Enasidenib - Uses, Dosage, Side Effects, Interaction

Enasidenib is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity. Upon administration, enasidenib specifically inhibits various mutant forms of IDH2, including the IDH2 variants R140Q, R172S, and R172K, which inhibits the formation of 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH2-expressing tumor cells. IDH2, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by blocking differentiation and the production of the oncometabolite 2HG.

Enasidenib is an orally available small molecule inhibitor of isocitrate dehydrogenase and antineoplastic agent that is used in the therapy of selected cases of acute myeloid leukemia (AML). Enasidenib is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.

Enasidenib is a 1,3,5-triazine that is substituted by (2-hydroxy-2-methyl propyl)nitrilo, 6-(trifluoromethyl)pyridine-2-yl and [2-(trifluoromethyl)pyridin-4-yl]nitrilo groups at positions 2,4 and 6, respectively. It is an isocitrate dehydrogenase-2 (IDH2) inhibitor that has been approved for the treatment of adults with relapsed or refractory acute myeloid leukemia (AML). It has a role as an antineoplastic agent and an EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor. It is an aminopyridine, an organofluorine compound, a secondary amino compound, a tertiary alcohol, a member of 1,3,5-triazines, and an aromatic amine.

Enasidenib Mesylate is the mesylate salt form of enasidenib, an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity. Upon administration, enasidenib specifically inhibits various mutant forms of IDH2, including the IDH2 variants R140Q, R172S, and R172K, which inhibits the formation of 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH2-expressing tumor cells. IDH2, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by blocking differentiation and the production of the oncometabolite 2HG.

Mechanism of action

Enasidenib is a selective inhibitor of IDH2, a mitochondria-localized enzyme involved in diverse cellular processes, including adaptation to hypoxia, histone demethylation, and DNA modification ^[rx]. Wild-type IDH proteins play a crucial role in the Krebs/citric acid cycle where it catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate. In comparison, mutant forms of IDH2 enzyme mediate a neomorphic activity and catalyze the reduction of α-KG to the (R) enantiomer of 2-hydroxyglutarate, which is associated with DNA and histone hypermethylation, altered gene expression, and blocked cellular differentiation of hematopoietic progenitor cells ^]rx]. Enasidenib primarily targets the mutant IDH2 variants R140Q, R172S, and R172K with higher potency than the wild-type enzyme form. Inhibition of the enzyme leads to decreased levels of 2-hydroxyglutarate (2-HG) and the promotion of proper differentiation and clonal proliferation of cells of the myeloid lineage ^[rx].

In a study involving adult patients with relapsed or refractory AML, the overall response rate of 40.3% was achieved in enasidenib therapy which was associated with cellular differentiation and maturation, typically without evidence of aplasia ^[rx]. Enasidenib is not shown to cause QTc prolongation.

Indications

Indicated for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation.
Treatment of acute myeloid leukaemia
Enasidenib is an orally available small molecule inhibitor of isocitrate dehydrogenase and antineoplastic agent that is used in the therapy of selected cases of acute myeloid leukemia (AML).
Enasidenib is used to treat relapsed or refractory acute myeloid leukemia in people with specific mutations of the IDH2 gene, determined by an FDA-approved IDH2 companion diagnostic test.^[rx]
Refractory Acute Myeloid Leukemia (AML)
Relapsed Acute Myelogenous Leukemia (AML)

Contraindications

high levels of white blood cells
the high amount of bilirubin in the blood
pregnancy
a patient who is producing milk and breastfeeding
a complication of treatment in certain types of leukemia called differentiation syndrome

Dosage

Strengths: 50 mg; 100 mg

Acute Myeloid Leukemia

100 mg orally once a day with or without food
Duration of Therapy: Treat until disease progression or unacceptable toxicity.
For patients without disease progression or unacceptable toxicity, treatment for a minimum of 6 months to allow time for clinical response.

Select patients based on the presence of isocitrate dehydrogenase-2 (IDH2) mutations in the blood or bone marrow as detected by an FDA-approved test, http://www.fda.gov/CompanionDiagnostics. Treatment of relapsed or refractory acute myeloid leukemia (AML) with an IDH2 mutation.

Dose Adjustments

MANAGING TOXICITIES:
Differentiation Syndrome:

If differentiation syndrome is suspected, administer systemic corticosteroids and initiate hemodynamic monitoring.
Interrupt treatment if severe pulmonary symptoms requiring intubation or ventilator support, and/or renal dysfunction persist for more than 48 hours after initiation of corticosteroids.
Resume treatment when signs/symptoms improve to Grade 2 or lower.

Noninfectious Leukocytosis [white blood cell (WBC) count greater than 30 x 10(9)/L]:

Initiate hydroxyurea, as per standard institutional practices.
Interrupt enasidenib if leukocytosis is not improved with hydroxyurea, and then resume enasidenib at 100 mg daily when WBC is less than 30 x 10(9)/L.

Other Treatment-Related Grade 3 or Higher Toxicity (e.g., tumor lysis syndrome):

Interrupt treatment until toxicity resolves to Grade 2 or lower.
Resume treatment at 50 mg/day; may increase to 100 mg/day if toxicities resolve to Grade 1 or lower.
Discontinue treatment if Grade 3 or higher toxicity recurs.

Side Effects

The Most Common

nausea
vomiting
diarrhea
decreased appetite
change in the way things taste
yellowing of your eyes or skin
muscle spasms or twitching; burning, prickling, or tingling feeling on the skin; irregular heartbeat; or seizures
fever, cough, trouble breathing;
bone pain;
rapid weight gain; or
swelling in your arms, legs, underarms, groin, or neck.
severe or ongoing vomiting or diarrhea; or
signs of tumor cell breakdown–tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth.
dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
loss of appetite; or
jaundice.
nausea, vomiting, diarrhea;

More common

Agitation
blue lips, fingernails, or skin
bone pain
chest pain
chills
confusion
cough
coughing that sometimes produces a pink frothy sputum
decreased awareness or responsiveness
decreased urine output
depression
difficult or troubled breathing
difficult, fast, noisy breathing
dizziness
eye pain
fainting
fast heartbeat
fever
a general feeling of illness
headache
hostility
increased sweating
irregular, fast or slow, or shallow breathing
irritability
lightheadedness
loss of consciousness
muscle or joint pain
muscle twitching
nausea
pale skin
rapid weight gain
rapid, shallow breathing
seizures
severe sleepiness
sore throat
swelling around the neck, groin, or underarm area
swelling of the arms, feet, or lower legs
swelling of the face, ankles, or hands
unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
yellow skin or eyes

Rare

changed sense of taste
decreased appetite
diarrhea
fatigue
nausea
vomiting
difficulty breathing at rest or worsens when lying down
fever
signs of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
signs of infection (e.g., fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
low levels of oxygen (hypoxia; changes in skin color, confusion, fast heart rate, rapid breathing, shortness of breath, sweating, wheezing)
symptoms of differentiation syndrome (e.g., fever, cough, shortness of breath, arm, leg, or neck swelling, fast weight gain, dizziness, lightheadedness, bone pain)
symptoms of tumor lysis syndrome (e.g., producing less urine, cloudy urine, kidney problems, muscle spasms, nausea, shortness of breath)

