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Flutamide is an Androgen Receptor Inhibitor. The mechanism of action of flutamide is as an Androgen Receptor Antagonist. Flutamide is a nonsteroidal antiandrogen that acts by binding to and blocking intracellular androgen receptors in target tissues including testes, prostate, skin, and hair follicles. Flutamide is frequently associated with minor serum aminotransferase elevations and has been linked to numerous cases of acute liver injury, which are frequently severe and can be fatal.
Flutamide is a monocarboxylic acid amide and a member of (trifluoromethyl)benzenes. It has a role as an androgen antagonist and an antineoplastic agent.
Flutamide is a nonsteroidal antiandrogen (NSAA) that is used primarily to treat prostate cancer. It is also used in the treatment of androgen-dependent conditions like acne, excessive hair growth, and high androgen levels in women.[rx] It is taken by mouth, usually three times per day
Mechanism of Action
Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition, Flutamide is a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen.
Flutamide is a nonsteroidal antiandrogen. In animal studies, flutamide demonstrates potent antiandrogenic effects. It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting the nuclear binding of androgen in target tissues or both. Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g. castration. Elevations of plasma testosterone and estradiol levels have been noted following flutamide administration.
Indications
- For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate
- Flutamide is a nonsteroidal antiandrogen that acts by binding to and blocking intracellular androgen receptors in target tissues including testes, prostate, skin, and hair follicles.
- Flutamide is approved to treat: Prostate cancer that may be locally advanced or has metastasized (spread to other parts of the body). It is used with a type of drug called a luteinizing hormone-releasing hormone agonist. Flutamide is also being studied in the treatment of other conditions and types of cancer.
- Antineoplastic agents are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on the removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias
- Flutamide has been used in case reports to decrease the frequency of spontaneous orgasms, for instance in men with post-orgasmic illness syndrome
- Flutamide has been researched and used extensively in the treatment of androgen-dependent skin and hair conditions in women including acne, seborrhea, hirsutism, and scalp hair loss, as well as in hyperandrogenism (e.g., in polycystic ovary syndrome or congenital adrenal hyperplasia), and is effective in improving the symptoms of these conditions.
- Flutamide has been found to be effective in the treatment of acne and seborrhea in women in a number of studies.[rx][rx] In a long-term study of 230 women with acne, 211 of whom also had seborrhea, very-low-dose flutamide alone or in combination with an oral contraceptive caused a marked decrease in acne and seborrhea after 6 months of treatment, with maximal effect by 1 year of treatment and benefits maintained in the years thereafter
- Flutamide has been found to be effective in the treatment of hirsutism (excessive body/facial hair growth) in numerous studies.[rx][rx] It possesses moderate effectiveness for this indication, and the overall quality of the evidence is considered to be moderate
- Flutamide has been found to be effective in the treatment of female pattern hair loss in a number of studies. In one study of 101 pre- and postmenopausal women, flutamide alone or in combination with an oral contraceptive produced a marked decrease in hair loss scores after 1 year of treatment, with maximum effect after 2 years of treatment and benefits maintained for another 2 years
Use in Cancer
Flutamide is approved to treat:
- Prostate cancer that may be locally advanced or has metastasized (spread to other parts of the body). It is used with a type of drug called a luteinizing hormone-releasing hormone agonist.
Flutamide is also being studied in the treatment of other conditions and types of cancer.
Contraindications
- glucose-6-phosphate dehydrogenase (G6PD) deficiency
- deficiency of the blood enzyme cytochrome b5 reductase
- methemoglobinemia, a type of blood disorder
- liver failure
- liver problems
- severe liver disease
- high amount of bilirubin in the blood
- abnormal liver function tests
- pregnancy
- a patient who is producing milk and breastfeeding
- anemia from pyruvate kinase and G6PD deficiencies
Dosage
Strengths: 125 mg, 250 mg
Prostate Cancer
- 250 mg orally every 8 hours
- This drug may be taken with or without food.
- Stage B2-C Prostatic Carcinoma: Treatment with this drug and the goserelin acetate implant starts 8 weeks prior to initiating radiation therapy and continues during radiation therapy.
- Stage D2 Metastatic Carcinoma: This drug should be initiated with the LHRH-agonist and continued until progression.
- Locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate
Side Effects
The Most Common
- diarrhea
- nausea
- vomiting
- loss of appetite
- hot flashes
- decrease in sexual ability or desire
- breast enlargement in men
- drowsiness
- confusion
- depression
- anxiety
- swelling of the hands, feet, ankles, or lower legs
- blue-green or orange-colored urine
- nausea, upper stomach pain, loss of appetite;
- itching, tiredness, flu-like symptoms;
- dark urine, clay-colored stools; or
- jaundice (yellowing of the skin or eyes).
- breast swelling or tenderness;
- hot flashes;
- vomiting, nausea, diarrhea; or
- impotence, loss of interest in sex.
More common
- Black, tarry stools
- bloody or cloudy urine
- continuing diarrhea
- continuing stomach pain
- difficult, burning, or painful urination
- frequent urge to urinate
- pale skin
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
- appetite changes
- constipation
- diarrhea
- dizziness
- drowsiness
- headache
- hot flashes
- impotence
- nausea
- indigestion
- nervousness
- reduction in sexual desire
- sleeping problems
- swelling of breasts with pain or tenderness
- vomiting
Rare
- Blurred vision
- chest pain
- chills
- cough
- difficulty with breathing
- dizziness
- drowsiness
- fever
- headache
- nervousness
- pounding in the ears
- shortness of breath
- slow or fast heartbeat
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swelling
- swollen glands
- Abdominal or stomach pain
- clay-colored stools
- dark urine
- general tiredness and weakness
- itching
- light-colored stools
- loss of appetite
- nausea and vomiting
- rash
- tumor
- unpleasant breath odor
- upper right abdominal pain
- vomiting of blood
- yellow eyes and skin
- Back, leg, or stomach pains
- bleeding gums
- blistering, peeling, or loosening of the skin
- bluish-colored lips, fingernails, or palms
- discoloration of the urine
- dizziness or lightheadedness
- flushing or redness of the skin
- general body swelling
- headache
- itching
- joint or muscle pain
- nosebleeds
- rapid heart rate
- red irritated eyes
- red skin lesions, often with a purple center
- unusually warm skin
Drug interaction
DRUG | INTERACTION |
---|---|
Abacavir | Flutamide may decrease the excretion rate of Abacavir which could result in a higher serum level. |
Abametapir | The serum concentration of Flutamide can be increased when it is combined with Abametapir. |
Abatacept | The metabolism of Flutamide can be increased when combined with Abatacept. |
Abiraterone | The serum concentration of Flutamide can be increased when it is combined with Abiraterone. |
Acalabrutinib | The metabolism of Flutamide can be decreased when combined with Acalabrutinib. |
Aceclofenac | Aceclofenac may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Acemetacin | Acemetacin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Acenocoumarol | The metabolism of Acenocoumarol can be decreased when combined with Flutamide. |
Acetaminophen | The risk or severity of methemoglobinemia can be increased when Acetaminophen is combined with Flutamide. |
Acetazolamide | Acetazolamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Acetylsalicylic | Acetylsalicylic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Aclidinium | Flutamide may decrease the excretion rate of Aclidinium which could result in a higher serum level. |
Acrivastine | Flutamide may decrease the excretion rate of Acrivastine which could result in a higher serum level. |
Acyclovir | The metabolism of Acyclovir can be decreased when combined with Flutamide. |
Adalimumab | The metabolism of Flutamide can be increased when combined with Adalimumab. |
Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Agomelatine | The metabolism of Agomelatine can be decreased when combined with Flutamide. |
Albendazole | The metabolism of Flutamide can be increased when combined with Albendazole. |
Albutrepenonacog | Flutamide may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level. |
Alclofenac | Alclofenac may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Aldesleukin | Aldesleukin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Alfentanil | The metabolism of Alfentanil can be decreased when combined with Flutamide. |
Allopurinol | Allopurinol may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Almasilate | Flutamide may decrease the excretion rate of Almasilate which could result in a higher serum level. |
Almotriptan | Flutamide may decrease the excretion rate of Almotriptan which could result in a higher serum level. |
Alogliptin | Flutamide may decrease the excretion rate of Alogliptin which could result in a higher serum level. |
Alosetron | The metabolism of Flutamide can be decreased when combined with Alosetron. |
Alprazolam | Alprazolam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Amantadine | Flutamide may decrease the excretion rate of Amantadine which could result in a higher serum level. |
Ambrisentan | The metabolism of Ambrisentan can be decreased when combined with Flutamide. |
Amikacin | Flutamide may decrease the excretion rate of Amikacin which could result in a higher serum level. |
Amiloride | Amiloride may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Aminophenazone | The metabolism of Aminophenazone can be decreased when combined with Flutamide. |
Aminophylline | The metabolism of Aminophylline can be decreased when combined with Flutamide. |
Aminosalicylic acid | The risk or severity of methemoglobinemia can be increased when Aminosalicylic acid is combined with Flutamide. |
Amiodarone | The metabolism of Flutamide can be decreased when combined with Amiodarone. |
Amitriptyline | The metabolism of Flutamide can be decreased when combined with Amitriptyline. |
Ammonium chloride | Flutamide may decrease the excretion rate of Ammonium chloride which could result in a higher serum level. |
Amoxicillin | Flutamide may decrease the excretion rate of Amoxicillin which could result in a higher serum level. |
Amphetamine | Amphetamine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Amphotericin B | Amphotericin B may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ampicillin | Ampicillin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Amprenavir | The metabolism of Flutamide can be decreased when combined with Amprenavir. |
Amrinone | Flutamide may decrease the excretion rate of Amrinone which could result in a higher serum level. |
Amyl Nitrite | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Amyl Nitrite. |
Anagrelide | The metabolism of Flutamide can be decreased when combined with Anagrelide. |
Anakinra | The metabolism of Flutamide can be increased when combined with Anakinra. |
Ancestim | Flutamide may decrease the excretion rate of Ancestim which could result in a higher serum level. |
Antihemophilic | Flutamide may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level. |
Antipyrine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Antipyrine. |
Antithrombin | Flutamide may decrease the excretion rate of Antithrombin III human which could result in a higher serum level. |
Antrafenine | Antrafenine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Apalutamide | The metabolism of Flutamide can be increased when combined with Apalutamide. |
Apixaban | The metabolism of Apixaban can be decreased when combined with Flutamide. |
Apomorphine | The metabolism of Apomorphine can be decreased when combined with Flutamide. |
Apremilast | The metabolism of Flutamide can be increased when combined with Apremilast. |
Aprepitant | The metabolism of Flutamide can be decreased when combined with Aprepitant. |
Arformoterol | Flutamide may decrease the excretion rate of Arformoterol which could result in a higher serum level. |
Aripiprazole | The metabolism of Aripiprazole can be decreased when combined with Flutamide. |
Aripiprazole | The metabolism of Aripiprazole lauroxil can be decreased when combined with Flutamide. |
Armodafinil | The metabolism of Flutamide can be increased when combined with Armodafinil. |
