Flutamide – Uses, Dosage, Side Effects, Interaction Flutamide is an Androgen Receptor Inhibitor. The mechanism of action of flutamide is as an Androgen Receptor Antagonist. Flutamide is a nonsteroidal antiandrogen that acts by binding to and blocking intracellular androgen receptors in target tissues including testes, prostate, skin, and hair follicles. Flutamide is frequently associated with minor serum aminotransferase elevations and has been linked to numerous cases of acute liver injury, which are frequently severe and can be fatal. Flutamide is a monocarboxylic acid amide and a member of (trifluoromethyl)benzenes. It has a role as an androgen antagonist and an antineoplastic agent. Flutamide is a nonsteroidal antiandrogen (NSAA) that is used primarily to treat prostate cancer. It is also used in the treatment of androgen-dependent conditions like acne, excessive hair growth, and high androgen levels in women.[rx] It is taken by mouth, usually three times per day Mechanism of Action Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition, Flutamide is a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen. Flutamide is a nonsteroidal antiandrogen. In animal studies, flutamide demonstrates potent antiandrogenic effects. It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting the nuclear binding of androgen in target tissues or both. Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g. castration. Elevations of plasma testosterone and estradiol levels have been noted following flutamide administration. Indications For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate Flutamide is a nonsteroidal antiandrogen that acts by binding to and blocking intracellular androgen receptors in target tissues including testes, prostate, skin, and hair follicles. Flutamide is approved to treat: Prostate cancer that may be locally advanced or has metastasized (spread to other parts of the body). It is used with a type of drug called a luteinizing hormone-releasing hormone agonist. Flutamide is also being studied in the treatment of other conditions and types of cancer. Antineoplastic agents are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on the removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias Flutamide has been used in case reports to decrease the frequency of spontaneous orgasms, for instance in men with post-orgasmic illness syndrome Flutamide has been researched and used extensively in the treatment of androgen-dependent skin and hair conditions in women including acne, seborrhea, hirsutism, and scalp hair loss, as well as in hyperandrogenism (e.g., in polycystic ovary syndrome or congenital adrenal hyperplasia), and is effective in improving the symptoms of these conditions. Flutamide has been found to be effective in the treatment of acne and seborrhea in women in a number of studies.[rx][rx] In a long-term study of 230 women with acne, 211 of whom also had seborrhea, very-low-dose flutamide alone or in combination with an oral contraceptive caused a marked decrease in acne and seborrhea after 6 months of treatment, with maximal effect by 1 year of treatment and benefits maintained in the years thereafter Flutamide has been found to be effective in the treatment of hirsutism (excessive body/facial hair growth) in numerous studies.[rx][rx] It possesses moderate effectiveness for this indication, and the overall quality of the evidence is considered to be moderate Flutamide has been found to be effective in the treatment of female pattern hair loss in a number of studies. In one study of 101 pre- and postmenopausal women, flutamide alone or in combination with an oral contraceptive produced a marked decrease in hair loss scores after 1 year of treatment, with maximum effect after 2 years of treatment and benefits maintained for another 2 years Use in Cancer Flutamide is approved to treat: Prostate cancer that may be locally advanced or has metastasized (spread to other parts of the body). It is used with a type of drug called a luteinizing hormone-releasing hormone agonist. Flutamide is also being studied in the treatment of other conditions and types of cancer. Contraindications glucose-6-phosphate dehydrogenase (G6PD) deficiency deficiency of the blood enzyme cytochrome b5 reductase methemoglobinemia, a type of blood disorder liver failure liver problems severe liver disease high amount of bilirubin in the blood abnormal liver function tests pregnancy a patient who is producing milk and breastfeeding anemia from pyruvate kinase and G6PD deficiencies Dosage Strengths: 125 mg, 250 mg Prostate Cancer 250 mg orally every 8 hours This drug may be taken with or without food. Stage B2-C Prostatic Carcinoma: Treatment with this drug and the goserelin acetate implant starts 8 weeks prior to initiating radiation therapy and continues during radiation therapy. Stage D2 Metastatic Carcinoma: This drug should be initiated with the LHRH-agonist and continued until progression. Locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate Side Effects The Most Common diarrhea nausea vomiting loss of appetite hot flashes decrease in sexual ability or desire breast enlargement in men drowsiness confusion depression anxiety swelling of the hands, feet, ankles, or lower legs blue-green or orange-colored urine nausea, upper stomach pain, loss of appetite; itching, tiredness, flu-like symptoms; dark urine, clay-colored stools; or jaundice (yellowing of the skin or eyes). breast swelling or tenderness; hot flashes; vomiting, nausea, diarrhea; or impotence, loss of interest in sex. More common Black, tarry stools bloody or cloudy urine continuing diarrhea continuing stomach pain difficult, burning, or painful urination frequent urge to urinate pale skin troubled breathing with exertion unusual bleeding or bruising unusual tiredness or weakness appetite changes constipation diarrhea dizziness drowsiness headache hot flashes impotence nausea indigestion nervousness reduction in sexual desire sleeping problems swelling of breasts with pain or tenderness vomiting Rare Blurred vision chest pain chills cough difficulty with breathing dizziness drowsiness fever headache nervousness pounding in the ears shortness of breath slow or fast heartbeat sore throat sores, ulcers, or white spots on the lips or in the mouth swelling swollen glands Abdominal or stomach pain clay-colored stools dark urine general tiredness and weakness itching light-colored stools loss of appetite nausea and vomiting rash tumor unpleasant breath odor upper right abdominal pain vomiting of blood yellow eyes and skin Back, leg, or stomach pains bleeding gums blistering, peeling, or loosening of the skin bluish-colored lips, fingernails, or palms discoloration of the urine dizziness or lightheadedness flushing or redness of the skin general body swelling headache itching joint or muscle pain nosebleeds rapid heart rate red irritated eyes red skin lesions, often with a purple center unusually warm skin Drug interaction DRUG INTERACTION Abacavir Flutamide may decrease the excretion rate of Abacavir which could result in a higher serum level. Abametapir The serum concentration of Flutamide can be increased when it is combined with Abametapir. Abatacept The metabolism of Flutamide can be increased when combined with Abatacept. Abiraterone The serum concentration of Flutamide can be increased when it is combined with Abiraterone. Acalabrutinib The metabolism of Flutamide can be decreased when combined with Acalabrutinib. Aceclofenac Aceclofenac may decrease the excretion rate of Flutamide which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Flutamide which could result in a higher serum level. Acenocoumarol The metabolism of Acenocoumarol can be decreased when combined with Flutamide. Acetaminophen The risk or severity of methemoglobinemia can be increased when Acetaminophen is combined with Flutamide. Acetazolamide Acetazolamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Acetylsalicylic Acetylsalicylic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. Aclidinium Flutamide may decrease the excretion rate of Aclidinium which could result in a higher serum level. Acrivastine Flutamide may decrease the excretion rate of Acrivastine which could result in a higher serum level. Acyclovir The metabolism of Acyclovir can be decreased when combined with Flutamide. Adalimumab The metabolism of Flutamide can be increased when combined with Adalimumab. Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Flutamide which could result in a higher serum level. Agomelatine The metabolism of Agomelatine can be decreased when combined with Flutamide. Albendazole The metabolism of Flutamide can be increased when combined with Albendazole. Albutrepenonacog Flutamide may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level. Alclofenac Alclofenac may decrease the excretion rate of Flutamide which could result in a higher serum level. Aldesleukin Aldesleukin may decrease the excretion rate of Flutamide which could result in a higher serum level. Alfentanil The metabolism of Alfentanil can be decreased when combined with Flutamide. Allopurinol Allopurinol may decrease the excretion rate of Flutamide which could result in a higher serum level. Almasilate Flutamide may decrease the excretion rate of Almasilate which could result in a higher serum level. Almotriptan Flutamide may decrease the excretion rate of Almotriptan which could result in a higher serum level. Alogliptin Flutamide may decrease the excretion rate of Alogliptin which could result in a higher serum level. Alosetron The metabolism of Flutamide can be decreased when combined with Alosetron. Alprazolam Alprazolam may decrease the excretion rate of Flutamide which could result in a higher serum level. Amantadine Flutamide may decrease the excretion rate of Amantadine which could result in a higher serum level. Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Flutamide. Amikacin Flutamide may decrease the excretion rate of Amikacin which could result in a higher serum level. Amiloride Amiloride may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Aminophenazone The metabolism of Aminophenazone can be decreased when combined with Flutamide. Aminophylline The metabolism of Aminophylline can be decreased when combined with Flutamide. Aminosalicylic acid The risk or severity of methemoglobinemia can be increased when Aminosalicylic acid is combined with Flutamide. Amiodarone The metabolism of Flutamide can be decreased when combined with Amiodarone. Amitriptyline The metabolism of Flutamide can be decreased when combined with Amitriptyline. Ammonium chloride Flutamide may decrease the excretion rate of Ammonium chloride which could result in a higher serum level. Amoxicillin Flutamide may decrease the excretion rate of Amoxicillin which could result in a higher serum level. Amphetamine Amphetamine may decrease the excretion rate of Flutamide which could result in a higher serum level. Amphotericin B Amphotericin B may decrease the excretion rate of Flutamide which could result in a higher serum level. Ampicillin Ampicillin may decrease the excretion rate of Flutamide which could result in a higher serum level. Amprenavir The metabolism of Flutamide can be decreased when combined with Amprenavir. Amrinone Flutamide may decrease the excretion rate of Amrinone which could result in a higher serum level. Amyl Nitrite The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Amyl Nitrite. Anagrelide The metabolism of Flutamide can be decreased when combined with Anagrelide. Anakinra The metabolism of Flutamide can be increased when combined with Anakinra. Ancestim Flutamide may decrease the excretion rate of Ancestim which could result in a higher serum level. Antihemophilic Flutamide may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level. Antipyrine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Antipyrine. Antithrombin Flutamide may decrease the excretion rate of Antithrombin III human which could result in a higher serum level. Antrafenine Antrafenine may decrease the excretion rate of Flutamide which could result in a higher serum level. Apalutamide The metabolism of Flutamide can be increased when combined with Apalutamide. Apixaban The metabolism of Apixaban can be decreased when combined with Flutamide. Apomorphine The metabolism of Apomorphine can be decreased when combined with Flutamide. Apremilast The metabolism of Flutamide can be increased when combined with Apremilast. Aprepitant The metabolism of Flutamide can be decreased when combined with Aprepitant. Arformoterol Flutamide may decrease the excretion rate of Arformoterol which could result in a higher serum level. Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Flutamide. Aripiprazole The metabolism of Aripiprazole lauroxil can be decreased when combined with Flutamide. Armodafinil The metabolism of Flutamide can be increased when combined with Armodafinil. Arsenic trioxide Flutamide may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level. Artemether The metabolism of Artemether can be decreased when combined with Flutamide. Articaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Articaine. Asenapine The metabolism of Asenapine can be decreased when combined with Flutamide. Astemizole The metabolism of Astemizole can be decreased when combined with Flutamide. Asunaprevir The metabolism of Asunaprevir can be decreased when combined with Flutamide. Atazanavir The metabolism of Flutamide can be decreased when combined with Atazanavir. Atomoxetine Atomoxetine may decrease the excretion rate of Flutamide which could result in a higher serum level. Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Flutamide. Auranofin Flutamide may decrease the excretion rate of Auranofin which could result in a higher serum level. Aurothioglucose Flutamide may decrease the excretion rate of Aurothioglucose which could result in a higher serum level. Avanafil The serum concentration of Avanafil can be increased when it is combined with Flutamide. Axitinib The metabolism of Axitinib can be decreased when combined with Flutamide. Azacitidine Flutamide may decrease the excretion rate of Azacitidine which could result in a higher serum level. Azathioprine The metabolism of Azathioprine can be decreased when combined with Flutamide. Azelaic acid Flutamide may decrease the excretion rate of Azelaic acid which could result in a higher serum level. Azelastine The metabolism of Azelastine can be decreased when combined with Flutamide. Aztreonam Aztreonam may decrease the excretion rate of Flutamide which could result in a higher serum level. Bacitracin Bacitracin may decrease the excretion rate of Flutamide which could result in a higher serum level. Baclofen Baclofen may decrease the excretion rate of Flutamide which could result in a higher serum level. Balsalazide Balsalazide may decrease the excretion rate of Flutamide which could result in a higher serum level. Baricitinib Flutamide may decrease the excretion rate of Baricitinib which could result in a higher serum level. Beclomethasone The metabolism of Flutamide can be increased when combined with Beclomethasone dipropionate. Belinostat The metabolism of Flutamide can be increased when combined with Belinostat. Bendamustine The metabolism of Bendamustine can be decreased when combined with Flutamide. Bendroflumethiazide Bendroflumethiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Benorilate Benorilate may decrease the excretion rate of Flutamide which could result in a higher serum level. Benoxaprofen Benoxaprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. Benserazide Flutamide may decrease the excretion rate of Benserazide which could result in a higher serum level. Benzatropine Benzatropine may decrease the excretion rate of Flutamide which could result in a higher serum level. Benznidazole Flutamide may decrease the excretion rate of Benznidazole which could result in a higher serum level. Benzocaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Benzocaine. Benzthiazide Benzthiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Benzydamine Benzydamine may decrease the excretion rate of Flutamide which could result in a higher serum level. Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Benzyl alcohol. Bepotastine Flutamide may decrease the excretion rate of Bepotastine which could result in a higher serum level. Berotralstat The metabolism of Flutamide can be decreased when combined with Berotralstat. Betamethasone The metabolism of Flutamide can be increased when combined with Betamethasone. Betamethasone The metabolism of Flutamide can be increased when combined with Betamethasone phosphate. Betaxolol The metabolism of Flutamide can be decreased when combined with Betaxolol. Bicisate Flutamide may decrease the excretion rate of Bicisate which could result in a higher serum level. Bimekizumab The metabolism of Flutamide can be increased when combined with Bimekizumab. Binimetinib The metabolism of Binimetinib can be decreased when combined with Flutamide. Bismuth subgallate Flutamide may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level. Bisoprolol Flutamide may decrease the excretion rate of Bisoprolol which could result in a higher serum level. Bisoxatin Flutamide may decrease the excretion rate of Bisoxatin which could result in a higher serum level. Bleomycin Bleomycin may decrease the excretion rate of Flutamide which could result in a higher serum level. Boceprevir The metabolism of Flutamide can be decreased when combined with Boceprevir. Bortezomib The metabolism of Flutamide can be decreased when combined with Bortezomib. Brivaracetam Flutamide may decrease the excretion rate of Brivaracetam which could result in a higher serum level. Bromazepam The metabolism of Bromazepam can be decreased when combined with Flutamide. Bromotheophylline Bromotheophylline may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Budesonide The metabolism of Flutamide can be increased when combined with Budesonide. Bumadizone Bumadizone may decrease the excretion rate of Flutamide which could result in a higher serum level. Bumetanide Bumetanide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Bupivacaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Bupivacaine. Buprenorphine The metabolism of Buprenorphine can be decreased when combined with Flutamide. Bupropion Flutamide may decrease the excretion rate of Bupropion which could result in a higher serum level. Buspirone Buspirone may decrease the excretion rate of Flutamide which could result in a higher serum level. Butabarbital Butabarbital may decrease the excretion rate of Flutamide which could result in a higher serum level. Butacaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Butacaine. Butalbital The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Flutamide. Butamben The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Butamben. Cabazitaxel The metabolism of Cabazitaxel can be decreased when combined with Flutamide. Caffeine The metabolism of Flutamide can be decreased when combined with Caffeine. Canagliflozin Canagliflozin may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Canakinumab The metabolism of Flutamide can be increased when combined with Canakinumab. Cannabidiol The metabolism of Flutamide can be decreased when combined with Cannabidiol. Canrenoic acid Canrenoic acid may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Capecitabine Flutamide may decrease the excretion rate of Capecitabine which could result in a higher serum level. Capmatinib The metabolism of Flutamide can be decreased when combined with Capmatinib. Capreomycin Flutamide may decrease the excretion rate of Capreomycin which could result in a higher serum level. Capromab pendetide Flutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent. Capsaicin The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Capsaicin. Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Flutamide. Carbidopa Carbidopa may decrease the excretion rate of Flutamide which could result in a higher serum level. Carboplatin Carboplatin may decrease the excretion rate of Flutamide which could result in a higher serum level. Carmustine The metabolism of Flutamide can be decreased when combined with Carmustine. Carprofen Carprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. Carvedilol The metabolism of Carvedilol can be decreased when combined with Flutamide. Cefaclor Cefaclor may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefadroxil Cefadroxil may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefalotin Cefalotin may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefamandole Cefamandole may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefapirin Cefapirin may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefazolin Cefazolin may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefdinir Flutamide may decrease the excretion rate of Cefdinir which could result in a higher serum level. Cefditoren Cefditoren may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefepime Cefepime may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefmenoxime Cefmenoxime may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefmetazole Cefmetazole may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefonicid Cefonicid may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefoperazone Cefoperazone may decrease the excretion rate of Flutamide which could result in a higher serum level. Ceforanide Ceforanide may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefotaxime Cefotaxime may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefotetan Cefotetan may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefotiam Cefotiam may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefoxitin Cefoxitin may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefpiramide Cefpiramide may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefpirome Cefpirome may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefpodoxime Cefpodoxime may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefprozil Cefprozil may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefradine Cefradine may decrease the excretion rate of Flutamide which could result in a higher serum level. Ceftaroline Ceftaroline fosamil may decrease the excretion rate of Flutamide which could result in a higher serum level. Ceftazidime Ceftazidime may decrease the excretion rate of Flutamide which could result in a higher serum level. Ceftibuten Ceftibuten may decrease the excretion rate of Flutamide which could result in a higher serum level. Ceftizoxime Ceftizoxime may decrease the excretion rate of Flutamide which could result in a higher serum level. Ceftobiprole Ceftobiprole may decrease the excretion rate of Flutamide which could result in a higher serum level. Ceftolozane Flutamide may decrease the excretion rate of Ceftolozane which could result in a higher serum level. Ceftriaxone Ceftriaxone may decrease the excretion rate of Flutamide which could result in a higher serum level. Cefuroxime Cefuroxime may decrease the excretion rate of Flutamide which could result in a higher serum level. Celecoxib The risk or severity of methemoglobinemia can be increased when Celecoxib is combined with Flutamide. Cenobamate The serum concentration of Flutamide can be decreased when it is combined with Cenobamate. Cephalexin Cephalexin may decrease the excretion rate of Flutamide which could result in a higher serum level. Cephaloglycin Cephaloglycin may decrease the excretion rate of Flutamide which could result in a higher serum level. Cerivastatin The metabolism of Flutamide can be decreased when combined with Cerivastatin. Certolizumab The metabolism of Flutamide can be increased when combined with Certolizumab pegol. Cetirizine Cetirizine may decrease the excretion rate of Flutamide which could result in a higher serum level. Cevimeline Cevimeline may decrease the excretion rate of Flutamide which could result in a higher serum level. Chloral hydrate Flutamide may decrease the excretion rate of Chloral hydrate which could result in a higher serum level. Chloramphenicol The metabolism of Flutamide can be decreased when combined with Chloramphenicol. Chloroprocaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Chloroprocaine. Chloroquine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Chloroquine. Chlorothiazide Chlorothiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Chloroxylenol Flutamide may decrease the excretion rate of Chloroxylenol which could result in a higher serum level. Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Flutamide. Chlorpromazine The metabolism of Flutamide can be decreased when combined with Chlorpromazine. Chlorpropamide Flutamide may decrease the excretion rate of Chlorpropamide which could result in a higher serum level. Chlorthalidone Chlorthalidone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Chlorzoxazone The metabolism of Flutamide can be decreased when combined with Chlorzoxazone. Choline C 11 Flutamide may decrease effectiveness of Choline C 11 as a diagnostic agent. Choline Choline magnesium trisalicylate may decrease the excretion rate of Flutamide which could result in a higher serum level. Choline salicylate Flutamide may decrease the excretion rate of Choline salicylate which could result in a higher serum level. Chondroitin sulfate Flutamide may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level. Chromic chloride Flutamide may decrease the excretion rate of Chromic chloride which could result in a higher serum level. Chromic nitrate Flutamide may decrease the excretion rate of Chromic nitrate which could result in a higher serum level. Chromium Flutamide may decrease the excretion rate of Chromium which could result in a higher serum level. Chromium gluconate Flutamide may decrease the excretion rate of Chromium gluconate which could result in a higher serum level. Chromium nicotinate Flutamide may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level. Chromous sulfate Flutamide may decrease the excretion rate of Chromous sulfate which could result in a higher serum level. Cidofovir Cidofovir may decrease the excretion rate of Flutamide which could result in a higher serum level. Cilostazol The metabolism of Cilostazol can be decreased when combined with Flutamide. Cimetidine The metabolism of Flutamide can be decreased when combined with Cimetidine. Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Flutamide. Cinchocaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Cinchocaine. Cinnarizine The metabolism of Cinnarizine can be decreased when combined with Flutamide. Cinoxacin The metabolism of Flutamide can be decreased when combined with Cinoxacin. Ciprofloxacin The metabolism of Flutamide can be decreased when combined with Ciprofloxacin. Cisapride The metabolism of Cisapride can be decreased when combined with Flutamide. Cisplatin Flutamide may decrease the excretion rate of Cisplatin which could result in a higher serum level. Citalopram The metabolism of Flutamide can be decreased when combined with Citalopram. Clarithromycin The metabolism of Flutamide can be decreased when combined with Clarithromycin. Clevidipine Flutamide may decrease the excretion rate of Clevidipine which could result in a higher serum level. Clindamycin The metabolism of Clindamycin can be decreased when combined with Flutamide. Clobazam Clobazam may decrease the excretion rate of Flutamide which could result in a higher serum level. Clobetasol The metabolism of Flutamide can be increased when combined with Clobetasol propionate. Clofarabine Flutamide may decrease the excretion rate of Clofarabine which could result in a higher serum level. Clofazimine The metabolism of Flutamide can be decreased when combined with Clofazimine. Clomipramine The metabolism of Clomipramine can be decreased when combined with Flutamide. Clonazepam Flutamide may decrease the excretion rate of Clonazepam which could result in a higher serum level. Clonidine The metabolism of Clonidine can be decreased when combined with Flutamide. Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Flutamide. Clorazepic acid Flutamide may decrease the excretion rate of Clorazepic acid which could result in a higher serum level. Clove oil Flutamide may decrease the excretion rate of Clove oil which could result in a higher serum level. Clozapine The metabolism of Flutamide can be decreased when combined with Clozapine. Cobicistat The metabolism of Flutamide can be decreased when combined with Cobicistat. Cocaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Cocaine. Colchicine Flutamide may decrease the excretion rate of Colchicine which could result in a higher serum level. Colistimethate Colistimethate may decrease the excretion rate of Flutamide which could result in a higher serum level. Colistin Flutamide may decrease the excretion rate of Colistin which could result in a higher serum level. Conivaptan The metabolism of Flutamide can be decreased when combined with Conivaptan. Conjugated The metabolism of Flutamide can be decreased when combined with Conjugated estrogens. Copanlisib The metabolism of Copanlisib can be decreased when combined with Flutamide. Corifollitropin alfa Flutamide may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. Cortisone acetate The metabolism of Flutamide can be increased when combined with Cortisone acetate. Crizotinib The metabolism of Crizotinib can be decreased when combined with Flutamide. Curcumin The metabolism of Flutamide can be decreased when combined with Curcumin. Cyanocobalamin Cyanocobalamin may decrease the excretion rate of Flutamide which could result in a higher serum level. Cyclobenzaprine The metabolism of Cyclobenzaprine can be decreased when combined with Flutamide. Cyclopenthiazide Cyclopenthiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Cyclophosphamide The metabolism of Cyclophosphamide can be decreased when combined with Flutamide. Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Flutamide. Cyclothiazide Cyclothiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Cyproterone acetate The metabolism of Flutamide can be increased when combined with Cyproterone acetate. Dabigatran etexilate Flutamide may decrease the excretion rate of Dabigatran etexilate which could result in a higher serum level. Dabrafenib The serum concentration of Flutamide can be decreased when it is combined with Dabrafenib. Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Flutamide. Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Flutamide. Dalfampridine Flutamide may decrease the excretion rate of Dalfampridine which could result in a higher serum level. Danazol The metabolism of Flutamide can be decreased when combined with Danazol. Dapagliflozin Dapagliflozin may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Dapsone The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Flutamide. Daptomycin Daptomycin may decrease the excretion rate of Flutamide which could result in a higher serum level. Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Flutamide. Darunavir The metabolism of Flutamide can be decreased when combined with Darunavir. Dasatinib The metabolism of Dasatinib can be decreased when combined with Flutamide. Daunorubicin The metabolism of Flutamide can be increased when combined with Daunorubicin. Deferasirox The serum concentration of Flutamide can be increased when it is combined with Deferasirox. Deferiprone Flutamide may decrease the excretion rate of Deferiprone which could result in a higher serum level. Delafloxacin Flutamide may decrease the excretion rate of Delafloxacin which could result in a higher serum level. Delavirdine The metabolism of Flutamide can be decreased when combined with Delavirdine. Desipramine Flutamide may decrease the excretion rate of Desipramine which could result in a higher serum level. Desmopressin Desmopressin may decrease the excretion rate of Flutamide which could result in a higher serum level. Desvenlafaxine The metabolism of Flutamide can be decreased when combined with Desvenlafaxine. Deutetrabenazine Flutamide may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level. Dexamethasone The metabolism of Flutamide can be increased when combined with Dexamethasone. Dexamethasone The metabolism of Flutamide can be increased when combined with Dexamethasone acetate. Dexfenfluramine The metabolism of Dexfenfluramine can be decreased when combined with Flutamide. Dexibuprofen Dexibuprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. Dexketoprofen Dexketoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. Dexmedetomidine The metabolism of Flutamide can be decreased when combined with Dexmedetomidine. Dexpanthenol Flutamide may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Dexrazoxane Dexrazoxane may decrease the excretion rate of Flutamide which could result in a higher serum level. Dextran Flutamide may decrease the excretion rate of Dextran which could result in a higher serum level. Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Flutamide. Diacerein The metabolism of Flutamide can be decreased when combined with Diacerein. Diatrizoate Diatrizoate may decrease the excretion rate of Flutamide which could result in a higher serum level. Diazepam Flutamide may decrease the excretion rate of Diazepam which could result in a higher serum level. Dichlorobenzyl Flutamide may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level. Diclofenac The metabolism of Diclofenac can be decreased when combined with Flutamide. Diclofenamide Diclofenamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Dicyclomine Flutamide may decrease the excretion rate of Dicyclomine which could result in a higher serum level. Didanosine Flutamide may decrease the excretion rate of Didanosine which could result in a higher serum level. Dienogest Flutamide may decrease the excretion rate of Dienogest which could result in a higher serum level. Diflunisal Diflunisal may decrease the excretion rate of Flutamide which could result in a higher serum level. Difluocortolone The metabolism of Flutamide can be increased when combined with Difluocortolone. Digoxin Flutamide may decrease the excretion rate of Digoxin which could result in a higher serum level. Dihydralazine The metabolism of Flutamide can be decreased when combined with Dihydralazine. Dihydrostreptom Dihydrostreptomycin may decrease the excretion rate of Flutamide which could result in a higher serum level. Diltiazem The metabolism of Flutamide can be decreased when combined with Diltiazem. Dimercaprol Flutamide may decrease the excretion rate of Dimercaprol which could result in a higher serum level. Dimethyl sulfoxide Flutamide may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. Diphenhydramine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Diphenhydramine. Disopyramide The metabolism of Flutamide can be decreased when combined with Disopyramide. Disulfiram The metabolism of Disulfiram can be decreased when combined with Flutamide. DMethylephedrine Flutamide may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level. Dobutamine Flutamide may decrease the excretion rate of Dobutamine which could result in a higher serum level. Docetaxel The metabolism of Docetaxel can be decreased when combined with Flutamide. Domperidone The metabolism of Domperidone can be decreased when combined with Flutamide. You Might Also Read Denosumab - Uses, Dosage, Side Effects, Interaction Dopamine Flutamide may decrease the excretion rate of Dopamine which could result in a higher serum level. Doravirine The metabolism of Doravirine can be decreased when combined with Flutamide. Doripenem Flutamide may decrease the excretion rate of Doripenem which could result in a higher serum level. Dosulepin The metabolism of Flutamide can be decreased when combined with Dosulepin. Doxacurium Flutamide may decrease the excretion rate of Doxacurium which could result in a higher serum level. Doxepin The metabolism of Doxepin can be decreased when combined with Flutamide. Doxycycline Doxycycline may decrease the excretion rate of Flutamide which could result in a higher serum level. Dronabinol The metabolism of Flutamide can be decreased when combined with Dronabinol. Dronedarone The metabolism of Dronedarone can be decreased when combined with Flutamide. Drospirenone Drospirenone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Droxidopa Flutamide may decrease the excretion rate of Droxidopa which could result in a higher serum level. Duloxetine Duloxetine may decrease the excretion rate of Flutamide which could result in a higher serum level. Dutasteride The metabolism of Dutasteride can be decreased when combined with Flutamide. Dyclonine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Dyclonine. Dyphylline Flutamide may decrease the excretion rate of Dyphylline which could result in a higher serum level. Edoxaban Flutamide may decrease the excretion rate of Edoxaban which could result in a higher serum level. Edrophonium Flutamide may decrease the excretion rate of Edrophonium which could result in a higher serum level. Efavirenz The metabolism of Flutamide can be decreased when combined with Efavirenz. Elbasvir The metabolism of Elbasvir can be decreased when combined with Flutamide. Elexacaftor The metabolism of Elexacaftor can be decreased when combined with Flutamide. Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Flutamide. Elvitegravir The metabolism of Flutamide can be decreased when combined with Elvitegravir. Emapalumab The metabolism of Flutamide can be increased when combined with Emapalumab. Enalaprilat Flutamide may decrease the excretion rate of Enalaprilat which could result in a higher serum level. Enasidenib The metabolism of Flutamide can be decreased when combined with Enasidenib. Enoxacin The metabolism of Flutamide can be decreased when combined with Enoxacin. Entecavir The metabolism of Flutamide can be decreased when combined with Entecavir. Enzalutamide The serum concentration of Flutamide can be decreased when it is combined with Enzalutamide. Eplerenone Eplerenone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Epoprostenol Flutamide may decrease the excretion rate of Epoprostenol which could result in a higher serum level. Ergotamine The metabolism of Flutamide can be decreased when combined with Ergotamine. Erlotinib The metabolism of Erlotinib can be decreased when combined with Flutamide. Ertapenem Ertapenem may decrease the excretion rate of Flutamide which could result in a higher serum level. Ertugliflozin Ertugliflozin may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Erythromycin The metabolism of Flutamide can be decreased when combined with Erythromycin. Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Flutamide. Estazolam Flutamide may decrease the excretion rate of Estazolam which could result in a higher serum level. Estradiol The metabolism of Estradiol can be decreased when combined with Flutamide. Estradiol acetate The metabolism of Flutamide can be decreased when combined with Estradiol acetate. Estradiol benzoate The metabolism of Estradiol benzoate can be decreased when combined with Flutamide. Estradiol cypionate The metabolism of Estradiol cypionate can be decreased when combined with Flutamide. Estradiol dienanthate The metabolism of Estradiol dienanthate can be decreased when combined with Flutamide. Estradiol valerate The metabolism of Estradiol valerate can be decreased when combined with Flutamide. Estrone sulfate The metabolism of Flutamide can be decreased when combined with Estrone sulfate. Eszopiclone Eszopiclone may decrease the excretion rate of Flutamide which could result in a higher serum level. Etacrynic acid Etacrynic acid may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Etafedrine Flutamide may decrease the excretion rate of Etafedrine which could result in a higher serum level. Etanercept The metabolism of Flutamide can be increased when combined with Etanercept. Ethambutol Ethambutol may decrease the excretion rate of Flutamide which could result in a higher serum level. Ethanol The metabolism of Ethanol can be decreased when combined with Flutamide. Ethinylestradiol The metabolism of Ethinylestradiol can be decreased when combined with Flutamide. Ethyl chloride The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Ethyl chloride. Etidocaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Etidocaine. Etodolac Etodolac may decrease the excretion rate of Flutamide which could result in a higher serum level. Etomidate Etomidate may decrease the excretion rate of Flutamide which could result in a higher serum level. Etonogestrel Etonogestrel may decrease the excretion rate of Flutamide which could result in a higher serum level. Etoposide The metabolism of Etoposide can be decreased when combined with Flutamide. Etoricoxib The metabolism of Etoricoxib can be decreased when combined with Flutamide. Eucalyptus oil Flutamide may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level. Ezogabine Flutamide may decrease the excretion rate of Ezogabine which could result in a higher serum level. Famotidine The metabolism of Flutamide can be decreased when combined with Famotidine. Felodipine The metabolism of Felodipine can be decreased when combined with Flutamide. Fenbufen Fenbufen may decrease the excretion rate of Flutamide which could result in a higher serum level. Fenfluramine The metabolism of Fenfluramine can be decreased when combined with Flutamide. Fenofibrate Flutamide may decrease the excretion rate of Fenofibrate which could result in a higher serum level. Fenofibric acid Flutamide may decrease the excretion rate of Fenofibric acid which could result in a higher serum level. Fenoldopam Flutamide may decrease the excretion rate of Fenoldopam which could result in a higher serum level. Fenoprofen Fenoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. Fentanyl Flutamide may decrease the excretion rate of Fentanyl which could result in a higher serum level. Fesoterodine Flutamide may decrease the excretion rate of Fesoterodine which could result in a higher serum level. Fexinidazole The metabolism of Flutamide can be decreased when combined with Fexinidazole. Finasteride