Drug Interactions

DRUG	INTERACTION
Abacavir	The metabolism of Abacavir can be decreased when combined with Enasidenib.
Abametapir	The serum concentration of Enasidenib can be increased when it is combined with Abametapir.
Abatacept	The metabolism of Enasidenib can be increased when combined with Abatacept.
Abemaciclib	The serum concentration of Abemaciclib can be increased when it is combined with Enasidenib.
Abiraterone	The serum concentration of Enasidenib can be increased when it is combined with Abiraterone.
Abrocitinib	The metabolism of Abrocitinib can be decreased when combined with Enasidenib.
Acalabrutinib	The metabolism of Acalabrutinib can be increased when combined with Enasidenib.
Acamprosate	The excretion of Acamprosate can be decreased when combined with Enasidenib.
Acebutolol	The metabolism of Enasidenib can be decreased when combined with Acebutolol.
Acenocoumarol	The serum concentration of Acenocoumarol can be increased when it is combined with Enasidenib.
Acetaminophen	The metabolism of Enasidenib can be increased when combined with Acetaminophen.
Acetazolamide	The metabolism of Enasidenib can be decreased when combined with Acetazolamide.
Acetohexamide	The metabolism of Acetohexamide can be decreased when combined with Enasidenib.
Acetyl sulfisoxazole	The metabolism of Enasidenib can be decreased when combined with Acetyl sulfisoxazole.
Acetylsalicylic acid	The metabolism of Acetylsalicylic acid can be decreased when combined with Enasidenib.
Acyclovir	The excretion of Acyclovir can be decreased when combined with Enasidenib.
Adalimumab	The metabolism of Enasidenib can be increased when combined with Adalimumab.
Adefovir dipivoxil	The excretion of Adefovir dipivoxil can be decreased when combined with Enasidenib.
Adenine	The metabolism of Enasidenib can be decreased when combined with Adenine.
Afatinib	The serum concentration of Afatinib can be increased when it is combined with Enasidenib.
Agomelatine	The metabolism of Enasidenib can be decreased when combined with Agomelatine.
Albendazole	The metabolism of Enasidenib can be increased when combined with Albendazole.
Aldesleukin	The metabolism of Enasidenib can be decreased when combined with Aldesleukin.
Alectinib	The metabolism of Alectinib can be increased when combined with Enasidenib.
Alfuzosin	The metabolism of Alfuzosin can be decreased when combined with Enasidenib.
Allopurinol	The excretion of Allopurinol can be decreased when combined with Enasidenib.
Almotriptan	The metabolism of Enasidenib can be decreased when combined with Almotriptan.
Alogliptin	The metabolism of Enasidenib can be decreased when combined with Alogliptin.
Alosetron	The metabolism of Enasidenib can be decreased when combined with Alosetron.
Alpelisib	The serum concentration of Alpelisib can be increased when it is combined with Enasidenib.
Alprazolam	The metabolism of Alprazolam can be decreased when combined with Enasidenib.
Alprostadil	The excretion of Alprostadil can be decreased when combined with Enasidenib.
Amantadine	The serum concentration of Amantadine can be increased when it is combined with Enasidenib.
Ambrisentan	The serum concentration of Ambrisentan can be increased when it is combined with Enasidenib.
Aminoglutethimide	The metabolism of Enasidenib can be increased when combined with Aminoglutethimide.
Aminohippuric acid	The excretion of Aminohippuric acid can be decreased when combined with Enasidenib.
Aminophenazone	The metabolism of Enasidenib can be decreased when combined with Aminophenazone.
Aminophylline	The metabolism of Aminophylline can be increased when combined with Enasidenib.
Amiodarone	The metabolism of Enasidenib can be decreased when combined with Amiodarone.
Amitriptyline	The metabolism of Amitriptyline can be decreased when combined with Enasidenib.
Amlodipine	The metabolism of Amlodipine can be increased when combined with Enasidenib.
Amobarbital	The metabolism of Enasidenib can be increased when combined with Amobarbital.
Amodiaquine	The metabolism of Enasidenib can be decreased when combined with Amodiaquine.
Amoxapine	The metabolism of Enasidenib can be decreased when combined with Amoxapine.
Amphetamine	The metabolism of Enasidenib can be decreased when combined with Amphetamine.
Amprenavir	The metabolism of Enasidenib can be decreased when combined with Amprenavir.
Anagrelide	The metabolism of Enasidenib can be decreased when combined with Anagrelide.
Anakinra	The metabolism of Enasidenib can be increased when combined with Anakinra.
Anastrozole	The metabolism of Enasidenib can be decreased when combined with Anastrozole.
Antipyrine	The metabolism of Enasidenib can be decreased when combined with Antipyrine.
Apalutamide	The serum concentration of Enasidenib can be increased when it is combined with Apalutamide.
Apixaban	The metabolism of Enasidenib can be decreased when combined with Apixaban.
Apomorphine	The metabolism of Enasidenib can be decreased when combined with Apomorphine.
Apremilast	The metabolism of Enasidenib can be increased when combined with Apremilast.
Aprepitant	The metabolism of Enasidenib can be decreased when combined with Aprepitant.
Arformoterol	The metabolism of Enasidenib can be decreased when combined with Arformoterol.
Aripiprazole	The metabolism of Aripiprazole can be increased when combined with Enasidenib.
Aripiprazole lauroxil	The metabolism of Aripiprazole lauroxil can be increased when combined with Enasidenib.
Armodafinil	The metabolism of Enasidenib can be increased when combined with Armodafinil.
Artemether	The metabolism of Enasidenib can be decreased when combined with Artemether.
Artenimol	The metabolism of Enasidenib can be decreased when combined with Artenimol.
Articaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Articaine.
Asciminib	The serum concentration of Enasidenib can be increased when it is combined with Asciminib.
Asenapine	The metabolism of Asenapine can be decreased when combined with Enasidenib.
Astemizole	The metabolism of Astemizole can be increased when combined with Enasidenib.
Asunaprevir	The metabolism of Enasidenib can be decreased when combined with Asunaprevir.
Atazanavir	The metabolism of Enasidenib can be decreased when combined with Atazanavir.
Atenolol	The metabolism of Enasidenib can be decreased when combined with Atenolol.
Atogepant	The serum concentration of Atogepant can be increased when it is combined with Enasidenib.
Atomoxetine	The metabolism of Atomoxetine can be decreased when combined with Enasidenib.
Atorvastatin	The metabolism of Atorvastatin can be decreased when combined with Enasidenib.
Atovaquone	The metabolism of Enasidenib can be decreased when combined with Atovaquone.
Avacopan	The metabolism of Enasidenib can be decreased when combined with Avacopan.
Avanafil	The serum concentration of Avanafil can be increased when it is combined with Enasidenib.
Avapritinib	The metabolism of Enasidenib can be decreased when combined with Avapritinib.
Avatrombopag	The metabolism of Enasidenib can be increased when combined with Avatrombopag.
Avibactam	The excretion of Avibactam can be decreased when combined with Enasidenib.
Axitinib	The serum concentration of Axitinib can be increased when it is combined with Enasidenib.
Azathioprine	The metabolism of Azathioprine can be decreased when combined with Enasidenib.
Azelastine	The metabolism of Enasidenib can be decreased when combined with Azelastine.
Azithromycin	The metabolism of Enasidenib can be decreased when combined with Azithromycin.
Baricitinib	The serum concentration of Baricitinib can be increased when it is combined with Enasidenib.
Bazedoxifene	The metabolism of Bazedoxifene can be decreased when combined with Enasidenib.
Beclomethasone	The metabolism of Enasidenib can be increased when combined with Beclomethasone dipropionate.
Belantamab	The serum concentration of Belantamab mafodotin can be increased when it is combined with Enasidenib.
Belinostat	The metabolism of Belinostat can be decreased when combined with Enasidenib.
Belumosudil	Belumosudil may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Belzutifan	The serum concentration of Enasidenib can be decreased when it is combined with Belzutifan.
Bempedoic acid	The excretion of Bempedoic acid can be decreased when combined with Enasidenib.
Bendamustine	The serum concentration of Bendamustine can be increased when it is combined with Enasidenib.
Benzatropine	The metabolism of Enasidenib can be decreased when combined with Benzatropine.
Benzocaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Benzocaine.
Benzphetamine	The metabolism of Enasidenib can be decreased when combined with Benzphetamine.
Benzyl alcohol	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Benzyl alcohol.
Benzylpenicillin	The excretion of Benzylpenicillin can be decreased when combined with Enasidenib.
Bepridil	The metabolism of Enasidenib can be decreased when combined with Bepridil.
Berotralstat	The serum concentration of Berotralstat can be increased when it is combined with Enasidenib.
Betamethasone	The metabolism of Enasidenib can be increased when combined with Betamethasone.
Betamethasone	The metabolism of Enasidenib can be increased when combined with Betamethasone phosphate.
Betaxolol	The metabolism of Enasidenib can be decreased when combined with Betaxolol.