Arsenic trioxide | Flutamide may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level. |
Artemether | The metabolism of Artemether can be decreased when combined with Flutamide. |
Articaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Articaine. |
Asenapine | The metabolism of Asenapine can be decreased when combined with Flutamide. |
Astemizole | The metabolism of Astemizole can be decreased when combined with Flutamide. |
Asunaprevir | The metabolism of Asunaprevir can be decreased when combined with Flutamide. |
Atazanavir | The metabolism of Flutamide can be decreased when combined with Atazanavir. |
Atomoxetine | Atomoxetine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Flutamide. |
Auranofin | Flutamide may decrease the excretion rate of Auranofin which could result in a higher serum level. |
Aurothioglucose | Flutamide may decrease the excretion rate of Aurothioglucose which could result in a higher serum level. |
Avanafil | The serum concentration of Avanafil can be increased when it is combined with Flutamide. |
Axitinib | The metabolism of Axitinib can be decreased when combined with Flutamide. |
Azacitidine | Flutamide may decrease the excretion rate of Azacitidine which could result in a higher serum level. |
Azathioprine | The metabolism of Azathioprine can be decreased when combined with Flutamide. |
Azelaic acid | Flutamide may decrease the excretion rate of Azelaic acid which could result in a higher serum level. |
Azelastine | The metabolism of Azelastine can be decreased when combined with Flutamide. |
Aztreonam | Aztreonam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Bacitracin | Bacitracin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Baclofen | Baclofen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Balsalazide | Balsalazide may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Baricitinib | Flutamide may decrease the excretion rate of Baricitinib which could result in a higher serum level. |
Beclomethasone | The metabolism of Flutamide can be increased when combined with Beclomethasone dipropionate. |
Belinostat | The metabolism of Flutamide can be increased when combined with Belinostat. |
Bendamustine | The metabolism of Bendamustine can be decreased when combined with Flutamide. |
Bendroflumethiazide | Bendroflumethiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Benorilate | Benorilate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Benoxaprofen | Benoxaprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Benserazide | Flutamide may decrease the excretion rate of Benserazide which could result in a higher serum level. |
Benzatropine | Benzatropine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Benznidazole | Flutamide may decrease the excretion rate of Benznidazole which could result in a higher serum level. |
Benzocaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Benzocaine. |
Benzthiazide | Benzthiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Benzydamine | Benzydamine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Benzyl alcohol | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Benzyl alcohol. |
Bepotastine | Flutamide may decrease the excretion rate of Bepotastine which could result in a higher serum level. |
Berotralstat | The metabolism of Flutamide can be decreased when combined with Berotralstat. |
Betamethasone | The metabolism of Flutamide can be increased when combined with Betamethasone. |
Betamethasone | The metabolism of Flutamide can be increased when combined with Betamethasone phosphate. |
Betaxolol | The metabolism of Flutamide can be decreased when combined with Betaxolol. |
Bicisate | Flutamide may decrease the excretion rate of Bicisate which could result in a higher serum level. |
Bimekizumab | The metabolism of Flutamide can be increased when combined with Bimekizumab. |
Binimetinib | The metabolism of Binimetinib can be decreased when combined with Flutamide. |
Bismuth subgallate | Flutamide may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level. |
Bisoprolol | Flutamide may decrease the excretion rate of Bisoprolol which could result in a higher serum level. |
Bisoxatin | Flutamide may decrease the excretion rate of Bisoxatin which could result in a higher serum level. |
Bleomycin | Bleomycin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Boceprevir | The metabolism of Flutamide can be decreased when combined with Boceprevir. |
Bortezomib | The metabolism of Flutamide can be decreased when combined with Bortezomib. |
Brivaracetam | Flutamide may decrease the excretion rate of Brivaracetam which could result in a higher serum level. |
Bromazepam | The metabolism of Bromazepam can be decreased when combined with Flutamide. |
Bromotheophylline | Bromotheophylline may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Budesonide | The metabolism of Flutamide can be increased when combined with Budesonide. |
Bumadizone | Bumadizone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Bumetanide | Bumetanide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Bupivacaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Bupivacaine. |
Buprenorphine | The metabolism of Buprenorphine can be decreased when combined with Flutamide. |
Bupropion | Flutamide may decrease the excretion rate of Bupropion which could result in a higher serum level. |
Buspirone | Buspirone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Butabarbital | Butabarbital may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Butacaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Butacaine. |
Butalbital | The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Flutamide. |
Butamben | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Butamben. |
Cabazitaxel | The metabolism of Cabazitaxel can be decreased when combined with Flutamide. |
Caffeine | The metabolism of Flutamide can be decreased when combined with Caffeine. |
Canagliflozin | Canagliflozin may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Canakinumab | The metabolism of Flutamide can be increased when combined with Canakinumab. |
Cannabidiol | The metabolism of Flutamide can be decreased when combined with Cannabidiol. |
Canrenoic acid | Canrenoic acid may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Capecitabine | Flutamide may decrease the excretion rate of Capecitabine which could result in a higher serum level. |
Capmatinib | The metabolism of Flutamide can be decreased when combined with Capmatinib. |
Capreomycin | Flutamide may decrease the excretion rate of Capreomycin which could result in a higher serum level. |
Capromab pendetide | Flutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent. |
Capsaicin | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Capsaicin. |
Carbamazepine | The metabolism of Carbamazepine can be decreased when combined with Flutamide. |
Carbidopa | Carbidopa may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Carboplatin | Carboplatin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Carmustine | The metabolism of Flutamide can be decreased when combined with Carmustine. |
Carprofen | Carprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Carvedilol | The metabolism of Carvedilol can be decreased when combined with Flutamide. |
Cefaclor | Cefaclor may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefadroxil | Cefadroxil may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefalotin | Cefalotin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefamandole | Cefamandole may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefapirin | Cefapirin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefazolin | Cefazolin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefdinir | Flutamide may decrease the excretion rate of Cefdinir which could result in a higher serum level. |
Cefditoren | Cefditoren may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefepime | Cefepime may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefmenoxime | Cefmenoxime may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefmetazole | Cefmetazole may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefonicid | Cefonicid may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefoperazone | Cefoperazone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ceforanide | Ceforanide may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefotaxime | Cefotaxime may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefotetan | Cefotetan may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefotiam | Cefotiam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefoxitin | Cefoxitin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefpiramide | Cefpiramide may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefpirome | Cefpirome may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefpodoxime | Cefpodoxime may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefprozil | Cefprozil may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefradine | Cefradine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ceftaroline | Ceftaroline fosamil may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ceftazidime | Ceftazidime may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ceftibuten | Ceftibuten may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ceftizoxime | Ceftizoxime may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ceftobiprole | Ceftobiprole may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ceftolozane | Flutamide may decrease the excretion rate of Ceftolozane which could result in a higher serum level. |
Ceftriaxone | Ceftriaxone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cefuroxime | Cefuroxime may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Celecoxib | The risk or severity of methemoglobinemia can be increased when Celecoxib is combined with Flutamide. |
Cenobamate | The serum concentration of Flutamide can be decreased when it is combined with Cenobamate. |
Cephalexin | Cephalexin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cephaloglycin | Cephaloglycin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cerivastatin | The metabolism of Flutamide can be decreased when combined with Cerivastatin. |
Certolizumab | The metabolism of Flutamide can be increased when combined with Certolizumab pegol. |
Cetirizine | Cetirizine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cevimeline | Cevimeline may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Chloral hydrate | Flutamide may decrease the excretion rate of Chloral hydrate which could result in a higher serum level. |
Chloramphenicol | The metabolism of Flutamide can be decreased when combined with Chloramphenicol. |
Chloroprocaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Chloroprocaine. |
Chloroquine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Chloroquine. |
Chlorothiazide | Chlorothiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Chloroxylenol | Flutamide may decrease the excretion rate of Chloroxylenol which could result in a higher serum level. |
Chlorpheniramine | The metabolism of Chlorpheniramine can be decreased when combined with Flutamide. |
Chlorpromazine | The metabolism of Flutamide can be decreased when combined with Chlorpromazine. |
Chlorpropamide | Flutamide may decrease the excretion rate of Chlorpropamide which could result in a higher serum level. |
Chlorthalidone | Chlorthalidone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Chlorzoxazone | The metabolism of Flutamide can be decreased when combined with Chlorzoxazone. |
Choline C 11 | Flutamide may decrease effectiveness of Choline C 11 as a diagnostic agent. |
Choline | Choline magnesium trisalicylate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Choline salicylate | Flutamide may decrease the excretion rate of Choline salicylate which could result in a higher serum level. |
Chondroitin sulfate | Flutamide may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level. |
Chromic chloride | Flutamide may decrease the excretion rate of Chromic chloride which could result in a higher serum level. |
Chromic nitrate | Flutamide may decrease the excretion rate of Chromic nitrate which could result in a higher serum level. |
Chromium | Flutamide may decrease the excretion rate of Chromium which could result in a higher serum level. |
Chromium gluconate | Flutamide may decrease the excretion rate of Chromium gluconate which could result in a higher serum level. |
Chromium nicotinate | Flutamide may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level. |
Chromous sulfate | Flutamide may decrease the excretion rate of Chromous sulfate which could result in a higher serum level. |
Cidofovir | Cidofovir may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cilostazol | The metabolism of Cilostazol can be decreased when combined with Flutamide. |
Cimetidine | The metabolism of Flutamide can be decreased when combined with Cimetidine. |