The metabolism of Finasteride can be decreased when combined with Flutamide. Finerenone Finerenone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Flavoxate Flutamide may decrease the excretion rate of Flavoxate which could result in a higher serum level. Flecainide The metabolism of Flecainide can be decreased when combined with Flutamide. Floctafenine Floctafenine may decrease the excretion rate of Flutamide which could result in a higher serum level. Florbetaben (18F) Flutamide may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level. Florbetapir (18F) Flutamide may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level. Floxuridine Floxuridine may decrease the excretion rate of Flutamide which could result in a higher serum level. Fluconazole The metabolism of Flutamide can be decreased when combined with Fluconazole. Flucytosine Flutamide may decrease the excretion rate of Flucytosine which could result in a higher serum level. Fludeoxyglucose Flutamide may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level. Flumazenil Flutamide may decrease the excretion rate of Flumazenil which could result in a higher serum level. Flunarizine The metabolism of Flunarizine can be decreased when combined with Flutamide. Fluocinolone Flutamide may decrease the excretion rate of Fluocinolone acetonide which could result in a higher serum level. Fluocinonide The metabolism of Flutamide can be increased when combined with Fluocinonide. Fluocortolone The metabolism of Flutamide can be increased when combined with Fluocortolone. Fluorouracil The metabolism of Fluorouracil can be decreased when combined with Flutamide. Fluoxetine The metabolism of Flutamide can be decreased when combined with Fluoxetine. Flurazepam Flutamide may decrease the excretion rate of Flurazepam which could result in a higher serum level. Flurbiprofen Flurbiprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. Fluticasone The metabolism of Flutamide can be decreased when combined with Fluticasone. Fluticasone The metabolism of Flutamide can be decreased when combined with Fluticasone furoate. Fluticasone The metabolism of Flutamide can be decreased when combined with Fluticasone propionate. Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Flutamide. Fluvoxamine The metabolism of Flutamide can be decreased when combined with Fluvoxamine. Folic acid Folic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. Fomepizole Flutamide may decrease the excretion rate of Fomepizole which could result in a higher serum level. Fondaparinux Flutamide may decrease the excretion rate of Fondaparinux which could result in a higher serum level. Formestane Flutamide may decrease the excretion rate of Formestane which could result in a higher serum level. Foscarnet Foscarnet may decrease the excretion rate of Flutamide which could result in a higher serum level. Fosfomycin Flutamide may decrease the excretion rate of Fosfomycin which could result in a higher serum level. Fosinopril Fosinopril may decrease the excretion rate of Flutamide which could result in a higher serum level. Fosnetupitant The metabolism of Flutamide can be decreased when combined with Fosnetupitant. Fosphenytoin The metabolism of Flutamide can be increased when combined with Fosphenytoin. Framycetin Framycetin may decrease the excretion rate of Flutamide which could result in a higher serum level. Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Flutamide. Furosemide Furosemide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Fusidic acid The metabolism of Flutamide can be decreased when combined with Fusidic acid. Gabapentin Flutamide may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level. Gadobenic acid Flutamide may decrease the excretion rate of Gadobenic acid which could result in a higher serum level. Gadodiamide Gadodiamide may decrease the excretion rate of Flutamide which could result in a higher serum level. Gadofosveset Flutamide may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level. Gadopentetic acid Flutamide may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level. Gadoteric acid Flutamide may decrease the excretion rate of Gadoteric acid which could result in a higher serum level. Gadoteridol Flutamide may decrease the excretion rate of Gadoteridol which could result in a higher serum level. Gallium Flutamide may increase effectiveness of Gallium Ga-68 gozetotide as a diagnostic agent. Ganciclovir Flutamide may decrease the excretion rate of Ganciclovir which could result in a higher serum level. Gatifloxacin The metabolism of Flutamide can be decreased when combined with Gatifloxacin. Gefitinib The metabolism of Flutamide can be decreased when combined with Gefitinib. Gemcitabine Gemcitabine may decrease the excretion rate of Flutamide which could result in a higher serum level. Gemfibrozil The metabolism of Flutamide can be decreased when combined with Gemfibrozil. Gemifloxacin The metabolism of Flutamide can be decreased when combined with Gemifloxacin. Gentamicin Flutamide may decrease the excretion rate of Gentamicin which could result in a higher serum level. Gimeracil Flutamide may decrease the excretion rate of Gimeracil which could result in a higher serum level. Givosiran The serum concentration of Flutamide can be increased when it is combined with Givosiran. Glipizide Flutamide may decrease the excretion rate of Glipizide which could result in a higher serum level. Glyburide The metabolism of Glyburide can be decreased when combined with Flutamide. Glycerol Flutamide may decrease the excretion rate of Glycerol phenylbutyrate which could result in a higher serum level. Golimumab The metabolism of Flutamide can be increased when combined with Golimumab. Golodirsen Flutamide may decrease the excretion rate of Golodirsen which could result in a higher serum level. Goserelin Goserelin may decrease the excretion rate of Flutamide which could result in a higher serum level. Grepafloxacin The metabolism of Flutamide can be decreased when combined with Grepafloxacin. Guanabenz The metabolism of Guanabenz can be decreased when combined with Flutamide. Guanethidine Flutamide may decrease the excretion rate of Guanethidine which could result in a higher serum level. Guanfacine Flutamide may decrease the excretion rate of Guanfacine which could result in a higher serum level. Halofantrine The metabolism of Halofantrine can be decreased when combined with Flutamide. Haloperidol The serum concentration of Haloperidol can be increased when it is combined with Flutamide. Hydralazine Flutamide may decrease the excretion rate of Hydralazine which could result in a higher serum level. Hydrochlorothiazide Hydrochlorothiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Flutamide. Hydrocortisone The metabolism of Hydrocortisone acetate can be decreased when combined with Flutamide. Hydrocortisone The metabolism of Hydrocortisone butyrate can be decreased when combined with Flutamide. Hydrocortisone e The metabolism of Hydrocortisone cypionate can be decreased when combined with Flutamide. Hydrocortisone The metabolism of Hydrocortisone phosphate can be decreased when combined with Flutamide. Hydroflumethiazide Hydroflumethiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Hydromorphone Hydromorphone may decrease the excretion rate of Flutamide which could result in a higher serum level. Hydroxocobalamin Hydroxocobalamin may decrease the excretion rate of Flutamide which could result in a higher serum level. Hydroxyethyl Starch Flutamide may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level. Hydroxyprogesterone The metabolism of Hydroxyprogesterone caproate can be decreased when combined with Flutamide. Hydroxyurea The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Hydroxyurea. Hydroxyzine The metabolism of Hydroxyzine can be decreased when combined with Flutamide. Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Flutamide. Ibuprofen Ibuprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. Ibutilide Ibutilide may decrease the excretion rate of Flutamide which could result in a higher serum level. Icatibant Flutamide may decrease the excretion rate of Icatibant which could result in a higher serum level. Icosapent Icosapent may decrease the excretion rate of Flutamide which could result in a higher serum level. Idarucizumab Flutamide may decrease the excretion rate of Idarucizumab which could result in a higher serum level. Idebenone Flutamide may decrease the excretion rate of Idebenone which could result in a higher serum level. Ifosfamide The metabolism of Ifosfamide can be decreased when combined with Flutamide. Iloperidone The metabolism of Iloperidone can be decreased when combined with Flutamide. Imatinib The metabolism of Flutamide can be decreased when combined with Imatinib. Imipramine The metabolism of Flutamide can be decreased when combined with Imipramine. Indapamide Indapamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Indigotindisulfonic Flutamide may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level. Indinavir The metabolism of Flutamide can be decreased when combined with Indinavir. Indomethacin Indomethacin may decrease the excretion rate of Flutamide which could result in a higher serum level. Infliximab The metabolism of Flutamide can be increased when combined with Infliximab. Inosine pranobex Flutamide may decrease the excretion rate of Inosine pranobex which could result in a higher serum level. Inositol Flutamide may decrease the excretion rate of Inositol which could result in a higher serum level. Inotersen Inotersen may decrease the excretion rate of Flutamide which could result in a higher serum level. Insulin beef The metabolism of Flutamide can be increased when combined with Insulin beef. Insulin pork The metabolism of Flutamide can be increased when combined with Insulin pork. Interferon alfa-2a The metabolism of Flutamide can be decreased when combined with Interferon alfa-2a. Interferon alfa-2b The metabolism of Flutamide can be decreased when combined with Interferon alfa-2b. Interferon alfa-n1 The metabolism of Flutamide can be decreased when combined with Interferon alfa-n1. Interferon alfa-n3 The metabolism of Flutamide can be decreased when combined with Interferon alfa-n3. Interferon alfacon-1 The metabolism of Flutamide can be decreased when combined with Interferon alfacon-1. Interferon beta-1a The metabolism of Flutamide can be decreased when combined with Interferon beta-1a. Interferon beta-1b The metabolism of Flutamide can be decreased when combined with Interferon beta-1b. Interferon gamma The metabolism of Flutamide can be decreased when combined with Interferon gamma-1b. Iobenguane sulfate Flutamide may decrease the excretion rate of Iobenguane sulfate I-123 which could result in a higher serum level. Iodixanol Flutamide may decrease the excretion rate of Iodixanol which could result in a higher serum level. Ioflupane I-123 Flutamide may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level. Iopromide Flutamide may decrease the excretion rate of Iopromide which could result in a higher serum level. Iothalamic acid Flutamide may decrease the excretion rate of Iothalamic acid which could result in a higher serum level. Ioversol Flutamide may decrease the excretion rate of Ioversol which could result in a higher serum level. Ioxilan Flutamide may decrease the excretion rate of Ioxilan which could result in a higher serum level. Ipecac Flutamide may decrease the excretion rate of Ipecac which could result in a higher serum level. Ipilimumab Flutamide may decrease the excretion rate of Ipilimumab which could result in a higher serum level. Irinotecan The metabolism of Irinotecan can be decreased when combined with Flutamide. Isavuconazole The metabolism of Flutamide can be decreased when combined with Isavuconazole. Isavuconazonium The metabolism of Flutamide can be decreased when combined with Isavuconazonium. Isometheptene The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Isometheptene. Isoniazid The metabolism of Flutamide can be decreased when combined with Isoniazid. Isosorbide Isosorbide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Isosorbide dinitrate The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Isosorbide dinitrate. Isosorbide The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Isosorbide mononitrate. Isosulfan blue Flutamide may decrease the excretion rate of Isosulfan blue which could result in a higher serum level. Isotretinoin Flutamide may decrease the excretion rate of Isotretinoin which could result in a higher serum level. You Might Also Read Aconitine; Uses, Dosage, Site Effects, Interactions, Pregnancy Isoxicam Isoxicam may decrease the excretion rate of Flutamide which could result in a higher serum level. Isradipine The metabolism of Flutamide can be decreased when combined with Isradipine. Istradefylline The metabolism of Istradefylline can be decreased when combined with Flutamide. Itraconazole The metabolism of Flutamide can be decreased when combined with Itraconazole. Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Flutamide. Ivosidenib The metabolism of Flutamide can be increased when combined with Ivosidenib. Ixazomib Flutamide may decrease the excretion rate of Ixazomib which could result in a higher serum level. Kanamycin Flutamide may decrease the excretion rate of Kanamycin which could result in a higher serum level. Ketamine Flutamide may decrease the excretion rate of Ketamine which could result in a higher serum level. Ketazolam Flutamide may decrease the excretion rate of Ketazolam which could result in a higher serum level. Ketoconazole The metabolism of Flutamide can be decreased when combined with Ketoconazole. Ketoprofen Ketoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. Ketorolac Ketorolac may decrease the excretion rate of Flutamide which could result in a higher serum level. Labetalol Flutamide may decrease the excretion rate of Labetalol which could result in a higher serum level. Lamivudine Flutamide may decrease the excretion rate of Lamivudine which could result in a higher serum level. Lamotrigine Flutamide may decrease the excretion rate of Lamotrigine which could result in a higher serum level. Lapatinib The metabolism of Lapatinib can be decreased when combined with Flutamide. Latamoxef Latamoxef may decrease the excretion rate of Flutamide which could result in a higher serum level. Ledipasvir Flutamide may decrease the excretion rate of Ledipasvir which could result in a higher serum level. Leflunomide The serum concentration of Flutamide can be decreased when it is combined with Leflunomide. Lemborexant The metabolism of Lemborexant can be decreased when combined with Flutamide. Lenalidomide Lenalidomide may decrease the excretion rate of Flutamide which could result in a higher serum level. Lercanidipine The metabolism of Lercanidipine can be decreased when combined with Flutamide. Lesinurad Flutamide may decrease the excretion rate of Lesinurad which could result in a higher serum level. Letermovir The metabolism of Flutamide can be decreased when combined with Letermovir. Leuprolide Leuprolide may decrease the excretion rate of Flutamide which could result in a higher serum level. Levamlodipine The metabolism of Levamlodipine can be decreased when combined with Flutamide. Levobupivacaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Levobupivacaine. Levocarnitine Flutamide may decrease the excretion rate of Levocarnitine which could result in a higher serum level. Levocetirizine Flutamide may decrease the excretion rate of Levocetirizine which could result in a higher serum level. Levofloxacin Flutamide may decrease the excretion rate of Levofloxacin which could result in a higher serum level. Levoketoconazole The metabolism of Flutamide can be decreased when combined with Levoketoconazole. Levomilnacipran Flutamide may decrease the excretion rate of Levomilnacipran which could result in a higher serum level. Levonorgestrel The metabolism of Flutamide can be decreased when combined with Levonorgestrel. Levosalbutamol Flutamide may decrease the excretion rate of Levosalbutamol which could result in a higher serum level. Lidocaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Lidocaine. Linagliptin The metabolism of Flutamide can be decreased when combined with Linagliptin. Liothyronine Liothyronine may decrease the excretion rate of Flutamide which could result in a higher serum level. Lisinopril Flutamide may decrease the excretion rate of Lisinopril which could result in a higher serum level. Lithium carbonate Flutamide may decrease the excretion rate of Lithium carbonate which could result in a higher serum level. Lithium citrate Lithium citrate may decrease the excretion rate of Flutamide which could result in a higher serum level. Lixisenatide Flutamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level. Lofexidine The metabolism of Lofexidine can be decreased when combined with Flutamide. Lomefloxacin The metabolism of Lomefloxacin can be decreased when combined with Flutamide. Lonafarnib The metabolism of Flutamide can be decreased when combined with Lonafarnib. Lonapegsomat The metabolism of Flutamide can be increased when combined with Lonapegsomatropin. Lopinavir The metabolism of Flutamide can be decreased when combined with Lopinavir. Loracarbef Loracarbef may decrease the excretion rate of Flutamide which could result in a higher serum level. Lorazepam Lorazepam may decrease the excretion rate of Flutamide which could result in a higher serum level. Lorcaserin The metabolism of Lorcaserin can be decreased when combined with Flutamide. Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Flutamide. Lornoxicam Lornoxicam may decrease the excretion rate of Flutamide which could result in a higher serum level. Lorpiprazole Flutamide may decrease the excretion rate of Lorpiprazole which could result in a higher serum level. Lovastatin The metabolism of Flutamide can be decreased when combined with Lovastatin. Loxoprofen Loxoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. Lubiprostone Flutamide may decrease the excretion rate of Lubiprostone which could result in a higher serum level. Lumacaftor The metabolism of Flutamide can be increased when combined with Lumacaftor. Lumiracoxib Lumiracoxib may decrease the excretion rate of Flutamide which could result in a higher serum level. Macitentan Flutamide may decrease the excretion rate of Macitentan which could result in a higher serum level. Magnesium carbonate Flutamide may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level. Magnesium chloride Flutamide may decrease the excretion rate of Magnesium chloride which could result in a higher serum level. Magnesium Flutamide may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. Magnesium Flutamide may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level. Mangafodipir Flutamide may decrease the excretion rate of Mangafodipir which could result in a higher serum level. Mannitol Mannitol may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Maprotiline The metabolism of Maprotiline can be decreased when combined with Flutamide. Mavacamten The serum concentration of Flutamide can be decreased when it is combined with Mavacamten. Mecamylamine Flutamide may decrease the excretion rate of Mecamylamine which could result in a higher serum level. Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. Medroxyprogeste Flutamide may decrease the excretion rate of Medroxyprogesterone acetate which could result in a higher serum level. Mefenamic acid The metabolism of Mefenamic acid can be decreased when combined with Flutamide. Megestrol acetate Megestrol acetate may decrease the excretion rate of Flutamide which could result in a higher serum level. Melatonin The metabolism of Melatonin can be decreased when combined with Flutamide. Meloxicam The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Meloxicam. Memantine Flutamide may decrease the excretion rate of Memantine which could result in a higher serum level. Meperidine Meperidine may decrease the excretion rate of Flutamide which could result in a higher serum level. Mephenytoin The metabolism of Mephenytoin can be decreased when combined with Flutamide. Mepivacaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Mepivacaine. Meprednisone The metabolism of Flutamide can be increased when combined with Meprednisone. Meropenem Flutamide may decrease the excretion rate of Meropenem which could result in a higher serum level. Mesalazine Mesalazine may decrease the excretion rate of Flutamide which could result in a higher serum level. Metamfetamine Flutamide may decrease the excretion rate of Metamfetamine which could result in a higher serum level. Metamizole Metamizole may decrease the excretion rate of Flutamide which could result in a higher serum level. Metaxalone Flutamide may decrease the excretion rate of Metaxalone which could result in a higher serum level. Metformin Metformin may decrease the excretion rate of Flutamide which could result in a higher serum level. Methadone Methadone may decrease the excretion rate of Flutamide which could result in a higher serum level. Methazolamide Methazolamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Methimazole The metabolism of Flutamide can be decreased when combined with Methimazole. Methotrexate Methotrexate may decrease the excretion rate of Flutamide which could result in a higher serum level. Methoxsalen The metabolism of Flutamide can be decreased when combined with Methoxsalen. Methoxy The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Flutamide. Methyldopa Flutamide may decrease the excretion rate of Methyldopa which could result in a higher serum level. Methylene blue The metabolism of Flutamide can be decreased when combined with Methylene blue. Methylnaltrexone Flutamide may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level. Methyltestosterone Flutamide may decrease the excretion rate of Methyltestosterone which could result in a higher serum level. Meticrane Meticrane may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Metoclopramide The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Metoclopramide. Metolazone Metolazone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Metoprolol Metoprolol may decrease the excretion rate of Flutamide which could result in a higher serum level. Metreleptin The metabolism of Flutamide can be increased when combined with Metreleptin. Metronidazole The metabolism of Metronidazole can be decreased when combined with Flutamide. Metyrapone Flutamide may decrease the excretion rate of Metyrapone which could result in a higher serum level. Mexiletine The metabolism of Flutamide can be decreased when combined with Mexiletine. Mianserin The metabolism of Mianserin can be decreased when combined with Flutamide. Miconazole The metabolism of Flutamide can be decreased when combined with Miconazole. Midazolam Flutamide may decrease the excretion rate of Midazolam which could result in a higher serum level. Midostaurin The metabolism of Flutamide can be decreased when combined with Midostaurin. Mifepristone The metabolism of Mifepristone can be decreased when combined with Flutamide. Migalastat Flutamide may decrease the excretion rate of Migalastat which could result in a higher serum level. Milnacipran The metabolism of Flutamide can be decreased when combined with Milnacipran. Milrinone Milrinone may decrease the excretion rate of Flutamide which could result in a higher serum level. Mirabegron Flutamide may decrease the excretion rate of Mirabegron which could result in a higher serum level. Mirtazapine The metabolism of Flutamide can be decreased when combined with Mirtazapine. Mitotane The metabolism of Flutamide can be increased when combined with Mitotane. Mobocertinib The metabolism of Mobocertinib can be decreased when combined with Flutamide. Modafinil The metabolism of Flutamide can be increased when combined with Modafinil. Mometasone The metabolism of Flutamide can be increased when combined with Mometasone furoate. Moxifloxacin The metabolism of Flutamide can be decreased when combined with Moxifloxacin. Moxisylyte Flutamide may decrease the excretion rate of Moxisylyte which could result in a higher serum level. Muzolimine Muzolimine may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Mycophenolate Flutamide may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level. Mycophenolic acid Flutamide may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level. N-acetyltyrosine Flutamide may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level. Nabumetone The metabolism of Flutamide can be decreased when combined with Nabumetone. Nadolol Flutamide may decrease the excretion rate of Nadolol which could result in a higher serum level. Nafcillin The metabolism of Flutamide can be increased when combined with Nafcillin. Naldemedine Flutamide may decrease the excretion rate of Naldemedine which could result in a higher serum level. Nalidixic acid The metabolism of Flutamide can be decreased when combined with Nalidixic acid. Nalmefene Flutamide may decrease the excretion rate of Nalmefene which could result in a higher serum level. Naloxone The metabolism of Flutamide can be decreased when combined with Naloxone. Naproxen The metabolism of Naproxen can be decreased when combined with Flutamide. Nateglinide Flutamide may decrease the excretion rate of Nateglinide which could result in a higher serum level. Nedaplatin Flutamide may decrease the excretion rate of Nedaplatin which could result in a higher serum level. Nedocromil Flutamide may decrease the excretion rate of Nedocromil which could result in a higher serum level. Nefazodone The metabolism of Flutamide can be decreased when combined with Nefazodone. Nelfinavir The metabolism of Flutamide can be decreased when combined with Nelfinavir. Neomycin Flutamide may decrease the excretion rate of Neomycin which could result in a higher serum level. Netilmicin Flutamide may decrease the excretion rate of Netilmicin which could result in a higher serum level. Netupitant The metabolism of Flutamide can be decreased when combined with Netupitant. Nevirapine The metabolism of Flutamide can be decreased when combined with Nevirapine. Nicardipine The metabolism of Flutamide can be decreased when combined with Nicardipine. Niclosamide The metabolism of Flutamide can be decreased when combined with Niclosamide. Nicorandil Flutamide may decrease the excretion rate of Nicorandil which could result in a higher serum level. Nifedipine The metabolism of Nifedipine can be decreased when combined with Flutamide. Nilotinib The metabolism of Flutamide can be decreased when combined with Nilotinib. Nilutamide Flutamide may decrease the excretion rate of Nilutamide which could result in a higher serum level. Nilvadipine The metabolism of Flutamide can be decreased when combined with Nilvadipine. Nimesulide Nimesulide may decrease the excretion rate of Flutamide which could result in a higher serum level. Nisoldipine Nisoldipine may decrease the excretion rate of Flutamide which could result in a higher serum level. Nitrendipine The metabolism of Nitrendipine can be decreased when combined with Flutamide. Nitric Oxide The risk or severity of methemoglobinemia can be increased when Nitric Oxide is combined with Flutamide. Nitrofurantoin The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Nitrofurantoin. Nitroglycerin The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Nitroglycerin. Nitroprusside The risk or severity of methemoglobinemia can be increased when Nitroprusside is combined with Flutamide. Nitrous oxide The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Nitrous oxide. Norethisterone The metabolism of Norethisterone can be decreased when combined with Flutamide. Norfloxacin The metabolism of Flutamide can be decreased when combined with Norfloxacin. Obeticholic acid The metabolism of Flutamide can be decreased when combined with Obeticholic acid. Octinoxate Flutamide may decrease the excretion rate of Octinoxate which could result in a higher serum level. Olanzapine The metabolism of Flutamide can be decreased when combined with Olanzapine. Olaparib The metabolism of Olaparib can be decreased when combined with Flutamide. Olsalazine Olsalazine may decrease the excretion rate of Flutamide which could result in a higher serum level. Omeprazole The metabolism of Flutamide can be increased when combined with Omeprazole. Ondansetron The metabolism of Ondansetron can be decreased when combined with Flutamide. Opium Flutamide may decrease the excretion rate of Opium which could result in a higher serum level. Orphenadrine The metabolism of Flutamide can be decreased when combined with Orphenadrine. Oseltamivir Oseltamivir may decrease the excretion rate of Flutamide which could result in a higher serum level. Osilodrostat The metabolism of Flutamide can be decreased when combined with Osilodrostat. Osimertinib The serum concentration of Flutamide can be decreased when it is combined with Osimertinib. Oxacillin Flutamide may decrease the excretion rate of Oxacillin which could result in a higher serum level. Oxaprozin Oxaprozin may decrease the excretion rate of Flutamide which could result in a higher serum level. Oxazepam Flutamide may decrease the excretion rate of Oxazepam which could result in a higher serum level. Oxcarbazepine The metabolism of Flutamide can be increased when combined with Oxcarbazepine. Oxetacaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Oxetacaine. Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Flutamide. Oxybenzone Flutamide may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Oxybuprocaine. Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Flutamide. Oxycodone The metabolism of Flutamide can be decreased when combined with Oxycodone. Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Flutamide which could result in a higher serum level. Oxyquinoline Flutamide may decrease the excretion rate of Oxyquinoline which could result in a higher serum level. Paclitaxel The metabolism of Paclitaxel can be decreased when combined with Flutamide. Pacritinib The metabolism of Flutamide can be decreased when combined with Pacritinib. Paliperidone Flutamide may decrease the excretion rate of Paliperidone which could result in a higher serum level. Palonosetron Palonosetron may decrease the excretion rate of Flutamide which could result in a higher serum level. Pamidronic acid Pamidronic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. Pantoprazole Pantoprazole may decrease the excretion rate of Flutamide which could result in a higher serum level. Parecoxib Parecoxib may decrease the excretion rate of Flutamide which could result in a higher serum level. Paritaprevir The metabolism of Paritaprevir can be decreased when combined with Flutamide. Paromomycin Paromomycin may decrease the excretion rate of Flutamide which could result in a higher serum level. Paroxetine The metabolism of Paroxetine can be decreased when combined with Flutamide. Patent Blue Flutamide may decrease the excretion rate of Patent Blue which could result in a higher serum level. Pazopanib The metabolism of Pazopanib can be decreased when combined with Flutamide. Pefloxacin The metabolism of Flutamide can be decreased when combined with Pefloxacin. Pegaptanib Flutamide may decrease the excretion rate of Pegaptanib which could result in a higher serum level. Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Flutamide. Peginterferon alfa The metabolism of Flutamide can be decreased when combined with Peginterferon alfa-2a. Peginterferon alfa The serum concentration of Flutamide can be increased when it is combined with Peginterferon alfa-2b. Pemetrexed Flutamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level. Penbutolol Flutamide may decrease the excretion rate of Penbutolol which could result in a higher serum level. Penciclovir The metabolism of Flutamide can be decreased when combined with Penciclovir. Pentaerythritol Flutamide may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level. Pentamidine Pentamidine may decrease the excretion rate of Flutamide which could result in a higher serum level. Pentastarch Flutamide may decrease the excretion rate of Pentastarch which could result in a higher serum level. Pentetic acid Flutamide may decrease the excretion rate of Pentetic acid which could result in a higher serum level. Pentobarbital The metabolism of Flutamide can be increased when combined with Pentobarbital. Pentostatin Flutamide may decrease the excretion rate of Pentostatin which could result in a higher serum level. Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Flutamide. Perampanel The metabolism of Perampanel can be decreased when combined with Flutamide. Perindopril Flutamide may decrease the excretion rate of Perindopril which could result in a higher serum level. Permethrin Flutamide may decrease the excretion rate of Permethrin which could result in a higher serum level. Perphenazine The metabolism of Perphenazine can be decreased when combined with Flutamide. Phenazopyridine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Phenazopyridine. Phenelzine Flutamide may decrease the excretion rate of Phenelzine which could result in a higher serum level. Phenobarbital The metabolism of Flutamide can be increased when combined with Phenobarbital. Phenol The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Phenol. Phentolamine Flutamide may decrease the excretion rate of Phentolamine which could result in a higher serum level. Phenylbutazone Phenylbutazone may decrease the excretion rate of Flutamide which could result in a higher serum level. Phenylephrine The metabolism of Flutamide can be increased when combined with Phenylephrine. Phenytoin The metabolism of Flutamide can be increased when combined with Phenytoin. Pholcodine Flutamide may decrease the excretion rate of Pholcodine which could result in a higher serum level. Phosphoric acid Flutamide may decrease the excretion rate of Phosphoric acid which could result in a higher serum level. Phylloquinone Flutamide may decrease the excretion rate of Phylloquinone which could result in a higher serum level. Picosulfuric acid Flutamide may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level. Piflufolastat F 18 Flutamide may decrease effectiveness of Piflufolastat F 18 as a diagnostic agent. Pimozide The metabolism of Pimozide can be decreased when combined with Flutamide. Pindolol Flutamide may decrease the excretion rate of Pindolol which could result in a higher serum level. Piperacillin Piperacillin may decrease the excretion rate of Flutamide which could result in a higher serum level. Piracetam Flutamide may decrease the excretion rate of Piracetam which could result in a higher serum level. Piretanide Piretanide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Flutamide. Piroxicam Piroxicam may decrease the excretion rate of Flutamide which could result in a higher serum level. Pitolisant The serum concentration of Flutamide can be decreased when it is combined with Pitolisant. Plazomicin Flutamide may decrease the excretion rate of Plazomicin which could result in a higher serum level. Plerixafor Flutamide may decrease the excretion rate of Plerixafor which could result in a higher serum level. Polythiazide Polythiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Flutamide. Ponatinib The metabolism of Ponatinib can be decreased when combined with Flutamide. Ponesimod The metabolism of Ponesimod can be decreased when combined with Flutamide. Posaconazole The metabolism of Flutamide can be decreased when combined with Posaconazole. Potassium Potassium may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Potassium acetate Flutamide may decrease the excretion rate of Potassium acetate which could result in a higher serum level. Potassium Flutamide may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level. Potassium cation Potassium cation may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Potassium chloride Flutamide may decrease the excretion rate of Potassium chloride which could result in a higher serum level. Potassium citrate Potassium citrate may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Potassium nitrate Flutamide may decrease the excretion rate of Potassium nitrate which could result in a higher serum level. Potassium Flutamide may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level. Potassium sulfate Flutamide may decrease the excretion rate of Potassium sulfate which could result in a higher serum level. Pralatrexate Flutamide may decrease the excretion rate of Pralatrexate which could result in a higher serum level. Pralidoxime Flutamide may decrease the excretion rate of Pralidoxime which could result in a higher serum level. Pralsetinib The metabolism of Flutamide can be decreased when combined with Pralsetinib. Pramipexole Pramipexole may decrease the excretion rate of Flutamide which could result in a higher serum level. Pramocaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Pramocaine. Prasugrel Flutamide may decrease the excretion rate of Prasugrel which could result in a higher serum level. Praziquantel The metabolism of Praziquantel can be decreased when combined with Flutamide. Prednisolone The metabolism of Flutamide can be increased when combined with Prednisolone phosphate. Prednisone Flutamide may decrease the excretion rate of Prednisone which could result in a higher serum level. Prednisone The metabolism of Flutamide can be increased when combined with Prednisone acetate. Pregabalin Pregabalin may decrease the excretion rate of Flutamide which could result in a higher serum level. Prilocaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Prilocaine. Primaquine The metabolism of Flutamide can be decreased when combined with Primaquine. Primidone The metabolism of Flutamide can be increased when combined with Primidone. Probenecid Flutamide may decrease the excretion rate of Probenecid which could result in a higher serum level. Procainamide Flutamide may decrease the excretion rate of Procainamide which could result in a higher serum level. Procaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Procaine. Procaine Flutamide may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level. Progesterone The metabolism of Flutamide can be decreased when combined with Progesterone. Promazine The metabolism of Flutamide can be decreased when combined with Promazine. Promethazine Flutamide may decrease the excretion rate of Promethazine which could result in a higher serum level. Propafenone The metabolism of Flutamide can be decreased when combined with Propafenone. Propantheline Flutamide may decrease the excretion rate of Propantheline which could result in a higher serum level. Proparacaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Proparacaine. Propiverine Flutamide may decrease the excretion rate of Propiverine which could result in a higher serum level. Propoxycaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Propoxycaine. Propranolol The metabolism of Propranolol can be decreased when combined with Flutamide. Prucalopride Flutamide may decrease the excretion rate of Prucalopride which could result in a higher serum level. Pyrantel Flutamide may decrease the excretion rate of Pyrantel which could result in a higher serum level. Pyrazinamide Pyrazinamide may decrease the excretion rate of Flutamide which could result in a higher serum level. Pyridoxine Pyridoxine may decrease the excretion rate of Flutamide which could result in a higher serum level. Pyrithione Flutamide may decrease the excretion rate of Pyrithione which could result in a higher serum level. Quetiapine Flutamide may decrease the excretion rate of Quetiapine which could result in a higher serum level. Quinethazone Quinethazone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Quinidine The metabolism of Flutamide can be decreased when combined with Quinidine. Quinine The risk or severity of methemoglobinemia can be increased when Quinine is combined with Flutamide. Rabeprazole Flutamide may decrease the excretion rate of Rabeprazole which could result in a higher serum level. Ramelteon The metabolism of Ramelteon can be decreased when combined with Flutamide. Ranitidine The metabolism of Ranitidine can be decreased when combined with Flutamide. Ranolazine Ranolazine may decrease the excretion rate of Flutamide which could result in a higher serum level. Rasagiline The metabolism of Rasagiline can be decreased when combined with Flutamide. Rasburicase The risk or severity of methemoglobinemia can be increased when Rasburicase is combined with Flutamide. Relugolix The metabolism of Relugolix can be decreased when combined with Flutamide. Reserpine The metabolism of Flutamide can be increased when combined with Reserpine. Resorcinol Flutamide may decrease the excretion rate of Resorcinol which could result in a higher serum level. Ribavirin Flutamide may decrease the excretion rate of Ribavirin which could result in a higher serum level. Ribociclib The metabolism of Flutamide can be decreased when combined with Ribociclib. Ribostamycin Flutamide may decrease the excretion rate of Ribostamycin which could result in a higher serum level. Rifampicin The metabolism of Flutamide can be increased when combined with Rifampicin. Rifamycin The metabolism of Flutamide can be increased when combined with Rifamycin. Rifapentine The metabolism of Flutamide can be increased when combined with Rifapentine. You Might Also Read Betaxolol ; Uses, Dosage, Side Effects, Interactions, Pregnancy Rilonacept The metabolism of Flutamide can be increased when combined with Rilonacept. Riluzole The metabolism of Riluzole can be decreased when combined with Flutamide. Risperidone The metabolism of Risperidone can be decreased when combined with Flutamide. Ritonavir The serum concentration of Flutamide can be increased when it is combined with Ritonavir. Rivaroxaban Flutamide may decrease the excretion rate of Rivaroxaban which could result in a higher serum level. Rizatriptan Flutamide may decrease the excretion rate of Rizatriptan which could result in a higher serum level. Rofecoxib The metabolism of Flutamide can be decreased when combined with Rofecoxib. Roflumilast The metabolism of Roflumilast can be decreased when combined with Flutamide. Romidepsin The metabolism of Romidepsin can be decreased when combined with Flutamide. Ropeginterferon The metabolism of Flutamide can be decreased when combined with Ropeginterferon alfa-2b. Ropivacaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Ropivacaine. Rosiglitazone Rosiglitazone may decrease the excretion rate of Flutamide which could result in a higher serum level. Rosoxacin The metabolism of Flutamide can be decreased when combined with Rosoxacin. Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Flutamide. Rucaparib The metabolism of Flutamide can be decreased when combined with Rucaparib. Ruxolitinib Flutamide may decrease the excretion rate of Ruxolitinib which could result in a higher serum level. Sacubitril Flutamide may decrease the excretion rate of Sacubitril which could result in a higher serum level. Salbutamol Flutamide may decrease the excretion rate of Salbutamol which could result in a higher serum level. Salicylamide Salicylamide may decrease the excretion rate of Flutamide which could result in a higher serum level. Salicylic acid Salicylic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. Salmeterol The metabolism of Salmeterol can be decreased when combined with Flutamide. Salmon Salmon calcitonin may decrease the excretion rate of Flutamide which could result in a higher serum level. Salsalate Salsalate may decrease the excretion rate of Flutamide which could result in a higher serum level. Saquinavir The metabolism of Flutamide can be decreased when combined with Saquinavir. Satralizumab The serum concentration of Flutamide can be decreased when it is combined with Satralizumab. Saxagliptin Flutamide may decrease the excretion rate of Saxagliptin which could result in a higher serum level. Secobarbital Secobarbital may decrease the excretion rate of Flutamide which could result in a higher serum level. Secukinumab The metabolism of Flutamide can be increased when combined with Secukinumab. Selegiline The metabolism of Selegiline can be decreased when combined with Flutamide. Selenious acid Flutamide may decrease the excretion rate of Selenious acid which could result in a higher serum level. Selenium Flutamide may decrease the excretion rate of Selenium which could result in a higher serum level. Selumetinib The metabolism of Selumetinib can be decreased when combined with Flutamide. Sibutramine Flutamide may decrease the excretion rate of Sibutramine which could result in a higher serum level. Sildenafil The metabolism of Flutamide can be decreased when combined with Sildenafil. Siltuximab The metabolism of Flutamide can be increased when combined with Siltuximab. Simeprevir The metabolism of Flutamide can be decreased when combined with Simeprevir. Simvastatin The metabolism of Simvastatin can be decreased when combined with Flutamide. Sirolimus The metabolism of Sirolimus can be decreased when combined with Flutamide. Sitagliptin Flutamide may decrease the excretion rate of Sitagliptin which could result in a higher serum level. Sodium acetate Flutamide may decrease the excretion rate of Sodium acetate which could result in a higher serum level. Sodium Flutamide may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. Sodium fluoride Flutamide may decrease the excretion rate of Sodium fluoride which could result in a higher serum level. Sodium sulfate Flutamide may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Sofosbuvir Flutamide may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. Solriamfetol Flutamide may decrease the excretion rate of Solriamfetol which could result in a higher serum level. Somapacitan The metabolism of Flutamide can be increased when combined with Somapacitan. Somatotropin The metabolism of Flutamide can be increased when combined with Somatotropin. Somatrem The metabolism of Flutamide can be increased when combined with Somatrem. Somatrogon The metabolism of Flutamide can be increased when combined with Somatrogon. Sorafenib The metabolism of Sorafenib can be decreased when combined with Flutamide. Sorbitol Flutamide may decrease the excretion rate of Sorbitol which could result in a higher serum level. Sotorasib The serum concentration of Flutamide can be decreased when it is combined with Sotorasib. Spironolactone Spironolactone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. St. John’s Wort The metabolism of Flutamide can be increased when combined with St. John’s Wort. Stiripentol The metabolism of Flutamide can be decreased when combined with Stiripentol. Streptomycin Flutamide may decrease the excretion rate of Streptomycin which could result in a higher serum level. Strontium chloride Flutamide may decrease the excretion rate of Strontium chloride which could result in a higher serum level. Sucralfate Sucralfate may decrease the excretion rate of Flutamide which could result in a higher serum level. Sulbactam Flutamide may decrease the excretion rate of Sulbactam which could result in a higher serum level. Sulfadiazine The risk or severity of methemoglobinemia can be increased when Sulfadiazine is combined with Flutamide. Sulfamethoxazole The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Sulfamethoxazole. Sulfapyridine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Sulfapyridine. Sulfasalazine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Sulfasalazine. Sulindac Sulindac may decrease the excretion rate of Flutamide which could result in a higher serum level. Sumatriptan Flutamide may decrease the excretion rate of Sumatriptan which could result in a higher serum level. Sunitinib The metabolism of Sunitinib can be decreased when combined with Flutamide. S Estrogens, A Flutamide may decrease the excretion rate of Synthetic Conjugated Estrogens, A which could result in a higher serum level. S Estrogens, B Flutamide may decrease the excretion rate of Synthetic Conjugated Estrogens, B which could result in a higher serum level. Tacrine The metabolism of Flutamide can be decreased when combined with Tacrine. Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Flutamide. Tadalafil Flutamide may decrease the excretion rate of Tadalafil which could result in a higher serum level. Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Flutamide. Tamsulosin Flutamide may decrease the excretion rate of Tamsulosin which could result in a higher serum level. Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Flutamide. Technetium Flutamide may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level. Technetium Flutamide may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level. Technetium Flutamide may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level. Technetium Flutamide may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level. Teduglutide Flutamide may decrease the excretion rate of Teduglutide which could result in a higher serum level. Tegafur The metabolism of Tegafur can be decreased when combined with Flutamide. Tegaserod The metabolism of Flutamide can be decreased when combined with Tegaserod. Telaprevir The metabolism of Flutamide can be decreased when combined with Telaprevir. Telavancin Flutamide may decrease the excretion rate of Telavancin which could result in a higher serum level. Telithromycin The metabolism of Flutamide can be decreased when combined with Telithromycin. Telotristat ethyl The serum concentration of Flutamide can be decreased when it is combined with Telotristat ethyl. Temazepam Temazepam may decrease the excretion rate of Flutamide which could result in a higher serum level. Temozolomide Flutamide may decrease the excretion rate of Temozolomide which could result in a higher serum level. Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Flutamide. Teniposide The metabolism of Teniposide can be decreased when combined with Flutamide. Tenofovir The serum concentration of Tenofovir alafenamide can be increased when it is combined with Flutamide. Tenofovir Tenofovir disoproxil may decrease the excretion rate of Flutamide which could result in a higher serum level. Tenoxicam Tenoxicam may decrease the excretion rate of Flutamide which could result in a higher serum level. Terbinafine The metabolism of Terbinafine can be decreased when combined with Flutamide. Terbutaline Flutamide may decrease the excretion rate of Terbutaline which could result in a higher serum level. Terfenadine The metabolism of Flutamide can be decreased when combined with Terfenadine. Teriflunomide The serum concentration of Flutamide can be decreased when it is combined with Teriflunomide. Testolactone Flutamide may decrease the excretion rate of Testolactone which could result in a higher serum level. Testosterone Flutamide may decrease the excretion rate of Testosterone which could result in a higher serum level. Tetracaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Tetracaine. Tetracycline Flutamide may decrease the excretion rate of Tetracycline which could result in a higher serum level. Tetradecyl Flutamide may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level. Tezacaftor The metabolism of Tezacaftor can be decreased when combined with Flutamide. Thalidomide The metabolism of Flutamide can be increased when combined with Thalidomide. Theophylline The metabolism of Flutamide can be decreased when combined with Theophylline. Thiabendazole The metabolism of Flutamide can be decreased when combined with Thiabendazole. Thiethylperazine Thiethylperazine may decrease the excretion rate of Flutamide which could result in a higher serum level. Thiothixene The metabolism of Thiothixene can be decreased when combined with Flutamide. Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. Ticagrelor The metabolism of Ticagrelor can be decreased when combined with Flutamide. Ticlopidine The metabolism of Flutamide can be decreased when combined with Ticlopidine. Tiludronic acid Flutamide may decrease the excretion rate of Tiludronic acid which could result in a higher serum level. Timolol Timolol may decrease the excretion rate of Flutamide which could result in a higher serum level. Tinidazole Flutamide may decrease the excretion rate of Tinidazole which could result in a higher serum level. Tiopronin Flutamide may decrease the excretion rate of Tiopronin which could result in a higher serum level. Tiotropium Flutamide may decrease the excretion rate of Tiotropium which could result in a higher serum level. Tipranavir The metabolism of Flutamide can be decreased when combined with Tipranavir. Tirofiban Flutamide may decrease the excretion rate of Tirofiban which could result in a higher serum level. Tixocortol Flutamide may decrease the excretion rate of Tixocortol which could result in a higher serum level. Tizanidine The metabolism of Tizanidine can be decreased when combined with Flutamide. Tobramycin Flutamide may decrease the excretion rate of Tobramycin which could result in a higher serum level. Tocainide The metabolism of Tocainide can be decreased when combined with Flutamide. Tocilizumab The metabolism of Flutamide can be increased when combined with Tocilizumab. Tocopherol Flutamide may decrease the excretion rate of Tocopherol which could result in a higher serum level. Tolazamide Flutamide may decrease the excretion rate of Tolazamide which could result in a higher serum level. Tolbutamide Flutamide may decrease the excretion rate of Tolbutamide which could result in a higher serum level. Tolcapone Tolcapone may decrease the excretion rate of Flutamide which could result in a higher serum level. Tolfenamic acid Tolfenamic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. Tolmetin Tolmetin may decrease the excretion rate of Flutamide which could result in a higher serum level. Tolterodine Flutamide may decrease the excretion rate of Tolterodine which could result in a higher serum level. Tolvaptan Tolvaptan may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Topiramate Topiramate may decrease the excretion rate of Flutamide which could result in a higher serum level. Topotecan Flutamide may decrease the excretion rate of Topotecan which could result in a higher serum level. Torasemide Torasemide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Tositumomab Tositumomab may decrease the excretion rate of Flutamide which could result in a higher serum level. Tramadol Tramadol may decrease the excretion rate of Flutamide which could result in a higher serum level. Trametinib Flutamide may decrease the excretion rate of Trametinib which could result in a higher serum level. Trastuzumab The metabolism of Trastuzumab emtansine can be decreased when combined with Flutamide. Trazodone The metabolism of Trazodone can be decreased when combined with Flutamide. Tretinoin The metabolism of Tretinoin can be decreased when combined with Flutamide. Triamcinolone The metabolism of Flutamide can be increased when combined with Triamcinolone. Triamterene Triamterene may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Triazolam Flutamide may decrease the excretion rate of Triazolam which could result in a higher serum level. Trichlormethiazide Trichlormethiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Triclabendazole The metabolism of Flutamide can be decreased when combined with Triclabendazole. Triethylenetetra Flutamide may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level. Trifluoperazine The metabolism of Trifluoperazine can be decreased when combined with Flutamide. Trifluridine Trifluridine may decrease the excretion rate of Flutamide which could result in a higher serum level. Trilaciclib The metabolism of Flutamide can be increased when combined with Trilaciclib. Trimebutine Flutamide may decrease the excretion rate of Trimebutine which could result in a higher serum level. Trimethoprim Trimethoprim may decrease the excretion rate of Flutamide which could result in a higher serum level. Trimetrexate Flutamide may decrease the excretion rate of Trimetrexate which could result in a