Betrixaban	The serum concentration of Betrixaban can be increased when it is combined with Enasidenib.
Bexarotene	The metabolism of Enasidenib can be increased when combined with Bexarotene.
Bezafibrate	The metabolism of Enasidenib can be decreased when combined with Bezafibrate.
Bicalutamide	The metabolism of Bicalutamide can be increased when combined with Enasidenib.
Bictegravir	The metabolism of Bictegravir can be decreased when combined with Enasidenib.
Bifonazole	The metabolism of Enasidenib can be decreased when combined with Bifonazole.
Bimekizumab	The metabolism of Enasidenib can be increased when combined with Bimekizumab.
Binimetinib	The serum concentration of Binimetinib can be increased when it is combined with Enasidenib.
Biperiden	The metabolism of Enasidenib can be decreased when combined with Biperiden.
Bisoprolol	The serum concentration of Bisoprolol can be increased when it is combined with Enasidenib.
Boceprevir	The metabolism of Enasidenib can be decreased when combined with Boceprevir.
Bortezomib	The serum concentration of Bortezomib can be increased when it is combined with Enasidenib.
Bosentan	The metabolism of Enasidenib can be increased when combined with Bosentan.
Bosutinib	The serum concentration of Bosutinib can be increased when it is combined with Enasidenib.
Brentuximab	The serum concentration of Brentuximab vedotin can be increased when it is combined with Enasidenib.
Brexpiprazole	The metabolism of Enasidenib can be decreased when combined with Brexpiprazole.
Brigatinib	The metabolism of Brigatinib can be increased when combined with Enasidenib.
Brincidofovir	The serum concentration of Brincidofovir can be increased when it is combined with Enasidenib.
Brivaracetam	The metabolism of Enasidenib can be decreased when combined with Brivaracetam.
Bromazepam	The metabolism of Bromazepam can be decreased when combined with Enasidenib.
Bromotheophylline	The metabolism of Bromotheophylline can be decreased when combined with Enasidenib.
Brompheniramine	The metabolism of Enasidenib can be decreased when combined with Brompheniramine.
Budesonide	The metabolism of Enasidenib can be increased when combined with Budesonide.
Bumetanide	The excretion of Bumetanide can be decreased when combined with Enasidenib.
Bupivacaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Bupivacaine.
Buprenorphine	The metabolism of Enasidenib can be decreased when combined with Buprenorphine.
Bupropion	The serum concentration of Bupropion can be increased when it is combined with Enasidenib.
Buspirone	The metabolism of Enasidenib can be decreased when combined with Buspirone.
Busulfan	The metabolism of Busulfan can be increased when combined with Enasidenib.
Butacaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Butacaine.
Butalbital	The metabolism of Enasidenib can be increased when combined with Butalbital.
Butamben	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Butamben.
Cabazitaxel	The serum concentration of Cabazitaxel can be increased when it is combined with Enasidenib.
Cabergoline	The serum concentration of Cabergoline can be increased when it is combined with Enasidenib.
Cabotegravir	The metabolism of Cabotegravir can be decreased when combined with Enasidenib.
Cabozantinib	The metabolism of Enasidenib can be decreased when combined with Cabozantinib.
Caffeine	The metabolism of Enasidenib can be decreased when combined with Caffeine.
Calcitriol	The metabolism of Enasidenib can be increased when combined with Calcitriol.
Canagliflozin	The serum concentration of Canagliflozin can be increased when it is combined with Enasidenib.
Canakinumab	The metabolism of Enasidenib can be increased when combined with Canakinumab.
Candesartan	The metabolism of Enasidenib can be decreased when combined with Candesartan cilexetil.
Candicidin	The metabolism of Enasidenib can be decreased when combined with Candicidin.
Cannabidiol	The metabolism of Enasidenib can be decreased when combined with Cannabidiol.
Capecitabine	The metabolism of Capecitabine can be decreased when combined with Enasidenib.
Capmatinib	The serum concentration of Capmatinib can be decreased when it is combined with Enasidenib.
Capsaicin	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Capsaicin.
Captopril	The excretion of Captopril can be decreased when combined with Enasidenib.
Carbamazepine	The metabolism of Enasidenib can be increased when combined with Carbamazepine.
Carfilzomib	The serum concentration of Carfilzomib can be increased when it is combined with Enasidenib.
Carisoprodol	The metabolism of Carisoprodol can be decreased when combined with Enasidenib.
Carmustine	The metabolism of Carmustine can be decreased when combined with Enasidenib.
Carvedilol	The metabolism of Enasidenib can be decreased when combined with Carvedilol.
Caspofungin	The excretion of Caspofungin can be decreased when combined with Enasidenib.
Cefaclor	The excretion of Cefaclor can be decreased when combined with Enasidenib.
Cefazolin	The excretion of Cefazolin can be decreased when combined with Enasidenib.
Cefdinir	The excretion of Cefdinir can be decreased when combined with Enasidenib.
Cefotiam	The excretion of Cefotiam can be decreased when combined with Enasidenib.
Cefradine	The metabolism of Enasidenib can be increased when combined with Cefradine.
Ceftibuten	The excretion of Ceftibuten can be decreased when combined with Enasidenib.
Ceftizoxime	The excretion of Ceftizoxime can be decreased when combined with Enasidenib.
Celecoxib	The metabolism of Enasidenib can be decreased when combined with Celecoxib.
Celiprolol	The metabolism of Enasidenib can be decreased when combined with Celiprolol.
Cenobamate	The serum concentration of Enasidenib can be decreased when it is combined with Cenobamate.
Cephalexin	The metabolism of Enasidenib can be decreased when combined with Cephalexin.
Ceritinib	The serum concentration of Ceritinib can be increased when it is combined with Enasidenib.
Cerivastatin	The metabolism of Enasidenib can be increased when combined with Cerivastatin.
Certolizumab pegol	The metabolism of Enasidenib can be increased when combined with Certolizumab pegol.
Cevimeline	The metabolism of Enasidenib can be decreased when combined with Cevimeline.
Chenodeoxycholic	The metabolism of Enasidenib can be decreased when combined with Chenodeoxycholic acid.
Chloramphenicol	The metabolism of Enasidenib can be decreased when combined with Chloramphenicol.
Chloroprocaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Chloroprocaine.
Chloroquine	The metabolism of Enasidenib can be decreased when combined with Chloroquine.
Chlorpheniramine	The metabolism of Enasidenib can be decreased when combined with Chlorpheniramine.
Chlorpromazine	The metabolism of Enasidenib can be decreased when combined with Chlorpromazine.
Chlorpropamide	The metabolism of Chlorpropamide can be decreased when combined with Enasidenib.
Chlorzoxazone	The metabolism of Enasidenib can be decreased when combined with Chlorzoxazone.
Cholecalciferol	The metabolism of Enasidenib can be decreased when combined with Cholecalciferol.
Cholecystokinin	The excretion of Cholecystokinin can be decreased when combined with Enasidenib.
Cholesterol	Cholesterol may increase the excretion rate of Enasidenib which could result in a lower serum level and potentially a reduction in efficacy.
Cholic Acid	The excretion of Cholic Acid can be decreased when combined with Enasidenib.
Choline	The serum concentration of Choline can be increased when it is combined with Enasidenib.
Choline salicylate	The serum concentration of Choline salicylate can be increased when it is combined with Enasidenib.
Ciclesonide	The metabolism of Enasidenib can be decreased when combined with Ciclesonide.
Cidofovir	The excretion of Cidofovir can be decreased when combined with Enasidenib.
Cilostazol	The serum concentration of Cilostazol can be increased when it is combined with Enasidenib.
Cimetidine	The metabolism of Enasidenib can be decreased when combined with Cimetidine.
Cinacalcet	The metabolism of Enasidenib can be decreased when combined with Cinacalcet.
Cinchocaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Cinchocaine.
Cinnarizine	The metabolism of Enasidenib can be decreased when combined with Cinnarizine.
Cinoxacin	The metabolism of Enasidenib can be decreased when combined with Cinoxacin.
Ciprofloxacin	The metabolism of Enasidenib can be decreased when combined with Ciprofloxacin.
Cisapride	The metabolism of Enasidenib can be decreased when combined with Cisapride.
Cisplatin	The metabolism of Enasidenib can be decreased when combined with Cisplatin.
Citalopram	Enasidenib may increase the QTc-prolonging activities of Citalopram.
Cladribine	Enasidenib may decrease the excretion rate of Cladribine which could result in a higher serum level.
Clarithromycin	The metabolism of Enasidenib can be decreased when combined with Clarithromycin.
Clemastine	The metabolism of Enasidenib can be decreased when combined with Clemastine.
Clevidipine	The metabolism of Enasidenib can be increased when combined with Clevidipine.
Clindamycin	The metabolism of Clindamycin can be increased when combined with Enasidenib.
Clobazam	The metabolism of Enasidenib can be decreased when combined with Clobazam.

