Enzalutamide is an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate-specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance.
Enzalutamide is a nonsteroidal antiandrogen used to treat metastatic castration-resistant prostate cancer. Enzalutamide is associated with a low rate of serum enzyme elevation during therapy but has not been linked to cases of clinically apparent liver injury with jaundice.
Enzalutamide is a benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of metastatic castration-resistant prostate cancer. It has a role as an antineoplastic agent and an androgen antagonist. It is a member of benzamides, an imidazolidinone, a thiocarbonyl compound, a nitrile, a member of (trifluoromethyl)benzenes, and a member of monofluorobenzenes.
Deutenzalutamide is a deuterated form of enzalutamide, an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Upon administration, deutenzalutamide competitively binds to and inhibits the activity of ARs expressed on prostate cancer cells, which impairs nuclear translocation and DNA binding, resulting in apoptosis of prostate cancer cells. This results in a reduction in prostate cancer cell growth. AR overexpression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance. Deuterium incorporation, by replacing the hydrogen atoms of the N-CH3 moiety with deuterium atoms, decreases enzalutamide‘s metabolism and allows for an increased pharmacokinetic profile, thereby enhancing its anti-tumor efficacy compared to non-deuterated enzalutamide. As the deuterated form can’t cross the blood-brain barrier (BBB), the deutenzalutamide form also reduces the unwanted brain-related side effects of enzalutamide and improves its safety profile.
Mechanism of Action
Enzalutamide is a competitive androgen receptor inhibitor that affects multiple stages of the signaling pathway. It is able to inhibit androgen binding to its receptor, androgen receptor nuclear translocation, and subsequent interaction with DNA. As a result, the proliferation of prostate cancer cells decreases which ultimately leads to apoptosis and decreased tumor volume.
Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic.[rx] It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[rx,rx] Although androgen deprivation therapy (ADT) is the first-line treatment of prostate cancer and remission can be achieved, arising resistance is inevitable, becoming castration-resistant prostate cancer.[rx] Until recently, docetaxel is the only treatment available for metastatic CRPC; however, AR inhibitors have been developed for more targeted therapy, although first-generation AR inhibitors like bicalutamide did not substantially increase the survival rate.[rx] Second-generation such as enzalutamide is more efficacious due to a higher affinity to AR and no partial agonist activity compared to bicalutamide.[rx,rx]
Enzalutamide is a second-generation antiandrogen that blocks the activity of androgen and androgen receptor (AR) in prostate cancer. AR activity and prostate cancer progression are closely related due to the normal physiology of prostate cells, providing the rationale for androgen deprivation therapy (ADT).[rx] However, resistance will eventually arise after the commencement of ADT in 2-3 years due to the accumulation of mutations, including constitutively active mutation, AR overexpression, and changes in AR splicing variants.[rx,rx] Enzalutamide was therefore designed to exploit these mutations.[rx] In vitro experiments in human prostate cancer cell line VCaP showed that enzalutamide can suppress cell growth and induce apoptosis while other antiandrogens like bicalutamide did not.[rx]
Clinical trials on prostate cancer patients indicated that enzalutamide can lead to a decrease in serum PSA for at least 12 weeks, although this response can be short-lived and thus result in enzalutamide resistance.[rx,rx] Patients receiving enzalutamide also had a 37% decrease in the risk of death compared to placebo.[rx]
Indications
- Enzalutamide is indicated for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel.
- Xtandi is indicated for the treatment of adult men with metastatic hormone-sensitive prostate cancer (mHSPC) in combination with androgen deprivation therapy the treatment of adult men with high-risk non-metastatic castration-resistant prostate cancer (CRPC) the treatment of adult men with metastatic CRPC who are asymptomatic or mildly symptomatic after failure of androgen deprivation therapy in whom chemotherapy is not yet clinically indicated the treatment of adult men with metastatic CRPC whose disease has progressed on or after docetaxel therapy.
- Enzalutamide is a nonsteroidal antiandrogen used to treat metastatic castration-resistant prostate cancer.
- It is indicated for use in conjunction with castration in the treatment of metastatic castration-resistant prostate cancer (mCRPC),[rx] nonmetastatic castration-resistant prostate cancer,[rx] and metastatic castration-sensitive prostate cancer (mCSPC).[rx] It is taken by mouth.[rx]
- Castration-Resistant Prostate Cancer
- Metastatic Castration Sensitive Prostate Cancer
Use in Cancer
Enzalutamide is approved to treat:
- Prostate cancer. It is used:
- In patients whose cancer is castrate-resistant (has not responded to treatments that lower testosterone levels).
- In patients whose cancer has metastasized and is castrate sensitive (has responded to treatments that lower testosterone levels).
Enzalutamide is also being studied in the treatment of other types of cancer.
Contraindications
- a low seizure threshold
- brain injury
- a low supply of oxygen-rich blood to the heart
- a transient ischemic attack, a type of stroke that lasts only a few minutes
- seizures
- pregnancy
- a patient who is producing milk and breastfeeding
- a type of brain disorder called posterior reversible encephalopathy syndrome
- history of stroke
Dosage
Strengths: 40 mg; 80 mg
Prostate Cancer
- 160 mg (four 40 mg capsules) orally once a day
- This drug can be taken with or without food.
- Swallow the capsules whole. Do not chew, dissolve, or open the capsules.
- Patients receiving this drug should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy.
- Metastatic and non-metastatic castration-resistant prostate cancer
Dose Adjustments
Grade 3 or more toxicity or intolerable side effect:
- Withhold dosing for one week or until symptoms improve to Grade 2 or less, then resume at the usual dose or reduce the dose to 120 mg or 80 mg once daily if necessary.
Strong CYP450 2C8 inhibitors:
- Avoid concomitant use. If concomitant use is necessary, reduce the dose to 80 mg once daily and return to the prior dose if the strong CYP450 2C8 inhibitor is discontinued.
Strong CYP450 3A4 inducers:
- The concomitant use of strong CYP450 3A4 inducers should be avoided if possible. If coadministration is necessary, increase the dose to 160 to 240 mg once daily. If the strong CYP450 3A4 is discontinued, the dose should be returned to the dose used prior to the initiation of the strong CYP450 3A4 inducer.
Administration advice:
- Take it with or without food.
- Swallow capsules whole with water. Do not chew, dissolve, or open the capsules.
Side Effects
The Most Common
- asthenia/fatigue,
- back pain,
- diarrhea,
- arthralgia,
- hot flush,
- peripheral edema,
- musculoskeletal pain,
- headache,
- upper respiratory infection,
- muscular weakness,
- dizziness, insomnia,
- lower respiratory infection,
- spinal cord compression and cauda equina syndrome,
- hematuria, paresthesia, anxiety, and hypertension.
More Common
- weakness
- tiredness
- joint pain
- muscle weakness or stiffness
- weight loss
- loss of appetite
- headache
- dizziness
- burning, numbness, or tingling in the arms, hands, or feet
- decreased sense of touch or ability to feel sensation
- hot flashes
- difficulty falling asleep or staying asleep
- anxiety
- difficulty remembering, thinking, or paying attention
- diarrhea
- constipation
- itching
- dry skin
- nosebleeds
- frequent urination
- taste changes
- seizures
- headache; confusion; or vision changes
- swelling of the face, tongue, lips, throat, arms, legs, hands, or feet
- fever, cough, sore throat, or other signs of infection
- chest pain
- shortness of breath
- pain in the back, muscles, and/or legs
- numbness or tingling in the buttocks or legs
- difficulty controlling urination or bowel movements
- difficulty breathing
- falling
- broken bones or fractures
- hallucinating (seeing things or hearing voices that do not exist)
- breast enlargement in men
- pink or red urine
Rare
- cough with mucus
- difficulty with breathing
- dizziness
- fever
- loss of bladder or bowel control
- nervousness
- painful or difficult urination
- pounding in the ears
- slow or fast heartbeat
- sore throat
- tingling of the hands or feet
- unable to move the legs
- unusual weight gain or loss
- Anxiety
- confusion or excitement
- depression
- fainting
- falling
- lightheadedness
- loss of memory
- memory or attention span problems
- nightmares or vivid dreams
- rapid, shallow breathing
- Headache
- hives, itching, skin rash
- hoarseness
- irritation
- joint pain, stiffness, or swelling
- redness of the skin
- swelling of the eyelids, face, lips, hands, or feet
- tightness in the chest
- trouble breathing or swallowing
- unusual drowsiness, tiredness, weakness, or feeling of sluggishness
Drug Interaction
| Benzodiazepine | The serum concentration of 1,2-Benzodiazepine can be decreased when it is combined with Enzalutamide. |
| Abacavir | Abacavir may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Abametapir | The serum concentration of Enzalutamide can be increased when it is combined with Abametapir. |
| Abatacept | The metabolism of Enzalutamide can be increased when combined with Abatacept. |
| Abemaciclib | The serum concentration of Abemaciclib can be decreased when it is combined with Enzalutamide. |
| Abiraterone | The metabolism of Abiraterone can be increased when combined with Enzalutamide. |
| Abrocitinib | The serum concentration of Abrocitinib can be decreased when it is combined with Enzalutamide. |
| Acalabrutinib | The serum concentration of Acalabrutinib can be decreased when it is combined with Enzalutamide. |
| Aceclofenac | Aceclofenac may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Acemetacin | Acemetacin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Acenocoumarol | The serum concentration of Acenocoumarol can be decreased when it is combined with Enzalutamide. |
| Acetaminophen | The serum concentration of Acetaminophen can be decreased when it is combined with Enzalutamide. |
| Acetazolamide | The serum concentration of Enzalutamide can be increased when it is combined with Acetazolamide. |
| Acetohexamide | The serum concentration of Acetohexamide can be decreased when it is combined with Enzalutamide. |
| Acetyl sulfisoxazole | The metabolism of Enzalutamide can be decreased when combined with Acetyl sulfisoxazole. |
| Acetylsalicylic acid | The serum concentration of Acetylsalicylic acid can be decreased when it is combined with Enzalutamide. |
| Aclidinium | Aclidinium may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Acrivastine | Enzalutamide may decrease the excretion rate of Acrivastine which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Adalimumab | The metabolism of Enzalutamide can be increased when combined with Adalimumab. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Agomelatine | The metabolism of Enzalutamide can be decreased when combined with Agomelatine. |
| Albendazole | The serum concentration of Albendazole can be decreased when it is combined with Enzalutamide. |
| Albutrepenonacog alfa | Enzalutamide may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level. |
| Alclofenac | Alclofenac may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Alclometasone | The serum concentration of Alclometasone can be decreased when it is combined with Enzalutamide. |
| Aldesleukin | The serum concentration of Enzalutamide can be increased when it is combined with Aldesleukin. |
| Alectinib | The metabolism of Alectinib can be increased when combined with Enzalutamide. |
| Alfentanil | The serum concentration of Alfentanil can be decreased when it is combined with Enzalutamide. |
| Alfuzosin | The serum concentration of Alfuzosin can be decreased when it is combined with Enzalutamide. |
| Aliskiren | The serum concentration of Aliskiren can be decreased when it is combined with Enzalutamide. |
| Allopurinol | Allopurinol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Almasilate | Enzalutamide may decrease the excretion rate of Almasilate which could result in a higher serum level. |
| Almotriptan | The serum concentration of Almotriptan can be decreased when it is combined with Enzalutamide. |
| Alogliptin | The serum concentration of Alogliptin can be decreased when it is combined with Enzalutamide. |
| Alosetron | The serum concentration of Alosetron can be decreased when it is combined with Enzalutamide. |
| Alpelisib | The serum concentration of Alpelisib can be decreased when it is combined with Enzalutamide. |
| Alprazolam | The serum concentration of Alprazolam can be decreased when it is combined with Enzalutamide. |
| Amantadine | Amantadine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ambrisentan | The serum concentration of Ambrisentan can be decreased when it is combined with Enzalutamide. |
| Ambroxol | The serum concentration of Ambroxol can be decreased when it is combined with Enzalutamide. |
| Amcinonide | The serum concentration of Amcinonide can be decreased when it is combined with Enzalutamide. |
| Amikacin | Enzalutamide may decrease the excretion rate of Amikacin which could result in a higher serum level. |
| Amiloride | Amiloride may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Aminophenazone | The serum concentration of Aminophenazone can be decreased when it is combined with Enzalutamide. |
| Aminophylline | The serum concentration of Aminophylline can be decreased when it is combined with Enzalutamide. |
| Amiodarone | The serum concentration of Amiodarone can be decreased when it is combined with Enzalutamide. |
| Amitriptyline | The serum concentration of Amitriptyline can be decreased when it is combined with Enzalutamide. |
| Amlodipine | The serum concentration of Amlodipine can be decreased when it is combined with Enzalutamide. |
| Ammonium chloride | Ammonium chloride may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Amodiaquine | The metabolism of Amodiaquine can be decreased when combined with Enzalutamide. |
| Amoxicillin | Amoxicillin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Amphetamine | Amphetamine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Amphotericin B | Amphotericin B may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ampicillin | Ampicillin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Amprenavir | The serum concentration of Amprenavir can be decreased when it is combined with Enzalutamide. |
| Amrinone | Amrinone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Anakinra | The metabolism of Enzalutamide can be increased when combined with Anakinra. |
| Anastrozole | The metabolism of Anastrozole can be decreased when combined with Enzalutamide. |
| Ancestim | Enzalutamide may decrease the excretion rate of Ancestim which could result in a higher serum level. |
| Antihemophilic | Enzalutamide may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level. |
| Antipyrine | The serum concentration of Antipyrine can be decreased when it is combined with Enzalutamide. |
| Antithrombin III | Enzalutamide may decrease the excretion rate of Antithrombin III human which could result in a higher serum level. |
| Antrafenine | Antrafenine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Apalutamide | The serum concentration of Apalutamide can be decreased when it is combined with Enzalutamide. |
| Apixaban | The serum concentration of Apixaban can be decreased when it is combined with Enzalutamide. |
| Apomorphine | The metabolism of Apomorphine can be decreased when combined with Enzalutamide. |
| Apremilast | The serum concentration of Apremilast can be decreased when it is combined with Enzalutamide. |
| Aprepitant | The serum concentration of Aprepitant can be decreased when it is combined with Enzalutamide. |
| Arformoterol | The serum concentration of Arformoterol can be decreased when it is combined with Enzalutamide. |
| Aripiprazole | The serum concentration of Aripiprazole can be decreased when it is combined with Enzalutamide. |
| Aripiprazole | The serum concentration of aripiprazole, an active metabolite of Enzalutamide, can be decreased when used in combination with Aripiprazole lauroxil. |
| Armodafinil | The metabolism of Enzalutamide can be increased when combined with Armodafinil. |
| Arsenic trioxide | Arsenic trioxide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Artemether | The serum concentration of Artemether can be decreased when it is combined with Enzalutamide. |
| Articaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Articaine. |
| Asciminib | The serum concentration of Asciminib can be decreased when it is combined with Enzalutamide. |
| Asenapine | The serum concentration of Asenapine can be decreased when it is combined with Enzalutamide. |
| Astemizole | The serum concentration of Astemizole can be decreased when it is combined with Enzalutamide. |
| Asunaprevir | The serum concentration of Asunaprevir can be decreased when it is combined with Enzalutamide. |
| Atazanavir | The serum concentration of Atazanavir can be decreased when it is combined with Enzalutamide. |
| Atogepant | The serum concentration of Atogepant can be decreased when it is combined with Enzalutamide. |
| Atomoxetine | Atomoxetine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Atorvastatin | The serum concentration of Atorvastatin can be decreased when it is combined with Enzalutamide. |
| Atovaquone | The serum concentration of Atovaquone can be decreased when it is combined with Enzalutamide. |