higher serum level. Troglitazone The metabolism of Flutamide can be decreased when combined with Troglitazone. Troleandomycin The metabolism of Flutamide can be decreased when combined with Troleandomycin. Tropisetron Flutamide may decrease the excretion rate of Tropisetron which could result in a higher serum level. Trovafloxacin The metabolism of Flutamide can be decreased when combined with Trovafloxacin. Tucatinib The metabolism of Tucatinib can be decreased when combined with Flutamide. Udenafil The metabolism of Udenafil can be decreased when combined with Flutamide. Vaborbactam Flutamide may decrease the excretion rate of Vaborbactam which could result in a higher serum level. Valaciclovir Valaciclovir may decrease the excretion rate of Flutamide which could result in a higher serum level. Valbenazine Flutamide may decrease the excretion rate of Valbenazine which could result in a higher serum level. Valdecoxib Valdecoxib may decrease the excretion rate of Flutamide which could result in a higher serum level. Valganciclovir Flutamide may decrease the excretion rate of Valganciclovir which could result in a higher serum level. Valproic acid The risk or severity of methemoglobinemia can be increased when Valproic acid is combined with Flutamide. Vancomycin Flutamide may decrease the excretion rate of Vancomycin which could result in a higher serum level. Vardenafil The metabolism of Vardenafil can be decreased when combined with Flutamide. Varenicline Flutamide may decrease the excretion rate of Varenicline which could result in a higher serum level. Vemurafenib The serum concentration of Flutamide can be increased when it is combined with Vemurafenib. Venetoclax The metabolism of Flutamide can be decreased when combined with Venetoclax. Venlafaxine Venlafaxine may decrease the excretion rate of Flutamide which could result in a higher serum level. Verapamil The metabolism of Flutamide can be decreased when combined with Verapamil. Vilanterol Flutamide may decrease the excretion rate of Vilanterol which could result in a higher serum level. Viloxazine The metabolism of Flutamide can be decreased when combined with Viloxazine. Vincristine The metabolism of Vincristine can be decreased when combined with Flutamide. Vonoprazan The metabolism of Vonoprazan can be decreased when combined with Flutamide. Voriconazole The metabolism of Flutamide can be decreased when combined with Voriconazole. Vortioxetine Flutamide may decrease the excretion rate of Vortioxetine which could result in a higher serum level. Voxilaprevir The metabolism of Voxilaprevir can be decreased when combined with Flutamide. Warfarin Flutamide may decrease the excretion rate of Warfarin which could result in a higher serum level. Zaleplon Flutamide may decrease the excretion rate of Zaleplon which could result in a higher serum level. Zanamivir Flutamide may decrease the excretion rate of Zanamivir which could result in a higher serum level. Zileuton The metabolism of Flutamide can be decreased when combined with Zileuton. Zimelidine The metabolism of Flutamide can be decreased when combined with Zimelidine. Ziprasidone The metabolism of Flutamide can be decreased when combined with Ziprasidone. Zolmitriptan The metabolism of Flutamide can be decreased when combined with Zolmitriptan. Zolpidem The metabolism of Flutamide can be decreased when combined with Zolpidem. Zonisamide Zonisamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. Zopiclone The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Zopiclone. Zotepine The metabolism of Zotepine can be decreased when combined with Flutamide. Pregnancy and Lactation FDA Pregnancy Category D Pregnancy There was decreased 24-hour survival in the offspring of pregnant rats treated with flutamide at doses of 30, 100, or 200 mg/kg/day (approximately 3, 9, and 19 times the human dose). A slight increase in minor variations in the development of the sternebrae and vertebrae was seen in fetuses of rats treated with two higher doses. Feminization of the male rats also occurred at the two higher dose levels. There was a decreased survival rate in the offspring of rabbits receiving the highest dose (15 mg/kg/day, equal to 1.4 times the human dose). Lactation This drug is not indicated for use in females. Excreted into human milk: Unknown Excreted into animal milk: Data not available The effects in the nursing infant are unknown. How should this medicine be used? Flutamide comes as a capsule to take by mouth. It is usually taken with or without food every 8 hours (three times a day.) Take flutamide at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take flutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take flutamide along with the LHRH agonist treatment even if you feel well. Do not stop taking either medication without talking to your doctor. Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient. What special precautions should I follow? Before taking flutamide, tell your doctor and pharmacist if you are allergic to flutamide or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention anticoagulants (”blood thinners”) such as warfarin (Coumadin). tell your doctor if you smoke and if you have or have ever had any inherited blood diseases such as glucose-6-phosphate dehydrogenase (G-6-PD) deficiency or hemoglobin M disease. you should know that flutamide is only for use in men. If taken by pregnant women, flutamide can harm the fetus. Women who are or may become pregnant should not take flutamide. If you take flutamide while you are pregnant, call your doctor. ask your doctor about the safe use of alcoholic beverages while you are taking flutamide. Flutamide may cause facial flushing, and drinking alcohol can make it worse. References https://www.accessdata.fda.gov/spl/data/6c1fd5b4-b5c7-4e48-8bb1-36f0cacf6f42/6c1fd5b4-b5c7-4e48-8bb1-36f0cacf6f42.xml https://www.accessdata.fda.gov/drugsatfda_docs/label/2001/18554s23lbl.pdf https://pubchem.ncbi.nlm.nih.gov/compound/Flutamide https://www.cancer.gov/about-cancer/treatment/drugs/flutamide https://go.drugbank.com/drugs/DB00499 https://www.drugs.com/flutamide.html https://www.ncbi.nlm.nih.gov/books/NBK482215/ https://www.mayoclinic.org/drugs-supplements/flutamide-oral-route/side-effects/drg-20072536 https://medlineplus.gov/druginfo/meds/a697045.html https://en.wikipedia.org/wiki/Flutamide https://www.webmd.com/drugs/2/drug-1549/flutamide-oral/details/list-contraindications Burnham Center for Chemical Genomics SID49675006 https://pubchem.ncbi.nlm.nih.gov/bioassay/1996#section=Data-Table DrugBank https://www.drugbank.ca/legal/terms_of_use Flutamide https://www.drugbank.ca/drugs/DB00499 Human Metabolome Database (HMDB) http://www.hmdb.ca/citing Flutamide http://www.hmdb.ca/metabolites/HMDB0014642 HMDB0014642_msms_2235943 https://hmdb.ca/metabolites/HMDB0014642#spectra CAS Common Chemistry https://creativecommons.org/licenses/by-nc/4.0/ Flutamide https://commonchemistry.cas.org/detail?cas_rn=13311-84-7 ChemIDplus LICENSE https://www.nlm.nih.gov/copyright.html Flutamide [USAN:USP:INN:BAN] https://chem.nlm.nih.gov/chemidplus/sid/0013311847 ChemIDplus Chemical Information Classification https://chem.nlm.nih.gov/chemidplus/ DTP/NCI https://www.cancer.gov/policies/copyright-reuse flutamide https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=757817 flutamide https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=147834 flutamide https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=215876 EPA DSSTox LICENSE https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources Flutamide https://comptox.epa.gov/dashboard/DTXSID7032004 CompTox Chemicals Dashboard Chemical Lists https://comptox.epa.gov/dashboard/chemical-lists/ European Chemicals Agency (ECHA) https://echa.europa.eu/web/guest/legal-notice Flutamide https://echa.europa.eu/substance-information/-/substanceinfo/100.033.024 Flutamide https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/59447 FDA Global Substance Registration System (GSRS) https://www.fda.gov/about-fda/about-website/website-policies#linking FLUTAMIDE https://gsrs.ncats.nih.gov/ginas/app/beta/substances/76W6J0943E CCSbase https://ccsbase.net/ ChEBI Flutamide http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5132 ChEBI Ontology http://www.ebi.ac.uk/chebi/userManualForward.do#ChEBI%20Ontology FDA Pharm Classes https://www.fda.gov/about-fda/about-website/website-policies#linking FLUTAMIDE https://dailymed.nlm.nih.gov/dailymed/browse-drug-classes.cfm FDA Pharmacological Classification https://www.fda.gov/ForIndustry/DataStandards/StructuredProductLabeling/ucm162549.htm LiverTox LICENSE https://www.nlm.nih.gov/copyright.html Flutamide https://www.ncbi.nlm.nih.gov/books/n/livertox/Flutamide/ ChEMBL http://www.ebi.ac.uk/Information/termsofuse.html https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL806/ ChEMBL Protein Target Tree https://www.ebi.ac.uk/chembl/g/#browse/targets Comparative Toxicogenomics Database (CTD) http://ctdbase.org/about/legal.jsp Flutamide https://ctdbase.org/detail.go?type=chem&acc=D005485 Drug Gene Interaction database (DGIdb) http://www.dgidb.org/downloads FLUTAMIDE https://www.dgidb.org/drugs/FLUTAMIDE IUPHAR/BPS Guide to PHARMACOLOGY https://www.guidetopharmacology.org/about.jsp#license flutamide https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6943 https://www.guidetopharmacology.org/targets.jsp Therapeutic Target Database (TTD) Flutamide http://idrblab.net/ttd/data/drug/details/D0Y0SW ClinicalTrials.gov https://clinicaltrials.gov/ct2/about-site/terms-conditions#Use https://clinicaltrials.gov/ DailyMed LICENSE https://www.nlm.nih.gov/copyright.html FLUTAMIDE https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=FLUTAMIDE Drug Induced Liver Injury Rank (DILIrank) Dataset https://www.fda.gov/about-fda/about-website/website-policies#linking flutamide https://www.fda.gov/science-research/liver-toxicity-knowledge-base-ltkb/drug-induced-liver-injury-rank-dilirank-dataset NORMAN Suspect List Exchange https://creativecommons.org/licenses/by/4.0/ https://www.norman-network.com/nds/SLE/ EU Clinical Trials Register https://www.clinicaltrialsregister.eu/ NITE-CMC https://www.nite.go.jp/chem/english/ghs/17-mhlw-0014e.html FDA Orange Book https://www.fda.gov/about-fda/about-website/website-policies#linking https://www.fda.gov/drugs/drug-approvals-and-databases/approved-drug-products-therapeutic-equivalence-evaluations-orange-book National Drug Code (NDC) Directory https://www.fda.gov/about-fda/about-website/website-policies#linking FLUTAMIDE https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory NIST Mass Spectrometry Data Center LICENSE https://www.nist.gov/srd/public-law Flutamide http://www.nist.gov/srd/nist1a.cfm MassBank Europe LICENSE https://github.com/MassBank/MassBank-web/blob/main/MassBank-Project/LICENSE.txt https://massbank.eu/MassBank/Result.jsp?inchikey=MKXKFYHWDHIYRV-UHFFFAOYSA-N MassBank of North America (MoNA) https://mona.fiehnlab.ucdavis.edu/documentation/license Flutamide https://mona.fiehnlab.ucdavis.edu/spectra/browse?query=compound.metaData%3Dq%3D%27name%3D%3D%22InChIKey%22%20and%20value%3D%3D%22MKXKFYHWDHIYRV-UHFFFAOYSA-N%22%27 NCI Cancer Drugs LICENSE https://www.cancer.gov/policies/copyright-reuse Flutamide https://www.cancer.gov/about-cancer/treatment/drugs/flutamide NIPH Clinical Trials Search of Japan https://rctportal.niph.go.jp/en/ SpectraBase Flutamide https://spectrabase.com/spectrum/7j5sSdfxukU Flutamide https://spectrabase.com/spectrum/1XtUXw3sscC Flutamide https://spectrabase.com/spectrum/JOuuD1quyXU Flutamide https://spectrabase.com/spectrum/GZbtC1LVhzS https://spectrabase.com/spectrum/HHCrlrtuV08 NLM RxNorm Terminology https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.html flutamide https://rxnav.nlm.nih.gov/id/rxnorm/4508 WHO Anatomical Therapeutic Chemical (ATC) Classification https://www.whocc.no/copyright_disclaimer/ https://www.whocc.no/atc/ ATC Code https://www.whocc.no/atc_ddd_index/ PubChem https://pubchem.ncbi.nlm.nih.gov https://gitlab.lcsb.uni.lu/eci/pubchem-docs/-/raw/main/pfas-tree/PFAS_Tree.pdf?inline=false Springer Nature https://pubchem.ncbi.nlm.nih.gov/substance/?source=15745&sourceid=19048289-468808612 Thieme Chemistry https://creativecommons.org/licenses/by-nc-nd/4.0/ https://pubchem.ncbi.nlm.nih.gov/substance/?source=22163&sourceid=19048289-468808612 WHO Model Lists of Essential Medicines https://www.who.int/about/who-we-are/publishing-policies/copyright Flutamide https://list.essentialmeds.org/medicines/640 Wikidata LICENSE CCZero https://creativecommons.org/publicdomain/zero/1.0/ Flutamide https://www.wikidata.org/wiki/Q418669 Medical Subject Headings (MeSH) https://www.nlm.nih.gov/copyright.html Flutamide https://www.ncbi.nlm.nih.gov/mesh/68005485 MeSH Tree http://www.nlm.nih.gov/mesh/meshhome.html Androgen Antagonists https://www.ncbi.nlm.nih.gov/mesh/68000726 Antineoplastic Agents, Hormonal https://www.ncbi.nlm.nih.gov/mesh/68018931 KEGG https://www.kegg.jp/kegg/legal.html Therapeutic category of drugs in Japan http://www.genome.jp/kegg-bin/get_htext?br08301.keg USP drug classification http://www.genome.jp/kegg-bin/get_htext?br08302.keg Anatomical Therapeutic Chemical (ATC) classification http://www.genome.jp/kegg-bin/get_htext?br08303.keg Target-based classification of drugs http://www.genome.jp/kegg-bin/get_htext?br08310.keg Drugs listed in the Japanese Pharmacopoeia http://www.genome.jp/kegg-bin/get_htext?br08311.keg Drug Groups http://www.genome.jp/kegg-bin/get_htext?br08330.keg Drug Classes http://www.genome.jp/kegg-bin/get_htext?br08332.keg UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) GHS Classification Tree http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html EPA Substance Registry Services LICENSE https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources EPA SRS List Classification https://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do PATENTSCOPE (WIPO) SID 402531211 https://pubchem.ncbi.nlm.nih.gov/substance/402531211 SID 403396348 https://pubchem.ncbi.nlm.nih.gov/substance/403396348 NCBI https://www.ncbi.nlm.nih.gov/projects/linkout Show More