACTION
Abacavir	Flutamide may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abametapir	The serum concentration of Flutamide can be increased when it is combined with Abametapir.
Abatacept	The metabolism of Flutamide can be increased when combined with Abatacept.
Abiraterone	The serum concentration of Flutamide can be increased when it is combined with Abiraterone.
Acalabrutinib	The metabolism of Flutamide can be decreased when combined with Acalabrutinib.
Aceclofenac	Aceclofenac may decrease the excretion rate of Flutamide which could result in a higher serum level.
Acemetacin	Acemetacin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Acenocoumarol	The metabolism of Acenocoumarol can be decreased when combined with Flutamide.
Acetaminophen	The risk or severity of methemoglobinemia can be increased when Acetaminophen is combined with Flutamide.
Acetazolamide	Acetazolamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic	Acetylsalicylic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Aclidinium	Flutamide may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine	Flutamide may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir	The metabolism of Acyclovir can be decreased when combined with Flutamide.
Adalimumab	The metabolism of Flutamide can be increased when combined with Adalimumab.
Adefovir dipivoxil	Adefovir dipivoxil may decrease the excretion rate of Flutamide which could result in a higher serum level.
Agomelatine	The metabolism of Agomelatine can be decreased when combined with Flutamide.
Albendazole	The metabolism of Flutamide can be increased when combined with Albendazole.
Albutrepenonacog	Flutamide may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alclofenac	Alclofenac may decrease the excretion rate of Flutamide which could result in a higher serum level.
Aldesleukin	Aldesleukin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Alfentanil	The metabolism of Alfentanil can be decreased when combined with Flutamide.
Allopurinol	Allopurinol may decrease the excretion rate of Flutamide which could result in a higher serum level.
Almasilate	Flutamide may decrease the excretion rate of Almasilate which could result in a higher serum level.
Almotriptan	Flutamide may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Alogliptin	Flutamide may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Alosetron	The metabolism of Flutamide can be decreased when combined with Alosetron.
Alprazolam	Alprazolam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Amantadine	Flutamide may decrease the excretion rate of Amantadine which could result in a higher serum level.
Ambrisentan	The metabolism of Ambrisentan can be decreased when combined with Flutamide.
Amikacin	Flutamide may decrease the excretion rate of Amikacin which could result in a higher serum level.
Amiloride	Amiloride may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Aminophenazone	The metabolism of Aminophenazone can be decreased when combined with Flutamide.
Aminophylline	The metabolism of Aminophylline can be decreased when combined with Flutamide.
Aminosalicylic acid	The risk or severity of methemoglobinemia can be increased when Aminosalicylic acid is combined with Flutamide.
Amiodarone	The metabolism of Flutamide can be decreased when combined with Amiodarone.
Amitriptyline	The metabolism of Flutamide can be decreased when combined with Amitriptyline.
Ammonium chloride	Flutamide may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
Amoxicillin	Flutamide may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Amphetamine	Amphetamine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Amphotericin B	Amphotericin B may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ampicillin	Ampicillin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Amprenavir	The metabolism of Flutamide can be decreased when combined with Amprenavir.
Amrinone	Flutamide may decrease the excretion rate of Amrinone which could result in a higher serum level.
Amyl Nitrite	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Amyl Nitrite.
Anagrelide	The metabolism of Flutamide can be decreased when combined with Anagrelide.
Anakinra	The metabolism of Flutamide can be increased when combined with Anakinra.
Ancestim	Flutamide may decrease the excretion rate of Ancestim which could result in a higher serum level.
Antihemophilic	Flutamide may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level.
Antipyrine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Antipyrine.
Antithrombin	Flutamide may decrease the excretion rate of Antithrombin III human which could result in a higher serum level.
Antrafenine	Antrafenine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Apalutamide	The metabolism of Flutamide can be increased when combined with Apalutamide.
Apixaban	The metabolism of Apixaban can be decreased when combined with Flutamide.
Apomorphine	The metabolism of Apomorphine can be decreased when combined with Flutamide.
Apremilast	The metabolism of Flutamide can be increased when combined with Apremilast.
Aprepitant	The metabolism of Flutamide can be decreased when combined with Aprepitant.
Arformoterol	Flutamide may decrease the excretion rate of Arformoterol which could result in a higher serum level.
Aripiprazole	The metabolism of Aripiprazole can be decreased when combined with Flutamide.
Aripiprazole	The metabolism of Aripiprazole lauroxil can be decreased when combined with Flutamide.
Armodafinil	The metabolism of Flutamide can be increased when combined with Armodafinil.
Arsenic trioxide	Flutamide may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Artemether	The metabolism of Artemether can be decreased when combined with Flutamide.
Articaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Articaine.
Asenapine	The metabolism of Asenapine can be decreased when combined with Flutamide.
Astemizole	The metabolism of Astemizole can be decreased when combined with Flutamide.
Asunaprevir	The metabolism of Asunaprevir can be decreased when combined with Flutamide.
Atazanavir	The metabolism of Flutamide can be decreased when combined with Atazanavir.
Atomoxetine	Atomoxetine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Atorvastatin	The metabolism of Atorvastatin can be decreased when combined with Flutamide.
Auranofin	Flutamide may decrease the excretion rate of Auranofin which could result in a higher serum level.
Aurothioglucose	Flutamide may decrease the excretion rate of Aurothioglucose which could result in a higher serum level.
Avanafil	The serum concentration of Avanafil can be increased when it is combined with Flutamide.
Axitinib	The metabolism of Axitinib can be decreased when combined with Flutamide.
Azacitidine	Flutamide may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Azathioprine	The metabolism of Azathioprine can be decreased when combined with Flutamide.
Azelaic acid	Flutamide may decrease the excretion rate of Azelaic acid which could result in a higher serum level.
Azelastine	The metabolism of Azelastine can be decreased when combined with Flutamide.
Aztreonam	Aztreonam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Bacitracin	Bacitracin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Baclofen	Baclofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Balsalazide	Balsalazide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Baricitinib	Flutamide may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Beclomethasone	The metabolism of Flutamide can be increased when combined with Beclomethasone dipropionate.
Belinostat	The metabolism of Flutamide can be increased when combined with Belinostat.
Bendamustine	The metabolism of Bendamustine can be decreased when combined with Flutamide.
Bendroflumethiazide	Bendroflumethiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Benorilate	Benorilate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Benoxaprofen	Benoxaprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Benserazide	Flutamide may decrease the excretion rate of Benserazide which could result in a higher serum level.
Benzatropine	Benzatropine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Benznidazole	Flutamide may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Benzocaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Benzocaine.
Benzthiazide	Benzthiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Benzydamine	Benzydamine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Benzyl alcohol	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Benzyl alcohol.
Bepotastine	Flutamide may decrease the excretion rate of Bepotastine which could result in a higher serum level.
Berotralstat	The metabolism of Flutamide can be decreased when combined with Berotralstat.
Betamethasone	The metabolism of Flutamide can be increased when combined with Betamethasone.
Betamethasone	The metabolism of Flutamide can be increased when combined with Betamethasone phosphate.