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Clobetasol	The metabolism of Enasidenib can be increased when combined with Clobetasol propionate.
Clofarabine	The serum concentration of Clofarabine can be increased when it is combined with Enasidenib.
Clofazimine	The metabolism of Enasidenib can be decreased when combined with Clofazimine.
Clofibrate	The metabolism of Enasidenib can be increased when combined with Clofibrate.
Clomifene	The serum concentration of Clomifene can be increased when it is combined with Enasidenib.
Clomipramine	The metabolism of Clomipramine can be increased when combined with Enasidenib.
Clonazepam	The metabolism of Clonazepam can be increased when combined with Enasidenib.
Clonidine	The metabolism of Clonidine can be increased when combined with Enasidenib.
Clopidogrel	The metabolism of Enasidenib can be decreased when combined with Clopidogrel.
Clotiazepam	The metabolism of Enasidenib can be decreased when combined with Clotiazepam.
Clozapine	The metabolism of Enasidenib can be decreased when combined with Clozapine.
Cobicistat	The metabolism of Enasidenib can be decreased when combined with Cobicistat.
Cobimetinib	The serum concentration of Cobimetinib can be increased when it is combined with Enasidenib.
Cocaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Cocaine.
Codeine	The metabolism of Enasidenib can be decreased when combined with Codeine.
Colchicine	The serum concentration of Colchicine can be increased when it is combined with Enasidenib.
Conivaptan	The metabolism of Enasidenib can be decreased when combined with Conivaptan.
Coestrogens	The metabolism of Enasidenib can be decreased when combined with Conjugated estrogens.
Copanlisib	The serum concentration of Copanlisib can be increased when it is combined with Enasidenib.
Corticotropin	The metabolism of Enasidenib can be increased when combined with Corticotropin.
Cortisone acetate	The metabolism of Enasidenib can be increased when combined with Cortisone acetate.
Crizotinib	The metabolism of Enasidenib can be decreased when combined with Crizotinib.
Curcumin	The metabolism of Enasidenib can be decreased when combined with Curcumin.
Cyclizine	The metabolism of Enasidenib can be decreased when combined with Cyclizine.
Cyclobenzaprine	The metabolism of Cyclobenzaprine can be decreased when combined with Enasidenib.
Cyclophosphamide	The metabolism of Enasidenib can be increased when combined with Cyclophosphamide.
Cyclosporine	The metabolism of Enasidenib can be decreased when combined with Cyclosporine.
Cyproterone acetate	The metabolism of Enasidenib can be increased when combined with Cyproterone acetate.
Dabigatran etexilate	The serum concentration of Dabigatran etexilate can be increased when it is combined with Enasidenib.
Dabrafenib	The serum concentration of Enasidenib can be decreased when it is combined with Dabrafenib.
Dacarbazine	The metabolism of Dacarbazine can be decreased when combined with Enasidenib.
Daclatasvir	Daclatasvir may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Dacomitinib	The serum concentration of Dacomitinib can be increased when it is combined with Enasidenib.
Dactinomycin	The serum concentration of Dactinomycin can be increased when it is combined with Enasidenib.
Dalfampridine	The serum concentration of Dalfampridine can be increased when it is combined with Enasidenib.
Dalfopristin	The metabolism of Enasidenib can be decreased when combined with Dalfopristin.
Danazol	The metabolism of Enasidenib can be decreased when combined with Danazol.
Dapagliflozin	The metabolism of Enasidenib can be decreased when combined with Dapagliflozin.
Dapsone	The metabolism of Enasidenib can be decreased when combined with Dapsone.
Daptomycin	The serum concentration of Daptomycin can be increased when it is combined with Enasidenib.
Darbepoetin alfa	The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Enasidenib.
Darifenacin	The metabolism of Enasidenib can be decreased when combined with Darifenacin.
Darolutamide	The serum concentration of Enasidenib can be increased when it is combined with Darolutamide.
Darunavir	The serum concentration of Enasidenib can be increased when it is combined with Darunavir.
Dasabuvir	The metabolism of Enasidenib can be decreased when combined with Dasabuvir.
Dasatinib	The serum concentration of Dasatinib can be increased when it is combined with Enasidenib.
Daunorubicin	The metabolism of Enasidenib can be decreased when combined with Daunorubicin.
Debrisoquine	The metabolism of Enasidenib can be decreased when combined with Debrisoquine.
Deferasirox	The serum concentration of Enasidenib can be increased when it is combined with Deferasirox.