Cinacalcet | The metabolism of Cinacalcet can be decreased when combined with Flutamide. |
Cinchocaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Cinchocaine. |
Cinnarizine | The metabolism of Cinnarizine can be decreased when combined with Flutamide. |
Cinoxacin | The metabolism of Flutamide can be decreased when combined with Cinoxacin. |
Ciprofloxacin | The metabolism of Flutamide can be decreased when combined with Ciprofloxacin. |
Cisapride | The metabolism of Cisapride can be decreased when combined with Flutamide. |
Cisplatin | Flutamide may decrease the excretion rate of Cisplatin which could result in a higher serum level. |
Citalopram | The metabolism of Flutamide can be decreased when combined with Citalopram. |
Clarithromycin | The metabolism of Flutamide can be decreased when combined with Clarithromycin. |
Clevidipine | Flutamide may decrease the excretion rate of Clevidipine which could result in a higher serum level. |
Clindamycin | The metabolism of Clindamycin can be decreased when combined with Flutamide. |
Clobazam | Clobazam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Clobetasol | The metabolism of Flutamide can be increased when combined with Clobetasol propionate. |
Clofarabine | Flutamide may decrease the excretion rate of Clofarabine which could result in a higher serum level. |
Clofazimine | The metabolism of Flutamide can be decreased when combined with Clofazimine. |
Clomipramine | The metabolism of Clomipramine can be decreased when combined with Flutamide. |
Clonazepam | Flutamide may decrease the excretion rate of Clonazepam which could result in a higher serum level. |
Clonidine | The metabolism of Clonidine can be decreased when combined with Flutamide. |
Clopidogrel | The metabolism of Clopidogrel can be decreased when combined with Flutamide. |
Clorazepic acid | Flutamide may decrease the excretion rate of Clorazepic acid which could result in a higher serum level. |
Clove oil | Flutamide may decrease the excretion rate of Clove oil which could result in a higher serum level. |
Clozapine | The metabolism of Flutamide can be decreased when combined with Clozapine. |
Cobicistat | The metabolism of Flutamide can be decreased when combined with Cobicistat. |
Cocaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Cocaine. |
Colchicine | Flutamide may decrease the excretion rate of Colchicine which could result in a higher serum level. |
Colistimethate | Colistimethate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Colistin | Flutamide may decrease the excretion rate of Colistin which could result in a higher serum level. |
Conivaptan | The metabolism of Flutamide can be decreased when combined with Conivaptan. |
Conjugated | The metabolism of Flutamide can be decreased when combined with Conjugated estrogens. |
Copanlisib | The metabolism of Copanlisib can be decreased when combined with Flutamide. |
Corifollitropin alfa | Flutamide may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
Cortisone acetate | The metabolism of Flutamide can be increased when combined with Cortisone acetate. |
Crizotinib | The metabolism of Crizotinib can be decreased when combined with Flutamide. |
Curcumin | The metabolism of Flutamide can be decreased when combined with Curcumin. |
Cyanocobalamin | Cyanocobalamin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Cyclobenzaprine | The metabolism of Cyclobenzaprine can be decreased when combined with Flutamide. |
Cyclopenthiazide | Cyclopenthiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Cyclophosphamide | The metabolism of Cyclophosphamide can be decreased when combined with Flutamide. |
Cyclosporine | The metabolism of Cyclosporine can be decreased when combined with Flutamide. |
Cyclothiazide | Cyclothiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Cyproterone acetate | The metabolism of Flutamide can be increased when combined with Cyproterone acetate. |
Dabigatran etexilate | Flutamide may decrease the excretion rate of Dabigatran etexilate which could result in a higher serum level. |
Dabrafenib | The serum concentration of Flutamide can be decreased when it is combined with Dabrafenib. |
Dacarbazine | The metabolism of Dacarbazine can be decreased when combined with Flutamide. |
Daclatasvir | The metabolism of Daclatasvir can be decreased when combined with Flutamide. |
Dalfampridine | Flutamide may decrease the excretion rate of Dalfampridine which could result in a higher serum level. |
Danazol | The metabolism of Flutamide can be decreased when combined with Danazol. |
Dapagliflozin | Dapagliflozin may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Dapsone | The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Flutamide. |
Daptomycin | Daptomycin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Darbepoetin alfa | The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Flutamide. |
Darunavir | The metabolism of Flutamide can be decreased when combined with Darunavir. |
Dasatinib | The metabolism of Dasatinib can be decreased when combined with Flutamide. |
Daunorubicin | The metabolism of Flutamide can be increased when combined with Daunorubicin. |
Deferasirox | The serum concentration of Flutamide can be increased when it is combined with Deferasirox. |
Deferiprone | Flutamide may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
Delafloxacin | Flutamide may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
Delavirdine | The metabolism of Flutamide can be decreased when combined with Delavirdine. |
Desipramine | Flutamide may decrease the excretion rate of Desipramine which could result in a higher serum level. |
Desmopressin | Desmopressin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Desvenlafaxine | The metabolism of Flutamide can be decreased when combined with Desvenlafaxine. |
Deutetrabenazine | Flutamide may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level. |
Dexamethasone | The metabolism of Flutamide can be increased when combined with Dexamethasone. |
Dexamethasone | The metabolism of Flutamide can be increased when combined with Dexamethasone acetate. |
Dexfenfluramine | The metabolism of Dexfenfluramine can be decreased when combined with Flutamide. |
Dexibuprofen | Dexibuprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Dexketoprofen | Dexketoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Dexmedetomidine | The metabolism of Flutamide can be decreased when combined with Dexmedetomidine. |
Dexpanthenol | Flutamide may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. |
Dexrazoxane | Dexrazoxane may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Dextran | Flutamide may decrease the excretion rate of Dextran which could result in a higher serum level. |
Dextromethorphan | The metabolism of Dextromethorphan can be decreased when combined with Flutamide. |
Diacerein | The metabolism of Flutamide can be decreased when combined with Diacerein. |
Diatrizoate | Diatrizoate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Diazepam | Flutamide may decrease the excretion rate of Diazepam which could result in a higher serum level. |
Dichlorobenzyl | Flutamide may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level. |
Diclofenac | The metabolism of Diclofenac can be decreased when combined with Flutamide. |
Diclofenamide | Diclofenamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Dicyclomine | Flutamide may decrease the excretion rate of Dicyclomine which could result in a higher serum level. |
Didanosine | Flutamide may decrease the excretion rate of Didanosine which could result in a higher serum level. |
Dienogest | Flutamide may decrease the excretion rate of Dienogest which could result in a higher serum level. |
Diflunisal | Diflunisal may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Difluocortolone | The metabolism of Flutamide can be increased when combined with Difluocortolone. |
Digoxin | Flutamide may decrease the excretion rate of Digoxin which could result in a higher serum level. |
Dihydralazine | The metabolism of Flutamide can be decreased when combined with Dihydralazine. |
Dihydrostreptom | Dihydrostreptomycin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Diltiazem | The metabolism of Flutamide can be decreased when combined with Diltiazem. |
Dimercaprol | Flutamide may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
Dimethyl sulfoxide | Flutamide may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. |
Diphenhydramine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Diphenhydramine. |
Disopyramide | The metabolism of Flutamide can be decreased when combined with Disopyramide. |
Disulfiram | The metabolism of Disulfiram can be decreased when combined with Flutamide. |
DMethylephedrine | Flutamide may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level. |
Dobutamine | Flutamide may decrease the excretion rate of Dobutamine which could result in a higher serum level. |
Docetaxel | The metabolism of Docetaxel can be decreased when combined with Flutamide. |
Domperidone | The metabolism of Domperidone can be decreased when combined with Flutamide. |
Dopamine | Flutamide may decrease the excretion rate of Dopamine which could result in a higher serum level. |
Doravirine | The metabolism of Doravirine can be decreased when combined with Flutamide. |
Doripenem | Flutamide may decrease the excretion rate of Doripenem which could result in a higher serum level. |
Dosulepin | The metabolism of Flutamide can be decreased when combined with Dosulepin. |
Doxacurium | Flutamide may decrease the excretion rate of Doxacurium which could result in a higher serum level. |
Doxepin | The metabolism of Doxepin can be decreased when combined with Flutamide. |
Doxycycline | Doxycycline may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Dronabinol | The metabolism of Flutamide can be decreased when combined with Dronabinol. |
Dronedarone | The metabolism of Dronedarone can be decreased when combined with Flutamide. |
Drospirenone | Drospirenone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Droxidopa | Flutamide may decrease the excretion rate of Droxidopa which could result in a higher serum level. |
Duloxetine | Duloxetine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Dutasteride | The metabolism of Dutasteride can be decreased when combined with Flutamide. |
Dyclonine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Dyclonine. |
Dyphylline | Flutamide may decrease the excretion rate of Dyphylline which could result in a higher serum level. |
Edoxaban | Flutamide may decrease the excretion rate of Edoxaban which could result in a higher serum level. |
Edrophonium | Flutamide may decrease the excretion rate of Edrophonium which could result in a higher serum level. |
Efavirenz | The metabolism of Flutamide can be decreased when combined with Efavirenz. |
Elbasvir | The metabolism of Elbasvir can be decreased when combined with Flutamide. |
Elexacaftor | The metabolism of Elexacaftor can be decreased when combined with Flutamide. |
Eltrombopag | The metabolism of Eltrombopag can be decreased when combined with Flutamide. |
Elvitegravir | The metabolism of Flutamide can be decreased when combined with Elvitegravir. |
Emapalumab | The metabolism of Flutamide can be increased when combined with Emapalumab. |
Enalaprilat | Flutamide may decrease the excretion rate of Enalaprilat which could result in a higher serum level. |
Enasidenib | The metabolism of Flutamide can be decreased when combined with Enasidenib. |
Enoxacin | The metabolism of Flutamide can be decreased when combined with Enoxacin. |
Entecavir | The metabolism of Flutamide can be decreased when combined with Entecavir. |
Enzalutamide | The serum concentration of Flutamide can be decreased when it is combined with Enzalutamide. |
Eplerenone | Eplerenone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Epoprostenol | Flutamide may decrease the excretion rate of Epoprostenol which could result in a higher serum level. |
Ergotamine | The metabolism of Flutamide can be decreased when combined with Ergotamine. |
Erlotinib | The metabolism of Erlotinib can be decreased when combined with Flutamide. |
Ertapenem | Ertapenem may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ertugliflozin | Ertugliflozin may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Erythromycin | The metabolism of Flutamide can be decreased when combined with Erythromycin. |
Erythropoietin | The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Flutamide. |
Estazolam | Flutamide may decrease the excretion rate of Estazolam which could result in a higher serum level. |
Estradiol | The metabolism of Estradiol can be decreased when combined with Flutamide. |
Estradiol acetate | The metabolism of Flutamide can be decreased when combined with Estradiol acetate. |
Estradiol benzoate | The metabolism of Estradiol benzoate can be decreased when combined with Flutamide. |
Estradiol cypionate | The metabolism of Estradiol cypionate can be decreased when combined with Flutamide. |