Betaxolol	The metabolism of Flutamide can be decreased when combined with Betaxolol.
Bicisate	Flutamide may decrease the excretion rate of Bicisate which could result in a higher serum level.
Bimekizumab	The metabolism of Flutamide can be increased when combined with Bimekizumab.
Binimetinib	The metabolism of Binimetinib can be decreased when combined with Flutamide.
Bismuth subgallate	Flutamide may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level.
Bisoprolol	Flutamide may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Bisoxatin	Flutamide may decrease the excretion rate of Bisoxatin which could result in a higher serum level.
Bleomycin	Bleomycin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Boceprevir	The metabolism of Flutamide can be decreased when combined with Boceprevir.
Bortezomib	The metabolism of Flutamide can be decreased when combined with Bortezomib.
Brivaracetam	Flutamide may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Bromazepam	The metabolism of Bromazepam can be decreased when combined with Flutamide.
Bromotheophylline	Bromotheophylline may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Budesonide	The metabolism of Flutamide can be increased when combined with Budesonide.
Bumadizone	Bumadizone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Bumetanide	Bumetanide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Bupivacaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Bupivacaine.
Buprenorphine	The metabolism of Buprenorphine can be decreased when combined with Flutamide.
Bupropion	Flutamide may decrease the excretion rate of Bupropion which could result in a higher serum level.
Buspirone	Buspirone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Butabarbital	Butabarbital may decrease the excretion rate of Flutamide which could result in a higher serum level.
Butacaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Butacaine.
Butalbital	The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Flutamide.
Butamben	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Butamben.
Cabazitaxel	The metabolism of Cabazitaxel can be decreased when combined with Flutamide.
Caffeine	The metabolism of Flutamide can be decreased when combined with Caffeine.
Canagliflozin	Canagliflozin may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Canakinumab	The metabolism of Flutamide can be increased when combined with Canakinumab.
Cannabidiol	The metabolism of Flutamide can be decreased when combined with Cannabidiol.
Canrenoic acid	Canrenoic acid may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Capecitabine	Flutamide may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Capmatinib	The metabolism of Flutamide can be decreased when combined with Capmatinib.
Capreomycin	Flutamide may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Capromab pendetide	Flutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Capsaicin	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Capsaicin.
Carbamazepine	The metabolism of Carbamazepine can be decreased when combined with Flutamide.
Carbidopa	Carbidopa may decrease the excretion rate of Flutamide which could result in a higher serum level.
Carboplatin	Carboplatin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Carmustine	The metabolism of Flutamide can be decreased when combined with Carmustine.
Carprofen	Carprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Carvedilol	The metabolism of Carvedilol can be decreased when combined with Flutamide.
Cefaclor	Cefaclor may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefadroxil	Cefadroxil may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefalotin	Cefalotin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefamandole	Cefamandole may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefapirin	Cefapirin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefazolin	Cefazolin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefdinir	Flutamide may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cefditoren	Cefditoren may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefepime	Cefepime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefmenoxime	Cefmenoxime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefmetazole	Cefmetazole may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefonicid	Cefonicid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefoperazone	Cefoperazone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceforanide	Ceforanide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefotaxime	Cefotaxime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefotetan	Cefotetan may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefotiam	Cefotiam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefoxitin	Cefoxitin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefpiramide	Cefpiramide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefpirome	Cefpirome may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefpodoxime	Cefpodoxime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefprozil	Cefprozil may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefradine	Cefradine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceftaroline	Ceftaroline fosamil may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceftazidime	Ceftazidime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceftibuten	Ceftibuten may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceftizoxime	Ceftizoxime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceftobiprole	Ceftobiprole may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceftolozane	Flutamide may decrease the excretion rate of Ceftolozane which could result in a higher serum level.
Ceftriaxone	Ceftriaxone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefuroxime	Cefuroxime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Celecoxib	The risk or severity of methemoglobinemia can be increased when Celecoxib is combined with Flutamide.
Cenobamate	The serum concentration of Flutamide can be decreased when it is combined with Cenobamate.
Cephalexin	Cephalexin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cephaloglycin	Cephaloglycin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cerivastatin	The metabolism of Flutamide can be decreased when combined with Cerivastatin.
Certolizumab	The metabolism of Flutamide can be increased when combined with Certolizumab pegol.
Cetirizine	Cetirizine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cevimeline	Cevimeline may decrease the excretion rate of Flutamide which could result in a higher serum level.
Chloral hydrate	Flutamide may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
Chloramphenicol	The metabolism of Flutamide can be decreased when combined with Chloramphenicol.
Chloroprocaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Chloroprocaine.
Chloroquine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Chloroquine.
Chlorothiazide	Chlorothiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Chloroxylenol	Flutamide may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
Chlorpheniramine	The metabolism of Chlorpheniramine can be decreased when combined with Flutamide.
Chlorpromazine	The metabolism of Flutamide can be decreased when combined with Chlorpromazine.
Chlorpropamide	Flutamide may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Chlorthalidone	Chlorthalidone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Chlorzoxazone	The metabolism of Flutamide can be decreased when combined with Chlorzoxazone.
Choline C 11	Flutamide may decrease effectiveness of Choline C 11 as a diagnostic agent.
Choline	Choline magnesium trisalicylate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Choline salicylate	Flutamide may decrease the excretion rate of Choline salicylate which could result in a higher serum level.
Chondroitin sulfate	Flutamide may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level.
Chromic chloride	Flutamide may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
Chromic nitrate	Flutamide may decrease the excretion rate of Chromic nitrate which could result in a higher serum level.
Chromium	Flutamide may decrease the excretion rate of Chromium which could result in a higher serum level.
Chromium gluconate	Flutamide may decrease the excretion rate of Chromium gluconate which could result in a higher serum level.
Chromium nicotinate	Flutamide may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level.

Chromous sulfate	Flutamide may decrease the excretion rate of Chromous sulfate which could result in a higher serum level.
Cidofovir	Cidofovir may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cilostazol	The metabolism of Cilostazol can be decreased when combined with Flutamide.
Cimetidine	The metabolism of Flutamide can be decreased when combined with Cimetidine.
Cinacalcet	The metabolism of Cinacalcet can be decreased when combined with Flutamide.
Cinchocaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Cinchocaine.
Cinnarizine	The metabolism of Cinnarizine can be decreased when combined with Flutamide.
Cinoxacin	The metabolism of Flutamide can be decreased when combined with Cinoxacin.
Ciprofloxacin	The metabolism of Flutamide can be decreased when combined with Ciprofloxacin.
Cisapride	The metabolism of Cisapride can be decreased when combined with Flutamide.
Cisplatin	Flutamide may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Citalopram	The metabolism of Flutamide can be decreased when combined with Citalopram.
Clarithromycin	The metabolism of Flutamide can be decreased when combined with Clarithromycin.
Clevidipine	Flutamide may decrease the excretion rate of Clevidipine which could result in a higher serum level.
Clindamycin	The metabolism of Clindamycin can be decreased when combined with Flutamide.
Clobazam	Clobazam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Clobetasol	The metabolism of Flutamide can be increased when combined with Clobetasol propionate.
Clofarabine	Flutamide may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Clofazimine	The metabolism of Flutamide can be decreased when combined with Clofazimine.
Clomipramine	The metabolism of Clomipramine can be decreased when combined with Flutamide.
Clonazepam	Flutamide may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Clonidine	The metabolism of Clonidine can be decreased when combined with Flutamide.
Clopidogrel	The metabolism of Clopidogrel can be decreased when combined with Flutamide.
Clorazepic acid	Flutamide may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Clove oil	Flutamide may decrease the excretion rate of Clove oil which could result in a higher serum level.
Clozapine	The metabolism of Flutamide can be decreased when combined with Clozapine.
Cobicistat	The metabolism of Flutamide can be decreased when combined with Cobicistat.
Cocaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Cocaine.
Colchicine	Flutamide may decrease the excretion rate of Colchicine which could result in a higher serum level.
Colistimethate	Colistimethate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Colistin	Flutamide may decrease the excretion rate of Colistin which could result in a higher serum level.
Conivaptan	The metabolism of Flutamide can be decreased when combined with Conivaptan.
Conjugated	The metabolism of Flutamide can be decreased when combined with Conjugated estrogens.
Copanlisib	The metabolism of Copanlisib can be decreased when combined with Flutamide.
Corifollitropin alfa	Flutamide may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level.
Cortisone acetate	The metabolism of Flutamide can be increased when combined with Cortisone acetate.
Crizotinib	The metabolism of Crizotinib can be decreased when combined with Flutamide.
Curcumin	The metabolism of Flutamide can be decreased when combined with Curcumin.
Cyanocobalamin	Cyanocobalamin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cyclobenzaprine	The metabolism of Cyclobenzaprine can be decreased when combined with Flutamide.
Cyclopenthiazide	Cyclopenthiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Cyclophosphamide	The metabolism of Cyclophosphamide can be decreased when combined with Flutamide.
Cyclosporine	The metabolism of Cyclosporine can be decreased when combined with Flutamide.
Cyclothiazide	Cyclothiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Cyproterone acetate	The metabolism of Flutamide can be increased when combined with Cyproterone acetate.
Dabigatran etexilate	Flutamide may decrease the excretion rate of Dabigatran etexilate which could result in a higher serum level.
Dabrafenib	The serum concentration of Flutamide can be decreased when it is combined with Dabrafenib.
Dacarbazine	The metabolism of Dacarbazine can be decreased when combined with Flutamide.
Daclatasvir	The metabolism of Daclatasvir can be decreased when combined with Flutamide.
Dalfampridine	Flutamide may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Danazol	The metabolism of Flutamide can be decreased when combined with Danazol.
Dapagliflozin	Dapagliflozin may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Dapsone	The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Flutamide.
Daptomycin	Daptomycin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Darbepoetin alfa	The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Flutamide.
Darunavir	The metabolism of Flutamide can be decreased when combined with Darunavir.
Dasatinib	The metabolism of Dasatinib can be decreased when combined with Flutamide.
Daunorubicin	The metabolism of Flutamide can be increased when combined with Daunorubicin.
Deferasirox	The serum concentration of Flutamide can be increased when it is combined with Deferasirox.
Deferiprone	Flutamide may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Delafloxacin	Flutamide may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Delavirdine	The metabolism of Flutamide can be decreased when combined with Delavirdine.
Desipramine	Flutamide may decrease the excretion rate of Desipramine which could result in a higher serum level.
Desmopressin	Desmopressin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Desvenlafaxine	The metabolism of Flutamide can be decreased when combined with Desvenlafaxine.
Deutetrabenazine	Flutamide may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Dexamethasone	The metabolism of Flutamide can be increased when combined with Dexamethasone.
Dexamethasone	The metabolism of Flutamide can be increased when combined with Dexamethasone acetate.
Dexfenfluramine	The metabolism of Dexfenfluramine can be decreased when combined with Flutamide.
Dexibuprofen	Dexibuprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Dexketoprofen	Dexketoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Dexmedetomidine	The metabolism of Flutamide can be decreased when combined with Dexmedetomidine.
Dexpanthenol	Flutamide may decrease the excretion rate of Dexpanthenol which could result in a higher serum level.
Dexrazoxane	Dexrazoxane may decrease the excretion rate of Flutamide which could result in a higher serum level.
Dextran	Flutamide may decrease the excretion rate of Dextran which could result in a higher serum level.
Dextromethorphan	The metabolism of Dextromethorphan can be decreased when combined with Flutamide.
Diacerein	The metabolism of Flutamide can be decreased when combined with Diacerein.
Diatrizoate	Diatrizoate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Diazepam	Flutamide may decrease the excretion rate of Diazepam which could result in a higher serum level.
Dichlorobenzyl	Flutamide may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Diclofenac	The metabolism of Diclofenac can be decreased when combined with Flutamide.
Diclofenamide	Diclofenamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Dicyclomine	Flutamide may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Didanosine	Flutamide may decrease the excretion rate of Didanosine which could result in a higher serum level.
Dienogest	Flutamide may decrease the excretion rate of Dienogest which could result in a higher serum level.
Diflunisal	Diflunisal may decrease the excretion rate of Flutamide which could result in a higher serum level.
Difluocortolone	The metabolism of Flutamide can be increased when combined with Difluocortolone.
Digoxin	Flutamide may decrease the excretion rate of Digoxin which could result in a higher serum level.
Dihydralazine	The metabolism of Flutamide can be decreased when combined with Dihydralazine.
Dihydrostreptom	Dihydrostreptomycin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Diltiazem	The metabolism of Flutamide can be decreased when combined with Diltiazem.
Dimercaprol	Flutamide may decrease the excretion rate of Dimercaprol which could result in a higher serum level.
Dimethyl sulfoxide	Flutamide may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level.
Diphenhydramine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Diphenhydramine.
Disopyramide	The metabolism of Flutamide can be decreased when combined with Disopyramide.
Disulfiram	The metabolism of Disulfiram can be decreased when combined with Flutamide.
DMethylephedrine	Flutamide may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level.
Dobutamine	Flutamide may decrease the excretion rate of Dobutamine which could result in a higher serum level.
Docetaxel	The metabolism of Docetaxel can be decreased when combined with Flutamide.
Domperidone	The metabolism of Domperidone can be decreased when combined with Flutamide.