| Auranofin | Auranofin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Aurothioglucose | Enzalutamide may decrease the excretion rate of Aurothioglucose which could result in a higher serum level. |
| Avacopan | The serum concentration of Avacopan can be decreased when it is combined with Enzalutamide. |
| Avanafil | The serum concentration of Avanafil can be decreased when it is combined with Enzalutamide. |
| Avapritinib | The serum concentration of Avapritinib can be decreased when it is combined with Enzalutamide. |
| Avatrombopag | The serum concentration of Enzalutamide can be decreased when it is combined with Avatrombopag. |
| Axitinib | The serum concentration of Axitinib can be decreased when it is combined with Enzalutamide. |
| Azacitidine | Azacitidine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Azathioprine | Azathioprine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Azelaic acid | Azelaic acid may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Azelastine | The serum concentration of Azelastine can be decreased when it is combined with Enzalutamide. |
| Azithromycin | The serum concentration of Azithromycin can be decreased when it is combined with Enzalutamide. |
| Aztreonam | Aztreonam may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Baclofen | Baclofen may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Baricitinib | The serum concentration of Baricitinib can be decreased when it is combined with Enzalutamide. |
| Beclomethasone | The serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Enzalutamide. |
| Bedaquiline | The serum concentration of Bedaquiline can be decreased when it is combined with Enzalutamide. |
| Belumosudil | The serum concentration of Belumosudil can be decreased when it is combined with Enzalutamide. |
| Belzutifan | The serum concentration of Belzutifan can be decreased when it is combined with Enzalutamide. |
| Bendroflumeth | Bendroflumethiazide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Benorilate | Benorilate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Benoxaprofen | Benoxaprofen may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Benserazide | Enzalutamide may decrease the excretion rate of Benserazide which could result in a higher serum level. |
| Benzatropine | Benzatropine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Benznidazole | Enzalutamide may decrease the excretion rate of Benznidazole which could result in a higher serum level. |
| Benzocaine | The serum concentration of Benzocaine can be decreased when it is combined with Enzalutamide. |
| Benzphetamine | The serum concentration of Benzphetamine can be decreased when it is combined with Enzalutamide. |
| Benzthiazide | Benzthiazide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Benzydamine | Benzydamine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Benzyl alcohol | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Benzyl alcohol. |
| Bepotastine | Bepotastine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Bepridil | The serum concentration of Bepridil can be decreased when it is combined with Enzalutamide. |
| Berotralstat | The metabolism of Enzalutamide can be decreased when combined with Berotralstat. |
| Betamethasone | The serum concentration of Betamethasone can be decreased when it is combined with Enzalutamide. |
| Betamethasone | The serum concentration of Betamethasone phosphate can be decreased when it is combined with Enzalutamide. |
| Bexarotene | The serum concentration of Bexarotene can be decreased when it is combined with Enzalutamide. |
| Bezafibrate | The serum concentration of Bezafibrate can be decreased when it is combined with Enzalutamide. |
| Bicalutamide | The serum concentration of Bicalutamide can be decreased when it is combined with Enzalutamide. |
| Bicisate | Enzalutamide may decrease the excretion rate of Bicisate which could result in a higher serum level. |
| Bictegravir | The serum concentration of Bictegravir can be decreased when it is combined with Enzalutamide. |
| Bifonazole | The serum concentration of Enzalutamide can be increased when it is combined with Bifonazole. |
| Bimekizumab | The metabolism of Enzalutamide can be increased when combined with Bimekizumab. |
| Bioallethrin | The serum concentration of Bioallethrin can be decreased when it is combined with Enzalutamide. |
| Bismuth | Enzalutamide may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level. |
| Bisoprolol | The serum concentration of Bisoprolol can be decreased when it is combined with Enzalutamide. |
| Bisoxatin | Enzalutamide may decrease the excretion rate of Bisoxatin which could result in a higher serum level. |
| Bleomycin | Bleomycin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Boceprevir | The serum concentration of Boceprevir can be decreased when it is combined with Enzalutamide. |
| Bortezomib | The metabolism of Bortezomib can be increased when combined with Enzalutamide. |
| Bosentan | The serum concentration of Bosentan can be decreased when it is combined with Enzalutamide. |
| Bosutinib | The serum concentration of Bosutinib can be decreased when it is combined with Enzalutamide. |
| Brentuximab | The serum concentration of Brentuximab vedotin can be decreased when it is combined with Enzalutamide. |
| Brexpiprazole | The metabolism of Brexpiprazole can be increased when combined with Enzalutamide. |
| Brigatinib | The serum concentration of Brigatinib can be decreased when it is combined with Enzalutamide. |
| Brinzolamide | The serum concentration of Brinzolamide can be decreased when it is combined with Enzalutamide. |
| Brivaracetam | The serum concentration of Brivaracetam can be decreased when it is combined with Enzalutamide. |
| Bromazepam | Bromazepam may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Bromocriptine | The serum concentration of Bromocriptine can be decreased when it is combined with Enzalutamide. |
| Bromotheophylline | Bromotheophylline may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Budesonide | The serum concentration of Budesonide can be decreased when it is combined with Enzalutamide. |
| Bumadizone | Bumadizone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Bumetanide | Bumetanide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Bupivacaine | The serum concentration of Bupivacaine can be decreased when it is combined with Enzalutamide. |
| Buprenorphine | The serum concentration of Buprenorphine can be decreased when it is combined with Enzalutamide. |
| Bupropion | The serum concentration of Bupropion can be decreased when it is combined with Enzalutamide. |
| Buspirone | The serum concentration of Buspirone can be decreased when it is combined with Enzalutamide. |
| Busulfan | The serum concentration of Busulfan can be decreased when it is combined with Enzalutamide. |
| Butabarbital | Butabarbital may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Butacaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Butacaine. |
| Butamben | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Butamben. |
| Cabazitaxel | The serum concentration of Cabazitaxel can be decreased when it is combined with Enzalutamide. |
| Cabergoline | The serum concentration of Cabergoline can be decreased when it is combined with Enzalutamide. |
| Cabozantinib | The metabolism of Cabozantinib can be increased when combined with Enzalutamide. |
| Calcitriol | The serum concentration of Calcitriol can be decreased when it is combined with Enzalutamide. |
| Canagliflozin | The serum concentration of Canagliflozin can be decreased when it is combined with Enzalutamide. |
| Canakinumab | The metabolism of Enzalutamide can be increased when combined with Canakinumab. |
| Candesartan | The serum concentration of Enzalutamide can be increased when it is combined with Candesartan cilexetil. |
| Candicidin | The serum concentration of Enzalutamide can be increased when it is combined with Candicidin. |
| Cannabidiol | The serum concentration of Cannabidiol can be decreased when it is combined with Enzalutamide. |
| Canrenoic acid | Canrenoic acid may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Capecitabine | The metabolism of Capecitabine can be increased when combined with Enzalutamide. |
| Capmatinib | The serum concentration of Capmatinib can be decreased when it is combined with Enzalutamide. |
| Capreomycin | Enzalutamide may decrease the excretion rate of Capreomycin which could result in a higher serum level. |
| Capromab | Enzalutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent. |
| Capsaicin | The serum concentration of Enzalutamide can be increased when it is combined with Capsaicin. |
| Carbamazepine | The serum concentration of Carbamazepine can be decreased when it is combined with Enzalutamide. |
| Carbidopa | Carbidopa may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cariprazine | The metabolism of Cariprazine can be increased when combined with Enzalutamide. |
| Carisoprodol | The serum concentration of Carisoprodol can be decreased when it is combined with Enzalutamide. |
| Carmustine | Carmustine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Carprofen | Carprofen may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Carvedilol | The serum concentration of Carvedilol can be decreased when it is combined with Enzalutamide. |
| Cefaclor | Cefaclor may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefdinir | Cefdinir may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefepime | Cefepime may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefotetan | Cefotetan may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefoxitin | Cefoxitin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefpirome | Cefpirome may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefpodoxime | Cefpodoxime may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefradine | Cefradine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ceftaroline | Ceftaroline fosamil may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ceftibuten | Ceftibuten may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ceftizoxime | Ceftizoxime may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ceftobiprole | Ceftobiprole may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ceftolozane | Enzalutamide may decrease the excretion rate of Ceftolozane which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Celecoxib | The serum concentration of Celecoxib can be decreased when it is combined with Enzalutamide. |
| Cenobamate | The serum concentration of Enzalutamide can be decreased when it is combined with Cenobamate. |
| Cephalexin | The serum concentration of Cephalexin can be decreased when it is combined with Enzalutamide. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ceritinib | The serum concentration of Ceritinib can be decreased when it is combined with Enzalutamide. |
| Cerivastatin | The serum concentration of Cerivastatin can be decreased when it is combined with Enzalutamide. |
| Certolizumab | The metabolism of Enzalutamide can be increased when combined with Certolizumab pegol. |
| Cetirizine | Cetirizine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cevimeline | The serum concentration of Cevimeline can be decreased when it is combined with Enzalutamide. |
| Chenodeoxycholic | The serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Enzalutamide. |
| Chloral hydrate | Chloral hydrate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Chloramphenicol | The serum concentration of Enzalutamide can be increased when it is combined with Chloramphenicol. |
| Chloroprocaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Chloroprocaine. |
| Chloroquine | The serum concentration of Chloroquine can be decreased when it is combined with Enzalutamide. |
| Chlorothiazide | Chlorothiazide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Chloroxylenol | Enzalutamide may decrease the excretion rate of Chloroxylenol which could result in a higher serum level. |
| Chlorpheniramine | The serum concentration of Chlorpheniramine can be decreased when it is combined with Enzalutamide. |
| Chlorpromazine | The serum concentration of Chlorpromazine can be decreased when it is combined with Enzalutamide. |
| Chlorpropamide | The serum concentration of Chlorpropamide can be decreased when it is combined with Enzalutamide. |
| Chlorthalidone | Chlorthalidone may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Chlorzoxazone | The serum concentration of Chlorzoxazone can be decreased when it is combined with Enzalutamide. |
| Cholecalciferol | The serum concentration of Cholecalciferol can be decreased when it is combined with Enzalutamide. |
| Choline C 11 | Enzalutamide may decrease effectiveness of Choline C 11 as a diagnostic agent. |
| Choline magnesium | Choline magnesium trisalicylate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Choline salicylate | Enzalutamide may decrease the excretion rate of Choline salicylate which could result in a higher serum level. |
| Chondroitin sulfate | Enzalutamide may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level. |
| Chromic chloride | Enzalutamide may decrease the excretion rate of Chromic chloride which could result in a higher serum level. |
| Chromic nitrate | Enzalutamide may decrease the excretion rate of Chromic nitrate which could result in a higher serum level. |
| Chromium | Enzalutamide may decrease the excretion rate of Chromium which could result in a higher serum level. |
| Chromium gluconate | Enzalutamide may decrease the excretion rate of Chromium gluconate which could result in a higher serum level. |
| Chromium nicotinate | Enzalutamide may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level. |
| Chromous sulfate | Enzalutamide may decrease the excretion rate of Chromous sulfate which could result in a higher serum level. |
| Ciclesonide | The serum concentration of Ciclesonide can be decreased when it is combined with Enzalutamide. |
| Cidofovir | Cidofovir may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cilostazol | The serum concentration of Cilostazol can be decreased when it is combined with Enzalutamide. |
| Cimetidine | The serum concentration of Enzalutamide can be increased when it is combined with Cimetidine. |
| Cinacalcet | The serum concentration of Cinacalcet can be decreased when it is combined with Enzalutamide. |
| Cinchocaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Cinchocaine. |
| Cinnarizine | The serum concentration of Cinnarizine can be decreased when it is combined with Enzalutamide. |
| Ciprofloxacin | The serum concentration of Enzalutamide can be increased when it is combined with Ciprofloxacin. |
| Cisapride | The serum concentration of Cisapride can be decreased when it is combined with Enzalutamide. |
| Cisplatin | Enzalutamide may decrease the excretion rate of Cisplatin which could result in a higher serum level. |
| Citalopram | The serum concentration of Citalopram can be decreased when it is combined with Enzalutamide. |
| Clarithromycin | The serum concentration of Clarithromycin can be decreased when it is combined with Enzalutamide. |
| Clevidipine | The serum concentration of Clevidipine can be decreased when it is combined with Enzalutamide. |
| Clindamycin | The metabolism of Clindamycin can be increased when combined with Enzalutamide. |
| Clobazam | The serum concentration of Clobazam can be decreased when it is combined with Enzalutamide. |
| Clobetasol | The serum concentration of Clobetasol can be decreased when it is combined with Enzalutamide. |
| Clobetasol propionate | The serum concentration of Clobetasol propionate can be decreased when it is combined with Enzalutamide. |
| Clobetasone | The serum concentration of Clobetasone can be decreased when it is combined with Enzalutamide. |
| Clofarabine | Clofarabine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Clofazimine | The serum concentration of Enzalutamide can be increased when it is combined with Clofazimine. |
| Clofibrate | The serum concentration of Clofibrate can be decreased when it is combined with Enzalutamide. |
| Clomipramine | The serum concentration of Clomipramine can be decreased when it is combined with Enzalutamide. |
| Clonazepam | The metabolism of Clonazepam can be increased when combined with Enzalutamide. |
| Clonidine | The serum concentration of Clonidine can be decreased when it is combined with Enzalutamide. |
| Clopidogrel | The serum concentration of Enzalutamide can be increased when it is combined with Clopidogrel. |
| Clorazepic acid | The serum concentration of Clorazepic acid can be decreased when it is combined with Enzalutamide. |
| Clotiazepam | The serum concentration of Clotiazepam can be decreased when it is combined with Enzalutamide. |
| Clove oil | Enzalutamide may decrease the excretion rate of Clove oil which could result in a higher serum level. |
| Clozapine | The serum concentration of Clozapine can be decreased when it is combined with Enzalutamide. |
| Cobicistat | The serum concentration of Cobicistat can be decreased when it is combined with Enzalutamide. |
| Cobimetinib | The serum concentration of Cobimetinib can be decreased when it is combined with Enzalutamide. |
| Cocaine | The serum concentration of Cocaine can be decreased when it is combined with Enzalutamide. |
| Codeine | The serum concentration of Codeine can be decreased when it is combined with Enzalutamide. |
| Colchicine | The serum concentration of Colchicine can be decreased when it is combined with Enzalutamide. |
| Colistimethate | Colistimethate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Colistin | Enzalutamide may decrease the excretion rate of Colistin which could result in a higher serum level. |
| Conivaptan | The serum concentration of Conivaptan can be decreased when it is combined with Enzalutamide. |
| C estrogens | The serum concentration of Conjugated estrogens can be decreased when it is combined with Enzalutamide. |
| Copanlisib | The serum concentration of Copanlisib can be decreased when it is combined with Enzalutamide. |