Estradiol dienanthate | The metabolism of Estradiol dienanthate can be decreased when combined with Flutamide. |
Estradiol valerate | The metabolism of Estradiol valerate can be decreased when combined with Flutamide. |
Estrone sulfate | The metabolism of Flutamide can be decreased when combined with Estrone sulfate. |
Eszopiclone | Eszopiclone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Etacrynic acid | Etacrynic acid may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Etafedrine | Flutamide may decrease the excretion rate of Etafedrine which could result in a higher serum level. |
Etanercept | The metabolism of Flutamide can be increased when combined with Etanercept. |
Ethambutol | Ethambutol may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ethanol | The metabolism of Ethanol can be decreased when combined with Flutamide. |
Ethinylestradiol | The metabolism of Ethinylestradiol can be decreased when combined with Flutamide. |
Ethyl chloride | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Ethyl chloride. |
Etidocaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Etidocaine. |
Etodolac | Etodolac may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Etomidate | Etomidate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Etonogestrel | Etonogestrel may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Etoposide | The metabolism of Etoposide can be decreased when combined with Flutamide. |
Etoricoxib | The metabolism of Etoricoxib can be decreased when combined with Flutamide. |
Eucalyptus oil | Flutamide may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level. |
Ezogabine | Flutamide may decrease the excretion rate of Ezogabine which could result in a higher serum level. |
Famotidine | The metabolism of Flutamide can be decreased when combined with Famotidine. |
Felodipine | The metabolism of Felodipine can be decreased when combined with Flutamide. |
Fenbufen | Fenbufen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Fenfluramine | The metabolism of Fenfluramine can be decreased when combined with Flutamide. |
Fenofibrate | Flutamide may decrease the excretion rate of Fenofibrate which could result in a higher serum level. |
Fenofibric acid | Flutamide may decrease the excretion rate of Fenofibric acid which could result in a higher serum level. |
Fenoldopam | Flutamide may decrease the excretion rate of Fenoldopam which could result in a higher serum level. |
Fenoprofen | Fenoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Fentanyl | Flutamide may decrease the excretion rate of Fentanyl which could result in a higher serum level. |
Fesoterodine | Flutamide may decrease the excretion rate of Fesoterodine which could result in a higher serum level. |
Fexinidazole | The metabolism of Flutamide can be decreased when combined with Fexinidazole. |
Finasteride | The metabolism of Finasteride can be decreased when combined with Flutamide. |
Finerenone | Finerenone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Flavoxate | Flutamide may decrease the excretion rate of Flavoxate which could result in a higher serum level. |
Flecainide | The metabolism of Flecainide can be decreased when combined with Flutamide. |
Floctafenine | Floctafenine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Florbetaben (18F) | Flutamide may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level. |
Florbetapir (18F) | Flutamide may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level. |
Floxuridine | Floxuridine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Fluconazole | The metabolism of Flutamide can be decreased when combined with Fluconazole. |
Flucytosine | Flutamide may decrease the excretion rate of Flucytosine which could result in a higher serum level. |
Fludeoxyglucose | Flutamide may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level. |
Flumazenil | Flutamide may decrease the excretion rate of Flumazenil which could result in a higher serum level. |
Flunarizine | The metabolism of Flunarizine can be decreased when combined with Flutamide. |
Fluocinolone | Flutamide may decrease the excretion rate of Fluocinolone acetonide which could result in a higher serum level. |
Fluocinonide | The metabolism of Flutamide can be increased when combined with Fluocinonide. |
Fluocortolone | The metabolism of Flutamide can be increased when combined with Fluocortolone. |
Fluorouracil | The metabolism of Fluorouracil can be decreased when combined with Flutamide. |
Fluoxetine | The metabolism of Flutamide can be decreased when combined with Fluoxetine. |
Flurazepam | Flutamide may decrease the excretion rate of Flurazepam which could result in a higher serum level. |
Flurbiprofen | Flurbiprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Fluticasone | The metabolism of Flutamide can be decreased when combined with Fluticasone. |
Fluticasone | The metabolism of Flutamide can be decreased when combined with Fluticasone furoate. |
Fluticasone | The metabolism of Flutamide can be decreased when combined with Fluticasone propionate. |
Fluvastatin | The metabolism of Fluvastatin can be decreased when combined with Flutamide. |
Fluvoxamine | The metabolism of Flutamide can be decreased when combined with Fluvoxamine. |
Folic acid | Folic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Fomepizole | Flutamide may decrease the excretion rate of Fomepizole which could result in a higher serum level. |
Fondaparinux | Flutamide may decrease the excretion rate of Fondaparinux which could result in a higher serum level. |
Formestane | Flutamide may decrease the excretion rate of Formestane which could result in a higher serum level. |
Foscarnet | Foscarnet may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Fosfomycin | Flutamide may decrease the excretion rate of Fosfomycin which could result in a higher serum level. |
Fosinopril | Fosinopril may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Fosnetupitant | The metabolism of Flutamide can be decreased when combined with Fosnetupitant. |
Fosphenytoin | The metabolism of Flutamide can be increased when combined with Fosphenytoin. |
Framycetin | Framycetin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Frovatriptan | The metabolism of Frovatriptan can be decreased when combined with Flutamide. |
Furosemide | Furosemide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Fusidic acid | The metabolism of Flutamide can be decreased when combined with Fusidic acid. |
Gabapentin | Flutamide may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level. |
Gadobenic acid | Flutamide may decrease the excretion rate of Gadobenic acid which could result in a higher serum level. |
Gadodiamide | Gadodiamide may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Gadofosveset | Flutamide may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level. |
Gadopentetic acid | Flutamide may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level. |
Gadoteric acid | Flutamide may decrease the excretion rate of Gadoteric acid which could result in a higher serum level. |
Gadoteridol | Flutamide may decrease the excretion rate of Gadoteridol which could result in a higher serum level. |
Gallium | Flutamide may increase effectiveness of Gallium Ga-68 gozetotide as a diagnostic agent. |
Ganciclovir | Flutamide may decrease the excretion rate of Ganciclovir which could result in a higher serum level. |
Gatifloxacin | The metabolism of Flutamide can be decreased when combined with Gatifloxacin. |
Gefitinib | The metabolism of Flutamide can be decreased when combined with Gefitinib. |
Gemcitabine | Gemcitabine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Gemfibrozil | The metabolism of Flutamide can be decreased when combined with Gemfibrozil. |
Gemifloxacin | The metabolism of Flutamide can be decreased when combined with Gemifloxacin. |
Gentamicin | Flutamide may decrease the excretion rate of Gentamicin which could result in a higher serum level. |
Gimeracil | Flutamide may decrease the excretion rate of Gimeracil which could result in a higher serum level. |
Givosiran | The serum concentration of Flutamide can be increased when it is combined with Givosiran. |
Glipizide | Flutamide may decrease the excretion rate of Glipizide which could result in a higher serum level. |
Glyburide | The metabolism of Glyburide can be decreased when combined with Flutamide. |
Glycerol | Flutamide may decrease the excretion rate of Glycerol phenylbutyrate which could result in a higher serum level. |
Golimumab | The metabolism of Flutamide can be increased when combined with Golimumab. |
Golodirsen | Flutamide may decrease the excretion rate of Golodirsen which could result in a higher serum level. |
Goserelin | Goserelin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Grepafloxacin | The metabolism of Flutamide can be decreased when combined with Grepafloxacin. |
Guanabenz | The metabolism of Guanabenz can be decreased when combined with Flutamide. |
Guanethidine | Flutamide may decrease the excretion rate of Guanethidine which could result in a higher serum level. |
Guanfacine | Flutamide may decrease the excretion rate of Guanfacine which could result in a higher serum level. |
Halofantrine | The metabolism of Halofantrine can be decreased when combined with Flutamide. |
Haloperidol | The serum concentration of Haloperidol can be increased when it is combined with Flutamide. |
Hydralazine | Flutamide may decrease the excretion rate of Hydralazine which could result in a higher serum level. |
Hydrochlorothiazide | Hydrochlorothiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Hydrocortisone | The metabolism of Hydrocortisone can be decreased when combined with Flutamide. |
Hydrocortisone | The metabolism of Hydrocortisone acetate can be decreased when combined with Flutamide. |
Hydrocortisone | The metabolism of Hydrocortisone butyrate can be decreased when combined with Flutamide. |
Hydrocortisone e | The metabolism of Hydrocortisone cypionate can be decreased when combined with Flutamide. |
Hydrocortisone | The metabolism of Hydrocortisone phosphate can be decreased when combined with Flutamide. |
Hydroflumethiazide | Hydroflumethiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Hydromorphone | Hydromorphone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Hydroxocobalamin | Hydroxocobalamin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Hydroxyethyl Starch | Flutamide may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level. |
Hydroxyprogesterone | The metabolism of Hydroxyprogesterone caproate can be decreased when combined with Flutamide. |
Hydroxyurea | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Hydroxyurea. |
Hydroxyzine | The metabolism of Hydroxyzine can be decreased when combined with Flutamide. |
Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Flutamide. |
Ibuprofen | Ibuprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ibutilide | Ibutilide may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Icatibant | Flutamide may decrease the excretion rate of Icatibant which could result in a higher serum level. |
Icosapent | Icosapent may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Idarucizumab | Flutamide may decrease the excretion rate of Idarucizumab which could result in a higher serum level. |
Idebenone | Flutamide may decrease the excretion rate of Idebenone which could result in a higher serum level. |
Ifosfamide | The metabolism of Ifosfamide can be decreased when combined with Flutamide. |
Iloperidone | The metabolism of Iloperidone can be decreased when combined with Flutamide. |
Imatinib | The metabolism of Flutamide can be decreased when combined with Imatinib. |
Imipramine | The metabolism of Flutamide can be decreased when combined with Imipramine. |
Indapamide | Indapamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Indigotindisulfonic | Flutamide may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level. |
Indinavir | The metabolism of Flutamide can be decreased when combined with Indinavir. |
Indomethacin | Indomethacin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Infliximab | The metabolism of Flutamide can be increased when combined with Infliximab. |
Inosine pranobex | Flutamide may decrease the excretion rate of Inosine pranobex which could result in a higher serum level. |
Inositol | Flutamide may decrease the excretion rate of Inositol which could result in a higher serum level. |
Inotersen | Inotersen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Insulin beef | The metabolism of Flutamide can be increased when combined with Insulin beef. |
Insulin pork | The metabolism of Flutamide can be increased when combined with Insulin pork. |
Interferon alfa-2a | The metabolism of Flutamide can be decreased when combined with Interferon alfa-2a. |
Interferon alfa-2b | The metabolism of Flutamide can be decreased when combined with Interferon alfa-2b. |
Interferon alfa-n1 | The metabolism of Flutamide can be decreased when combined with Interferon alfa-n1. |