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Dopamine	Flutamide may decrease the excretion rate of Dopamine which could result in a higher serum level.
Doravirine	The metabolism of Doravirine can be decreased when combined with Flutamide.
Doripenem	Flutamide may decrease the excretion rate of Doripenem which could result in a higher serum level.
Dosulepin	The metabolism of Flutamide can be decreased when combined with Dosulepin.
Doxacurium	Flutamide may decrease the excretion rate of Doxacurium which could result in a higher serum level.
Doxepin	The metabolism of Doxepin can be decreased when combined with Flutamide.
Doxycycline	Doxycycline may decrease the excretion rate of Flutamide which could result in a higher serum level.
Dronabinol	The metabolism of Flutamide can be decreased when combined with Dronabinol.
Dronedarone	The metabolism of Dronedarone can be decreased when combined with Flutamide.
Drospirenone	Drospirenone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Droxidopa	Flutamide may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Duloxetine	Duloxetine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Dutasteride	The metabolism of Dutasteride can be decreased when combined with Flutamide.
Dyclonine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Dyclonine.
Dyphylline	Flutamide may decrease the excretion rate of Dyphylline which could result in a higher serum level.
Edoxaban	Flutamide may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Edrophonium	Flutamide may decrease the excretion rate of Edrophonium which could result in a higher serum level.
Efavirenz	The metabolism of Flutamide can be decreased when combined with Efavirenz.
Elbasvir	The metabolism of Elbasvir can be decreased when combined with Flutamide.
Elexacaftor	The metabolism of Elexacaftor can be decreased when combined with Flutamide.
Eltrombopag	The metabolism of Eltrombopag can be decreased when combined with Flutamide.
Elvitegravir	The metabolism of Flutamide can be decreased when combined with Elvitegravir.
Emapalumab	The metabolism of Flutamide can be increased when combined with Emapalumab.
Enalaprilat	Flutamide may decrease the excretion rate of Enalaprilat which could result in a higher serum level.
Enasidenib	The metabolism of Flutamide can be decreased when combined with Enasidenib.
Enoxacin	The metabolism of Flutamide can be decreased when combined with Enoxacin.
Entecavir	The metabolism of Flutamide can be decreased when combined with Entecavir.
Enzalutamide	The serum concentration of Flutamide can be decreased when it is combined with Enzalutamide.
Eplerenone	Eplerenone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Epoprostenol	Flutamide may decrease the excretion rate of Epoprostenol which could result in a higher serum level.
Ergotamine	The metabolism of Flutamide can be decreased when combined with Ergotamine.
Erlotinib	The metabolism of Erlotinib can be decreased when combined with Flutamide.
Ertapenem	Ertapenem may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ertugliflozin	Ertugliflozin may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Erythromycin	The metabolism of Flutamide can be decreased when combined with Erythromycin.
Erythropoietin	The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Flutamide.
Estazolam	Flutamide may decrease the excretion rate of Estazolam which could result in a higher serum level.
Estradiol	The metabolism of Estradiol can be decreased when combined with Flutamide.
Estradiol acetate	The metabolism of Flutamide can be decreased when combined with Estradiol acetate.
Estradiol benzoate	The metabolism of Estradiol benzoate can be decreased when combined with Flutamide.
Estradiol cypionate	The metabolism of Estradiol cypionate can be decreased when combined with Flutamide.
Estradiol dienanthate	The metabolism of Estradiol dienanthate can be decreased when combined with Flutamide.
Estradiol valerate	The metabolism of Estradiol valerate can be decreased when combined with Flutamide.
Estrone sulfate	The metabolism of Flutamide can be decreased when combined with Estrone sulfate.
Eszopiclone	Eszopiclone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Etacrynic acid	Etacrynic acid may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Etafedrine	Flutamide may decrease the excretion rate of Etafedrine which could result in a higher serum level.
Etanercept	The metabolism of Flutamide can be increased when combined with Etanercept.
Ethambutol	Ethambutol may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ethanol	The metabolism of Ethanol can be decreased when combined with Flutamide.
Ethinylestradiol	The metabolism of Ethinylestradiol can be decreased when combined with Flutamide.
Ethyl chloride	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Ethyl chloride.
Etidocaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Etidocaine.
Etodolac	Etodolac may decrease the excretion rate of Flutamide which could result in a higher serum level.
Etomidate	Etomidate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Etonogestrel	Etonogestrel may decrease the excretion rate of Flutamide which could result in a higher serum level.
Etoposide	The metabolism of Etoposide can be decreased when combined with Flutamide.
Etoricoxib	The metabolism of Etoricoxib can be decreased when combined with Flutamide.
Eucalyptus oil	Flutamide may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level.
Ezogabine	Flutamide may decrease the excretion rate of Ezogabine which could result in a higher serum level.
Famotidine	The metabolism of Flutamide can be decreased when combined with Famotidine.
Felodipine	The metabolism of Felodipine can be decreased when combined with Flutamide.
Fenbufen	Fenbufen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Fenfluramine	The metabolism of Fenfluramine can be decreased when combined with Flutamide.
Fenofibrate	Flutamide may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Fenofibric acid	Flutamide may decrease the excretion rate of Fenofibric acid which could result in a higher serum level.
Fenoldopam	Flutamide may decrease the excretion rate of Fenoldopam which could result in a higher serum level.
Fenoprofen	Fenoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Fentanyl	Flutamide may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Fesoterodine	Flutamide may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Fexinidazole	The metabolism of Flutamide can be decreased when combined with Fexinidazole.
Finasteride	The metabolism of Finasteride can be decreased when combined with Flutamide.
Finerenone	Finerenone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Flavoxate	Flutamide may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Flecainide	The metabolism of Flecainide can be decreased when combined with Flutamide.
Floctafenine	Floctafenine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Florbetaben (18F)	Flutamide may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level.
Florbetapir (18F)	Flutamide may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level.
Floxuridine	Floxuridine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Fluconazole	The metabolism of Flutamide can be decreased when combined with Fluconazole.
Flucytosine	Flutamide may decrease the excretion rate of Flucytosine which could result in a higher serum level.
Fludeoxyglucose	Flutamide may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Flumazenil	Flutamide may decrease the excretion rate of Flumazenil which could result in a higher serum level.
Flunarizine	The metabolism of Flunarizine can be decreased when combined with Flutamide.
Fluocinolone	Flutamide may decrease the excretion rate of Fluocinolone acetonide which could result in a higher serum level.
Fluocinonide	The metabolism of Flutamide can be increased when combined with Fluocinonide.
Fluocortolone	The metabolism of Flutamide can be increased when combined with Fluocortolone.
Fluorouracil	The metabolism of Fluorouracil can be decreased when combined with Flutamide.
Fluoxetine	The metabolism of Flutamide can be decreased when combined with Fluoxetine.
Flurazepam	Flutamide may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Flurbiprofen	Flurbiprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Fluticasone	The metabolism of Flutamide can be decreased when combined with Fluticasone.
Fluticasone	The metabolism of Flutamide can be decreased when combined with Fluticasone furoate.
Fluticasone	The metabolism of Flutamide can be decreased when combined with Fluticasone propionate.
Fluvastatin	The metabolism of Fluvastatin can be decreased when combined with Flutamide.
Fluvoxamine	The metabolism of Flutamide can be decreased when combined with Fluvoxamine.
Folic acid	Folic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Fomepizole	Flutamide may decrease the excretion rate of Fomepizole which could result in a higher serum level.
Fondaparinux	Flutamide may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Formestane	Flutamide may decrease the excretion rate of Formestane which could result in a higher serum level.