| Corifollitropin alfa | Enzalutamide may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Corticotropin | The serum concentration of Corticotropin can be decreased when it is combined with Enzalutamide. |
| Cortisone acetate | The serum concentration of Cortisone acetate can be decreased when it is combined with Enzalutamide. |
| Crizotinib | The serum concentration of Crizotinib can be decreased when it is combined with Enzalutamide. |
| Curcumin | The serum concentration of Enzalutamide can be increased when it is combined with Curcumin. |
| Cyanocobalamin | Cyanocobalamin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Cyclandelate | The serum concentration of Cyclandelate can be decreased when it is combined with Enzalutamide. |
| Cyclizine | The metabolism of Enzalutamide can be decreased when combined with Cyclizine. |
| Cyclobenzaprine | The serum concentration of Cyclobenzaprine can be decreased when it is combined with Enzalutamide. |
| Cyclopenthiazide | Cyclopenthiazide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Cyclophosphamide | The serum concentration of Cyclophosphamide can be decreased when it is combined with Enzalutamide. |
| Cyclosporine | The serum concentration of Cyclosporine can be decreased when it is combined with Enzalutamide. |
| Cyclothiazide | Cyclothiazide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Cyproterone acetate | The serum concentration of Cyproterone acetate can be decreased when it is combined with Enzalutamide. |
| Dabigatran etexilate | Dabigatran etexilate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Dabrafenib | The serum concentration of Enzalutamide can be increased when it is combined with Dabrafenib. |
| Dacarbazine | Dacarbazine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Daclatasvir | The serum concentration of Daclatasvir can be decreased when it is combined with Enzalutamide. |
| Dacomitinib | The serum concentration of Dacomitinib can be decreased when it is combined with Enzalutamide. |
| Dalfampridine | Dalfampridine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Dalfopristin | The serum concentration of Enzalutamide can be increased when it is combined with Dalfopristin. |
| Danazol | The serum concentration of Enzalutamide can be increased when it is combined with Danazol. |
| Dapagliflozin | The serum concentration of Dapagliflozin can be decreased when it is combined with Enzalutamide. |
| Dapsone | The serum concentration of Dapsone can be decreased when it is combined with Enzalutamide. |
| Daptomycin | Daptomycin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Darbepoetin alfa | The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Enzalutamide. |
| Daridorexant | The metabolism of Daridorexant can be increased when combined with Enzalutamide. |
| Darifenacin | The serum concentration of Darifenacin can be decreased when it is combined with Enzalutamide. |
| Darolutamide | The serum concentration of Darolutamide can be decreased when it is combined with Enzalutamide. |
| Darunavir | The serum concentration of Darunavir can be decreased when it is combined with Enzalutamide. |
| Dasabuvir | The serum concentration of Dasabuvir can be decreased when it is combined with Enzalutamide. |
| Dasatinib | The serum concentration of Dasatinib can be decreased when it is combined with Enzalutamide. |
| Daunorubicin | The serum concentration of Enzalutamide can be increased when it is combined with Daunorubicin. |
| Deferasirox | The metabolism of Enzalutamide can be decreased when combined with Deferasirox. |
| Deferiprone | Deferiprone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Deflazacort | The serum concentration of Deflazacort can be decreased when it is combined with Enzalutamide. |
| Delafloxacin | Enzalutamide may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
| Delamanid | The serum concentration of Delamanid can be decreased when it is combined with Enzalutamide. |
| Delavirdine | The serum concentration of Delavirdine can be decreased when it is combined with Enzalutamide. |
| Desipramine | The serum concentration of Enzalutamide can be increased when it is combined with Desipramine. |
| Desmopressin | Desmopressin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Desogestrel | The serum concentration of Desogestrel can be decreased when it is combined with Enzalutamide. |
| Desonide | The serum concentration of Desonide can be decreased when it is combined with Enzalutamide. |
| Desoxycorticosterone | The serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Enzalutamide. |
| Desvenlafaxine | The serum concentration of Desvenlafaxine can be decreased when it is combined with Enzalutamide. |
| Deutetrabenazine | The serum concentration of Deutetrabenazine can be decreased when it is combined with Enzalutamide. |
| Dexamethasone | The serum concentration of Dexamethasone can be decreased when it is combined with Enzalutamide. |
| Dexamethasone | The serum concentration of Dexamethasone acetate can be decreased when it is combined with Enzalutamide. |
| Dexchlorpheniramine | The serum concentration of Dexchlorpheniramine maleate can be decreased when it is combined with Enzalutamide. |
| Dexibuprofen | The serum concentration of Dexibuprofen can be decreased when it is combined with Enzalutamide. |
| Dexketoprofen | The risk or severity of adverse effects can be increased when Dexketoprofen is combined with Enzalutamide. |
| Dexlansoprazole | The serum concentration of Dexlansoprazole can be decreased when it is combined with Enzalutamide. |
| Dexmedetomidine | Dexmedetomidine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Dexpanthenol | Enzalutamide may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. |
| Dexrazoxane | Dexrazoxane may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Dextran | Enzalutamide may decrease the excretion rate of Dextran which could result in a higher serum level. |
| Dextromethorphan | The serum concentration of Dextromethorphan can be decreased when it is combined with Enzalutamide. |
| Dextropropoxyphene | The serum concentration of Dextropropoxyphene can be decreased when it is combined with Enzalutamide. |
| Diacerein | The metabolism of Enzalutamide can be decreased when combined with Diacerein. |
| Diatrizoate | Diatrizoate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Diazepam | The serum concentration of Diazepam can be decreased when it is combined with Enzalutamide. |
| Dichlorobenzyl | Enzalutamide may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level. |
| Diclofenac | The serum concentration of Diclofenac can be decreased when it is combined with Enzalutamide. |
| Diclofenamide | Diclofenamide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Dicoumarol | The serum concentration of Dicoumarol can be decreased when it is combined with Enzalutamide. |
| Dicyclomine | Dicyclomine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Didanosine | Didanosine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Dienogest | The metabolism of Dienogest can be increased when combined with Enzalutamide. |
| Diethylstilbestrol | The serum concentration of Diethylstilbestrol can be decreased when it is combined with Enzalutamide. |
| Diflunisal | Diflunisal may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Difluocortolone | The serum concentration of Difluocortolone can be decreased when it is combined with Enzalutamide. |
| Difluprednate | The serum concentration of Difluprednate can be decreased when it is combined with Enzalutamide. |
| Digitoxin | The serum concentration of Digitoxin can be decreased when it is combined with Enzalutamide. |
| Digoxin | The serum concentration of Digoxin can be increased when it is combined with Enzalutamide. |
| Dihydro-alpha | The serum concentration of Dihydro-alpha-ergocryptine can be decreased when it is combined with Enzalutamide. |
| Dihydrocodeine | The serum concentration of Dihydrocodeine can be decreased when it is combined with Enzalutamide. |
| Dihydroergocornine | The serum concentration of Dihydroergocornine can be decreased when it is combined with Enzalutamide. |
| Dihydroergocristine | The serum concentration of Dihydroergocristine can be decreased when it is combined with Enzalutamide. |
| Dihydroergotamine | The serum concentration of Dihydroergotamine can be decreased when it is combined with Enzalutamide. |
| Dihydrostreptomycin | Dihydrostreptomycin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Diltiazem | The serum concentration of Diltiazem can be decreased when it is combined with Enzalutamide. |
| Dimercaprol | Dimercaprol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Dimethyl sulfoxide | The serum concentration of Enzalutamide can be increased when it is combined with Dimethyl sulfoxide. |
| Diosmin | The metabolism of Enzalutamide can be decreased when combined with Diosmin. |
| Diphenhydramine | The serum concentration of Diphenhydramine can be decreased when it is combined with Enzalutamide. |
| Disopyramide | The serum concentration of Disopyramide can be decreased when it is combined with Enzalutamide. |
| Disulfiram | The serum concentration of Disulfiram can be decreased when it is combined with Enzalutamide. |
| DL-Methylephedrine | Enzalutamide may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level. |
| Dobutamine | Dobutamine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Docetaxel | The serum concentration of Docetaxel can be decreased when it is combined with Enzalutamide. |
| Doconexent | The serum concentration of Doconexent can be decreased when it is combined with Enzalutamide. |
| Dofetilide | The serum concentration of Dofetilide can be decreased when it is combined with Enzalutamide. |
| Dolasetron | The serum concentration of Dolasetron can be decreased when it is combined with Enzalutamide. |
| Domperidone | The serum concentration of Domperidone can be decreased when it is combined with Enzalutamide. |
| Donepezil | The serum concentration of Donepezil can be decreased when it is combined with Enzalutamide. |
| Dopamine | Dopamine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Doravirine | The serum concentration of Doravirine can be decreased when it is combined with Enzalutamide. |
| Doripenem | Doripenem may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Doxacurium | Doxacurium may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Doxazosin | The serum concentration of Doxazosin can be decreased when it is combined with Enzalutamide. |
| Doxepin | The serum concentration of Doxepin can be decreased when it is combined with Enzalutamide. |
| Doxorubicin | The serum concentration of Doxorubicin can be decreased when it is combined with Enzalutamide. |
| Doxycycline | Doxycycline may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Dronabinol | The serum concentration of Dronabinol can be decreased when it is combined with Enzalutamide. |
| Dronedarone | The metabolism of Dronedarone can be increased when combined with Enzalutamide. |
| Drospirenone | The serum concentration of Drospirenone can be decreased when it is combined with Enzalutamide. |
| Droxidopa | Droxidopa may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Duloxetine | The serum concentration of Duloxetine can be decreased when it is combined with Enzalutamide. |
| Dutasteride | The metabolism of Dutasteride can be increased when combined with Enzalutamide. |
| Duvelisib | The serum concentration of Duvelisib can be decreased when it is combined with Enzalutamide. |
| Dyclonine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Dyclonine. |
| Dydrogesterone | The serum concentration of Dydrogesterone can be decreased when it is combined with Enzalutamide. |
| Dyphylline | Dyphylline may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ebastine | The serum concentration of Ebastine can be decreased when it is combined with Enzalutamide. |
| Econazole | The serum concentration of Enzalutamide can be increased when it is combined with Econazole. |
| Edoxaban | Enzalutamide may decrease the excretion rate of Edoxaban which could result in a higher serum level. |
| Edrophonium | Edrophonium may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Efavirenz | The serum concentration of Efavirenz can be decreased when it is combined with Enzalutamide. |
| Elagolix | The metabolism of Elagolix can be decreased when combined with Enzalutamide. |
| Elbasvir | The serum concentration of Elbasvir can be decreased when it is combined with Enzalutamide. |
| Eletriptan | The serum concentration of Eletriptan can be decreased when it is combined with Enzalutamide. |
| Elexacaftor | The serum concentration of Elexacaftor can be decreased when it is combined with Enzalutamide. |
| Eliglustat | The metabolism of Eliglustat can be increased when combined with Enzalutamide. |
| Eltrombopag | The metabolism of Enzalutamide can be decreased when combined with Eltrombopag. |
| Elvitegravir | The serum concentration of Elvitegravir can be decreased when it is combined with Enzalutamide. |
| Emapalumab | The metabolism of Enzalutamide can be increased when combined with Emapalumab. |
| Enalaprilat | Enzalutamide may decrease the excretion rate of Enalaprilat which could result in a higher serum level. |
| Enasidenib | The serum concentration of Enasidenib can be decreased when it is combined with Enzalutamide. |
| Encorafenib | The serum concentration of Encorafenib can be decreased when it is combined with Enzalutamide. |
| Enfortumab | The serum concentration of Enfortumab vedotin can be decreased when it is combined with Enzalutamide. |
| Entrectinib | The metabolism of Entrectinib can be increased when combined with Enzalutamide. |
| Epinastine | The serum concentration of Epinastine can be decreased when it is combined with Enzalutamide. |
| Epinephrine | The serum concentration of Enzalutamide can be increased when it is combined with Epinephrine. |
| Eplerenone | The serum concentration of Eplerenone can be decreased when it is combined with Enzalutamide. |
| Epoprostenol | Epoprostenol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Eravacycline | The serum concentration of Eravacycline can be decreased when it is combined with Enzalutamide. |
| Erdafitinib | The metabolism of Erdafitinib can be increased when combined with Enzalutamide. |
| Ergoloid mesylate | The serum concentration of Ergoloid mesylate can be decreased when it is combined with Enzalutamide. |
| Ergometrine | The serum concentration of Ergometrine can be decreased when it is combined with Enzalutamide. |
| Ergotamine | The serum concentration of Ergotamine can be decreased when it is combined with Enzalutamide. |
| Erlotinib | The metabolism of Erlotinib can be increased when combined with Enzalutamide. |
| Ertapenem | Ertapenem may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ertugliflozin | Ertugliflozin may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Erythromycin | The serum concentration of Erythromycin can be decreased when it is combined with Enzalutamide. |
| Erythropoietin | The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Enzalutamide. |
| Escitalopram | The serum concentration of Escitalopram can be decreased when it is combined with Enzalutamide. |
| Esketamine | The serum concentration of Esketamine can be decreased when it is combined with Enzalutamide. |
| Esomeprazole | The serum concentration of Esomeprazole can be decreased when it is combined with Enzalutamide. |
| Estazolam | The serum concentration of Estazolam can be decreased when it is combined with Enzalutamide. |
| E estrogens | The serum concentration of Esterified estrogens can be decreased when it is combined with Enzalutamide. |
| Estetrol | The serum concentration of Estetrol can be decreased when it is combined with Enzalutamide. |
| Estradiol | The serum concentration of Estradiol can be decreased when it is combined with Enzalutamide. |
| Estradiol acetate | The serum concentration of Estradiol acetate can be decreased when it is combined with Enzalutamide. |
| Estradiol benzoate | The serum concentration of Estradiol benzoate can be decreased when it is combined with Enzalutamide. |
| Estradiol cypionate | The serum concentration of Estradiol cypionate can be decreased when it is combined with Enzalutamide. |
| Estradiol dienanthate | The serum concentration of Estradiol dienanthate can be decreased when it is combined with Enzalutamide. |
| Estradiol valerate | The serum concentration of Estradiol valerate can be decreased when it is combined with Enzalutamide. |
| Estramustine | The serum concentration of Estramustine can be decreased when it is combined with Enzalutamide. |
| Estrone | The serum concentration of Estrone can be decreased when it is combined with Enzalutamide. |
| Estrone sulfate | The serum concentration of Estrone sulfate can be decreased when it is combined with Enzalutamide. |
| Eszopiclone | The serum concentration of Eszopiclone can be decreased when it is combined with Enzalutamide. |
| Etacrynic acid | Etacrynic acid may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Etafedrine | Enzalutamide may decrease the excretion rate of Etafedrine which could result in a higher serum level. |
| Etanercept | The metabolism of Enzalutamide can be increased when combined with Etanercept. |
| Ethambutol | Ethambutol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ethanol | The serum concentration of Ethanol can be decreased when it is combined with Enzalutamide. |
| Ethinylestradiol | The serum concentration of Ethinylestradiol can be decreased when it is combined with Enzalutamide. |
| Ethosuximide | The serum concentration of Ethosuximide can be decreased when it is combined with Enzalutamide. |
| Ethyl chloride | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Ethyl chloride. |
| Ethynodiol | The serum concentration of Ethynodiol diacetate can be decreased when it is combined with Enzalutamide. |
| Etidocaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Etidocaine. |