Interferon alfa-n3 | The metabolism of Flutamide can be decreased when combined with Interferon alfa-n3. |
Interferon alfacon-1 | The metabolism of Flutamide can be decreased when combined with Interferon alfacon-1. |
Interferon beta-1a | The metabolism of Flutamide can be decreased when combined with Interferon beta-1a. |
Interferon beta-1b | The metabolism of Flutamide can be decreased when combined with Interferon beta-1b. |
Interferon gamma | The metabolism of Flutamide can be decreased when combined with Interferon gamma-1b. |
Iobenguane sulfate | Flutamide may decrease the excretion rate of Iobenguane sulfate I-123 which could result in a higher serum level. |
Iodixanol | Flutamide may decrease the excretion rate of Iodixanol which could result in a higher serum level. |
Ioflupane I-123 | Flutamide may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level. |
Iopromide | Flutamide may decrease the excretion rate of Iopromide which could result in a higher serum level. |
Iothalamic acid | Flutamide may decrease the excretion rate of Iothalamic acid which could result in a higher serum level. |
Ioversol | Flutamide may decrease the excretion rate of Ioversol which could result in a higher serum level. |
Ioxilan | Flutamide may decrease the excretion rate of Ioxilan which could result in a higher serum level. |
Ipecac | Flutamide may decrease the excretion rate of Ipecac which could result in a higher serum level. |
Ipilimumab | Flutamide may decrease the excretion rate of Ipilimumab which could result in a higher serum level. |
Irinotecan | The metabolism of Irinotecan can be decreased when combined with Flutamide. |
Isavuconazole | The metabolism of Flutamide can be decreased when combined with Isavuconazole. |
Isavuconazonium | The metabolism of Flutamide can be decreased when combined with Isavuconazonium. |
Isometheptene | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Isometheptene. |
Isoniazid | The metabolism of Flutamide can be decreased when combined with Isoniazid. |
Isosorbide | Isosorbide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Isosorbide dinitrate | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Isosorbide dinitrate. |
Isosorbide | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Isosorbide mononitrate. |
Isosulfan blue | Flutamide may decrease the excretion rate of Isosulfan blue which could result in a higher serum level. |
Isotretinoin | Flutamide may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
Isoxicam | Isoxicam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Isradipine | The metabolism of Flutamide can be decreased when combined with Isradipine. |
Istradefylline | The metabolism of Istradefylline can be decreased when combined with Flutamide. |
Itraconazole | The metabolism of Flutamide can be decreased when combined with Itraconazole. |
Ivacaftor | The metabolism of Ivacaftor can be decreased when combined with Flutamide. |
Ivosidenib | The metabolism of Flutamide can be increased when combined with Ivosidenib. |
Ixazomib | Flutamide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
Kanamycin | Flutamide may decrease the excretion rate of Kanamycin which could result in a higher serum level. |
Ketamine | Flutamide may decrease the excretion rate of Ketamine which could result in a higher serum level. |
Ketazolam | Flutamide may decrease the excretion rate of Ketazolam which could result in a higher serum level. |
Ketoconazole | The metabolism of Flutamide can be decreased when combined with Ketoconazole. |
Ketoprofen | Ketoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ketorolac | Ketorolac may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Labetalol | Flutamide may decrease the excretion rate of Labetalol which could result in a higher serum level. |
Lamivudine | Flutamide may decrease the excretion rate of Lamivudine which could result in a higher serum level. |
Lamotrigine | Flutamide may decrease the excretion rate of Lamotrigine which could result in a higher serum level. |
Lapatinib | The metabolism of Lapatinib can be decreased when combined with Flutamide. |
Latamoxef | Latamoxef may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ledipasvir | Flutamide may decrease the excretion rate of Ledipasvir which could result in a higher serum level. |
Leflunomide | The serum concentration of Flutamide can be decreased when it is combined with Leflunomide. |
Lemborexant | The metabolism of Lemborexant can be decreased when combined with Flutamide. |
Lenalidomide | Lenalidomide may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Lercanidipine | The metabolism of Lercanidipine can be decreased when combined with Flutamide. |
Lesinurad | Flutamide may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
Letermovir | The metabolism of Flutamide can be decreased when combined with Letermovir. |
Leuprolide | Leuprolide may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Levamlodipine | The metabolism of Levamlodipine can be decreased when combined with Flutamide. |
Levobupivacaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Levobupivacaine. |
Levocarnitine | Flutamide may decrease the excretion rate of Levocarnitine which could result in a higher serum level. |
Levocetirizine | Flutamide may decrease the excretion rate of Levocetirizine which could result in a higher serum level. |
Levofloxacin | Flutamide may decrease the excretion rate of Levofloxacin which could result in a higher serum level. |
Levoketoconazole | The metabolism of Flutamide can be decreased when combined with Levoketoconazole. |
Levomilnacipran | Flutamide may decrease the excretion rate of Levomilnacipran which could result in a higher serum level. |
Levonorgestrel | The metabolism of Flutamide can be decreased when combined with Levonorgestrel. |
Levosalbutamol | Flutamide may decrease the excretion rate of Levosalbutamol which could result in a higher serum level. |
Lidocaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Lidocaine. |
Linagliptin | The metabolism of Flutamide can be decreased when combined with Linagliptin. |
Liothyronine | Liothyronine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Lisinopril | Flutamide may decrease the excretion rate of Lisinopril which could result in a higher serum level. |
Lithium carbonate | Flutamide may decrease the excretion rate of Lithium carbonate which could result in a higher serum level. |
Lithium citrate | Lithium citrate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Lixisenatide | Flutamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level. |
Lofexidine | The metabolism of Lofexidine can be decreased when combined with Flutamide. |
Lomefloxacin | The metabolism of Lomefloxacin can be decreased when combined with Flutamide. |
Lonafarnib | The metabolism of Flutamide can be decreased when combined with Lonafarnib. |
Lonapegsomat | The metabolism of Flutamide can be increased when combined with Lonapegsomatropin. |
Lopinavir | The metabolism of Flutamide can be decreased when combined with Lopinavir. |
Loracarbef | Loracarbef may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Lorazepam | Lorazepam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Lorcaserin | The metabolism of Lorcaserin can be decreased when combined with Flutamide. |
Lorlatinib | The metabolism of Lorlatinib can be decreased when combined with Flutamide. |
Lornoxicam | Lornoxicam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Lorpiprazole | Flutamide may decrease the excretion rate of Lorpiprazole which could result in a higher serum level. |
Lovastatin | The metabolism of Flutamide can be decreased when combined with Lovastatin. |
Loxoprofen | Loxoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Lubiprostone | Flutamide may decrease the excretion rate of Lubiprostone which could result in a higher serum level. |
Lumacaftor | The metabolism of Flutamide can be increased when combined with Lumacaftor. |
Lumiracoxib | Lumiracoxib may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Macitentan | Flutamide may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Magnesium carbonate | Flutamide may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level. |
Magnesium chloride | Flutamide may decrease the excretion rate of Magnesium chloride which could result in a higher serum level. |
Magnesium | Flutamide may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. |
Magnesium | Flutamide may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level. |
Mangafodipir | Flutamide may decrease the excretion rate of Mangafodipir which could result in a higher serum level. |
Mannitol | Mannitol may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Maprotiline | The metabolism of Maprotiline can be decreased when combined with Flutamide. |
Mavacamten | The serum concentration of Flutamide can be decreased when it is combined with Mavacamten. |
Mecamylamine | Flutamide may decrease the excretion rate of Mecamylamine which could result in a higher serum level. |
Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Medroxyprogeste | Flutamide may decrease the excretion rate of Medroxyprogesterone acetate which could result in a higher serum level. |
Mefenamic acid | The metabolism of Mefenamic acid can be decreased when combined with Flutamide. |
Megestrol acetate | Megestrol acetate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Melatonin | The metabolism of Melatonin can be decreased when combined with Flutamide. |
Meloxicam | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Meloxicam. |
Memantine | Flutamide may decrease the excretion rate of Memantine which could result in a higher serum level. |
Meperidine | Meperidine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Mephenytoin | The metabolism of Mephenytoin can be decreased when combined with Flutamide. |
Mepivacaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Mepivacaine. |
Meprednisone | The metabolism of Flutamide can be increased when combined with Meprednisone. |
Meropenem | Flutamide may decrease the excretion rate of Meropenem which could result in a higher serum level. |
Mesalazine | Mesalazine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Metamfetamine | Flutamide may decrease the excretion rate of Metamfetamine which could result in a higher serum level. |
Metamizole | Metamizole may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Metaxalone | Flutamide may decrease the excretion rate of Metaxalone which could result in a higher serum level. |
Metformin | Metformin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Methadone | Methadone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Methazolamide | Methazolamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Methimazole | The metabolism of Flutamide can be decreased when combined with Methimazole. |
Methotrexate | Methotrexate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Methoxsalen | The metabolism of Flutamide can be decreased when combined with Methoxsalen. |
Methoxy | The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Flutamide. |
Methyldopa | Flutamide may decrease the excretion rate of Methyldopa which could result in a higher serum level. |
Methylene blue | The metabolism of Flutamide can be decreased when combined with Methylene blue. |
Methylnaltrexone | Flutamide may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level. |
Methyltestosterone | Flutamide may decrease the excretion rate of Methyltestosterone which could result in a higher serum level. |
Meticrane | Meticrane may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Metoclopramide | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Metoclopramide. |
Metolazone | Metolazone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Metoprolol | Metoprolol may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Metreleptin | The metabolism of Flutamide can be increased when combined with Metreleptin. |
Metronidazole | The metabolism of Metronidazole can be decreased when combined with Flutamide. |
Metyrapone | Flutamide may decrease the excretion rate of Metyrapone which could result in a higher serum level. |
Mexiletine | The metabolism of Flutamide can be decreased when combined with Mexiletine. |
Mianserin | The metabolism of Mianserin can be decreased when combined with Flutamide. |
Miconazole | The metabolism of Flutamide can be decreased when combined with Miconazole. |
Midazolam | Flutamide may decrease the excretion rate of Midazolam which could result in a higher serum level. |
Midostaurin | The metabolism of Flutamide can be decreased when combined with Midostaurin. |
Mifepristone | The metabolism of Mifepristone can be decreased when combined with Flutamide. |
Migalastat | Flutamide may decrease the excretion rate of Migalastat which could result in a higher serum level. |
Milnacipran | The metabolism of Flutamide can be decreased when combined with Milnacipran. |