Foscarnet	Foscarnet may decrease the excretion rate of Flutamide which could result in a higher serum level.
Fosfomycin	Flutamide may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Fosinopril	Fosinopril may decrease the excretion rate of Flutamide which could result in a higher serum level.
Fosnetupitant	The metabolism of Flutamide can be decreased when combined with Fosnetupitant.
Fosphenytoin	The metabolism of Flutamide can be increased when combined with Fosphenytoin.
Framycetin	Framycetin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Frovatriptan	The metabolism of Frovatriptan can be decreased when combined with Flutamide.
Furosemide	Furosemide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Fusidic acid	The metabolism of Flutamide can be decreased when combined with Fusidic acid.
Gabapentin	Flutamide may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level.
Gadobenic acid	Flutamide may decrease the excretion rate of Gadobenic acid which could result in a higher serum level.
Gadodiamide	Gadodiamide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Gadofosveset	Flutamide may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Gadopentetic acid	Flutamide may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Gadoteric acid	Flutamide may decrease the excretion rate of Gadoteric acid which could result in a higher serum level.
Gadoteridol	Flutamide may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Gallium	Flutamide may increase effectiveness of Gallium Ga-68 gozetotide as a diagnostic agent.
Ganciclovir	Flutamide may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Gatifloxacin	The metabolism of Flutamide can be decreased when combined with Gatifloxacin.
Gefitinib	The metabolism of Flutamide can be decreased when combined with Gefitinib.
Gemcitabine	Gemcitabine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Gemfibrozil	The metabolism of Flutamide can be decreased when combined with Gemfibrozil.
Gemifloxacin	The metabolism of Flutamide can be decreased when combined with Gemifloxacin.
Gentamicin	Flutamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gimeracil	Flutamide may decrease the excretion rate of Gimeracil which could result in a higher serum level.
Givosiran	The serum concentration of Flutamide can be increased when it is combined with Givosiran.
Glipizide	Flutamide may decrease the excretion rate of Glipizide which could result in a higher serum level.
Glyburide	The metabolism of Glyburide can be decreased when combined with Flutamide.
Glycerol	Flutamide may decrease the excretion rate of Glycerol phenylbutyrate which could result in a higher serum level.
Golimumab	The metabolism of Flutamide can be increased when combined with Golimumab.
Golodirsen	Flutamide may decrease the excretion rate of Golodirsen which could result in a higher serum level.
Goserelin	Goserelin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Grepafloxacin	The metabolism of Flutamide can be decreased when combined with Grepafloxacin.
Guanabenz	The metabolism of Guanabenz can be decreased when combined with Flutamide.
Guanethidine	Flutamide may decrease the excretion rate of Guanethidine which could result in a higher serum level.
Guanfacine	Flutamide may decrease the excretion rate of Guanfacine which could result in a higher serum level.
Halofantrine	The metabolism of Halofantrine can be decreased when combined with Flutamide.
Haloperidol	The serum concentration of Haloperidol can be increased when it is combined with Flutamide.
Hydralazine	Flutamide may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Hydrochlorothiazide	Hydrochlorothiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Hydrocortisone	The metabolism of Hydrocortisone can be decreased when combined with Flutamide.
Hydrocortisone	The metabolism of Hydrocortisone acetate can be decreased when combined with Flutamide.
Hydrocortisone	The metabolism of Hydrocortisone butyrate can be decreased when combined with Flutamide.
Hydrocortisone e	The metabolism of Hydrocortisone cypionate can be decreased when combined with Flutamide.
Hydrocortisone	The metabolism of Hydrocortisone phosphate can be decreased when combined with Flutamide.
Hydroflumethiazide	Hydroflumethiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Hydromorphone	Hydromorphone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Hydroxocobalamin	Hydroxocobalamin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Hydroxyethyl Starch	Flutamide may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Hydroxyprogesterone	The metabolism of Hydroxyprogesterone caproate can be decreased when combined with Flutamide.
Hydroxyurea	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Hydroxyurea.
Hydroxyzine	The metabolism of Hydroxyzine can be decreased when combined with Flutamide.
Ibrutinib	The metabolism of Ibrutinib can be decreased when combined with Flutamide.
Ibuprofen	Ibuprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ibutilide	Ibutilide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Icatibant	Flutamide may decrease the excretion rate of Icatibant which could result in a higher serum level.
Icosapent	Icosapent may decrease the excretion rate of Flutamide which could result in a higher serum level.
Idarucizumab	Flutamide may decrease the excretion rate of Idarucizumab which could result in a higher serum level.
Idebenone	Flutamide may decrease the excretion rate of Idebenone which could result in a higher serum level.
Ifosfamide	The metabolism of Ifosfamide can be decreased when combined with Flutamide.
Iloperidone	The metabolism of Iloperidone can be decreased when combined with Flutamide.
Imatinib	The metabolism of Flutamide can be decreased when combined with Imatinib.
Imipramine	The metabolism of Flutamide can be decreased when combined with Imipramine.
Indapamide	Indapamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Indigotindisulfonic	Flutamide may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level.
Indinavir	The metabolism of Flutamide can be decreased when combined with Indinavir.
Indomethacin	Indomethacin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Infliximab	The metabolism of Flutamide can be increased when combined with Infliximab.
Inosine pranobex	Flutamide may decrease the excretion rate of Inosine pranobex which could result in a higher serum level.
Inositol	Flutamide may decrease the excretion rate of Inositol which could result in a higher serum level.
Inotersen	Inotersen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Insulin beef	The metabolism of Flutamide can be increased when combined with Insulin beef.
Insulin pork	The metabolism of Flutamide can be increased when combined with Insulin pork.
Interferon alfa-2a	The metabolism of Flutamide can be decreased when combined with Interferon alfa-2a.
Interferon alfa-2b	The metabolism of Flutamide can be decreased when combined with Interferon alfa-2b.
Interferon alfa-n1	The metabolism of Flutamide can be decreased when combined with Interferon alfa-n1.
Interferon alfa-n3	The metabolism of Flutamide can be decreased when combined with Interferon alfa-n3.
Interferon alfacon-1	The metabolism of Flutamide can be decreased when combined with Interferon alfacon-1.
Interferon beta-1a	The metabolism of Flutamide can be decreased when combined with Interferon beta-1a.
Interferon beta-1b	The metabolism of Flutamide can be decreased when combined with Interferon beta-1b.
Interferon gamma	The metabolism of Flutamide can be decreased when combined with Interferon gamma-1b.
Iobenguane sulfate	Flutamide may decrease the excretion rate of Iobenguane sulfate I-123 which could result in a higher serum level.
Iodixanol	Flutamide may decrease the excretion rate of Iodixanol which could result in a higher serum level.
Ioflupane I-123	Flutamide may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Iopromide	Flutamide may decrease the excretion rate of Iopromide which could result in a higher serum level.
Iothalamic acid	Flutamide may decrease the excretion rate of Iothalamic acid which could result in a higher serum level.
Ioversol	Flutamide may decrease the excretion rate of Ioversol which could result in a higher serum level.
Ioxilan	Flutamide may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ipecac	Flutamide may decrease the excretion rate of Ipecac which could result in a higher serum level.
Ipilimumab	Flutamide may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Irinotecan	The metabolism of Irinotecan can be decreased when combined with Flutamide.
Isavuconazole	The metabolism of Flutamide can be decreased when combined with Isavuconazole.
Isavuconazonium	The metabolism of Flutamide can be decreased when combined with Isavuconazonium.
Isometheptene	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Isometheptene.
Isoniazid	The metabolism of Flutamide can be decreased when combined with Isoniazid.
Isosorbide	Isosorbide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide dinitrate	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Isosorbide dinitrate.
Isosorbide	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Isosorbide mononitrate.
Isosulfan blue	Flutamide may decrease the excretion rate of Isosulfan blue which could result in a higher serum level.
Isotretinoin	Flutamide may decrease the excretion rate of Isotretinoin which could result in a higher serum level.