| Etodolac | The serum concentration of Etodolac can be decreased when it is combined with Enzalutamide. |
| Etomidate | Etomidate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Etonogestrel | The serum concentration of Etonogestrel can be decreased when it is combined with Enzalutamide. |
| Etoposide | The serum concentration of Etoposide can be decreased when it is combined with Enzalutamide. |
| Etoricoxib | The serum concentration of Etoricoxib can be decreased when it is combined with Enzalutamide. |
| Etravirine | The serum concentration of Etravirine can be decreased when it is combined with Enzalutamide. |
| Eucalyptus oil | Enzalutamide may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level. |
| Everolimus | The metabolism of Everolimus can be increased when combined with Enzalutamide. |
| Exemestane | The metabolism of Exemestane can be increased when combined with Enzalutamide. |
| Ezogabine | Ezogabine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Favipiravir | The metabolism of Enzalutamide can be decreased when combined with Favipiravir. |
| Fedratinib | The serum concentration of Fedratinib can be decreased when it is combined with Enzalutamide. |
| Felbamate | The serum concentration of Felbamate can be decreased when it is combined with Enzalutamide. |
| Felodipine | The serum concentration of Enzalutamide can be increased when it is combined with Felodipine. |
| Fenbufen | Fenbufen may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Fenofibrate | The serum concentration of Fenofibrate can be decreased when it is combined with Enzalutamide. |
| Fenofibric acid | Enzalutamide may decrease the excretion rate of Fenofibric acid which could result in a higher serum level. |
| Fenoldopam | Fenoldopam may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Fentanyl | The serum concentration of Fentanyl can be decreased when it is combined with Enzalutamide. |
| Fesoterodine | The serum concentration of Fesoterodine can be decreased when it is combined with Enzalutamide. |
| Fexinidazole | The serum concentration of Fexinidazole can be decreased when it is combined with Enzalutamide. |
| Finasteride | The serum concentration of Finasteride can be decreased when it is combined with Enzalutamide. |
| Finerenone | The therapeutic efficacy of Finerenone can be decreased when used in combination with Enzalutamide. |
| Fish oil | The serum concentration of Fish oil can be decreased when it is combined with Enzalutamide. |
| Flavoxate | Flavoxate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Flecainide | The metabolism of Enzalutamide can be decreased when combined with Flecainide. |
| Flibanserin | The serum concentration of Flibanserin can be decreased when it is combined with Enzalutamide. |
| Floctafenine | Floctafenine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Florbetaben | Enzalutamide may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level. |
| Florbetapir | Enzalutamide may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level. |
| Floxuridine | The metabolism of Enzalutamide can be decreased when combined with Floxuridine. |
| Fluconazole | The serum concentration of Enzalutamide can be increased when it is combined with Fluconazole. |
| Flucytosine | Flucytosine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Fludeoxyglucose | Enzalutamide may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level. |
| Fludrocortisone | The serum concentration of Fludrocortisone can be decreased when it is combined with Enzalutamide. |
| Fluindione | The serum concentration of Fluindione can be decreased when it is combined with Enzalutamide. |
| Flumazenil | Flumazenil may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Flumethasone | The serum concentration of Flumethasone can be decreased when it is combined with Enzalutamide. |
| Flunarizine | The serum concentration of Flunarizine can be decreased when it is combined with Enzalutamide. |
| Flunisolide | The serum concentration of Flunisolide can be decreased when it is combined with Enzalutamide. |
| Flunitrazepam | The serum concentration of Flunitrazepam can be decreased when it is combined with Enzalutamide. |
| Fluocinolone | The serum concentration of Fluocinolone acetonide can be decreased when it is combined with Enzalutamide. |
| Fluocinonide | The serum concentration of Fluocinonide can be decreased when it is combined with Enzalutamide. |
| Fluocortolone | The serum concentration of Fluocortolone can be decreased when it is combined with Enzalutamide. |
| Fluorometholone | The serum concentration of Fluorometholone can be decreased when it is combined with Enzalutamide. |
| Fluorouracil | The metabolism of Fluorouracil can be decreased when combined with Enzalutamide. |
| Fluoxetine | The serum concentration of Fluoxetine can be decreased when it is combined with Enzalutamide. |
| Fluprednisolone | The serum concentration of Fluprednisolone can be decreased when it is combined with Enzalutamide. |
| Flurandrenolide | The serum concentration of Flurandrenolide can be decreased when it is combined with Enzalutamide. |
| Flurazepam | The serum concentration of Flurazepam can be decreased when it is combined with Enzalutamide. |
| Flurbiprofen | The serum concentration of Flurbiprofen can be decreased when it is combined with Enzalutamide. |
| Fluspirilene | The serum concentration of Fluspirilene can be decreased when it is combined with Enzalutamide. |
| Flutamide | The serum concentration of Flutamide can be decreased when it is combined with Enzalutamide. |
| Fluticasone | The serum concentration of Enzalutamide can be increased when it is combined with Fluticasone. |
| Fluticasone furoate | The serum concentration of Enzalutamide can be increased when it is combined with Fluticasone furoate. |
| Fluticasone | The serum concentration of Enzalutamide can be increased when it is combined with Fluticasone propionate. |
| Fluvastatin | The serum concentration of Fluvastatin can be decreased when it is combined with Enzalutamide. |
| Fluvoxamine | The serum concentration of Fluvoxamine can be decreased when it is combined with Enzalutamide. |
| Folic acid | Folic acid may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Fomepizole | Fomepizole may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Fondaparinux | Fondaparinux may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Formestane | Enzalutamide may decrease the excretion rate of Formestane which could result in a higher serum level. |
| Formoterol | The serum concentration of Formoterol can be decreased when it is combined with Enzalutamide. |
| Fosamprenavir | The serum concentration of Fosamprenavir can be decreased when it is combined with Enzalutamide. |
| Fosaprepitant | The serum concentration of Fosaprepitant can be decreased when it is combined with Enzalutamide. |
| Foscarnet | Foscarnet may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Fosfomycin | Fosfomycin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Fosinopril | Fosinopril may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Fosnetupitant | The serum concentration of Fosnetupitant can be decreased when it is combined with Enzalutamide. |
| Fosphenytoin | The serum concentration of Fosphenytoin can be decreased when it is combined with Enzalutamide. |
| Fostamatinib | The serum concentration of Fostamatinib can be decreased when it is combined with Enzalutamide. |
| Fostemsavir | The serum concentration of Fostemsavir can be decreased when it is combined with Enzalutamide. |
| Framycetin | Framycetin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Furosemide | Furosemide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Fusidic acid | The serum concentration of Fusidic acid can be decreased when it is combined with Enzalutamide. |
| Futibatinib | The metabolism of Futibatinib can be increased when combined with Enzalutamide. |
| Gabapentin | Gabapentin enacarbil may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Gadobenic acid | Gadobenic acid may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Gadodiamide | Gadodiamide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Gadofosveset | Gadofosveset trisodium may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Gadopentetic acid | Gadopentetic acid may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Gadoteric acid | Enzalutamide may decrease the excretion rate of Gadoteric acid which could result in a higher serum level. |
| Gadoteridol | Gadoteridol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Galantamine | The serum concentration of Galantamine can be decreased when it is combined with Enzalutamide. |
| Gallium | Enzalutamide may increase effectiveness of Gallium Ga-68 gozetotide as a diagnostic agent. |
| Ganaxolone | The metabolism of Ganaxolone can be increased when combined with Enzalutamide. |
| Ganciclovir | Ganciclovir may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Gefitinib | The metabolism of Gefitinib can be increased when combined with Enzalutamide. |
| Gemcitabine | Gemcitabine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Gemfibrozil | The serum concentration of Enzalutamide can be decreased when it is combined with Gemfibrozil. |
| Gentamicin | Enzalutamide may decrease the excretion rate of Gentamicin which could result in a higher serum level. |
| Gestrinone | The serum concentration of Gestrinone can be decreased when it is combined with Enzalutamide. |
| Gilteritinib | The serum concentration of Gilteritinib can be decreased when it is combined with Enzalutamide. |
| Gimeracil | Enzalutamide may decrease the excretion rate of Gimeracil which could result in a higher serum level. |
| Ginkgo biloba | The metabolism of Enzalutamide can be decreased when combined with Ginkgo biloba. |
| Givosiran | Givosiran may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Glasdegib | The serum concentration of Glasdegib can be decreased when it is combined with Enzalutamide. |
| Gliclazide | The serum concentration of Gliclazide can be decreased when it is combined with Enzalutamide. |
| Glimepiride | The serum concentration of Glimepiride can be decreased when it is combined with Enzalutamide. |
| Glipizide | The serum concentration of Glipizide can be decreased when it is combined with Enzalutamide. |
| Gliquidone | The serum concentration of Gliquidone can be decreased when it is combined with Enzalutamide. |
| Glyburide | The serum concentration of Glyburide can be decreased when it is combined with Enzalutamide. |
| Glycerol | Enzalutamide may decrease the excretion rate of Glycerol phenylbutyrate which could result in a higher serum level. |
| Golimumab | The metabolism of Enzalutamide can be increased when combined with Golimumab. |
| Golodirsen | Enzalutamide may decrease the excretion rate of Golodirsen which could result in a higher serum level. |
| Goserelin | Goserelin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Granisetron | The serum concentration of Granisetron can be decreased when it is combined with Enzalutamide. |
| Grazoprevir | The serum concentration of Grazoprevir can be decreased when it is combined with Enzalutamide. |
| Grepafloxacin | The serum concentration of Grepafloxacin can be decreased when it is combined with Enzalutamide. |
| Guanethidine | Guanethidine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Guanfacine | The metabolism of Guanfacine can be increased when combined with Enzalutamide. |
| Halcinonide | The serum concentration of Halcinonide can be decreased when it is combined with Enzalutamide. |
| Halofantrine | The serum concentration of Halofantrine can be decreased when it is combined with Enzalutamide. |
| Haloperidol | The serum concentration of Haloperidol can be increased when it is combined with Enzalutamide. |
| Halothane | The serum concentration of Halothane can be decreased when it is combined with Enzalutamide. |
| Hydralazine | The serum concentration of Enzalutamide can be increased when it is combined with Hydralazine. |
| Hydrochlorothiazide | Hydrochlorothiazide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Hydrocodone | The metabolism of Hydrocodone can be increased when combined with Enzalutamide. |
| Hydrocortisone | The serum concentration of Hydrocortisone can be decreased when it is combined with Enzalutamide. |
| Hydrocortisone | The serum concentration of Hydrocortisone acetate can be decreased when it is combined with Enzalutamide. |
| Hydrocortisone | The serum concentration of Hydrocortisone butyrate can be decreased when it is combined with Enzalutamide. |
| Hydrocortisone | The serum concentration of Hydrocortisone cypionate can be decreased when it is combined with Enzalutamide. |
| Hydrocortisone | The serum concentration of Hydrocortisone phosphate can be decreased when it is combined with Enzalutamide. |
| Hydrocortisone e | The serum concentration of Hydrocortisone probate can be decreased when it is combined with Enzalutamide. |
| Hydrocortisone | The serum concentration of Hydrocortisone succinate can be decreased when it is combined with Enzalutamide. |
| Hydrocortisone | The serum concentration of Hydrocortisone valerate can be decreased when it is combined with Enzalutamide. |
| Hydroflumethiazide | Hydroflumethiazide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Hydromorphone | The serum concentration of Hydromorphone can be decreased when it is combined with Enzalutamide. |
| Hydroxocobalamin | Hydroxocobalamin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Hydroxychloroquine | The serum concentration of Hydroxychloroquine can be decreased when it is combined with Enzalutamide. |
| Hydroxyethyl Starch | Enzalutamide may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level. |
| Hydroxyprogesterone | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Enzalutamide. |
| Hydroxyzine | The serum concentration of Hydroxyzine can be decreased when it is combined with Enzalutamide. |
| Ibrexafungerp | The serum concentration of Ibrexafungerp can be decreased when it is combined with Enzalutamide. |
| Ibrutinib | The serum concentration of Ibrutinib can be decreased when it is combined with Enzalutamide. |
| Ibuprofen | The serum concentration of Ibuprofen can be decreased when it is combined with Enzalutamide. |
| Ibutilide | Ibutilide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Icatibant | Icatibant may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Icosapent | Icosapent may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Idarubicin | The serum concentration of Idarubicin can be decreased when it is combined with Enzalutamide. |
| Idarucizumab | Enzalutamide may decrease the excretion rate of Idarucizumab which could result in a higher serum level. |
| Idebenone | Enzalutamide may decrease the excretion rate of Idebenone which could result in a higher serum level. |
| Idelalisib | The serum concentration of Idelalisib can be decreased when it is combined with Enzalutamide. |
| Ifosfamide | The metabolism of Ifosfamide can be increased when combined with Enzalutamide. |
| Iloperidone | The serum concentration of Iloperidone can be decreased when it is combined with Enzalutamide. |
| Imatinib | The metabolism of Imatinib can be increased when combined with Enzalutamide. |
| Imipramine | The serum concentration of Imipramine can be decreased when it is combined with Enzalutamide. |
| Imiquimod | The serum concentration of Imiquimod can be decreased when it is combined with Enzalutamide. |
| Indacaterol | The serum concentration of Indacaterol can be decreased when it is combined with Enzalutamide. |
| Indapamide | The serum concentration of Indapamide can be decreased when it is combined with Enzalutamide. |
| Indigotindisulfonic | Enzalutamide may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level. |
| Indinavir | The serum concentration of Indinavir can be decreased when it is combined with Enzalutamide. |
| Indomethacin | The serum concentration of Indomethacin can be decreased when it is combined with Enzalutamide. |
| Infigratinib | The metabolism of Infigratinib can be increased when combined with Enzalutamide. |
| Infliximab | The metabolism of Enzalutamide can be increased when combined with Infliximab. |
| Inosine pranobex | Enzalutamide may decrease the excretion rate of Inosine pranobex which could result in a higher serum level. |
| Inositol | Enzalutamide may decrease the excretion rate of Inositol which could result in a higher serum level. |
| Inotersen | Inotersen may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Iobenguane sulfate | Enzalutamide may decrease the excretion rate of Iobenguane sulfate I-123 which could result in a higher serum level. |
| Iodixanol | Iodixanol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ioflupane I-123 | Ioflupane I-123 may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Iopromide | Enzalutamide may decrease the excretion rate of Iopromide which could result in a higher serum level. |
| Iothalamic acid | Enzalutamide may decrease the excretion rate of Iothalamic acid which could result in a higher serum level. |
| Ioversol | Enzalutamide may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ioxilan | Enzalutamide may decrease the excretion rate of Ioxilan which could result in a higher serum level. |
| Ipecac | The serum concentration of Ipecac can be decreased when it is combined with Enzalutamide. |
| Ipilimumab | Ipilimumab may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Irbesartan | The serum concentration of Irbesartan can be decreased when it is combined with Enzalutamide. |
| Irinotecan | The metabolism of Irinotecan can be increased when combined with Enzalutamide. |
| Isavuconazole | The serum concentration of Isavuconazole can be decreased when it is combined with Enzalutamide. |
| Isavuconazonium | The serum concentration of Isavuconazonium can be decreased when it is combined with Enzalutamide. |
| Isoniazid | The serum concentration of Enzalutamide can be increased when it is combined with Isoniazid. |