Milrinone | Milrinone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Mirabegron | Flutamide may decrease the excretion rate of Mirabegron which could result in a higher serum level. |
Mirtazapine | The metabolism of Flutamide can be decreased when combined with Mirtazapine. |
Mitotane | The metabolism of Flutamide can be increased when combined with Mitotane. |
Mobocertinib | The metabolism of Mobocertinib can be decreased when combined with Flutamide. |
Modafinil | The metabolism of Flutamide can be increased when combined with Modafinil. |
Mometasone | The metabolism of Flutamide can be increased when combined with Mometasone furoate. |
Moxifloxacin | The metabolism of Flutamide can be decreased when combined with Moxifloxacin. |
Moxisylyte | Flutamide may decrease the excretion rate of Moxisylyte which could result in a higher serum level. |
Muzolimine | Muzolimine may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Mycophenolate | Flutamide may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level. |
Mycophenolic acid | Flutamide may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level. |
N-acetyltyrosine | Flutamide may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level. |
Nabumetone | The metabolism of Flutamide can be decreased when combined with Nabumetone. |
Nadolol | Flutamide may decrease the excretion rate of Nadolol which could result in a higher serum level. |
Nafcillin | The metabolism of Flutamide can be increased when combined with Nafcillin. |
Naldemedine | Flutamide may decrease the excretion rate of Naldemedine which could result in a higher serum level. |
Nalidixic acid | The metabolism of Flutamide can be decreased when combined with Nalidixic acid. |
Nalmefene | Flutamide may decrease the excretion rate of Nalmefene which could result in a higher serum level. |
Naloxone | The metabolism of Flutamide can be decreased when combined with Naloxone. |
Naproxen | The metabolism of Naproxen can be decreased when combined with Flutamide. |
Nateglinide | Flutamide may decrease the excretion rate of Nateglinide which could result in a higher serum level. |
Nedaplatin | Flutamide may decrease the excretion rate of Nedaplatin which could result in a higher serum level. |
Nedocromil | Flutamide may decrease the excretion rate of Nedocromil which could result in a higher serum level. |
Nefazodone | The metabolism of Flutamide can be decreased when combined with Nefazodone. |
Nelfinavir | The metabolism of Flutamide can be decreased when combined with Nelfinavir. |
Neomycin | Flutamide may decrease the excretion rate of Neomycin which could result in a higher serum level. |
Netilmicin | Flutamide may decrease the excretion rate of Netilmicin which could result in a higher serum level. |
Netupitant | The metabolism of Flutamide can be decreased when combined with Netupitant. |
Nevirapine | The metabolism of Flutamide can be decreased when combined with Nevirapine. |
Nicardipine | The metabolism of Flutamide can be decreased when combined with Nicardipine. |
Niclosamide | The metabolism of Flutamide can be decreased when combined with Niclosamide. |
Nicorandil | Flutamide may decrease the excretion rate of Nicorandil which could result in a higher serum level. |
Nifedipine | The metabolism of Nifedipine can be decreased when combined with Flutamide. |
Nilotinib | The metabolism of Flutamide can be decreased when combined with Nilotinib. |
Nilutamide | Flutamide may decrease the excretion rate of Nilutamide which could result in a higher serum level. |
Nilvadipine | The metabolism of Flutamide can be decreased when combined with Nilvadipine. |
Nimesulide | Nimesulide may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Nisoldipine | Nisoldipine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Nitrendipine | The metabolism of Nitrendipine can be decreased when combined with Flutamide. |
Nitric Oxide | The risk or severity of methemoglobinemia can be increased when Nitric Oxide is combined with Flutamide. |
Nitrofurantoin | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Nitrofurantoin. |
Nitroglycerin | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Nitroglycerin. |
Nitroprusside | The risk or severity of methemoglobinemia can be increased when Nitroprusside is combined with Flutamide. |
Nitrous oxide | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Nitrous oxide. |
Norethisterone | The metabolism of Norethisterone can be decreased when combined with Flutamide. |
Norfloxacin | The metabolism of Flutamide can be decreased when combined with Norfloxacin. |
Obeticholic acid | The metabolism of Flutamide can be decreased when combined with Obeticholic acid. |
Octinoxate | Flutamide may decrease the excretion rate of Octinoxate which could result in a higher serum level. |
Olanzapine | The metabolism of Flutamide can be decreased when combined with Olanzapine. |
Olaparib | The metabolism of Olaparib can be decreased when combined with Flutamide. |
Olsalazine | Olsalazine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Omeprazole | The metabolism of Flutamide can be increased when combined with Omeprazole. |
Ondansetron | The metabolism of Ondansetron can be decreased when combined with Flutamide. |
Opium | Flutamide may decrease the excretion rate of Opium which could result in a higher serum level. |
Orphenadrine | The metabolism of Flutamide can be decreased when combined with Orphenadrine. |
Oseltamivir | Oseltamivir may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Osilodrostat | The metabolism of Flutamide can be decreased when combined with Osilodrostat. |
Osimertinib | The serum concentration of Flutamide can be decreased when it is combined with Osimertinib. |
Oxacillin | Flutamide may decrease the excretion rate of Oxacillin which could result in a higher serum level. |
Oxaprozin | Oxaprozin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Oxazepam | Flutamide may decrease the excretion rate of Oxazepam which could result in a higher serum level. |
Oxcarbazepine | The metabolism of Flutamide can be increased when combined with Oxcarbazepine. |
Oxetacaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Oxetacaine. |
Oxtriphylline | The metabolism of Oxtriphylline can be decreased when combined with Flutamide. |
Oxybenzone | Flutamide may decrease the excretion rate of Oxybenzone which could result in a higher serum level. |
Oxybuprocaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Oxybuprocaine. |
Oxybutynin | The metabolism of Oxybutynin can be decreased when combined with Flutamide. |
Oxycodone | The metabolism of Flutamide can be decreased when combined with Oxycodone. |
Oxyphenbutazone | Oxyphenbutazone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Oxyquinoline | Flutamide may decrease the excretion rate of Oxyquinoline which could result in a higher serum level. |
Paclitaxel | The metabolism of Paclitaxel can be decreased when combined with Flutamide. |
Pacritinib | The metabolism of Flutamide can be decreased when combined with Pacritinib. |
Paliperidone | Flutamide may decrease the excretion rate of Paliperidone which could result in a higher serum level. |
Palonosetron | Palonosetron may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Pamidronic acid | Pamidronic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Pantoprazole | Pantoprazole may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Parecoxib | Parecoxib may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Paritaprevir | The metabolism of Paritaprevir can be decreased when combined with Flutamide. |
Paromomycin | Paromomycin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Paroxetine | The metabolism of Paroxetine can be decreased when combined with Flutamide. |
Patent Blue | Flutamide may decrease the excretion rate of Patent Blue which could result in a higher serum level. |
Pazopanib | The metabolism of Pazopanib can be decreased when combined with Flutamide. |
Pefloxacin | The metabolism of Flutamide can be decreased when combined with Pefloxacin. |
Pegaptanib | Flutamide may decrease the excretion rate of Pegaptanib which could result in a higher serum level. |
Peginesatide | The risk or severity of Thrombosis can be increased when Peginesatide is combined with Flutamide. |
Peginterferon alfa | The metabolism of Flutamide can be decreased when combined with Peginterferon alfa-2a. |
Peginterferon alfa | The serum concentration of Flutamide can be increased when it is combined with Peginterferon alfa-2b. |
Pemetrexed | Flutamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level. |
Penbutolol | Flutamide may decrease the excretion rate of Penbutolol which could result in a higher serum level. |
Penciclovir | The metabolism of Flutamide can be decreased when combined with Penciclovir. |
Pentaerythritol | Flutamide may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level. |
Pentamidine | Pentamidine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Pentastarch | Flutamide may decrease the excretion rate of Pentastarch which could result in a higher serum level. |
Pentetic acid | Flutamide may decrease the excretion rate of Pentetic acid which could result in a higher serum level. |
Pentobarbital | The metabolism of Flutamide can be increased when combined with Pentobarbital. |
Pentostatin | Flutamide may decrease the excretion rate of Pentostatin which could result in a higher serum level. |
Pentoxifylline | The metabolism of Pentoxifylline can be decreased when combined with Flutamide. |
Perampanel | The metabolism of Perampanel can be decreased when combined with Flutamide. |
Perindopril | Flutamide may decrease the excretion rate of Perindopril which could result in a higher serum level. |
Permethrin | Flutamide may decrease the excretion rate of Permethrin which could result in a higher serum level. |
Perphenazine | The metabolism of Perphenazine can be decreased when combined with Flutamide. |
Phenazopyridine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Phenazopyridine. |
Phenelzine | Flutamide may decrease the excretion rate of Phenelzine which could result in a higher serum level. |
Phenobarbital | The metabolism of Flutamide can be increased when combined with Phenobarbital. |
Phenol | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Phenol. |
Phentolamine | Flutamide may decrease the excretion rate of Phentolamine which could result in a higher serum level. |
Phenylbutazone | Phenylbutazone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Phenylephrine | The metabolism of Flutamide can be increased when combined with Phenylephrine. |
Phenytoin | The metabolism of Flutamide can be increased when combined with Phenytoin. |
Pholcodine | Flutamide may decrease the excretion rate of Pholcodine which could result in a higher serum level. |
Phosphoric acid | Flutamide may decrease the excretion rate of Phosphoric acid which could result in a higher serum level. |
Phylloquinone | Flutamide may decrease the excretion rate of Phylloquinone which could result in a higher serum level. |
Picosulfuric acid | Flutamide may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level. |
Piflufolastat F 18 | Flutamide may decrease effectiveness of Piflufolastat F 18 as a diagnostic agent. |
Pimozide | The metabolism of Pimozide can be decreased when combined with Flutamide. |
Pindolol | Flutamide may decrease the excretion rate of Pindolol which could result in a higher serum level. |
Piperacillin | Piperacillin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Piracetam | Flutamide may decrease the excretion rate of Piracetam which could result in a higher serum level. |
Piretanide | Piretanide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Pirfenidone | The metabolism of Pirfenidone can be decreased when combined with Flutamide. |
Piroxicam | Piroxicam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Pitolisant | The serum concentration of Flutamide can be decreased when it is combined with Pitolisant. |
Plazomicin | Flutamide may decrease the excretion rate of Plazomicin which could result in a higher serum level. |
Plerixafor | Flutamide may decrease the excretion rate of Plerixafor which could result in a higher serum level. |
Polythiazide | Polythiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Pomalidomide | The metabolism of Pomalidomide can be decreased when combined with Flutamide. |
Ponatinib | The metabolism of Ponatinib can be decreased when combined with Flutamide. |
Ponesimod | The metabolism of Ponesimod can be decreased when combined with Flutamide. |
Posaconazole | The metabolism of Flutamide can be decreased when combined with Posaconazole. |
Potassium | Potassium may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Potassium acetate | Flutamide may decrease the excretion rate of Potassium acetate which could result in a higher serum level. |
Potassium | Flutamide may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level. |
Potassium cation | Potassium cation may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Potassium chloride | Flutamide may decrease the excretion rate of Potassium chloride which could result in a higher serum level. |