Deflazacort	The metabolism of Enasidenib can be increased when combined with Deflazacort.
Delafloxacin	The metabolism of Enasidenib can be increased when combined with Delafloxacin.
Delavirdine	The metabolism of Enasidenib can be decreased when combined with Delavirdine.
Desipramine	The metabolism of Enasidenib can be decreased when combined with Desipramine.
Desogestrel	The metabolism of Enasidenib can be increased when combined with Desogestrel.
Desvenlafaxine	The metabolism of Enasidenib can be decreased when combined with Desvenlafaxine.
Deutetrabenazine	The metabolism of Enasidenib can be decreased when combined with Deutetrabenazine.
Dexamethasone	The metabolism of Enasidenib can be increased when combined with Dexamethasone.
Dexamethasone	The metabolism of Enasidenib can be increased when combined with Dexamethasone acetate.
Dexchlorpheniramine	The metabolism of Enasidenib can be decreased when combined with Dexchlorpheniramine maleate.
Dexfenfluramine	The metabolism of Enasidenib can be decreased when combined with Dexfenfluramine.
Dexibuprofen	The metabolism of Enasidenib can be decreased when combined with Dexibuprofen.
Dexlansoprazole	The metabolism of Enasidenib can be decreased when combined with Dexlansoprazole.
Dexmedetomidine	The metabolism of Enasidenib can be decreased when combined with Dexmedetomidine.
Dextroamphetamine	The metabolism of Enasidenib can be decreased when combined with Dextroamphetamine.
Dextromethorphan	The metabolism of Enasidenib can be decreased when combined with Dextromethorphan.
Dextropropoxyphene	The metabolism of Enasidenib can be decreased when combined with Dextropropoxyphene.
Diacerein	The metabolism of Enasidenib can be decreased when combined with Diacerein.
Diazepam	The metabolism of Diazepam can be decreased when combined with Enasidenib.
Diclofenac	The metabolism of Enasidenib can be decreased when combined with Diclofenac.
Dicloxacillin	The metabolism of Enasidenib can be increased when combined with Dicloxacillin.
Dicoumarol	The metabolism of Dicoumarol can be decreased when combined with Enasidenib.
Didanosine	The excretion of Didanosine can be decreased when combined with Enasidenib.
Dienogest	The metabolism of Dienogest can be increased when combined with Enasidenib.
Diethylstilbestrol	The metabolism of Enasidenib can be decreased when combined with Diethylstilbestrol.
Diflunisal	The metabolism of Enasidenib can be decreased when combined with Diflunisal.
Difluocortolone	The metabolism of Enasidenib can be increased when combined with Difluocortolone.
Digitoxin	The serum concentration of Digitoxin can be increased when it is combined with Enasidenib.
Digoxin	Enasidenib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Dihydralazine	The metabolism of Enasidenib can be decreased when combined with Dihydralazine.
Dihydrocodeine	The metabolism of Enasidenib can be decreased when combined with Dihydrocodeine.
Dihydroergocornine	The metabolism of Enasidenib can be decreased when combined with Dihydroergocornine.
Dihydroergocristine	The metabolism of Enasidenib can be decreased when combined with Dihydroergocristine.
Dihydroergotamine	The metabolism of Dihydroergotamine can be increased when combined with Enasidenib.
Diltiazem	The metabolism of Enasidenib can be decreased when combined with Diltiazem.
Dimethyl sulfoxide	The metabolism of Enasidenib can be decreased when combined with Dimethyl sulfoxide.
Dinoprostone	The excretion of Dinoprostone can be decreased when combined with Enasidenib.
Diosmin	The metabolism of Enasidenib can be decreased when combined with Diosmin.
Diphenhydramine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Diphenhydramine.
Disopyramide	The metabolism of Disopyramide can be decreased when combined with Enasidenib.
Docetaxel	The metabolism of Docetaxel can be increased when combined with Enasidenib.
Doconexent	The metabolism of Enasidenib can be decreased when combined with Doconexent.
Dofetilide	The metabolism of Dofetilide can be increased when combined with Enasidenib.
Dolasetron	The metabolism of Enasidenib can be decreased when combined with Dolasetron.
Dolutegravir	Enasidenib may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Domperidone	The metabolism of Enasidenib can be decreased when combined with Domperidone.
Donepezil	The metabolism of Enasidenib can be decreased when combined with Donepezil.
Dopamine	The serum concentration of Dopamine can be increased when it is combined with Enasidenib.
Doripenem	The excretion of Doripenem can be decreased when combined with Enasidenib.
Dosulepin	The metabolism of Enasidenib can be decreased when combined with Dosulepin.
Doxazosin	The metabolism of Enasidenib can be decreased when combined with Doxazosin.