| Isosorbide | Isosorbide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Isosorbide | Isosorbide mononitrate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Isosulfan blue | Enzalutamide may decrease the excretion rate of Isosulfan blue which could result in a higher serum level. |
| Isotretinoin | The serum concentration of Isotretinoin can be decreased when it is combined with Enzalutamide. |
| Isoxicam | Isoxicam may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Isradipine | The serum concentration of Isradipine can be decreased when it is combined with Enzalutamide. |
| Istradefylline | The serum concentration of Istradefylline can be decreased when it is combined with Enzalutamide. |
| Itraconazole | The serum concentration of Enzalutamide can be increased when it is combined with Itraconazole. |
| Ivabradine | The serum concentration of Ivabradine can be decreased when it is combined with Enzalutamide. |
| Ivacaftor | The serum concentration of Ivacaftor can be decreased when it is combined with Enzalutamide. |
| Ivermectin | The serum concentration of Ivermectin can be decreased when it is combined with Enzalutamide. |
| Ivosidenib | The metabolism of Ivosidenib can be increased when combined with Enzalutamide. |
| Ixabepilone | The metabolism of Ixabepilone can be increased when combined with Enzalutamide. |
| Ixazomib | The serum concentration of Ixazomib can be decreased when it is combined with Enzalutamide. |
| Kanamycin | Enzalutamide may decrease the excretion rate of Kanamycin which could result in a higher serum level. |
| Ketamine | The serum concentration of Ketamine can be decreased when it is combined with Enzalutamide. |
| Ketazolam | The serum concentration of Ketazolam can be decreased when it is combined with Enzalutamide. |
| Ketoconazole | The serum concentration of Ketoconazole can be decreased when it is combined with Enzalutamide. |
| Ketoprofen | The risk or severity of adverse effects can be increased when Ketoprofen is combined with Enzalutamide. |
| Ketorolac | The serum concentration of Ketorolac can be decreased when it is combined with Enzalutamide. |
| Labetalol | The serum concentration of Labetalol can be decreased when it is combined with Enzalutamide. |
| Lacidipine | The serum concentration of Lacidipine can be decreased when it is combined with Enzalutamide. |
| Lacosamide | The serum concentration of Lacosamide can be decreased when it is combined with Enzalutamide. |
| Lamivudine | Lamivudine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Lamotrigine | Lamotrigine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Lanreotide | The serum concentration of Enzalutamide can be increased when it is combined with Lanreotide. |
| Lansoprazole | The serum concentration of Lansoprazole can be decreased when it is combined with Enzalutamide. |
| Lapatinib | The metabolism of Lapatinib can be increased when combined with Enzalutamide. |
| Larotrectinib | The serum concentration of Larotrectinib can be decreased when it is combined with Enzalutamide. |
| Latamoxef | Latamoxef may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ledipasvir | Enzalutamide may decrease the excretion rate of Ledipasvir which could result in a higher serum level. |
| Lefamulin | The metabolism of Lefamulin can be increased when combined with Enzalutamide. |
| Leflunomide | The serum concentration of Leflunomide can be decreased when it is combined with Enzalutamide. |
| Lemborexant | The serum concentration of Lemborexant can be decreased when it is combined with Enzalutamide. |
| Lenalidomide | Lenalidomide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Lercanidipine | The serum concentration of Lercanidipine can be decreased when it is combined with Enzalutamide. |
| Lesinurad | The serum concentration of Lesinurad can be decreased when it is combined with Enzalutamide. |
| Letermovir | The serum concentration of Enzalutamide can be increased when it is combined with Letermovir. |
| Letrozole | The serum concentration of Letrozole can be decreased when it is combined with Enzalutamide. |
| Leuprolide | Leuprolide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Levacetylmethadol | The serum concentration of Levacetylmethadol can be decreased when it is combined with Enzalutamide. |
| Levamlodipine | The serum concentration of Levamlodipine can be decreased when it is combined with Enzalutamide. |
| Levobupivacaine | The serum concentration of Levobupivacaine can be decreased when it is combined with Enzalutamide. |
| Levocarnitine | Levocarnitine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Levocetirizine | The serum concentration of Levocetirizine can be decreased when it is combined with Enzalutamide. |
| Levofloxacin | Levofloxacin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Levoketoconazole | The serum concentration of Levoketoconazole can be decreased when it is combined with Enzalutamide. |
| Levomenthol | The serum concentration of Levomenthol can be decreased when it is combined with Enzalutamide. |
| Levomilnacipran | The serum concentration of Levomilnacipran can be decreased when it is combined with Enzalutamide. |
| Levonorgestrel | The serum concentration of Levonorgestrel can be decreased when it is combined with Enzalutamide. |
| Levosalbutamol | Enzalutamide may decrease the excretion rate of Levosalbutamol which could result in a higher serum level. |
| Levothyroxine | The metabolism of Enzalutamide can be decreased when combined with Levothyroxine. |
| Lidocaine | The serum concentration of Lidocaine can be decreased when it is combined with Enzalutamide. |
| Lidoflazine | The serum concentration of Lidoflazine can be decreased when it is combined with Enzalutamide. |
| Linagliptin | The serum concentration of Linagliptin can be decreased when it is combined with Enzalutamide. |
| Linzagolix | The serum concentration of Enzalutamide can be increased when it is combined with Linzagolix. |
| Liothyronine | Liothyronine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Liotrix | The serum concentration of Liotrix can be decreased when it is combined with Enzalutamide. |
| Lisinopril | Lisinopril may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Lisuride | The serum concentration of Lisuride can be decreased when it is combined with Enzalutamide. |
| Lithium carbonate | Enzalutamide may decrease the excretion rate of Lithium carbonate which could result in a higher serum level. |
| Lithium citrate | Lithium citrate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Lixisenatide | Enzalutamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level. |
| Lofexidine | Lofexidine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Lomitapide | The serum concentration of Lomitapide can be decreased when it is combined with Enzalutamide. |
| Lonafarnib | The serum concentration of Lonafarnib can be decreased when it is combined with Enzalutamide. |
| Loperamide | The serum concentration of Loperamide can be decreased when it is combined with Enzalutamide. |
| Lopinavir | The serum concentration of Lopinavir can be decreased when it is combined with Enzalutamide. |
| Loracarbef | Loracarbef may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Loratadine | The serum concentration of Loratadine can be decreased when it is combined with Enzalutamide. |
| Lorazepam | The serum concentration of Lorazepam can be decreased when it is combined with Enzalutamide. |
| Lorcaserin | The serum concentration of Lorcaserin can be decreased when it is combined with Enzalutamide. |
| Lorlatinib | The serum concentration of Lorlatinib can be decreased when it is combined with Enzalutamide. |
| Lornoxicam | The serum concentration of Lornoxicam can be decreased when it is combined with Enzalutamide. |
| Lorpiprazole | The serum concentration of Lorpiprazole can be decreased when it is combined with Enzalutamide. |
| Losartan | The serum concentration of Losartan can be decreased when it is combined with Enzalutamide. |
| Lovastatin | The serum concentration of Lovastatin can be decreased when it is combined with Enzalutamide. |
| Loxoprofen | Loxoprofen may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Lubiprostone | Lubiprostone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Luliconazole | The serum concentration of Enzalutamide can be increased when it is combined with Luliconazole. |
| Lumacaftor | The serum concentration of Enzalutamide can be decreased when it is combined with Lumacaftor. |
| Lumateperone | The serum concentration of Lumateperone can be decreased when it is combined with Enzalutamide. |
| Lumefantrine | The serum concentration of Lumefantrine can be decreased when it is combined with Enzalutamide. |
| Lumiracoxib | The serum concentration of Lumiracoxib can be decreased when it is combined with Enzalutamide. |
| Lurasidone | The serum concentration of Lurasidone can be decreased when it is combined with Enzalutamide. |
| Lurbinectedin | The serum concentration of Lurbinectedin can be decreased when it is combined with Enzalutamide. |
| Lynestrenol | The serum concentration of Lynestrenol can be decreased when it is combined with Enzalutamide. |
| Macimorelin | The serum concentration of Macimorelin can be decreased when it is combined with Enzalutamide. |
| Macitentan | The serum concentration of Macitentan can be decreased when it is combined with Enzalutamide. |
| Magnesium | Enzalutamide may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level. |
| Magnesium | Enzalutamide may decrease the excretion rate of Magnesium chloride which could result in a higher serum level. |
| Magnesium | Enzalutamide may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. |
| Magnesium trisilicate | Enzalutamide may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level. |
| Mangafodipir | Mangafodipir may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Manidipine | The serum concentration of Manidipine can be decreased when it is combined with Enzalutamide. |
| Mannitol | Mannitol may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Maprotiline | Maprotiline may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Maraviroc | The metabolism of Maraviroc can be increased when combined with Enzalutamide. |
| Maribavir | The serum concentration of Maribavir can be decreased when it is combined with Enzalutamide. |
| Mavacamten | The serum concentration of Mavacamten can be decreased when it is combined with Enzalutamide. |
| Mecamylamine | Mecamylamine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Medrogestone | The serum concentration of Medrogestone can be decreased when it is combined with Enzalutamide. |
| Medroxyprog | The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Enzalutamide. |
| Medrysone | The serum concentration of Medrysone can be decreased when it is combined with Enzalutamide. |
| Mefenamic acid | The serum concentration of Mefenamic acid can be decreased when it is combined with Enzalutamide. |
| Mefloquine | The serum concentration of Mefloquine can be decreased when it is combined with Enzalutamide. |
| Megestrol acetate | The serum concentration of Megestrol acetate can be decreased when it is combined with Enzalutamide. |
| Meloxicam | The serum concentration of Meloxicam can be decreased when it is combined with Enzalutamide. |
| Memantine | Memantine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Meperidine | The serum concentration of Meperidine can be decreased when it is combined with Enzalutamide. |
| Mephenytoin | The serum concentration of Mephenytoin can be decreased when it is combined with Enzalutamide. |
| Mepivacaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Mepivacaine. |
| Meprednisone | The serum concentration of Meprednisone can be decreased when it is combined with Enzalutamide. |
| Meropenem | Meropenem may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Mestranol | The serum concentration of Mestranol can be decreased when it is combined with Enzalutamide. |
| Metamfetamine | Metamfetamine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Metamizole | Metamizole may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Metaxalone | Metaxalone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Metformin | Metformin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Methadone | The serum concentration of Methadone can be decreased when it is combined with Enzalutamide. |
| Methazolamide | Methazolamide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Methimazole | The serum concentration of Enzalutamide can be increased when it is combined with Methimazole. |
| Methotrexate | The serum concentration of Methotrexate can be decreased when it is combined with Enzalutamide. |
| Methoxsalen | Methoxsalen may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Methoxy | The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Enzalutamide. |
| Methoxyflurane | The serum concentration of Methoxyflurane can be decreased when it is combined with Enzalutamide. |
| Methsuximide | The serum concentration of Methsuximide can be decreased when it is combined with Enzalutamide. |
| Methyldopa | Methyldopa may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Methylene blue | The serum concentration of Methylene blue can be decreased when it is combined with Enzalutamide. |
| Methylergometrine | The serum concentration of Methylergometrine can be decreased when it is combined with Enzalutamide. |
| Methylnaltrexone | Methylnaltrexone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Methylphenobarbital | The serum concentration of Methylphenobarbital can be decreased when it is combined with Enzalutamide. |
| Methylprednisolone | The serum concentration of Methylprednisolone can be decreased when it is combined with Enzalutamide. |
| Methylprednisone | The serum concentration of Methylprednisone can be decreased when it is combined with Enzalutamide. |
| Methyltestosterone | The serum concentration of Methyltestosterone can be decreased when it is combined with Enzalutamide. |
| Methysergide | The serum concentration of Methysergide can be decreased when it is combined with Enzalutamide. |
| Meticrane | Meticrane may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Metoclopramide | The serum concentration of Metoclopramide can be decreased when it is combined with Enzalutamide. |
| Metolazone | Metolazone may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Metoprolol | Metoprolol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Metreleptin | The metabolism of Enzalutamide can be increased when combined with Metreleptin. |
| Metronidazole | The serum concentration of Enzalutamide can be increased when it is combined with Metronidazole. |
| Metyrapone | The serum concentration of Enzalutamide can be increased when it is combined with Metyrapone. |
| Mexiletine | The serum concentration of Mexiletine can be decreased when it is combined with Enzalutamide. |
| Mianserin | The serum concentration of Mianserin can be decreased when it is combined with Enzalutamide. |
| Miconazole | The serum concentration of Enzalutamide can be increased when it is combined with Miconazole. |
| Midazolam | The serum concentration of Midazolam can be decreased when it is combined with Enzalutamide. |
| Midostaurin | The serum concentration of Midostaurin can be decreased when it is combined with Enzalutamide. |
| Mifepristone | The serum concentration of Enzalutamide can be increased when it is combined with Mifepristone. |
| Migalastat | Migalastat may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Milnacipran | The serum concentration of Milnacipran can be decreased when it is combined with Enzalutamide. |
| Milrinone | Milrinone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Mirabegron | The serum concentration of Mirabegron can be decreased when it is combined with Enzalutamide. |
| Mirtazapine | The serum concentration of Mirtazapine can be decreased when it is combined with Enzalutamide. |
| Mitapivat | The metabolism of Mitapivat can be increased when combined with Enzalutamide. |
| Mitotane | The serum concentration of Enzalutamide can be decreased when it is combined with Mitotane. |
| Mobocertinib | The serum concentration of Mobocertinib can be decreased when it is combined with Enzalutamide. |
| Moclobemide | The serum concentration of Moclobemide can be decreased when it is combined with Enzalutamide. |
| Modafinil | The serum concentration of Modafinil can be decreased when it is combined with Enzalutamide. |
| Mometasone | The serum concentration of Enzalutamide can be increased when it is combined with Mometasone furoate. |
| Montelukast | The serum concentration of Montelukast can be decreased when it is combined with Enzalutamide. |
| Morphine | The serum concentration of Morphine can be decreased when it is combined with Enzalutamide. |
| Moxisylyte | Enzalutamide may decrease the excretion rate of Moxisylyte which could result in a higher serum level. |
| Muzolimine | Muzolimine may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Mycophenolate | The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Enzalutamide. |
| Mycophenolic acid | Mycophenolic acid may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| N-acetyl tyrosine | Enzalutamide may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level. |
| Nabilone | The serum concentration of Nabilone can be decreased when it is combined with Enzalutamide. |
| Nabumetone | The serum concentration of Nabumetone can be decreased when it is combined with Enzalutamide. |
| Nadolol | Nadolol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Naldemedine | Enzalutamide may decrease the excretion rate of Naldemedine which could result in a higher serum level. |
| Nalmefene | Nalmefene may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Naloxegol | The serum concentration of Naloxegol can be decreased when it is combined with Enzalutamide. |
| Naloxone | The serum concentration of Enzalutamide can be increased when it is combined with Naloxone. |
| Naproxen | The serum concentration of Naproxen can be decreased when it is combined with Enzalutamide. |