Potassium citrate | Potassium citrate may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Potassium nitrate | Flutamide may decrease the excretion rate of Potassium nitrate which could result in a higher serum level. |
Potassium | Flutamide may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level. |
Potassium sulfate | Flutamide may decrease the excretion rate of Potassium sulfate which could result in a higher serum level. |
Pralatrexate | Flutamide may decrease the excretion rate of Pralatrexate which could result in a higher serum level. |
Pralidoxime | Flutamide may decrease the excretion rate of Pralidoxime which could result in a higher serum level. |
Pralsetinib | The metabolism of Flutamide can be decreased when combined with Pralsetinib. |
Pramipexole | Pramipexole may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Pramocaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Pramocaine. |
Prasugrel | Flutamide may decrease the excretion rate of Prasugrel which could result in a higher serum level. |
Praziquantel | The metabolism of Praziquantel can be decreased when combined with Flutamide. |
Prednisolone | The metabolism of Flutamide can be increased when combined with Prednisolone phosphate. |
Prednisone | Flutamide may decrease the excretion rate of Prednisone which could result in a higher serum level. |
Prednisone | The metabolism of Flutamide can be increased when combined with Prednisone acetate. |
Pregabalin | Pregabalin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Prilocaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Prilocaine. |
Primaquine | The metabolism of Flutamide can be decreased when combined with Primaquine. |
Primidone | The metabolism of Flutamide can be increased when combined with Primidone. |
Probenecid | Flutamide may decrease the excretion rate of Probenecid which could result in a higher serum level. |
Procainamide | Flutamide may decrease the excretion rate of Procainamide which could result in a higher serum level. |
Procaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Procaine. |
Procaine | Flutamide may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level. |
Progesterone | The metabolism of Flutamide can be decreased when combined with Progesterone. |
Promazine | The metabolism of Flutamide can be decreased when combined with Promazine. |
Promethazine | Flutamide may decrease the excretion rate of Promethazine which could result in a higher serum level. |
Propafenone | The metabolism of Flutamide can be decreased when combined with Propafenone. |
Propantheline | Flutamide may decrease the excretion rate of Propantheline which could result in a higher serum level. |
Proparacaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Proparacaine. |
Propiverine | Flutamide may decrease the excretion rate of Propiverine which could result in a higher serum level. |
Propoxycaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Propoxycaine. |
Propranolol | The metabolism of Propranolol can be decreased when combined with Flutamide. |
Prucalopride | Flutamide may decrease the excretion rate of Prucalopride which could result in a higher serum level. |
Pyrantel | Flutamide may decrease the excretion rate of Pyrantel which could result in a higher serum level. |
Pyrazinamide | Pyrazinamide may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Pyridoxine | Pyridoxine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Pyrithione | Flutamide may decrease the excretion rate of Pyrithione which could result in a higher serum level. |
Quetiapine | Flutamide may decrease the excretion rate of Quetiapine which could result in a higher serum level. |
Quinethazone | Quinethazone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Quinidine | The metabolism of Flutamide can be decreased when combined with Quinidine. |
Quinine | The risk or severity of methemoglobinemia can be increased when Quinine is combined with Flutamide. |
Rabeprazole | Flutamide may decrease the excretion rate of Rabeprazole which could result in a higher serum level. |
Ramelteon | The metabolism of Ramelteon can be decreased when combined with Flutamide. |
Ranitidine | The metabolism of Ranitidine can be decreased when combined with Flutamide. |
Ranolazine | Ranolazine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Rasagiline | The metabolism of Rasagiline can be decreased when combined with Flutamide. |
Rasburicase | The risk or severity of methemoglobinemia can be increased when Rasburicase is combined with Flutamide. |
Relugolix | The metabolism of Relugolix can be decreased when combined with Flutamide. |
Reserpine | The metabolism of Flutamide can be increased when combined with Reserpine. |
Resorcinol | Flutamide may decrease the excretion rate of Resorcinol which could result in a higher serum level. |
Ribavirin | Flutamide may decrease the excretion rate of Ribavirin which could result in a higher serum level. |
Ribociclib | The metabolism of Flutamide can be decreased when combined with Ribociclib. |
Ribostamycin | Flutamide may decrease the excretion rate of Ribostamycin which could result in a higher serum level. |
Rifampicin | The metabolism of Flutamide can be increased when combined with Rifampicin. |
Rifamycin | The metabolism of Flutamide can be increased when combined with Rifamycin. |
Rifapentine | The metabolism of Flutamide can be increased when combined with Rifapentine. |
Rilonacept | The metabolism of Flutamide can be increased when combined with Rilonacept. |
Riluzole | The metabolism of Riluzole can be decreased when combined with Flutamide. |
Risperidone | The metabolism of Risperidone can be decreased when combined with Flutamide. |
Ritonavir | The serum concentration of Flutamide can be increased when it is combined with Ritonavir. |
Rivaroxaban | Flutamide may decrease the excretion rate of Rivaroxaban which could result in a higher serum level. |
Rizatriptan | Flutamide may decrease the excretion rate of Rizatriptan which could result in a higher serum level. |
Rofecoxib | The metabolism of Flutamide can be decreased when combined with Rofecoxib. |
Roflumilast | The metabolism of Roflumilast can be decreased when combined with Flutamide. |
Romidepsin | The metabolism of Romidepsin can be decreased when combined with Flutamide. |
Ropeginterferon | The metabolism of Flutamide can be decreased when combined with Ropeginterferon alfa-2b. |
Ropivacaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Ropivacaine. |
Rosiglitazone | Rosiglitazone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Rosoxacin | The metabolism of Flutamide can be decreased when combined with Rosoxacin. |
Rosuvastatin | The metabolism of Rosuvastatin can be decreased when combined with Flutamide. |
Rucaparib | The metabolism of Flutamide can be decreased when combined with Rucaparib. |
Ruxolitinib | Flutamide may decrease the excretion rate of Ruxolitinib which could result in a higher serum level. |
Sacubitril | Flutamide may decrease the excretion rate of Sacubitril which could result in a higher serum level. |
Salbutamol | Flutamide may decrease the excretion rate of Salbutamol which could result in a higher serum level. |
Salicylamide | Salicylamide may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Salicylic acid | Salicylic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Salmeterol | The metabolism of Salmeterol can be decreased when combined with Flutamide. |
Salmon | Salmon calcitonin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Salsalate | Salsalate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Saquinavir | The metabolism of Flutamide can be decreased when combined with Saquinavir. |
Satralizumab | The serum concentration of Flutamide can be decreased when it is combined with Satralizumab. |
Saxagliptin | Flutamide may decrease the excretion rate of Saxagliptin which could result in a higher serum level. |
Secobarbital | Secobarbital may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Secukinumab | The metabolism of Flutamide can be increased when combined with Secukinumab. |
Selegiline | The metabolism of Selegiline can be decreased when combined with Flutamide. |
Selenious acid | Flutamide may decrease the excretion rate of Selenious acid which could result in a higher serum level. |
Selenium | Flutamide may decrease the excretion rate of Selenium which could result in a higher serum level. |
Selumetinib | The metabolism of Selumetinib can be decreased when combined with Flutamide. |
Sibutramine | Flutamide may decrease the excretion rate of Sibutramine which could result in a higher serum level. |
Sildenafil | The metabolism of Flutamide can be decreased when combined with Sildenafil. |
Siltuximab | The metabolism of Flutamide can be increased when combined with Siltuximab. |
Simeprevir | The metabolism of Flutamide can be decreased when combined with Simeprevir. |
Simvastatin | The metabolism of Simvastatin can be decreased when combined with Flutamide. |
Sirolimus | The metabolism of Sirolimus can be decreased when combined with Flutamide. |
Sitagliptin | Flutamide may decrease the excretion rate of Sitagliptin which could result in a higher serum level. |
Sodium acetate | Flutamide may decrease the excretion rate of Sodium acetate which could result in a higher serum level. |
Sodium | Flutamide may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. |
Sodium fluoride | Flutamide may decrease the excretion rate of Sodium fluoride which could result in a higher serum level. |
Sodium sulfate | Flutamide may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. |
Sofosbuvir | Flutamide may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
Solriamfetol | Flutamide may decrease the excretion rate of Solriamfetol which could result in a higher serum level. |
Somapacitan | The metabolism of Flutamide can be increased when combined with Somapacitan. |
Somatotropin | The metabolism of Flutamide can be increased when combined with Somatotropin. |
Somatrem | The metabolism of Flutamide can be increased when combined with Somatrem. |
Somatrogon | The metabolism of Flutamide can be increased when combined with Somatrogon. |
Sorafenib | The metabolism of Sorafenib can be decreased when combined with Flutamide. |
Sorbitol | Flutamide may decrease the excretion rate of Sorbitol which could result in a higher serum level. |
Sotorasib | The serum concentration of Flutamide can be decreased when it is combined with Sotorasib. |
Spironolactone | Spironolactone may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
St. John’s Wort | The metabolism of Flutamide can be increased when combined with St. John’s Wort. |
Stiripentol | The metabolism of Flutamide can be decreased when combined with Stiripentol. |
Streptomycin | Flutamide may decrease the excretion rate of Streptomycin which could result in a higher serum level. |
Strontium chloride | Flutamide may decrease the excretion rate of Strontium chloride which could result in a higher serum level. |
Sucralfate | Sucralfate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Sulbactam | Flutamide may decrease the excretion rate of Sulbactam which could result in a higher serum level. |
Sulfadiazine | The risk or severity of methemoglobinemia can be increased when Sulfadiazine is combined with Flutamide. |
Sulfamethoxazole | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Sulfamethoxazole. |
Sulfapyridine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Sulfapyridine. |
Sulfasalazine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Sulfasalazine. |
Sulindac | Sulindac may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Sumatriptan | Flutamide may decrease the excretion rate of Sumatriptan which could result in a higher serum level. |
Sunitinib | The metabolism of Sunitinib can be decreased when combined with Flutamide. |
S Estrogens, A | Flutamide may decrease the excretion rate of Synthetic Conjugated Estrogens, A which could result in a higher serum level. |
S Estrogens, B | Flutamide may decrease the excretion rate of Synthetic Conjugated Estrogens, B which could result in a higher serum level. |
Tacrine | The metabolism of Flutamide can be decreased when combined with Tacrine. |
Tacrolimus | The metabolism of Tacrolimus can be decreased when combined with Flutamide. |
Tadalafil | Flutamide may decrease the excretion rate of Tadalafil which could result in a higher serum level. |
Tamoxifen | The metabolism of Tamoxifen can be decreased when combined with Flutamide. |
Tamsulosin | Flutamide may decrease the excretion rate of Tamsulosin which could result in a higher serum level. |
Tasimelteon | The metabolism of Tasimelteon can be decreased when combined with Flutamide. |
Technetium | Flutamide may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level. |
Technetium | Flutamide may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level. |