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Isoxicam	Isoxicam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Isradipine	The metabolism of Flutamide can be decreased when combined with Isradipine.
Istradefylline	The metabolism of Istradefylline can be decreased when combined with Flutamide.
Itraconazole	The metabolism of Flutamide can be decreased when combined with Itraconazole.
Ivacaftor	The metabolism of Ivacaftor can be decreased when combined with Flutamide.
Ivosidenib	The metabolism of Flutamide can be increased when combined with Ivosidenib.
Ixazomib	Flutamide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Kanamycin	Flutamide may decrease the excretion rate of Kanamycin which could result in a higher serum level.
Ketamine	Flutamide may decrease the excretion rate of Ketamine which could result in a higher serum level.
Ketazolam	Flutamide may decrease the excretion rate of Ketazolam which could result in a higher serum level.
Ketoconazole	The metabolism of Flutamide can be decreased when combined with Ketoconazole.
Ketoprofen	Ketoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ketorolac	Ketorolac may decrease the excretion rate of Flutamide which could result in a higher serum level.
Labetalol	Flutamide may decrease the excretion rate of Labetalol which could result in a higher serum level.
Lamivudine	Flutamide may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Lamotrigine	Flutamide may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Lapatinib	The metabolism of Lapatinib can be decreased when combined with Flutamide.
Latamoxef	Latamoxef may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ledipasvir	Flutamide may decrease the excretion rate of Ledipasvir which could result in a higher serum level.
Leflunomide	The serum concentration of Flutamide can be decreased when it is combined with Leflunomide.
Lemborexant	The metabolism of Lemborexant can be decreased when combined with Flutamide.
Lenalidomide	Lenalidomide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Lercanidipine	The metabolism of Lercanidipine can be decreased when combined with Flutamide.
Lesinurad	Flutamide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Letermovir	The metabolism of Flutamide can be decreased when combined with Letermovir.
Leuprolide	Leuprolide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Levamlodipine	The metabolism of Levamlodipine can be decreased when combined with Flutamide.
Levobupivacaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Levobupivacaine.
Levocarnitine	Flutamide may decrease the excretion rate of Levocarnitine which could result in a higher serum level.
Levocetirizine	Flutamide may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Levofloxacin	Flutamide may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Levoketoconazole	The metabolism of Flutamide can be decreased when combined with Levoketoconazole.
Levomilnacipran	Flutamide may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Levonorgestrel	The metabolism of Flutamide can be decreased when combined with Levonorgestrel.
Levosalbutamol	Flutamide may decrease the excretion rate of Levosalbutamol which could result in a higher serum level.
Lidocaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Lidocaine.
Linagliptin	The metabolism of Flutamide can be decreased when combined with Linagliptin.
Liothyronine	Liothyronine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Lisinopril	Flutamide may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Lithium carbonate	Flutamide may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Lithium citrate	Lithium citrate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Lixisenatide	Flutamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Lofexidine	The metabolism of Lofexidine can be decreased when combined with Flutamide.
Lomefloxacin	The metabolism of Lomefloxacin can be decreased when combined with Flutamide.
Lonafarnib	The metabolism of Flutamide can be decreased when combined with Lonafarnib.
Lonapegsomat	The metabolism of Flutamide can be increased when combined with Lonapegsomatropin.
Lopinavir	The metabolism of Flutamide can be decreased when combined with Lopinavir.
Loracarbef	Loracarbef may decrease the excretion rate of Flutamide which could result in a higher serum level.
Lorazepam	Lorazepam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Lorcaserin	The metabolism of Lorcaserin can be decreased when combined with Flutamide.
Lorlatinib	The metabolism of Lorlatinib can be decreased when combined with Flutamide.
Lornoxicam	Lornoxicam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Lorpiprazole	Flutamide may decrease the excretion rate of Lorpiprazole which could result in a higher serum level.
Lovastatin	The metabolism of Flutamide can be decreased when combined with Lovastatin.
Loxoprofen	Loxoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Lubiprostone	Flutamide may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Lumacaftor	The metabolism of Flutamide can be increased when combined with Lumacaftor.
Lumiracoxib	Lumiracoxib may decrease the excretion rate of Flutamide which could result in a higher serum level.
Macitentan	Flutamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Magnesium carbonate	Flutamide may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
Magnesium chloride	Flutamide may decrease the excretion rate of Magnesium chloride which could result in a higher serum level.
Magnesium	Flutamide may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium	Flutamide may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.
Mangafodipir	Flutamide may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Mannitol	Mannitol may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Maprotiline	The metabolism of Maprotiline can be decreased when combined with Flutamide.
Mavacamten	The serum concentration of Flutamide can be decreased when it is combined with Mavacamten.
Mecamylamine	Flutamide may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
Meclofenamic acid	Meclofenamic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Medroxyprogeste	Flutamide may decrease the excretion rate of Medroxyprogesterone acetate which could result in a higher serum level.
Mefenamic acid	The metabolism of Mefenamic acid can be decreased when combined with Flutamide.
Megestrol acetate	Megestrol acetate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Melatonin	The metabolism of Melatonin can be decreased when combined with Flutamide.
Meloxicam	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Meloxicam.
Memantine	Flutamide may decrease the excretion rate of Memantine which could result in a higher serum level.
Meperidine	Meperidine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Mephenytoin	The metabolism of Mephenytoin can be decreased when combined with Flutamide.
Mepivacaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Mepivacaine.
Meprednisone	The metabolism of Flutamide can be increased when combined with Meprednisone.
Meropenem	Flutamide may decrease the excretion rate of Meropenem which could result in a higher serum level.
Mesalazine	Mesalazine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Metamfetamine	Flutamide may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Metamizole	Metamizole may decrease the excretion rate of Flutamide which could result in a higher serum level.
Metaxalone	Flutamide may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Metformin	Metformin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Methadone	Methadone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Methazolamide	Methazolamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole	The metabolism of Flutamide can be decreased when combined with Methimazole.
Methotrexate	Methotrexate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Methoxsalen	The metabolism of Flutamide can be decreased when combined with Methoxsalen.
Methoxy	The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Flutamide.
Methyldopa	Flutamide may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Methylene blue	The metabolism of Flutamide can be decreased when combined with Methylene blue.
Methylnaltrexone	Flutamide may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Methyltestosterone	Flutamide may decrease the excretion rate of Methyltestosterone which could result in a higher serum level.
Meticrane	Meticrane may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Metoclopramide	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Metoclopramide.
Metolazone	Metolazone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Metoprolol	Metoprolol may decrease the excretion rate of Flutamide which could result in a higher serum level.
Metreleptin	The metabolism of Flutamide can be increased when combined with Metreleptin.