Doxepin	The metabolism of Enasidenib can be decreased when combined with Doxepin.
Doxorubicin	The serum concentration of Doxorubicin can be increased when it is combined with Enasidenib.
Dronabinol	The serum concentration of Dronabinol can be increased when it is combined with Enasidenib.
Dronedarone	The serum concentration of Enasidenib can be increased when it is combined with Dronedarone.
Drospirenone	The metabolism of Enasidenib can be decreased when combined with Drospirenone.
Duloxetine	The metabolism of Enasidenib can be decreased when combined with Duloxetine.
Duvelisib	The metabolism of Enasidenib can be decreased when combined with Duvelisib.
Dyclonine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Dyclonine.
Ebastine	The metabolism of Enasidenib can be decreased when combined with Ebastine.
Echinacea	The metabolism of Enasidenib can be increased when combined with Echinacea.
Edoxaban	The serum concentration of Edoxaban can be increased when it is combined with Enasidenib.
Efavirenz	The metabolism of Enasidenib can be decreased when combined with Efavirenz.
Elagolix	The metabolism of Enasidenib can be decreased when combined with Elagolix.
Elbasvir	Elbasvir may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Eletriptan	The metabolism of Enasidenib can be decreased when combined with Eletriptan.
Elexacaftor	The metabolism of Enasidenib can be decreased when combined with Elexacaftor.
Eliglustat	The metabolism of Eliglustat can be decreased when combined with Enasidenib.
Eltrombopag	The metabolism of Enasidenib can be decreased when combined with Eltrombopag.
Eluxadoline	The serum concentration of Eluxadoline can be increased when it is combined with Enasidenib.
Elvitegravir	The metabolism of Enasidenib can be decreased when combined with Elvitegravir.
Emapalumab	The metabolism of Enasidenib can be increased when combined with Emapalumab.
Enalapril	The excretion of Enalapril can be decreased when combined with Enasidenib.
Encainide	The metabolism of Enasidenib can be decreased when combined with Encainide.
Encorafenib	The metabolism of Enasidenib can be decreased when combined with Encorafenib.
Enfortumab vedotin	The serum concentration of Enfortumab vedotin can be increased when it is combined with Enasidenib.
Enoxacin	The metabolism of Enasidenib can be decreased when combined with Enoxacin.
Entacapone	The metabolism of Enasidenib can be decreased when combined with Entacapone.
Entecavir	The metabolism of Entecavir can be decreased when combined with Enasidenib.
Entrectinib	The metabolism of Entrectinib can be increased when combined with Enasidenib.
Enzalutamide	The serum concentration of Enasidenib can be decreased when it is combined with Enzalutamide.
Epinastine	The metabolism of Enasidenib can be decreased when combined with Epinastine.
Epinephrine	The metabolism of Enasidenib can be decreased when combined with Epinephrine.
Erdafitinib	The metabolism of Erdafitinib can be increased when combined with Enasidenib.
Ergotamine	The metabolism of Enasidenib can be decreased when combined with Ergotamine.
Erlotinib	The serum concentration of Erlotinib can be decreased when it is combined with Enasidenib.
Ertugliflozin	The metabolism of Enasidenib can be decreased when combined with Ertugliflozin.
Erythromycin	The metabolism of Enasidenib can be decreased when combined with Erythromycin.
Erythropoietin	The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Enasidenib.
Escitalopram	The serum concentration of Enasidenib can be increased when it is combined with Escitalopram.
Esketamine	The metabolism of Enasidenib can be increased when combined with Esketamine.
Eslicarbazepine	The metabolism of Enasidenib can be increased when combined with Eslicarbazepine.
Eslicarbazepine	The metabolism of Enasidenib can be increased when combined with Eslicarbazepine acetate.
Esmolol	The metabolism of Enasidenib can be decreased when combined with Esmolol.
Esomeprazole	The metabolism of Enasidenib can be decreased when combined with Esomeprazole.
Estetrol	The metabolism of Enasidenib can be decreased when combined with Estetrol.
Estradiol	The metabolism of Enasidenib can be decreased when combined with Estradiol.
Estradiol acetate	The metabolism of Enasidenib can be increased when combined with Estradiol acetate.
Estradiol benzoate	The metabolism of Enasidenib can be increased when combined with Estradiol benzoate.
Estradiol cypionate	The metabolism of Enasidenib can be increased when combined with Estradiol cypionate.
Estradiol dienanthate	The metabolism of Enasidenib can be increased when combined with Estradiol dienanthate.
Estradiol valerate	The metabolism of Enasidenib can be increased when combined with Estradiol valerate.
Estrone sulfate	The metabolism of Enasidenib can be decreased when combined with Estrone sulfate.
Eszopiclone	The serum concentration of Eszopiclone can be decreased when it is combined with Enasidenib.
Etanercept	The metabolism of Enasidenib can be increased when combined with Etanercept.
Ethambutol	The metabolism of Enasidenib can be decreased when combined with Ethambutol.
Ethanol	The metabolism of Enasidenib can be increased when combined with Ethanol.
Ethinylestradiol	The metabolism of Enasidenib can be decreased when combined with Ethinylestradiol.
Ethyl chloride	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Ethyl chloride.
Ethynodiol diacetate	The metabolism of Ethynodiol diacetate can be increased when combined with Enasidenib.
Etidocaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Etidocaine.
Etodolac	The metabolism of Etodolac can be decreased when combined with Enasidenib.
Etonogestrel	The metabolism of Etonogestrel can be increased when combined with Enasidenib.
Etoposide	The serum concentration of Etoposide can be increased when it is combined with Enasidenib.
Etoricoxib	The metabolism of Enasidenib can be decreased when combined with Etoricoxib.
Etravirine	The metabolism of Enasidenib can be increased when combined with Etravirine.
Everolimus	The serum concentration of Everolimus can be increased when it is combined with Enasidenib.
Ezetimibe	Enasidenib may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Ezogabine	The metabolism of Ezogabine can be decreased when combined with Enasidenib.
Famotidine	The metabolism of Enasidenib can be decreased when combined with Famotidine.
Favipiravir	The metabolism of Enasidenib can be decreased when combined with Favipiravir.
Febuxostat	The excretion of Enasidenib can be decreased when combined with Febuxostat.
Fedratinib	The metabolism of Enasidenib can be decreased when combined with Fedratinib.
Felbamate	The metabolism of Enasidenib can be increased when combined with Felbamate.
Felodipine	The metabolism of Enasidenib can be decreased when combined with Felodipine.
Fenfluramine	The metabolism of Enasidenib can be decreased when combined with Fenfluramine.
Fenofibrate	The metabolism of Enasidenib can be decreased when combined with Fenofibrate.
Fentanyl	The metabolism of Fentanyl can be decreased when combined with Enasidenib.
Fesoterodine	The metabolism of Enasidenib can be decreased when combined with Fesoterodine.
Fexinidazole	The metabolism of Enasidenib can be decreased when combined with Fexinidazole.
Fexofenadine	The excretion of Fexofenadine can be decreased when combined with Enasidenib.
Filgotinib	The serum concentration of Enasidenib can be increased when it is combined with Filgotinib.
Finerenone	The serum concentration of Finerenone can be increased when it is combined with Enasidenib.
Flecainide	The metabolism of Enasidenib can be decreased when combined with Flecainide.
Floxuridine	The metabolism of Enasidenib can be decreased when combined with Floxuridine.
Flucloxacillin	The metabolism of Enasidenib can be increased when combined with Flucloxacillin.
Fluconazole	The metabolism of Enasidenib can be decreased when combined with Fluconazole.
Fluindione	The metabolism of Fluindione can be decreased when combined with Enasidenib.
Flunarizine	The metabolism of Enasidenib can be decreased when combined with Flunarizine.
Flunisolide	The metabolism of Enasidenib can be increased when combined with Flunisolide.
Flunitrazepam	The metabolism of Enasidenib can be decreased when combined with Flunitrazepam.
Fluocinolone	The metabolism of Enasidenib can be increased when combined with Fluocinolone acetonide.
Fluocinonide	The metabolism of Enasidenib can be increased when combined with Fluocinonide.
Fluocortolone	The metabolism of Enasidenib can be increased when combined with Fluocortolone.
Fluorescein	The excretion of Fluorescein can be decreased when combined with Enasidenib.
Fluorouracil	The metabolism of Fluorouracil can be decreased when combined with Enasidenib.
Fluoxetine	The serum concentration of Enasidenib can be increased when it is combined with Fluoxetine.
Fluphenazine	The metabolism of Enasidenib can be decreased when combined with Fluphenazine.
Flurbiprofen	The metabolism of Enasidenib can be decreased when combined with Flurbiprofen.
Flutamide	The metabolism of Flutamide can be decreased when combined with Enasidenib.
Fluticasone	The metabolism of Enasidenib can be increased when combined with Fluticasone.