Technetium | Flutamide may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level. |
Technetium | Flutamide may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level. |
Teduglutide | Flutamide may decrease the excretion rate of Teduglutide which could result in a higher serum level. |
Tegafur | The metabolism of Tegafur can be decreased when combined with Flutamide. |
Tegaserod | The metabolism of Flutamide can be decreased when combined with Tegaserod. |
Telaprevir | The metabolism of Flutamide can be decreased when combined with Telaprevir. |
Telavancin | Flutamide may decrease the excretion rate of Telavancin which could result in a higher serum level. |
Telithromycin | The metabolism of Flutamide can be decreased when combined with Telithromycin. |
Telotristat ethyl | The serum concentration of Flutamide can be decreased when it is combined with Telotristat ethyl. |
Temazepam | Temazepam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Temozolomide | Flutamide may decrease the excretion rate of Temozolomide which could result in a higher serum level. |
Temsirolimus | The metabolism of Temsirolimus can be decreased when combined with Flutamide. |
Teniposide | The metabolism of Teniposide can be decreased when combined with Flutamide. |
Tenofovir | The serum concentration of Tenofovir alafenamide can be increased when it is combined with Flutamide. |
Tenofovir | Tenofovir disoproxil may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Tenoxicam | Tenoxicam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Terbinafine | The metabolism of Terbinafine can be decreased when combined with Flutamide. |
Terbutaline | Flutamide may decrease the excretion rate of Terbutaline which could result in a higher serum level. |
Terfenadine | The metabolism of Flutamide can be decreased when combined with Terfenadine. |
Teriflunomide | The serum concentration of Flutamide can be decreased when it is combined with Teriflunomide. |
Testolactone | Flutamide may decrease the excretion rate of Testolactone which could result in a higher serum level. |
Testosterone | Flutamide may decrease the excretion rate of Testosterone which could result in a higher serum level. |
Tetracaine | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Tetracaine. |
Tetracycline | Flutamide may decrease the excretion rate of Tetracycline which could result in a higher serum level. |
Tetradecyl | Flutamide may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level. |
Tezacaftor | The metabolism of Tezacaftor can be decreased when combined with Flutamide. |
Thalidomide | The metabolism of Flutamide can be increased when combined with Thalidomide. |
Theophylline | The metabolism of Flutamide can be decreased when combined with Theophylline. |
Thiabendazole | The metabolism of Flutamide can be decreased when combined with Thiabendazole. |
Thiethylperazine | Thiethylperazine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Thiothixene | The metabolism of Thiothixene can be decreased when combined with Flutamide. |
Tiaprofenic acid | Tiaprofenic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Ticagrelor | The metabolism of Ticagrelor can be decreased when combined with Flutamide. |
Ticlopidine | The metabolism of Flutamide can be decreased when combined with Ticlopidine. |
Tiludronic acid | Flutamide may decrease the excretion rate of Tiludronic acid which could result in a higher serum level. |
Timolol | Timolol may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Tinidazole | Flutamide may decrease the excretion rate of Tinidazole which could result in a higher serum level. |
Tiopronin | Flutamide may decrease the excretion rate of Tiopronin which could result in a higher serum level. |
Tiotropium | Flutamide may decrease the excretion rate of Tiotropium which could result in a higher serum level. |
Tipranavir | The metabolism of Flutamide can be decreased when combined with Tipranavir. |
Tirofiban | Flutamide may decrease the excretion rate of Tirofiban which could result in a higher serum level. |
Tixocortol | Flutamide may decrease the excretion rate of Tixocortol which could result in a higher serum level. |
Tizanidine | The metabolism of Tizanidine can be decreased when combined with Flutamide. |
Tobramycin | Flutamide may decrease the excretion rate of Tobramycin which could result in a higher serum level. |
Tocainide | The metabolism of Tocainide can be decreased when combined with Flutamide. |
Tocilizumab | The metabolism of Flutamide can be increased when combined with Tocilizumab. |
Tocopherol | Flutamide may decrease the excretion rate of Tocopherol which could result in a higher serum level. |
Tolazamide | Flutamide may decrease the excretion rate of Tolazamide which could result in a higher serum level. |
Tolbutamide | Flutamide may decrease the excretion rate of Tolbutamide which could result in a higher serum level. |
Tolcapone | Tolcapone may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Tolfenamic acid | Tolfenamic acid may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Tolmetin | Tolmetin may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Tolterodine | Flutamide may decrease the excretion rate of Tolterodine which could result in a higher serum level. |
Tolvaptan | Tolvaptan may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Topiramate | Topiramate may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Topotecan | Flutamide may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Torasemide | Torasemide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Tositumomab | Tositumomab may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Tramadol | Tramadol may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Trametinib | Flutamide may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Trastuzumab | The metabolism of Trastuzumab emtansine can be decreased when combined with Flutamide. |
Trazodone | The metabolism of Trazodone can be decreased when combined with Flutamide. |
Tretinoin | The metabolism of Tretinoin can be decreased when combined with Flutamide. |
Triamcinolone | The metabolism of Flutamide can be increased when combined with Triamcinolone. |
Triamterene | Triamterene may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Triazolam | Flutamide may decrease the excretion rate of Triazolam which could result in a higher serum level. |
Trichlormethiazide | Trichlormethiazide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Triclabendazole | The metabolism of Flutamide can be decreased when combined with Triclabendazole. |
Triethylenetetra | Flutamide may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level. |
Trifluoperazine | The metabolism of Trifluoperazine can be decreased when combined with Flutamide. |
Trifluridine | Trifluridine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Trilaciclib | The metabolism of Flutamide can be increased when combined with Trilaciclib. |
Trimebutine | Flutamide may decrease the excretion rate of Trimebutine which could result in a higher serum level. |
Trimethoprim | Trimethoprim may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Trimetrexate | Flutamide may decrease the excretion rate of Trimetrexate which could result in a higher serum level. |
Troglitazone | The metabolism of Flutamide can be decreased when combined with Troglitazone. |
Troleandomycin | The metabolism of Flutamide can be decreased when combined with Troleandomycin. |
Tropisetron | Flutamide may decrease the excretion rate of Tropisetron which could result in a higher serum level. |
Trovafloxacin | The metabolism of Flutamide can be decreased when combined with Trovafloxacin. |
Tucatinib | The metabolism of Tucatinib can be decreased when combined with Flutamide. |
Udenafil | The metabolism of Udenafil can be decreased when combined with Flutamide. |
Vaborbactam | Flutamide may decrease the excretion rate of Vaborbactam which could result in a higher serum level. |
Valaciclovir | Valaciclovir may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Valbenazine | Flutamide may decrease the excretion rate of Valbenazine which could result in a higher serum level. |
Valdecoxib | Valdecoxib may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Valganciclovir | Flutamide may decrease the excretion rate of Valganciclovir which could result in a higher serum level. |
Valproic acid | The risk or severity of methemoglobinemia can be increased when Valproic acid is combined with Flutamide. |
Vancomycin | Flutamide may decrease the excretion rate of Vancomycin which could result in a higher serum level. |
Vardenafil | The metabolism of Vardenafil can be decreased when combined with Flutamide. |
Varenicline | Flutamide may decrease the excretion rate of Varenicline which could result in a higher serum level. |
Vemurafenib | The serum concentration of Flutamide can be increased when it is combined with Vemurafenib. |
Venetoclax | The metabolism of Flutamide can be decreased when combined with Venetoclax. |
Venlafaxine | Venlafaxine may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Verapamil | The metabolism of Flutamide can be decreased when combined with Verapamil. |
Vilanterol | Flutamide may decrease the excretion rate of Vilanterol which could result in a higher serum level. |
Viloxazine | The metabolism of Flutamide can be decreased when combined with Viloxazine. |
Vincristine | The metabolism of Vincristine can be decreased when combined with Flutamide. |
Vonoprazan | The metabolism of Vonoprazan can be decreased when combined with Flutamide. |
Voriconazole | The metabolism of Flutamide can be decreased when combined with Voriconazole. |
Vortioxetine | Flutamide may decrease the excretion rate of Vortioxetine which could result in a higher serum level. |
Voxilaprevir | The metabolism of Voxilaprevir can be decreased when combined with Flutamide. |
Warfarin | Flutamide may decrease the excretion rate of Warfarin which could result in a higher serum level. |
Zaleplon | Flutamide may decrease the excretion rate of Zaleplon which could result in a higher serum level. |
Zanamivir | Flutamide may decrease the excretion rate of Zanamivir which could result in a higher serum level. |
Zileuton | The metabolism of Flutamide can be decreased when combined with Zileuton. |
Zimelidine | The metabolism of Flutamide can be decreased when combined with Zimelidine. |
Ziprasidone | The metabolism of Flutamide can be decreased when combined with Ziprasidone. |
Zolmitriptan | The metabolism of Flutamide can be decreased when combined with Zolmitriptan. |
Zolpidem | The metabolism of Flutamide can be decreased when combined with Zolpidem. |
Zonisamide | Zonisamide may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy. |
Zopiclone | The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Zopiclone. |
Zotepine | The metabolism of Zotepine can be decreased when combined with Flutamide. |
Pregnancy and Lactation
FDA Pregnancy Category D
Pregnancy
There was decreased 24-hour survival in the offspring of pregnant rats treated with flutamide at doses of 30, 100, or 200 mg/kg/day (approximately 3, 9, and 19 times the human dose). A slight increase in minor variations in the development of the sternebrae and vertebrae was seen in fetuses of rats treated with two higher doses. Feminization of the male rats also occurred at the two higher dose levels. There was a decreased survival rate in the offspring of rabbits receiving the highest dose (15 mg/kg/day, equal to 1.4 times the human dose).
Lactation
- This drug is not indicated for use in females.
- Excreted into human milk: Unknown
- Excreted into animal milk: Data not available
- The effects in the nursing infant are unknown.
How should this medicine be used?
Flutamide comes as a capsule to take by mouth. It is usually taken with or without food every 8 hours (three times a day.) Take flutamide at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take flutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take flutamide along with the LHRH agonist treatment even if you feel well. Do not stop taking either medication without talking to your doctor. Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
What special precautions should I follow?
Before taking flutamide,
- tell your doctor and pharmacist if you are allergic to flutamide or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention anticoagulants (”blood thinners”) such as warfarin (Coumadin).
- tell your doctor if you smoke and if you have or have ever had any inherited blood diseases such as glucose-6-phosphate dehydrogenase (G-6-PD) deficiency or hemoglobin M disease.
- you should know that flutamide is only for use in men. If taken by pregnant women, flutamide can harm the fetus. Women who are or may become pregnant should not take flutamide. If you take flutamide while you are pregnant, call your doctor.
- ask your doctor about the safe use of alcoholic beverages while you are taking flutamide. Flutamide may cause facial flushing, and drinking alcohol can make it worse.
References