| Nateglinide | The serum concentration of Nateglinide can be decreased when it is combined with Enzalutamide. |
| Nebivolol | The serum concentration of Nebivolol can be decreased when it is combined with Enzalutamide. |
| Nedaplatin | Enzalutamide may decrease the excretion rate of Nedaplatin which could result in a higher serum level. |
| Nedocromil | Nedocromil may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Nefazodone | The serum concentration of Nefazodone can be decreased when it is combined with Enzalutamide. |
| Nelfinavir | The serum concentration of Nelfinavir can be decreased when it is combined with Enzalutamide. |
| Neomycin | Enzalutamide may decrease the excretion rate of Neomycin which could result in a higher serum level. |
| Neratinib | The serum concentration of Neratinib can be decreased when it is combined with Enzalutamide. |
| Netilmicin | Enzalutamide may decrease the excretion rate of Netilmicin which could result in a higher serum level. |
| Netupitant | The serum concentration of Netupitant can be decreased when it is combined with Enzalutamide. |
| Nevirapine | The serum concentration of Nevirapine can be decreased when it is combined with Enzalutamide. |
| Nicardipine | The serum concentration of Nicardipine can be decreased when it is combined with Enzalutamide. |
| Niclosamide | The serum concentration of Niclosamide can be decreased when it is combined with Enzalutamide. |
| Nicorandil | Enzalutamide may decrease the excretion rate of Nicorandil which could result in a higher serum level. |
| Nifedipine | The serum concentration of Nifedipine can be decreased when it is combined with Enzalutamide. |
| Nilotinib | The serum concentration of Nilotinib can be decreased when it is combined with Enzalutamide. |
| Nilutamide | The serum concentration of Nilutamide can be decreased when it is combined with Enzalutamide. |
| Nilvadipine | The serum concentration of Nilvadipine can be decreased when it is combined with Enzalutamide. |
| Nimesulide | The serum concentration of Nimesulide can be decreased when it is combined with Enzalutamide. |
| Nimodipine | The serum concentration of Nimodipine can be decreased when it is combined with Enzalutamide. |
| Nintedanib | The serum concentration of Nintedanib can be decreased when it is combined with Enzalutamide. |
| Nirmatrelvir | The serum concentration of Nirmatrelvir can be decreased when it is combined with Enzalutamide. |
| Nisoldipine | The serum concentration of Nisoldipine can be decreased when it is combined with Enzalutamide. |
| Nitrazepam | The serum concentration of Nitrazepam can be decreased when it is combined with Enzalutamide. |
| Nitrendipine | The serum concentration of Nitrendipine can be decreased when it is combined with Enzalutamide. |
| Nitric Oxide | The serum concentration of Enzalutamide can be increased when it is combined with Nitric Oxide. |
| Nitrofurantoin | Nitrofurantoin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Nitroprusside | Nitroprusside may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Nomegestrol | The serum concentration of Nomegestrol can be decreased when it is combined with Enzalutamide. |
| Nomegestrol | The serum concentration of Nomegestrol acetate can be decreased when it is combined with Enzalutamide. |
| Norelgestromin | The serum concentration of Norelgestromin can be decreased when it is combined with Enzalutamide. |
| Norethisterone | The serum concentration of Norethisterone can be decreased when it is combined with Enzalutamide. |
| Norethynodrel | The serum concentration of Norethynodrel can be decreased when it is combined with Enzalutamide. |
| Norfloxacin | The serum concentration of Enzalutamide can be increased when it is combined with Norfloxacin. |
| Norgestimate | The serum concentration of Norgestimate can be decreased when it is combined with Enzalutamide. |
| Norgestrel | The serum concentration of Norgestrel can be decreased when it is combined with Enzalutamide. |
| Nortriptyline | The serum concentration of Nortriptyline can be decreased when it is combined with Enzalutamide. |
| Noscapine | The serum concentration of Enzalutamide can be increased when it is combined with Noscapine. |
| Nylidrin | The serum concentration of Nylidrin can be decreased when it is combined with Enzalutamide. |
| Octinoxate | Enzalutamide may decrease the excretion rate of Octinoxate which could result in a higher serum level. |
| Octreotide | The serum concentration of Enzalutamide can be increased when it is combined with Octreotide. |
| Olanzapine | The metabolism of Enzalutamide can be decreased when combined with Olanzapine. |
| Olaparib | The metabolism of Olaparib can be increased when combined with Enzalutamide. |
| Oliceridine | The serum concentration of Oliceridine can be decreased when it is combined with Enzalutamide. |
| Olodaterol | The serum concentration of Olodaterol can be decreased when it is combined with Enzalutamide. |
| Olsalazine | Olsalazine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ombitasvir | The metabolism of Ombitasvir can be decreased when combined with Enzalutamide. |
| Omeprazole | The serum concentration of Omeprazole can be decreased when it is combined with Enzalutamide. |
| Ondansetron | The serum concentration of Ondansetron can be decreased when it is combined with Enzalutamide. |
| Opium | The serum concentration of Opium can be decreased when it is combined with Enzalutamide. |
| Oritavancin | The metabolism of Enzalutamide can be decreased when combined with Oritavancin. |
| Orphenadrine | The serum concentration of Orphenadrine can be decreased when it is combined with Enzalutamide. |
| Oseltamivir | Oseltamivir may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Osilodrostat | The serum concentration of Osilodrostat can be decreased when it is combined with Enzalutamide. |
| Osimertinib | The metabolism of Osimertinib can be increased when combined with Enzalutamide. |
| Ospemifene | The serum concentration of Ospemifene can be decreased when it is combined with Enzalutamide. |
| Oxacillin | Oxacillin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Oxandrolone | The metabolism of Enzalutamide can be decreased when combined with Oxandrolone. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Oxazepam | Oxazepam may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Oxcarbazepine | The serum concentration of Enzalutamide can be increased when it is combined with Oxcarbazepine. |
| Oxetacaine | The serum concentration of Enzalutamide can be increased when it is combined with Oxetacaine. |
| Oxybenzone | Oxybenzone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Oxybuprocaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Oxybuprocaine. |
| Oxybutynin | The serum concentration of Oxybutynin can be decreased when it is combined with Enzalutamide. |
| Oxycodone | The serum concentration of Oxycodone can be decreased when it is combined with Enzalutamide. |
| Oxymetholone | The serum concentration of Enzalutamide can be increased when it is combined with Oxymetholone. |
| Oxymorphone | The serum concentration of Oxymorphone can be decreased when it is combined with Enzalutamide. |
| Oxyphenbutazone | Oxyphenbutazone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Oxyquinoline | Enzalutamide may decrease the excretion rate of Oxyquinoline which could result in a higher serum level. |
| Ozanimod | The metabolism of Ozanimod can be decreased when combined with Enzalutamide. |
| Paclitaxel | The serum concentration of Paclitaxel can be decreased when it is combined with Enzalutamide. |
| Pacritinib | The serum concentration of Pacritinib can be decreased when it is combined with Enzalutamide. |
| Palbociclib | The serum concentration of Palbociclib can be decreased when it is combined with Enzalutamide. |
| Paliperidone | The serum concentration of Paliperidone can be decreased when it is combined with Enzalutamide. |
| Palonosetron | The serum concentration of Palonosetron can be decreased when it is combined with Enzalutamide. |
| Palovarotene | The serum concentration of Palovarotene can be decreased when it is combined with Enzalutamide. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Panobinostat | The serum concentration of Panobinostat can be decreased when it is combined with Enzalutamide. |
| Pantoprazole | The serum concentration of Pantoprazole can be decreased when it is combined with Enzalutamide. |
| Paramethadione | The serum concentration of Paramethadione can be decreased when it is combined with Enzalutamide. |
| Parecoxib | The serum concentration of Parecoxib can be decreased when it is combined with Enzalutamide. |
| Paricalcitol | The serum concentration of Paricalcitol can be decreased when it is combined with Enzalutamide. |
| Paritaprevir | The serum concentration of Paritaprevir can be decreased when it is combined with Enzalutamide. |
| Paromomycin | Paromomycin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Paroxetine | The serum concentration of Paroxetine can be decreased when it is combined with Enzalutamide. |
| Pasireotide | The serum concentration of Enzalutamide can be increased when it is combined with Pasireotide. |
| Patent Blue | Enzalutamide may decrease the excretion rate of Patent Blue which could result in a higher serum level. |
| Pazopanib | The serum concentration of Pazopanib can be decreased when it is combined with Enzalutamide. |
| Pegaptanib | Pegaptanib may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Peginesatide | The risk or severity of Thrombosis can be increased when Peginesatide is combined with Enzalutamide. |
| Peginterferon | The metabolism of Enzalutamide can be increased when combined with Peginterferon alfa-2b. |
| Pemetrexed | Enzalutamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level. |
| Pemigatinib | The metabolism of Pemigatinib can be increased when combined with Enzalutamide. |
| Penbutolol | Penbutolol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Pentaerythritol | Pentaerythritol tetranitrate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Pentamidine | The serum concentration of Pentamidine can be decreased when it is combined with Enzalutamide. |
| Pentastar | Enzalutamide may decrease the excretion rate of Pentastarch which could result in a higher serum level. |
| Pentetic acid | Enzalutamide may decrease the excretion rate of Pentetic acid which could result in a higher serum level. |
| Pentobarbital | The serum concentration of Pentobarbital can be decreased when it is combined with Enzalutamide. |
| Pentostatin | Enzalutamide may decrease the excretion rate of Pentostatin which could result in a higher serum level. |
| Pentoxifylline | Pentoxifylline may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Peppermint oil | The serum concentration of Enzalutamide can be increased when it is combined with Peppermint oil. |
| Perampanel | The metabolism of Perampanel can be increased when combined with Enzalutamide. |
| Perhexiline | The serum concentration of Perhexiline can be decreased when it is combined with Enzalutamide. |
| Perindopril | Perindopril may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Permethrin | Permethrin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Pexidartinib | The metabolism of Pexidartinib can be increased when combined with Enzalutamide. |
| Phenazopyridine | Phenazopyridine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Phenelzine | The serum concentration of Enzalutamide can be increased when it is combined with Phenelzine. |
| Phenobarbital | The serum concentration of Phenobarbital can be decreased when it is combined with Enzalutamide. |
| Phenol | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Phenol. |
| Phenprocoumon | The serum concentration of Phenprocoumon can be decreased when it is combined with Enzalutamide. |
| Phentermine | The serum concentration of Phentermine can be decreased when it is combined with Enzalutamide. |
| Phentolamine | Phentolamine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Phenylbutazone | The serum concentration of Phenylbutazone can be decreased when it is combined with Enzalutamide. |
| Phenytoin | The serum concentration of Phenytoin can be decreased when it is combined with Enzalutamide. |
| Pholcodine | Enzalutamide may decrease the excretion rate of Pholcodine which could result in a higher serum level. |
| Phosphoric acid | Enzalutamide may decrease the excretion rate of Phosphoric acid which could result in a higher serum level. |
| Phylloquinone | Phylloquinone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Picosulfuric acid | Enzalutamide may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level. |
| Piflufolastat F 18 | Enzalutamide may decrease effectiveness of Piflufolastat F 18 as a diagnostic agent. |
| Pilocarpine | The serum concentration of Enzalutamide can be increased when it is combined with Pilocarpine. |
| Pimavanserin | The metabolism of Pimavanserin can be increased when combined with Enzalutamide. |
| Pimecrolimus | The serum concentration of Pimecrolimus can be decreased when it is combined with Enzalutamide. |
| Pimozide | The serum concentration of Pimozide can be decreased when it is combined with Enzalutamide. |
| Pinacidil | The serum concentration of Pinacidil can be decreased when it is combined with Enzalutamide. |
| Pinaverium | The serum concentration of Pinaverium can be decreased when it is combined with Enzalutamide. |
| Pindolol | Pindolol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Pioglitazone | The serum concentration of Pioglitazone can be decreased when it is combined with Enzalutamide. |
| Piperacillin | Piperacillin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Piperaquine | The serum concentration of Piperaquine can be decreased when it is combined with Enzalutamide. |
| Pipotiazine | The serum concentration of Pipotiazine can be decreased when it is combined with Enzalutamide. |
| Piracetam | Enzalutamide may decrease the excretion rate of Piracetam which could result in a higher serum level. |
| Piretanide | Piretanide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Pirfenidone | The serum concentration of Pirfenidone can be decreased when it is combined with Enzalutamide. |
| Piroxicam | The serum concentration of Piroxicam can be decreased when it is combined with Enzalutamide. |
| Pitavastatin | The serum concentration of Pitavastatin can be decreased when it is combined with Enzalutamide. |
| Pitolisant | The metabolism of Pitolisant can be increased when combined with Enzalutamide. |
| Plazomicin | Enzalutamide may decrease the excretion rate of Plazomicin which could result in a higher serum level. |
| Plerixafor | Plerixafor may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Polatuzumab | The risk or severity of adverse effects can be decreased when Enzalutamide is combined with Polatuzumab vedotin. |
| Polythiazide | Polythiazide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Pomalidomide | The serum concentration of Pomalidomide can be decreased when it is combined with Enzalutamide. |
| Ponatinib | The serum concentration of Ponatinib can be decreased when it is combined with Enzalutamide. |
| Ponesimod | The serum concentration of Ponesimod can be decreased when it is combined with Enzalutamide. |
| Posaconazole | The serum concentration of Posaconazole can be decreased when it is combined with Enzalutamide. |
| Potassium | Potassium may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Potassium acetate | Enzalutamide may decrease the excretion rate of Potassium acetate which could result in a higher serum level. |
| Potassium bica | Enzalutamide may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level. |
| Potassium cation | Potassium cation may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Potassium chloride | Potassium chloride may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Potassium citrate | Potassium citrate may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Potassium nitrate | Enzalutamide may decrease the excretion rate of Potassium nitrate which could result in a higher serum level. |
| Potassium perchlorate | Enzalutamide may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level. |
| Potassium sulfate | Enzalutamide may decrease the excretion rate of Potassium sulfate which could result in a higher serum level. |
| Pralatrexate | Pralatrexate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Pralidoxime | Pralidoxime may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Pralsetinib | The serum concentration of Pralsetinib can be decreased when it is combined with Enzalutamide. |
| Pramipexole | Pramipexole may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Pramocaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Pramocaine. |
| Prasterone | The serum concentration of Prasterone can be decreased when it is combined with Enzalutamide. |
| Prasugrel | The serum concentration of Prasugrel can be decreased when it is combined with Enzalutamide. |
| Prazepam | The serum concentration of Prazepam can be decreased when it is combined with Enzalutamide. |
| Praziquantel | The metabolism of Praziquantel can be increased when combined with Enzalutamide. |
| Prednicarbate | The serum concentration of Prednicarbate can be decreased when it is combined with Enzalutamide. |
| Prednisolone | The serum concentration of Prednisolone can be decreased when it is combined with Enzalutamide. |
| Prednisolone acetate | The serum concentration of Prednisolone acetate can be decreased when it is combined with Enzalutamide. |
| Prednisolone | The serum concentration of Prednisolone phosphate can be decreased when it is combined with Enzalutamide. |
| Prednisone | The serum concentration of Prednisone can be decreased when it is combined with Enzalutamide. |
| Prednisone acetate | The metabolism of Enzalutamide can be increased when combined with Prednisone acetate. |
| Pregabalin | Pregabalin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Pregnenolone | The serum concentration of Pregnenolone can be decreased when it is combined with Enzalutamide. |