Metronidazole	The metabolism of Metronidazole can be decreased when combined with Flutamide.
Metyrapone	Flutamide may decrease the excretion rate of Metyrapone which could result in a higher serum level.
Mexiletine	The metabolism of Flutamide can be decreased when combined with Mexiletine.
Mianserin	The metabolism of Mianserin can be decreased when combined with Flutamide.
Miconazole	The metabolism of Flutamide can be decreased when combined with Miconazole.
Midazolam	Flutamide may decrease the excretion rate of Midazolam which could result in a higher serum level.
Midostaurin	The metabolism of Flutamide can be decreased when combined with Midostaurin.
Mifepristone	The metabolism of Mifepristone can be decreased when combined with Flutamide.
Migalastat	Flutamide may decrease the excretion rate of Migalastat which could result in a higher serum level.
Milnacipran	The metabolism of Flutamide can be decreased when combined with Milnacipran.
Milrinone	Milrinone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Mirabegron	Flutamide may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Mirtazapine	The metabolism of Flutamide can be decreased when combined with Mirtazapine.
Mitotane	The metabolism of Flutamide can be increased when combined with Mitotane.
Mobocertinib	The metabolism of Mobocertinib can be decreased when combined with Flutamide.
Modafinil	The metabolism of Flutamide can be increased when combined with Modafinil.
Mometasone	The metabolism of Flutamide can be increased when combined with Mometasone furoate.
Moxifloxacin	The metabolism of Flutamide can be decreased when combined with Moxifloxacin.
Moxisylyte	Flutamide may decrease the excretion rate of Moxisylyte which could result in a higher serum level.
Muzolimine	Muzolimine may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Mycophenolate	Flutamide may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level.
Mycophenolic acid	Flutamide may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
N-acetyltyrosine	Flutamide may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Nabumetone	The metabolism of Flutamide can be decreased when combined with Nabumetone.
Nadolol	Flutamide may decrease the excretion rate of Nadolol which could result in a higher serum level.
Nafcillin	The metabolism of Flutamide can be increased when combined with Nafcillin.
Naldemedine	Flutamide may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Nalidixic acid	The metabolism of Flutamide can be decreased when combined with Nalidixic acid.
Nalmefene	Flutamide may decrease the excretion rate of Nalmefene which could result in a higher serum level.
Naloxone	The metabolism of Flutamide can be decreased when combined with Naloxone.
Naproxen	The metabolism of Naproxen can be decreased when combined with Flutamide.
Nateglinide	Flutamide may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Nedaplatin	Flutamide may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Nedocromil	Flutamide may decrease the excretion rate of Nedocromil which could result in a higher serum level.
Nefazodone	The metabolism of Flutamide can be decreased when combined with Nefazodone.
Nelfinavir	The metabolism of Flutamide can be decreased when combined with Nelfinavir.
Neomycin	Flutamide may decrease the excretion rate of Neomycin which could result in a higher serum level.
Netilmicin	Flutamide may decrease the excretion rate of Netilmicin which could result in a higher serum level.
Netupitant	The metabolism of Flutamide can be decreased when combined with Netupitant.
Nevirapine	The metabolism of Flutamide can be decreased when combined with Nevirapine.
Nicardipine	The metabolism of Flutamide can be decreased when combined with Nicardipine.
Niclosamide	The metabolism of Flutamide can be decreased when combined with Niclosamide.
Nicorandil	Flutamide may decrease the excretion rate of Nicorandil which could result in a higher serum level.
Nifedipine	The metabolism of Nifedipine can be decreased when combined with Flutamide.
Nilotinib	The metabolism of Flutamide can be decreased when combined with Nilotinib.
Nilutamide	Flutamide may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Nilvadipine	The metabolism of Flutamide can be decreased when combined with Nilvadipine.
Nimesulide	Nimesulide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Nisoldipine	Nisoldipine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Nitrendipine	The metabolism of Nitrendipine can be decreased when combined with Flutamide.
Nitric Oxide	The risk or severity of methemoglobinemia can be increased when Nitric Oxide is combined with Flutamide.
Nitrofurantoin	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Nitrofurantoin.
Nitroglycerin	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Nitroglycerin.
Nitroprusside	The risk or severity of methemoglobinemia can be increased when Nitroprusside is combined with Flutamide.
Nitrous oxide	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Nitrous oxide.
Norethisterone	The metabolism of Norethisterone can be decreased when combined with Flutamide.
Norfloxacin	The metabolism of Flutamide can be decreased when combined with Norfloxacin.
Obeticholic acid	The metabolism of Flutamide can be decreased when combined with Obeticholic acid.
Octinoxate	Flutamide may decrease the excretion rate of Octinoxate which could result in a higher serum level.
Olanzapine	The metabolism of Flutamide can be decreased when combined with Olanzapine.
Olaparib	The metabolism of Olaparib can be decreased when combined with Flutamide.
Olsalazine	Olsalazine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Omeprazole	The metabolism of Flutamide can be increased when combined with Omeprazole.
Ondansetron	The metabolism of Ondansetron can be decreased when combined with Flutamide.
Opium	Flutamide may decrease the excretion rate of Opium which could result in a higher serum level.
Orphenadrine	The metabolism of Flutamide can be decreased when combined with Orphenadrine.
Oseltamivir	Oseltamivir may decrease the excretion rate of Flutamide which could result in a higher serum level.
Osilodrostat	The metabolism of Flutamide can be decreased when combined with Osilodrostat.
Osimertinib	The serum concentration of Flutamide can be decreased when it is combined with Osimertinib.
Oxacillin	Flutamide may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Oxaprozin	Oxaprozin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Oxazepam	Flutamide may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Oxcarbazepine	The metabolism of Flutamide can be increased when combined with Oxcarbazepine.
Oxetacaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Oxetacaine.
Oxtriphylline	The metabolism of Oxtriphylline can be decreased when combined with Flutamide.
Oxybenzone	Flutamide may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
Oxybuprocaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Oxybuprocaine.
Oxybutynin	The metabolism of Oxybutynin can be decreased when combined with Flutamide.
Oxycodone	The metabolism of Flutamide can be decreased when combined with Oxycodone.
Oxyphenbutazone	Oxyphenbutazone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Oxyquinoline	Flutamide may decrease the excretion rate of Oxyquinoline which could result in a higher serum level.
Paclitaxel	The metabolism of Paclitaxel can be decreased when combined with Flutamide.
Pacritinib	The metabolism of Flutamide can be decreased when combined with Pacritinib.
Paliperidone	Flutamide may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Palonosetron	Palonosetron may decrease the excretion rate of Flutamide which could result in a higher serum level.
Pamidronic acid	Pamidronic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Pantoprazole	Pantoprazole may decrease the excretion rate of Flutamide which could result in a higher serum level.
Parecoxib	Parecoxib may decrease the excretion rate of Flutamide which could result in a higher serum level.
Paritaprevir	The metabolism of Paritaprevir can be decreased when combined with Flutamide.
Paromomycin	Paromomycin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Paroxetine	The metabolism of Paroxetine can be decreased when combined with Flutamide.
Patent Blue	Flutamide may decrease the excretion rate of Patent Blue which could result in a higher serum level.
Pazopanib	The metabolism of Pazopanib can be decreased when combined with Flutamide.
Pefloxacin	The metabolism of Flutamide can be decreased when combined with Pefloxacin.
Pegaptanib	Flutamide may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Peginesatide	The risk or severity of Thrombosis can be increased when Peginesatide is combined with Flutamide.
Peginterferon alfa	The metabolism of Flutamide can be decreased when combined with Peginterferon alfa-2a.
Peginterferon alfa	The serum concentration of Flutamide can be increased when it is combined with Peginterferon alfa-2b.
Pemetrexed	Flutamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Penbutolol	Flutamide may decrease the excretion rate of Penbutolol which could result in a higher serum level.

Penciclovir	The metabolism of Flutamide can be decreased when combined with Penciclovir.
Pentaerythritol	Flutamide may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level.
Pentamidine	Pentamidine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Pentastarch	Flutamide may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Pentetic acid	Flutamide may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Pentobarbital	The metabolism of Flutamide can be increased when combined with Pentobarbital.
Pentostatin	Flutamide may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Pentoxifylline	The metabolism of Pentoxifylline can be decreased when combined with Flutamide.
Perampanel	The metabolism of Perampanel can be decreased when combined with Flutamide.
Perindopril	Flutamide may decrease the excretion rate of Perindopril which could result in a higher serum level.
Permethrin	Flutamide may decrease the excretion rate of Permethrin which could result in a higher serum level.
Perphenazine	The metabolism of Perphenazine can be decreased when combined with Flutamide.
Phenazopyridine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Phenazopyridine.
Phenelzine	Flutamide may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Phenobarbital	The metabolism of Flutamide can be increased when combined with Phenobarbital.
Phenol	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Phenol.
Phentolamine	Flutamide may decrease the excretion rate of Phentolamine which could result in a higher serum level.
Phenylbutazone	Phenylbutazone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Phenylephrine	The metabolism of Flutamide can be increased when combined with Phenylephrine.
Phenytoin	The metabolism of Flutamide can be increased when combined with Phenytoin.
Pholcodine	Flutamide may decrease the excretion rate of Pholcodine which could result in a higher serum level.
Phosphoric acid	Flutamide may decrease the excretion rate of Phosphoric acid which could result in a higher serum level.
Phylloquinone	Flutamide may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Picosulfuric acid	Flutamide may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level.
Piflufolastat F 18	Flutamide may decrease effectiveness of Piflufolastat F 18 as a diagnostic agent.
Pimozide	The metabolism of Pimozide can be decreased when combined with Flutamide.
Pindolol	Flutamide may decrease the excretion rate of Pindolol which could result in a higher serum level.
Piperacillin	Piperacillin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Piracetam	Flutamide may decrease the excretion rate of Piracetam which could result in a higher serum level.
Piretanide	Piretanide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Pirfenidone	The metabolism of Pirfenidone can be decreased when combined with Flutamide.
Piroxicam	Piroxicam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Pitolisant	The serum concentration of Flutamide can be decreased when it is combined with Pitolisant.
Plazomicin	Flutamide may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Plerixafor	Flutamide may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Polythiazide	Polythiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Pomalidomide	The metabolism of Pomalidomide can be decreased when combined with Flutamide.
Ponatinib	The metabolism of Ponatinib can be decreased when combined with Flutamide.
Ponesimod	The metabolism of Ponesimod can be decreased when combined with Flutamide.
Posaconazole	The metabolism of Flutamide can be decreased when combined with Posaconazole.
Potassium	Potassium may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Potassium acetate	Flutamide may decrease the excretion rate of Potassium acetate which could result in a higher serum level.
Potassium	Flutamide may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level.
Potassium cation	Potassium cation may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Potassium chloride	Flutamide may decrease the excretion rate of Potassium chloride which could result in a higher serum level.
Potassium citrate	Potassium citrate may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Potassium nitrate	Flutamide may decrease the excretion rate of Potassium nitrate which could result in a higher serum level.
Potassium	Flutamide may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level.
Potassium sulfate	Flutamide may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
Pralatrexate	Flutamide may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Pralidoxime	Flutamide may decrease the excretion rate of Pralidoxime which could result in a higher serum level.
Pralsetinib	The metabolism of Flutamide can be decreased when combined with Pralsetinib.
Pramipexole	Pramipexole may decrease the excretion rate of Flutamide which could result in a higher serum level.
Pramocaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Pramocaine.
Prasugrel	Flutamide may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Praziquantel	The metabolism of Praziquantel can be decreased when combined with Flutamide.
Prednisolone	The metabolism of Flutamide can be increased when combined with Prednisolone phosphate.
Prednisone	Flutamide may decrease the excretion rate of Prednisone which could result in a higher serum level.
Prednisone	The metabolism of Flutamide can be increased when combined with Prednisone acetate.
Pregabalin	Pregabalin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Prilocaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Prilocaine.
Primaquine	The metabolism of Flutamide can be decreased when combined with Primaquine.
Primidone	The metabolism of Flutamide can be increased when combined with Primidone.
Probenecid	Flutamide may decrease the excretion rate of Probenecid which could result in a higher serum level.
Procainamide	Flutamide may decrease the excretion rate of Procainamide which could result in a higher serum level.
Procaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Procaine.
Procaine	Flutamide may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Progesterone	The metabolism of Flutamide can be decreased when combined with Progesterone.
Promazine	The metabolism of Flutamide can be decreased when combined with Promazine.
Promethazine	Flutamide may decrease the excretion rate of Promethazine which could result in a higher serum level.
Propafenone	The metabolism of Flutamide can be decreased when combined with Propafenone.
Propantheline	Flutamide may decrease the excretion rate of Propantheline which could result in a higher serum level.
Proparacaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Proparacaine.
Propiverine	Flutamide may decrease the excretion rate of Propiverine which could result in a higher serum level.
Propoxycaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Propoxycaine.
Propranolol	The metabolism of Propranolol can be decreased when combined with Flutamide.
Prucalopride	Flutamide may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Pyrantel	Flutamide may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Pyrazinamide	Pyrazinamide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Pyridoxine	Pyridoxine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Pyrithione	Flutamide may decrease the excretion rate of Pyrithione which could result in a higher serum level.
Quetiapine	Flutamide may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Quinethazone	Quinethazone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Quinidine	The metabolism of Flutamide can be decreased when combined with Quinidine.
Quinine	The risk or severity of methemoglobinemia can be increased when Quinine is combined with Flutamide.
Rabeprazole	Flutamide may decrease the excretion rate of Rabeprazole which could result in a higher serum level.
Ramelteon	The metabolism of Ramelteon can be decreased when combined with Flutamide.
Ranitidine	The metabolism of Ranitidine can be decreased when combined with Flutamide.
Ranolazine	Ranolazine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Rasagiline	The metabolism of Rasagiline can be decreased when combined with Flutamide.
Rasburicase	The risk or severity of methemoglobinemia can be increased when Rasburicase is combined with Flutamide.
Relugolix	The metabolism of Relugolix can be decreased when combined with Flutamide.
Reserpine	The metabolism of Flutamide can be increased when combined with Reserpine.
Resorcinol	Flutamide may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ribavirin	Flutamide may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Ribociclib	The metabolism of Flutamide can be decreased when combined with Ribociclib.
Ribostamycin	Flutamide may decrease the excretion rate of Ribostamycin which could result in a higher serum level.
Rifampicin	The metabolism of Flutamide can be increased when combined with Rifampicin.
Rifamycin	The metabolism of Flutamide can be increased when combined with Rifamycin.
Rifapentine	The metabolism of Flutamide can be increased when combined with Rifapentine.