Fluticasone	The metabolism of Enasidenib can be decreased when combined with Fluticasone propionate.
Fluvastatin	The metabolism of Enasidenib can be decreased when combined with Fluvastatin.
Fluvoxamine	The metabolism of Enasidenib can be decreased when combined with Fluvoxamine.
Folic acid	Enasidenib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Formestane	The metabolism of Enasidenib can be increased when combined with Formestane.
Formoterol	The metabolism of Enasidenib can be decreased when combined with Formoterol.
Fosamprenavir	The metabolism of Enasidenib can be decreased when combined with Fosamprenavir.
Fosaprepitant	The metabolism of Enasidenib can be increased when combined with Fosaprepitant.
Fosnetupitant	The metabolism of Enasidenib can be decreased when combined with Fosnetupitant.
Fosphenytoin	The metabolism of Enasidenib can be increased when combined with Fosphenytoin.
Fostamatinib	The metabolism of Enasidenib can be decreased when combined with Fostamatinib.
Fostemsavir	Fostemsavir may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Frovatriptan	The metabolism of Frovatriptan can be decreased when combined with Enasidenib.
Fulvestrant	The metabolism of Fulvestrant can be decreased when combined with Enasidenib.
Furosemide	The metabolism of Furosemide can be decreased when combined with Enasidenib.
Fusidic acid	The metabolism of Enasidenib can be decreased when combined with Fusidic acid.
Futibatinib	The serum concentration of Futibatinib can be increased when it is combined with Enasidenib.
Gadoxetic acid	The excretion of Gadoxetic acid can be decreased when combined with Enasidenib.
Galantamine	The metabolism of Enasidenib can be decreased when combined with Galantamine.
Gatifloxacin	The metabolism of Enasidenib can be decreased when combined with Gatifloxacin.
Gefitinib	The metabolism of Enasidenib can be decreased when combined with Gefitinib.
Gemcitabine	The serum concentration of Gemcitabine can be increased when it is combined with Enasidenib.
Gemfibrozil	The metabolism of Enasidenib can be decreased when combined with Gemfibrozil.
Gemifloxacin	The metabolism of Enasidenib can be decreased when combined with Gemifloxacin.
Gentamicin	The serum concentration of Gentamicin can be increased when it is combined with Enasidenib.
Gestrinone	The metabolism of Gestrinone can be increased when combined with Enasidenib.
Gilteritinib	The metabolism of Enasidenib can be decreased when combined with Gilteritinib.
Ginkgo biloba	The metabolism of Enasidenib can be decreased when combined with Ginkgo biloba.
Givosiran	The serum concentration of Enasidenib can be increased when it is combined with Givosiran.
Glasdegib	The metabolism of Enasidenib can be decreased when combined with Glasdegib.
Glecaprevir	The metabolism of Enasidenib can be decreased when combined with Glecaprevir.
Gliclazide	The metabolism of Gliclazide can be decreased when combined with Enasidenib.
Glimepiride	The metabolism of Glimepiride can be decreased when combined with Enasidenib.
Glipizide	The metabolism of Glipizide can be decreased when combined with Enasidenib.
Gliquidone	The metabolism of Gliquidone can be decreased when combined with Enasidenib.
Glyburide	The metabolism of Enasidenib can be decreased when combined with Glyburide.
Glycerol	The metabolism of Enasidenib can be increased when combined with Glycerol phenylbutyrate.
Golimumab	The metabolism of Enasidenib can be increased when combined with Golimumab.
Grazoprevir	Grazoprevir may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Grepafloxacin	The metabolism of Enasidenib can be decreased when combined with Grepafloxacin.
Griseofulvin	The metabolism of Enasidenib can be increased when combined with Griseofulvin.
Guanabenz	The metabolism of Guanabenz can be decreased when combined with Enasidenib.
Halofantrine	The metabolism of Enasidenib can be decreased when combined with Halofantrine.
Haloperidol	The serum concentration of Haloperidol can be increased when it is combined with Enasidenib.
Halothane	The metabolism of Enasidenib can be decreased when combined with Halothane.
Histamine	The serum concentration of Histamine can be increased when it is combined with Enasidenib.
Hydralazine	The metabolism of Enasidenib can be decreased when combined with Hydralazine.
Hydrochlorothiazide	The excretion of Hydrochlorothiazide can be decreased when combined with Enasidenib.
Hydrocodone	The metabolism of Enasidenib can be decreased when combined with Hydrocodone.
Hydrocortamate	The metabolism of Enasidenib can be increased when combined with Hydrocortamate.
Hydrocortisone	The metabolism of Enasidenib can be increased when combined with Hydrocortisone.
Hydrocortisone acetate	The metabolism of Enasidenib can be increased when combined with Hydrocortisone acetate.
Hydrocortisone butye	The metabolism of Enasidenib can be increased when combined with Hydrocortisone butyrate.
Hydrocortisone succ	The metabolism of Enasidenib can be increased when combined with Hydrocortisone succinate.
Hydromorphone	The metabolism of Hydromorphone can be decreased when combined with Enasidenib.
Hydroxychloroquine	The metabolism of Enasidenib can be decreased when combined with Hydroxychloroquine.
Hydroxyprogesterone	The metabolism of Hydroxyprogesterone caproate can be increased when combined with Enasidenib.
Hydroxyzine	The metabolism of Enasidenib can be decreased when combined with Hydroxyzine.
Ibrutinib	The metabolism of Ibrutinib can be decreased when combined with Enasidenib.
Ibuprofen	The metabolism of Enasidenib can be decreased when combined with Ibuprofen.
Idarubicin	The metabolism of Enasidenib can be decreased when combined with Idarubicin.
Idelalisib	The metabolism of Idelalisib can be increased when combined with Enasidenib.
Ifosfamide	The metabolism of Ifosfamide can be increased when combined with Enasidenib.
Iloperidone	The metabolism of Iloperidone can be decreased when combined with Enasidenib.
Imatinib	The serum concentration of Enasidenib can be increased when it is combined with Imatinib.
Imipramine	The metabolism of Enasidenib can be decreased when combined with Imipramine.
Indacaterol	The serum concentration of Indacaterol can be increased when it is combined with Enasidenib.
Indinavir	The metabolism of Enasidenib can be decreased when combined with Indinavir.
Indomethacin	The metabolism of Enasidenib can be decreased when combined with Indomethacin.
Infigratinib	The metabolism of Enasidenib can be decreased when combined with Infigratinib.
Infliximab	The metabolism of Enasidenib can be increased when combined with Infliximab.
Inotuzumab	The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Enasidenib.
Insulin beef	The metabolism of Enasidenib can be increased when combined with Insulin beef.
Insulin pork	The metabolism of Enasidenib can be increased when combined with Insulin pork.
Interferon alfa-2a	The metabolism of Enasidenib can be decreased when combined with Interferon alfa-2a.
Interferon alfa-2b	The metabolism of Enasidenib can be decreased when combined with Interferon alfa-2b.
Interferon alfa-n1	The metabolism of Enasidenib can be decreased when combined with Interferon alfa-n1.
Interferon alfa-n3	The metabolism of Enasidenib can be decreased when combined with Interferon alfa-n3.
Interferon alfacon-1	The metabolism of Enasidenib can be decreased when combined with Interferon alfacon-1.
Interferon beta-1a	The metabolism of Enasidenib can be decreased when combined with Interferon beta-1a.
Interferon beta-1b	The metabolism of Enasidenib can be decreased when combined with Interferon beta-1b.
Interferon gamma	The metabolism of Enasidenib can be decreased when combined with Interferon gamma-1b.
Ipecac	The metabolism of Enasidenib can be decreased when combined with Ipecac.
Irbesartan	The metabolism of Enasidenib can be decreased when combined with Irbesartan.
Irinotecan	The risk or severity of neutropenia can be increased when Enasidenib is combined with Irinotecan.
Isavuconazole	The metabolism of Enasidenib can be increased when combined with Isavuconazole.
Isavuconazonium	The metabolism of Enasidenib can be increased when combined with Isavuconazonium.
Isoflurane	The metabolism of Enasidenib can be decreased when combined with Isoflurane.
Isoniazid	The metabolism of Enasidenib can be decreased when combined with Isoniazid.
Isradipine	The metabolism of Enasidenib can be decreased when combined with Isradipine.
Istradefylline	The metabolism of Enasidenib can be decreased when combined with Istradefylline.
Itraconazole	The metabolism of Enasidenib can be decreased when combined with Itraconazole.
Ivacaftor	The metabolism of Enasidenib can be decreased when combined with Ivacaftor.
Ivermectin	Enasidenib may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Ivosidenib	The metabolism of Enasidenib can be increased when combined with Ivosidenib.
Ixabepilone	The metabolism of Ixabepilone can be increased when combined with Enasidenib.
Ixazomib	The metabolism of Ixazomib can be increased when combined with Enasidenib.
Ketamine	The metabolism of Enasidenib can be decreased when combined with Ketamine.
Ketazolam	The metabolism of Enasidenib can be decreased when combined with Ketazolam.