| Prenylamine | The serum concentration of Prenylamine can be decreased when it is combined with Enzalutamide. |
| Pretomanid | The serum concentration of Pretomanid can be decreased when it is combined with Enzalutamide. |
| Prilocaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Prilocaine. |
| Primaquine | The serum concentration of Primaquine can be decreased when it is combined with Enzalutamide. |
| Primidone | The serum concentration of Primidone can be decreased when it is combined with Enzalutamide. |
| Probenecid | The serum concentration of Enzalutamide can be decreased when it is combined with Probenecid. |
| Procainamide | Enzalutamide may decrease the excretion rate of Procainamide which could result in a higher serum level. |
| Procaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Procaine. |
| Procaine | Enzalutamide may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level. |
| Prochlorperazine | The serum concentration of Prochlorperazine can be decreased when it is combined with Enzalutamide. |
| Progesterone | The serum concentration of Progesterone can be decreased when it is combined with Enzalutamide. |
| Proguanil | The serum concentration of Proguanil can be decreased when it is combined with Enzalutamide. |
| Promazine | The serum concentration of Promazine can be decreased when it is combined with Enzalutamide. |
| Promethazine | The metabolism of Enzalutamide can be decreased when combined with Promethazine. |
| Propafenone | The serum concentration of Propafenone can be decreased when it is combined with Enzalutamide. |
| Propantheline | Propantheline may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Proparacaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Proparacaine. |
| Propiverine | The serum concentration of Propiverine can be decreased when it is combined with Enzalutamide. |
| Propofol | The serum concentration of Propofol can be decreased when it is combined with Enzalutamide. |
| Propoxycaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Propoxycaine. |
| Propranolol | The serum concentration of Propranolol can be decreased when it is combined with Enzalutamide. |
| Prucalopride | The serum concentration of Prucalopride can be decreased when it is combined with Enzalutamide. |
| Pyrantel | Enzalutamide may decrease the excretion rate of Pyrantel which could result in a higher serum level. |
| Pyrazinamide | Pyrazinamide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Pyridoxine | Pyridoxine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Pyrimethamine | The metabolism of Enzalutamide can be decreased when combined with Pyrimethamine. |
| Pyrithione | Pyrithione may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Quazepam | The serum concentration of Quazepam can be decreased when it is combined with Enzalutamide. |
| Quetiapine | The metabolism of Quetiapine can be increased when combined with Enzalutamide. |
| Quinethazone | Quinethazone may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Quinidine | The serum concentration of Quinidine can be decreased when it is combined with Enzalutamide. |
| Quinine | The serum concentration of Quinine can be decreased when it is combined with Enzalutamide. |
| Quinupristin | The serum concentration of Enzalutamide can be increased when it is combined with Quinupristin. |
| Rabeprazole | The serum concentration of Rabeprazole can be decreased when it is combined with Enzalutamide. |
| Raloxifene | The serum concentration of Enzalutamide can be increased when it is combined with Raloxifene. |
| Ramelteon | The serum concentration of Ramelteon can be decreased when it is combined with Enzalutamide. |
| Ranitidine | Ranitidine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ranolazine | The metabolism of Ranolazine can be increased when combined with Enzalutamide. |
| Rasagiline | Rasagiline may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Reboxetine | The serum concentration of Reboxetine can be decreased when it is combined with Enzalutamide. |
| Regorafenib | The serum concentration of Regorafenib can be decreased when it is combined with Enzalutamide. |
| Relugolix | The serum concentration of Relugolix can be decreased when it is combined with Enzalutamide. |
| Remdesivir | The serum concentration of Remdesivir can be decreased when it is combined with Enzalutamide. |
| Repaglinide | The serum concentration of Repaglinide can be decreased when it is combined with Enzalutamide. |
| Reserpine | The metabolism of Enzalutamide can be increased when combined with Reserpine. |
| Resorcinol | Enzalutamide may decrease the excretion rate of Resorcinol which could result in a higher serum level. |
| Retapamulin | The serum concentration of Retapamulin can be decreased when it is combined with Enzalutamide. |
| Ribavirin | Ribavirin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ribociclib | The serum concentration of Ribociclib can be decreased when it is combined with Enzalutamide. |
| Ribostamycin | Enzalutamide may decrease the excretion rate of Ribostamycin which could result in a higher serum level. |
| Rifabutin | The serum concentration of Rifabutin can be decreased when it is combined with Enzalutamide. |
| Rifampicin | The serum concentration of Enzalutamide can be decreased when it is combined with Rifampicin. |
| Rifamycin | The serum concentration of Enzalutamide can be decreased when it is combined with Rifamycin. |
| Rifapentine | The serum concentration of Rifapentine can be decreased when it is combined with Enzalutamide. |
| Rifaximin | The serum concentration of Enzalutamide can be decreased when it is combined with Rifaximin. |
| Rilonacept | The metabolism of Enzalutamide can be increased when combined with Rilonacept. |
| Rilpivirine | The serum concentration of Rilpivirine can be decreased when it is combined with Enzalutamide. |
| Rimegepant | The metabolism of Rimegepant can be increased when combined with Enzalutamide. |
| Rimexolone | The serum concentration of Rimexolone can be decreased when it is combined with Enzalutamide. |
| Rimonabant | The serum concentration of Rimonabant can be decreased when it is combined with Enzalutamide. |
| Riociguat | The serum concentration of Riociguat can be decreased when it is combined with Enzalutamide. |
| Ripretinib | The serum concentration of Ripretinib can be decreased when it is combined with Enzalutamide. |
| Risperidone | The serum concentration of Risperidone can be decreased when it is combined with Enzalutamide. |
| Ritonavir | The serum concentration of Enzalutamide can be increased when it is combined with Ritonavir. |
| Rivaroxaban | The serum concentration of Rivaroxaban can be decreased when it is combined with Enzalutamide. |
| Rizatriptan | Rizatriptan may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Rofecoxib | The serum concentration of Rofecoxib can be decreased when it is combined with Enzalutamide. |
| Roflumilast | The serum concentration of Roflumilast can be decreased when it is combined with Enzalutamide. |
| Rolapitant | The serum concentration of Rolapitant can be decreased when it is combined with Enzalutamide. |
| Romidepsin | The serum concentration of Romidepsin can be decreased when it is combined with Enzalutamide. |
| Ropivacaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Ropivacaine. |
| Rosiglitazone | The serum concentration of Rosiglitazone can be decreased when it is combined with Enzalutamide. |
| Rosuvastatin | The serum concentration of Rosuvastatin can be decreased when it is combined with Enzalutamide. |
| Rotigotine | The serum concentration of Rotigotine can be decreased when it is combined with Enzalutamide. |
| Roxadustat | The metabolism of Roxadustat can be decreased when combined with Enzalutamide. |
| Roxithromycin | The serum concentration of Roxithromycin can be decreased when it is combined with Enzalutamide. |
| Rucaparib | The serum concentration of Rucaparib can be decreased when it is combined with Enzalutamide. |
| Rupatadine | The serum concentration of Rupatadine can be decreased when it is combined with Enzalutamide. |
| Rutin | The serum concentration of Enzalutamide can be increased when it is combined with Rutin. |
| Ruxolitinib | The serum concentration of Ruxolitinib can be decreased when it is combined with Enzalutamide. |
| Sacubitril | Enzalutamide may decrease the excretion rate of Sacubitril which could result in a higher serum level. |
| Safinamide | The serum concentration of Safinamide can be decreased when it is combined with Enzalutamide. |
| Salbutamol | Salbutamol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Salicylamide | Salicylamide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Salicylic acid | The serum concentration of Salicylic acid can be decreased when it is combined with Enzalutamide. |
| Salmeterol | The serum concentration of Enzalutamide can be increased when it is combined with Salmeterol. |
| Salmon calcitonin | Salmon calcitonin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Salsalate | Salsalate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Samidorphan | The serum concentration of Samidorphan can be decreased when it is combined with Enzalutamide. |
| Saquinavir | The serum concentration of Saquinavir can be decreased when it is combined with Enzalutamide. |
| Sarilumab | The serum concentration of Enzalutamide can be increased when it is combined with Sarilumab. |
| Satralizumab | The serum concentration of Enzalutamide can be decreased when it is combined with Satralizumab. |
| Saxagliptin | The serum concentration of Saxagliptin can be decreased when it is combined with Enzalutamide. |
| Scopolamine | The serum concentration of Scopolamine can be decreased when it is combined with Enzalutamide. |
| Secobarbital | The serum concentration of Enzalutamide can be decreased when it is combined with Secobarbital. |
| Secukinumab | The metabolism of Enzalutamide can be increased when combined with Secukinumab. |
| Segesterone | The metabolism of Segesterone acetate can be increased when combined with Enzalutamide. |
| Selegiline | The serum concentration of Selegiline can be decreased when it is combined with Enzalutamide. |
| Selenious acid | Enzalutamide may decrease the excretion rate of Selenious acid which could result in a higher serum level. |
| Selenium | Enzalutamide may decrease the excretion rate of Selenium which could result in a higher serum level. |
| Selexipag | The serum concentration of Selexipag can be decreased when it is combined with Enzalutamide. |
| Selinexor | The serum concentration of Selinexor can be decreased when it is combined with Enzalutamide. |
| Selpercatinib | The serum concentration of Selpercatinib can be decreased when it is combined with Enzalutamide. |
| Selumetinib | The serum concentration of Selumetinib can be decreased when it is combined with Enzalutamide. |
| Sertindole | The serum concentration of Sertindole can be decreased when it is combined with Enzalutamide. |
| Sertraline | The serum concentration of Sertraline can be decreased when it is combined with Enzalutamide. |
| Sevoflurane | The serum concentration of Sevoflurane can be decreased when it is combined with Enzalutamide. |
| Sibutramine | The serum concentration of Sibutramine can be decreased when it is combined with Enzalutamide. |
| Sildenafil | The serum concentration of Sildenafil can be decreased when it is combined with Enzalutamide. |
| Silodosin | The serum concentration of Silodosin can be decreased when it is combined with Enzalutamide. |
| Siltuximab | The serum concentration of Enzalutamide can be increased when it is combined with Siltuximab. |
| Simeprevir | The serum concentration of Simeprevir can be decreased when it is combined with Enzalutamide. |
| Simvastatin | The serum concentration of Simvastatin can be decreased when it is combined with Enzalutamide. |
| Siponimod | The therapeutic efficacy of Siponimod can be decreased when used in combination with Enzalutamide. |
| Sirolimus | The serum concentration of Sirolimus can be decreased when it is combined with Enzalutamide. |
| Sitagliptin | The serum concentration of Sitagliptin can be decreased when it is combined with Enzalutamide. |
| Sitaxentan | The serum concentration of Sitaxentan can be decreased when it is combined with Enzalutamide. |
| Sodium acetate | Enzalutamide may decrease the excretion rate of Sodium acetate which could result in a higher serum level. |
| Sodium aurothio | Enzalutamide may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. |
| Sodium fluoride | Enzalutamide may decrease the excretion rate of Sodium fluoride which could result in a higher serum level. |
| Sodium sulfate | Enzalutamide may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. |
| Sofosbuvir | Enzalutamide may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
| Solifenacin | The serum concentration of Solifenacin can be decreased when it is combined with Enzalutamide. |
| Solriamfetol | Enzalutamide may decrease the excretion rate of Solriamfetol which could result in a higher serum level. |
| Somatostatin | The serum concentration of Enzalutamide can be increased when it is combined with Somatostatin. |
| Somatrogon | The metabolism of Enzalutamide can be increased when combined with Somatrogon. |
| Sonidegib | The serum concentration of Sonidegib can be decreased when it is combined with Enzalutamide. |
| Sorafenib | The serum concentration of Enzalutamide can be increased when it is combined with Sorafenib. |
| Sorbitol | Sorbitol may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Sotagliflozin | The serum concentration of Sotagliflozin can be decreased when it is combined with Enzalutamide. |
| Sotorasib | The serum concentration of Sotorasib can be decreased when it is combined with Enzalutamide. |
| Spironolactone | The metabolism of Enzalutamide can be decreased when combined with Spironolactone. |
| St. John’s Wort | The serum concentration of St. John’s Wort can be decreased when it is combined with Enzalutamide. |
| Stiripentol | The metabolism of Enzalutamide can be decreased when combined with Stiripentol. |
| Streptomycin | Enzalutamide may decrease the excretion rate of Streptomycin which could result in a higher serum level. |
| Strontium | Enzalutamide may decrease the excretion rate of Strontium chloride which could result in a higher serum level. |
| Sucralfate | Sucralfate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Sufentanil | The serum concentration of Sufentanil can be decreased when it is combined with Enzalutamide. |
| Sulbactam | Enzalutamide may decrease the excretion rate of Sulbactam which could result in a higher serum level. |
| Sulfadiazine | The serum concentration of Sulfadiazine can be decreased when it is combined with Enzalutamide. |
| Sulfamethizole | The metabolism of Enzalutamide can be decreased when combined with Sulfamethizole. |
| Sulfamethoxazole | The serum concentration of Sulfamethoxazole can be decreased when it is combined with Enzalutamide. |
| Sulfanilamide | The serum concentration of Enzalutamide can be increased when it is combined with Sulfanilamide. |
| Sulfaphenazole | The metabolism of Enzalutamide can be decreased when combined with Sulfaphenazole. |
| Sulfapyridine | The metabolism of Enzalutamide can be decreased when combined with Sulfapyridine. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Sulfinpyrazone | The serum concentration of Sulfinpyrazone can be decreased when it is combined with Enzalutamide. |
| Sulfisoxazole | The metabolism of Enzalutamide can be decreased when combined with Sulfisoxazole. |
| Sulindac | Sulindac may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Sumatriptan | Sumatriptan may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Sunitinib | The serum concentration of Sunitinib can be decreased when it is combined with Enzalutamide. |
| Suprofen | The serum concentration of Suprofen can be decreased when it is combined with Enzalutamide. |
| Suvorexant | The serum concentration of Suvorexant can be decreased when it is combined with Enzalutamide. |
| S Estrogens, A | The serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Enzalutamide. |
| S Estrogens, B | The serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Enzalutamide. |
| Tacrolimus | The serum concentration of Tacrolimus can be decreased when it is combined with Enzalutamide. |
| Tadalafil | The serum concentration of Tadalafil can be decreased when it is combined with Enzalutamide. |
| Tamoxifen | The serum concentration of Tamoxifen can be decreased when it is combined with Enzalutamide. |
| Tamsulosin | The serum concentration of Tamsulosin can be decreased when it is combined with Enzalutamide. |
| Tasimelteon | The serum concentration of Tasimelteon can be decreased when it is combined with Enzalutamide. |
| Tazarotene | The metabolism of Tazarotene can be decreased when combined with Enzalutamide. |
| Tazemetostat | The serum concentration of Tazemetostat can be decreased when it is combined with Enzalutamide. |
| Technetium | Enzalutamide may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level. |
| Technetium | Enzalutamide may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level. |
| Technetium | Enzalutamide may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level. |
| Technetium | Enzalutamide may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level. |
| Tecovirimat | The serum concentration of Enzalutamide can be decreased when it is combined with Tecovirimat. |
| Teduglutide | Enzalutamide may decrease the excretion rate of Teduglutide which could result in a higher serum level. |
| Tegafur | The metabolism of Tegafur can be increased when combined with Enzalutamide. |
| Tegaserod | The metabolism of Enzalutamide can be decreased when combined with Tegaserod. |
| Telaprevir | The serum concentration of Telaprevir can be decreased when it is combined with Enzalutamide. |