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Rilonacept	The metabolism of Flutamide can be increased when combined with Rilonacept.
Riluzole	The metabolism of Riluzole can be decreased when combined with Flutamide.
Risperidone	The metabolism of Risperidone can be decreased when combined with Flutamide.
Ritonavir	The serum concentration of Flutamide can be increased when it is combined with Ritonavir.
Rivaroxaban	Flutamide may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Rizatriptan	Flutamide may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Rofecoxib	The metabolism of Flutamide can be decreased when combined with Rofecoxib.
Roflumilast	The metabolism of Roflumilast can be decreased when combined with Flutamide.
Romidepsin	The metabolism of Romidepsin can be decreased when combined with Flutamide.
Ropeginterferon	The metabolism of Flutamide can be decreased when combined with Ropeginterferon alfa-2b.
Ropivacaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Ropivacaine.
Rosiglitazone	Rosiglitazone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Rosoxacin	The metabolism of Flutamide can be decreased when combined with Rosoxacin.
Rosuvastatin	The metabolism of Rosuvastatin can be decreased when combined with Flutamide.
Rucaparib	The metabolism of Flutamide can be decreased when combined with Rucaparib.
Ruxolitinib	Flutamide may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Sacubitril	Flutamide may decrease the excretion rate of Sacubitril which could result in a higher serum level.
Salbutamol	Flutamide may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Salicylamide	Salicylamide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Salicylic acid	Salicylic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Salmeterol	The metabolism of Salmeterol can be decreased when combined with Flutamide.
Salmon	Salmon calcitonin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Salsalate	Salsalate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Saquinavir	The metabolism of Flutamide can be decreased when combined with Saquinavir.
Satralizumab	The serum concentration of Flutamide can be decreased when it is combined with Satralizumab.
Saxagliptin	Flutamide may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Secobarbital	Secobarbital may decrease the excretion rate of Flutamide which could result in a higher serum level.
Secukinumab	The metabolism of Flutamide can be increased when combined with Secukinumab.
Selegiline	The metabolism of Selegiline can be decreased when combined with Flutamide.
Selenious acid	Flutamide may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Selenium	Flutamide may decrease the excretion rate of Selenium which could result in a higher serum level.
Selumetinib	The metabolism of Selumetinib can be decreased when combined with Flutamide.
Sibutramine	Flutamide may decrease the excretion rate of Sibutramine which could result in a higher serum level.
Sildenafil	The metabolism of Flutamide can be decreased when combined with Sildenafil.
Siltuximab	The metabolism of Flutamide can be increased when combined with Siltuximab.
Simeprevir	The metabolism of Flutamide can be decreased when combined with Simeprevir.
Simvastatin	The metabolism of Simvastatin can be decreased when combined with Flutamide.
Sirolimus	The metabolism of Sirolimus can be decreased when combined with Flutamide.
Sitagliptin	Flutamide may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Sodium acetate	Flutamide may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
Sodium	Flutamide may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Sodium fluoride	Flutamide may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
Sodium sulfate	Flutamide may decrease the excretion rate of Sodium sulfate which could result in a higher serum level.
Sofosbuvir	Flutamide may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Solriamfetol	Flutamide may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Somapacitan	The metabolism of Flutamide can be increased when combined with Somapacitan.
Somatotropin	The metabolism of Flutamide can be increased when combined with Somatotropin.
Somatrem	The metabolism of Flutamide can be increased when combined with Somatrem.
Somatrogon	The metabolism of Flutamide can be increased when combined with Somatrogon.
Sorafenib	The metabolism of Sorafenib can be decreased when combined with Flutamide.
Sorbitol	Flutamide may decrease the excretion rate of Sorbitol which could result in a higher serum level.
Sotorasib	The serum concentration of Flutamide can be decreased when it is combined with Sotorasib.
Spironolactone	Spironolactone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
St. John’s Wort	The metabolism of Flutamide can be increased when combined with St. John’s Wort.
Stiripentol	The metabolism of Flutamide can be decreased when combined with Stiripentol.
Streptomycin	Flutamide may decrease the excretion rate of Streptomycin which could result in a higher serum level.
Strontium chloride	Flutamide may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Sucralfate	Sucralfate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Sulbactam	Flutamide may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Sulfadiazine	The risk or severity of methemoglobinemia can be increased when Sulfadiazine is combined with Flutamide.
Sulfamethoxazole	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Sulfamethoxazole.
Sulfapyridine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Sulfapyridine.
Sulfasalazine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Sulfasalazine.
Sulindac	Sulindac may decrease the excretion rate of Flutamide which could result in a higher serum level.
Sumatriptan	Flutamide may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Sunitinib	The metabolism of Sunitinib can be decreased when combined with Flutamide.
S Estrogens, A	Flutamide may decrease the excretion rate of Synthetic Conjugated Estrogens, A which could result in a higher serum level.
S Estrogens, B	Flutamide may decrease the excretion rate of Synthetic Conjugated Estrogens, B which could result in a higher serum level.
Tacrine	The metabolism of Flutamide can be decreased when combined with Tacrine.
Tacrolimus	The metabolism of Tacrolimus can be decreased when combined with Flutamide.
Tadalafil	Flutamide may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Tamoxifen	The metabolism of Tamoxifen can be decreased when combined with Flutamide.
Tamsulosin	Flutamide may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Tasimelteon	The metabolism of Tasimelteon can be decreased when combined with Flutamide.
Technetium	Flutamide may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level.
Technetium	Flutamide may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Technetium	Flutamide may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level.
Technetium	Flutamide may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level.
Teduglutide	Flutamide may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tegafur	The metabolism of Tegafur can be decreased when combined with Flutamide.
Tegaserod	The metabolism of Flutamide can be decreased when combined with Tegaserod.
Telaprevir	The metabolism of Flutamide can be decreased when combined with Telaprevir.
Telavancin	Flutamide may decrease the excretion rate of Telavancin which could result in a higher serum level.
Telithromycin	The metabolism of Flutamide can be decreased when combined with Telithromycin.
Telotristat ethyl	The serum concentration of Flutamide can be decreased when it is combined with Telotristat ethyl.
Temazepam	Temazepam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Temozolomide	Flutamide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Temsirolimus	The metabolism of Temsirolimus can be decreased when combined with Flutamide.
Teniposide	The metabolism of Teniposide can be decreased when combined with Flutamide.
Tenofovir	The serum concentration of Tenofovir alafenamide can be increased when it is combined with Flutamide.
Tenofovir	Tenofovir disoproxil may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tenoxicam	Tenoxicam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Terbinafine	The metabolism of Terbinafine can be decreased when combined with Flutamide.
Terbutaline	Flutamide may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Terfenadine	The metabolism of Flutamide can be decreased when combined with Terfenadine.
Teriflunomide	The serum concentration of Flutamide can be decreased when it is combined with Teriflunomide.
Testolactone	Flutamide may decrease the excretion rate of Testolactone which could result in a higher serum level.
Testosterone	Flutamide may decrease the excretion rate of Testosterone which could result in a higher serum level.