| Telavancin | Telavancin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Telithromycin | The serum concentration of Telithromycin can be decreased when it is combined with Enzalutamide. |
| Telotristat ethyl | The serum concentration of Enzalutamide can be decreased when it is combined with Telotristat ethyl. |
| Temazepam | Temazepam may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Temozolomide | Temozolomide may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Temsirolimus | The serum concentration of Temsirolimus can be decreased when it is combined with Enzalutamide. |
| Teniposide | The serum concentration of Teniposide can be decreased when it is combined with Enzalutamide. |
| Tenofovir | The serum concentration of Tenofovir alafenamide can be decreased when it is combined with Enzalutamide. |
| Tenofovir | Tenofovir disoproxil may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Tenoxicam | The serum concentration of Tenoxicam can be decreased when it is combined with Enzalutamide. |
| Tepotinib | The serum concentration of Tepotinib can be decreased when it is combined with Enzalutamide. |
| Terbinafine | The serum concentration of Terbinafine can be decreased when it is combined with Enzalutamide. |
| Terbutaline | Terbutaline may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Terfenadine | The serum concentration of Terfenadine can be decreased when it is combined with Enzalutamide. |
| Teriflunomide | The metabolism of Enzalutamide can be decreased when combined with Teriflunomide. |
| Testolactone | Testolactone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Testosterone | The serum concentration of Testosterone can be decreased when it is combined with Enzalutamide. |
| Testosterone | The serum concentration of Testosterone cypionate can be decreased when it is combined with Enzalutamide. |
| Testosterone | The serum concentration of Testosterone enanthate can be decreased when it is combined with Enzalutamide. |
| Testosterone | The serum concentration of Testosterone propionate can be decreased when it is combined with Enzalutamide. |
| Testosterone | The serum concentration of Enzalutamide can be increased when it is combined with Testosterone undecanoate. |
| Tetracaine | The risk or severity of methemoglobinemia can be increased when Enzalutamide is combined with Tetracaine. |
| Tetracycline | The serum concentration of Tetracycline can be decreased when it is combined with Enzalutamide. |
| Tetradecyl | Enzalutamide may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level. |
| Tezacaftor | The serum concentration of Tezacaftor can be decreased when it is combined with Enzalutamide. |
| Thalidomide | The serum concentration of Thalidomide can be decreased when it is combined with Enzalutamide. |
| Theophylline | The serum concentration of Theophylline can be decreased when it is combined with Enzalutamide. |
| Thiabendazole | Thiabendazole may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Thiamylal | The serum concentration of Thiamylal can be decreased when it is combined with Enzalutamide. |
| Thiethylperazine | Thiethylperazine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Thiopental | The serum concentration of Thiopental can be decreased when it is combined with Enzalutamide. |
| Thioridazine | The serum concentration of Thioridazine can be decreased when it is combined with Enzalutamide. |
| Thiotepa | The serum concentration of Thiotepa can be decreased when it is combined with Enzalutamide. |
| Tiagabine | The serum concentration of Tiagabine can be decreased when it is combined with Enzalutamide. |
| Tiaprofenic acid | Tiaprofenic acid may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Ticagrelor | The metabolism of Ticagrelor can be increased when combined with Enzalutamide. |
| Ticlopidine | The serum concentration of Ticlopidine can be decreased when it is combined with Enzalutamide. |
| Tiludronic acid | Tiludronic acid may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Timolol | The serum concentration of Timolol can be decreased when it is combined with Enzalutamide. |
| Tinidazole | The serum concentration of Tinidazole can be decreased when it is combined with Enzalutamide. |
| Tioconazole | The serum concentration of Enzalutamide can be increased when it is combined with Tioconazole. |
| Tiopronin | Tiopronin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Tiotropium | The serum concentration of Tiotropium can be decreased when it is combined with Enzalutamide. |
| Tipranavir | The serum concentration of Tipranavir can be decreased when it is combined with Enzalutamide. |
| Tirofiban | Tirofiban may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Tisotumab vedotin | The serum concentration of Tisotumab vedotin can be decreased when it is combined with Enzalutamide. |
| Tivozanib | The metabolism of Tivozanib can be increased when combined with Enzalutamide. |
| Tixocortol | Enzalutamide may decrease the excretion rate of Tixocortol which could result in a higher serum level. |
| Tobramycin | Enzalutamide may decrease the excretion rate of Tobramycin which could result in a higher serum level. |
| Tocilizumab | The metabolism of Enzalutamide can be increased when combined with Tocilizumab. |
| Tocofersolan | The serum concentration of Tocofersolan can be decreased when it is combined with Enzalutamide. |
| Tocopherol | The serum concentration of Tocopherol can be decreased when it is combined with Enzalutamide. |
| Tofacitinib | The serum concentration of Tofacitinib can be decreased when it is combined with Enzalutamide. |
| Tolazamide | The serum concentration of Tolazamide can be decreased when it is combined with Enzalutamide. |
| Tolbutamide | The serum concentration of Tolbutamide can be decreased when it is combined with Enzalutamide. |
| Tolcapone | Tolcapone may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Tolfenamic acid | The serum concentration of Tolfenamic acid can be decreased when it is combined with Enzalutamide. |
| Tolmetin | Tolmetin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Tolterodine | The serum concentration of Tolterodine can be decreased when it is combined with Enzalutamide. |
| Tolvaptan | The serum concentration of Tolvaptan can be decreased when it is combined with Enzalutamide. |
| Topiramate | Topiramate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Topotecan | The serum concentration of Enzalutamide can be increased when it is combined with Topotecan. |
| Torasemide | The serum concentration of Torasemide can be decreased when it is combined with Enzalutamide. |
| Toremifene | The serum concentration of Toremifene can be decreased when it is combined with Enzalutamide. |
| Tositumomab | Tositumomab may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Trabectedin | The serum concentration of Trabectedin can be decreased when it is combined with Enzalutamide. |
| Tramadol | The metabolism of Tramadol can be increased when combined with Enzalutamide. |
| Trametinib | The serum concentration of Enzalutamide can be increased when it is combined with Trametinib. |
| Tranylcypromine | The serum concentration of Enzalutamide can be increased when it is combined with Tranylcypromine. |
| Trastuzumab | The serum concentration of Trastuzumab emtansine can be decreased when it is combined with Enzalutamide. |
| Trazodone | The serum concentration of Trazodone can be decreased when it is combined with Enzalutamide. |
| Treprostinil | The serum concentration of Treprostinil can be decreased when it is combined with Enzalutamide. |
| Tretinoin | The serum concentration of Tretinoin can be decreased when it is combined with Enzalutamide. |
| Triamcinolone | The serum concentration of Triamcinolone can be decreased when it is combined with Enzalutamide. |
| Triamterene | Triamterene may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Triazolam | The serum concentration of Triazolam can be decreased when it is combined with Enzalutamide. |
| Trichlormethiazide | Trichlormethiazide may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy. |
| Triclabendazole | The serum concentration of Triclabendazole can be decreased when it is combined with Enzalutamide. |
| Triethylenetetramine | Triethylenetetramine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Trifluridine | Trifluridine may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Trimebutine | The serum concentration of Trimebutine can be decreased when it is combined with Enzalutamide. |
| Trimethadione | The serum concentration of Trimethadione can be decreased when it is combined with Enzalutamide. |
| Trimethoprim | The serum concentration of Trimethoprim can be decreased when it is combined with Enzalutamide. |
| Trimetrexate | Trimetrexate may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Trimipramine | The serum concentration of Trimipramine can be decreased when it is combined with Enzalutamide. |
| Troglitazone | The serum concentration of Troglitazone can be decreased when it is combined with Enzalutamide. |
| Troleandomycin | The serum concentration of Troleandomycin can be decreased when it is combined with Enzalutamide. |
| Tropisetron | Enzalutamide may decrease the excretion rate of Tropisetron which could result in a higher serum level. |
| Tucatinib | The metabolism of Tucatinib can be increased when combined with Enzalutamide. |
| Ubrogepant | The serum concentration of Ubrogepant can be decreased when it is combined with Enzalutamide. |
| Udenafil | The serum concentration of Udenafil can be decreased when it is combined with Enzalutamide. |
| Ulipristal | The metabolism of Ulipristal can be increased when combined with Enzalutamide. |
| Upadacitinib | The metabolism of Upadacitinib can be increased when combined with Enzalutamide. |
| Vaborbactam | Enzalutamide may decrease the excretion rate of Vaborbactam which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Valbenazine | The serum concentration of Valbenazine can be decreased when it is combined with Enzalutamide. |
| Valdecoxib | The serum concentration of Valdecoxib can be decreased when it is combined with Enzalutamide. |
| Valganciclovir | Valganciclovir may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Valproic acid | The serum concentration of Valproic acid can be decreased when it is combined with Enzalutamide. |
| Valsartan | The serum concentration of Valsartan can be decreased when it is combined with Enzalutamide. |
| Vancomycin | Enzalutamide may decrease the excretion rate of Vancomycin which could result in a higher serum level. |
| Vandetanib | The serum concentration of Vandetanib can be decreased when it is combined with Enzalutamide. |
| Vardenafil | The serum concentration of Vardenafil can be decreased when it is combined with Enzalutamide. |
| Varenicline | Varenicline may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Velpatasvir | The serum concentration of Velpatasvir can be decreased when it is combined with Enzalutamide. |
| Vemurafenib | The serum concentration of Vemurafenib can be decreased when it is combined with Enzalutamide. |
| Venetoclax | The serum concentration of Venetoclax can be decreased when it is combined with Enzalutamide. |
| Venlafaxine | The serum concentration of Venlafaxine can be decreased when it is combined with Enzalutamide. |
| Verapamil | The serum concentration of Verapamil can be decreased when it is combined with Enzalutamide. |
| Vilanterol | The serum concentration of Vilanterol can be decreased when it is combined with Enzalutamide. |
| Vilazodone | The metabolism of Vilazodone can be increased when combined with Enzalutamide. |
| Viloxazine | The serum concentration of Enzalutamide can be increased when it is combined with Viloxazine. |
| Vinblastine | The serum concentration of Vinblastine can be decreased when it is combined with Enzalutamide. |
| Vincristine | The serum concentration of Vincristine can be decreased when it is combined with Enzalutamide. |
| Vindesine | The serum concentration of Vindesine can be decreased when it is combined with Enzalutamide. |
| Vinflunine | The serum concentration of Vinflunine can be decreased when it is combined with Enzalutamide. |
| Vinorelbine | The serum concentration of Vinorelbine can be decreased when it is combined with Enzalutamide. |
| Vismodegib | The serum concentration of Vismodegib can be decreased when it is combined with Enzalutamide. |
| Vitamin D | The serum concentration of Vitamin D can be decreased when it is combined with Enzalutamide. |
| Vitamin E | The serum concentration of Vitamin E can be decreased when it is combined with Enzalutamide. |
| Voclosporin | The metabolism of Voclosporin can be increased when combined with Enzalutamide. |
| Vonoprazan | The therapeutic efficacy of Vonoprazan can be decreased when used in combination with Enzalutamide. |
| Vorapaxar | The serum concentration of Vorapaxar can be decreased when it is combined with Enzalutamide. |
| Voriconazole | The serum concentration of Voriconazole can be decreased when it is combined with Enzalutamide. |
| Vortioxetine | The metabolism of Vortioxetine can be increased when combined with Enzalutamide. |
| Voxelotor | The serum concentration of Voxelotor can be decreased when it is combined with Enzalutamide. |
| Voxilaprevir | The serum concentration of Voxilaprevir can be decreased when it is combined with Enzalutamide. |
| Warfarin | The serum concentration of Warfarin can be decreased when it is combined with Enzalutamide. |
| Ximelagatran | The serum concentration of Ximelagatran can be decreased when it is combined with Enzalutamide. |
| Yohimbine | The serum concentration of Yohimbine can be decreased when it is combined with Enzalutamide. |
| Zafirlukast | The serum concentration of Zafirlukast can be decreased when it is combined with Enzalutamide. |
| Zaleplon | The serum concentration of Zaleplon can be decreased when it is combined with Enzalutamide. |
| Zanamivir | Zanamivir may decrease the excretion rate of Enzalutamide which could result in a higher serum level. |
| Zanubrutinib | The metabolism of Zanubrutinib can be increased when combined with Enzalutamide. |
| Zidovudine | The serum concentration of Zidovudine can be decreased when it is combined with Enzalutamide. |
| Zileuton | The serum concentration of Zileuton can be decreased when it is combined with Enzalutamide. |
| Zimelidine | The serum concentration of Enzalutamide can be increased when it is combined with Zimelidine. |
Pregnancy and Lactation
AU TGA pregnancy category: X
US FDA pregnancy category: Not assigned.
Pregnancy
There are no data on pregnant women; however, in animal studies giving this drug during organogenesis caused adverse developmental effects at doses lower than the equivalent maximum recommended human dose (MRHD). This drug is not indicated for use in females. This drug should not be handled by women who are or may become pregnant. Male patients with female partners of reproductive potential should use effective contraception during therapy and for 3 months after the last dose. This drug may impair fertility in males of reproductive potential.
Lactation
- This drug is not indicated for use in female patients.
- Excreted into human milk: Unknown
- Excreted into animal milk: Yes
- This drug is not indicated for use in females.
- The effects on the nursing infant are unknown.
What special precautions should I follow?
Before taking enzalutamide,
- tell your doctor and pharmacist if you are allergic to enzalutamide, any other medications, or any of the ingredients in enzalutamide tablets or capsules. Ask your pharmacist or check the manufacturer’s information for the patient for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants (‘blood thinners) such as warfarin (Coumadin, Jantoven), carbamazepine (Carbatrol, Equetro, Tegretol, others), clopidogrel (Plavix), cyclosporine (Gengraf, Neoral, Sandimmune), dihydroergotamine (D.H.E. 45, Migranal), ergotamine (in Migergot, in Cafergot), fentanyl (Actiq, Duragesic, Fentora, Subsys, others), gemfibrozil (Lopid), itraconazole (Onmel, Sporanox), omeprazole (Prilosec), midazolam, phenobarbital, phenytoin (Dilantin, Phenytek), pimozide (Orap), quinidine (in Nuedexta), rifabutin (Mycobutin, in Talicia), rifampin (Rimactane, in Rifamate, in Rifater), rifapentine (Priftin), sirolimus (Rapamune), and tacrolimus (Prograf). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with enzalutamide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor what herbal products you are taking, especially St. John’s wort.
- tell your doctor if you have or have ever had seizures, a brain injury, a brain tumor, a brain arteriovenous malformation (an abnormal connection between arteries and veins in the brain that forms before birth and may cause bleeding in the brain), broken bones, osteoporosis (a condition in which the bones become thin and weak and break easily), diabetes, high cholesterol levels, high blood pressure, heart disease, or have had a stroke or ministroke.
- you should know that enzalutamide is only for use in men. Women should not take this medication, especially if they are or may become pregnant or are breastfeeding. Women, especially those who are or who may become pregnant should not touch enzalutamide capsules. If taken by pregnant women, enzalutamide may harm the fetus. If a pregnant woman takes enzalutamide, she should call her doctor immediately.
- you should know that this medication may decrease fertility in men. However, you should not assume that your female partner cannot become pregnant. If your partner is pregnant, you must use a condom whenever you have sex during your treatment with enzalutamide and for 3 months after your final dose. If your partner is not pregnant but could become pregnant, you must use effective birth control whenever you have sex during your treatment and for 3 months after your final dose.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking enzalutamide.
- you should know that enzalutamide may cause seizures. Do not drive a car or operate machinery until you know how this medication affects you.
References