Tetracaine	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Tetracaine.
Tetracycline	Flutamide may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Tetradecyl	Flutamide may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level.
Tezacaftor	The metabolism of Tezacaftor can be decreased when combined with Flutamide.
Thalidomide	The metabolism of Flutamide can be increased when combined with Thalidomide.
Theophylline	The metabolism of Flutamide can be decreased when combined with Theophylline.
Thiabendazole	The metabolism of Flutamide can be decreased when combined with Thiabendazole.
Thiethylperazine	Thiethylperazine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Thiothixene	The metabolism of Thiothixene can be decreased when combined with Flutamide.
Tiaprofenic acid	Tiaprofenic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ticagrelor	The metabolism of Ticagrelor can be decreased when combined with Flutamide.
Ticlopidine	The metabolism of Flutamide can be decreased when combined with Ticlopidine.
Tiludronic acid	Flutamide may decrease the excretion rate of Tiludronic acid which could result in a higher serum level.
Timolol	Timolol may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tinidazole	Flutamide may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Tiopronin	Flutamide may decrease the excretion rate of Tiopronin which could result in a higher serum level.
Tiotropium	Flutamide may decrease the excretion rate of Tiotropium which could result in a higher serum level.
Tipranavir	The metabolism of Flutamide can be decreased when combined with Tipranavir.
Tirofiban	Flutamide may decrease the excretion rate of Tirofiban which could result in a higher serum level.
Tixocortol	Flutamide may decrease the excretion rate of Tixocortol which could result in a higher serum level.
Tizanidine	The metabolism of Tizanidine can be decreased when combined with Flutamide.
Tobramycin	Flutamide may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Tocainide	The metabolism of Tocainide can be decreased when combined with Flutamide.
Tocilizumab	The metabolism of Flutamide can be increased when combined with Tocilizumab.
Tocopherol	Flutamide may decrease the excretion rate of Tocopherol which could result in a higher serum level.
Tolazamide	Flutamide may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Tolbutamide	Flutamide may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolcapone	Tolcapone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tolfenamic acid	Tolfenamic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tolmetin	Tolmetin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tolterodine	Flutamide may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Tolvaptan	Tolvaptan may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Topiramate	Topiramate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Topotecan	Flutamide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Torasemide	Torasemide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Tositumomab	Tositumomab may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tramadol	Tramadol may decrease the excretion rate of Flutamide which could result in a higher serum level.
Trametinib	Flutamide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Trastuzumab	The metabolism of Trastuzumab emtansine can be decreased when combined with Flutamide.
Trazodone	The metabolism of Trazodone can be decreased when combined with Flutamide.
Tretinoin	The metabolism of Tretinoin can be decreased when combined with Flutamide.
Triamcinolone	The metabolism of Flutamide can be increased when combined with Triamcinolone.
Triamterene	Triamterene may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Triazolam	Flutamide may decrease the excretion rate of Triazolam which could result in a higher serum level.
Trichlormethiazide	Trichlormethiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Triclabendazole	The metabolism of Flutamide can be decreased when combined with Triclabendazole.
Triethylenetetra	Flutamide may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level.
Trifluoperazine	The metabolism of Trifluoperazine can be decreased when combined with Flutamide.
Trifluridine	Trifluridine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Trilaciclib	The metabolism of Flutamide can be increased when combined with Trilaciclib.
Trimebutine	Flutamide may decrease the excretion rate of Trimebutine which could result in a higher serum level.
Trimethoprim	Trimethoprim may decrease the excretion rate of Flutamide which could result in a higher serum level.
Trimetrexate	Flutamide may decrease the excretion rate of Trimetrexate which could result in a higher serum level.
Troglitazone	The metabolism of Flutamide can be decreased when combined with Troglitazone.
Troleandomycin	The metabolism of Flutamide can be decreased when combined with Troleandomycin.
Tropisetron	Flutamide may decrease the excretion rate of Tropisetron which could result in a higher serum level.
Trovafloxacin	The metabolism of Flutamide can be decreased when combined with Trovafloxacin.
Tucatinib	The metabolism of Tucatinib can be decreased when combined with Flutamide.
Udenafil	The metabolism of Udenafil can be decreased when combined with Flutamide.
Vaborbactam	Flutamide may decrease the excretion rate of Vaborbactam which could result in a higher serum level.
Valaciclovir	Valaciclovir may decrease the excretion rate of Flutamide which could result in a higher serum level.
Valbenazine	Flutamide may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Valdecoxib	Valdecoxib may decrease the excretion rate of Flutamide which could result in a higher serum level.
Valganciclovir	Flutamide may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Valproic acid	The risk or severity of methemoglobinemia can be increased when Valproic acid is combined with Flutamide.
Vancomycin	Flutamide may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Vardenafil	The metabolism of Vardenafil can be decreased when combined with Flutamide.
Varenicline	Flutamide may decrease the excretion rate of Varenicline which could result in a higher serum level.
Vemurafenib	The serum concentration of Flutamide can be increased when it is combined with Vemurafenib.
Venetoclax	The metabolism of Flutamide can be decreased when combined with Venetoclax.
Venlafaxine	Venlafaxine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Verapamil	The metabolism of Flutamide can be decreased when combined with Verapamil.
Vilanterol	Flutamide may decrease the excretion rate of Vilanterol which could result in a higher serum level.
Viloxazine	The metabolism of Flutamide can be decreased when combined with Viloxazine.
Vincristine	The metabolism of Vincristine can be decreased when combined with Flutamide.
Vonoprazan	The metabolism of Vonoprazan can be decreased when combined with Flutamide.
Voriconazole	The metabolism of Flutamide can be decreased when combined with Voriconazole.
Vortioxetine	Flutamide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Voxilaprevir	The metabolism of Voxilaprevir can be decreased when combined with Flutamide.
Warfarin	Flutamide may decrease the excretion rate of Warfarin which could result in a higher serum level.
Zaleplon	Flutamide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Zanamivir	Flutamide may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Zileuton	The metabolism of Flutamide can be decreased when combined with Zileuton.
Zimelidine	The metabolism of Flutamide can be decreased when combined with Zimelidine.
Ziprasidone	The metabolism of Flutamide can be decreased when combined with Ziprasidone.
Zolmitriptan	The metabolism of Flutamide can be decreased when combined with Zolmitriptan.
Zolpidem	The metabolism of Flutamide can be decreased when combined with Zolpidem.
Zonisamide	Zonisamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Zopiclone	The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Zopiclone.
Zotepine	The metabolism of Zotepine can be decreased when combined with Flutamide.

Pregnancy and Lactation

FDA Pregnancy Category D

Pregnancy

There was decreased 24-hour survival in the offspring of pregnant rats treated with flutamide at doses of 30, 100, or 200 mg/kg/day (approximately 3, 9, and 19 times the human dose). A slight increase in minor variations in the development of the sternebrae and vertebrae was seen in fetuses of rats treated with two higher doses. Feminization of the male rats also occurred at the two higher dose levels. There was a decreased survival rate in the offspring of rabbits receiving the highest dose (15 mg/kg/day, equal to 1.4 times the human dose).

Lactation

This drug is not indicated for use in females.
Excreted into human milk: Unknown
Excreted into animal milk: Data not available
The effects in the nursing infant are unknown.

How should this medicine be used?

Flutamide comes as a capsule to take by mouth. It is usually taken with or without food every 8 hours (three times a day.) Take flutamide at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take flutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take flutamide along with the LHRH agonist treatment even if you feel well. Do not stop taking either medication without talking to your doctor. Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

What special precautions should I follow?

Before taking flutamide,

tell your doctor and pharmacist if you are allergic to flutamide or any other medications.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention anticoagulants (”blood thinners”) such as warfarin (Coumadin).
tell your doctor if you smoke and if you have or have ever had any inherited blood diseases such as glucose-6-phosphate dehydrogenase (G-6-PD) deficiency or hemoglobin M disease.
you should know that flutamide is only for use in men. If taken by pregnant women, flutamide can harm the fetus. Women who are or may become pregnant should not take flutamide. If you take flutamide while you are pregnant, call your doctor.
ask your doctor about the safe use of alcoholic beverages while you are taking flutamide. Flutamide may cause facial flushing, and drinking alcohol can make it worse.

References