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Ketoconazole	The metabolism of Enasidenib can be decreased when combined with Ketoconazole.
Ketoprofen	The metabolism of Enasidenib can be decreased when combined with Ketoprofen.
Ketorolac	The metabolism of Enasidenib can be decreased when combined with Ketorolac.
Labetalol	The metabolism of Enasidenib can be decreased when combined with Labetalol.
Lacosamide	The metabolism of Enasidenib can be decreased when combined with Lacosamide.
Lamivudine	Enasidenib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Lamotrigine	The metabolism of Enasidenib can be increased when combined with Lamotrigine.
Lanreotide	The metabolism of Enasidenib can be decreased when combined with Lanreotide.
Lansoprazole	The metabolism of Enasidenib can be decreased when combined with Lansoprazole.
Lapatinib	The metabolism of Enasidenib can be decreased when combined with Lapatinib.
Larotrectinib	The serum concentration of Larotrectinib can be increased when it is combined with Enasidenib.
Lasmiditan	The serum concentration of Enasidenib can be increased when it is combined with Lasmiditan.
Ledipasvir	The serum concentration of Ledipasvir can be increased when it is combined with Enasidenib.
Lefamulin	Enasidenib may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Leflunomide	The serum concentration of Enasidenib can be decreased when it is combined with Leflunomide.
Lemborexant	The serum concentration of Lemborexant can be decreased when it is combined with Enasidenib.
Lenvatinib	Enasidenib may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Lesinurad	The metabolism of Enasidenib can be increased when combined with Lesinurad.
Letermovir	The metabolism of Enasidenib can be decreased when combined with Letermovir.
Letrozole	The metabolism of Enasidenib can be decreased when combined with Letrozole.
Leucovorin	The excretion of Leucovorin can be decreased when combined with Enasidenib.
Levacetylmethadol	The metabolism of Levacetylmethadol can be increased when combined with Enasidenib.
Levamlodipine	The serum concentration of Levamlodipine can be increased when it is combined with Enasidenib.
Levobetaxolol	The metabolism of Enasidenib can be decreased when combined with Levobetaxolol.
Levobupivacaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Levobupivacaine.
Levocarnitine	The excretion of Levocarnitine can be decreased when combined with Enasidenib.
Levofloxacin	The excretion of Levofloxacin can be decreased when combined with Enasidenib.
Levoketoconazole	The metabolism of Enasidenib can be decreased when combined with Levoketoconazole.
Levomilnacipran	The metabolism of Levomilnacipran can be increased when combined with Enasidenib.
Levonorgestrel	The metabolism of Levonorgestrel can be increased when combined with Enasidenib.
Levosalbutamol	The excretion of Levosalbutamol can be decreased when combined with Enasidenib.
Levothyroxine	The metabolism of Enasidenib can be decreased when combined with Levothyroxine.
Lidocaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Lidocaine.
Linagliptin	The metabolism of Enasidenib can be decreased when combined with Linagliptin.
Linzagolix	The serum concentration of Enasidenib can be increased when it is combined with Linzagolix.
Liothyronine	The metabolism of Liothyronine can be decreased when combined with Enasidenib.
Liotrix	The metabolism of Enasidenib can be decreased when combined with Liotrix.
Lisdexamfetamine	The metabolism of Enasidenib can be decreased when combined with Lisdexamfetamine.
Lisuride	The metabolism of Enasidenib can be decreased when combined with Lisuride.
Lofexidine	The metabolism of Enasidenib can be decreased when combined with Lofexidine.
Lomefloxacin	The metabolism of Lomefloxacin can be decreased when combined with Enasidenib.
Lomitapide	The metabolism of Lomitapide can be increased when combined with Enasidenib.
Lonafarnib	The serum concentration of Lonafarnib can be increased when it is combined with Enasidenib.
Lonapegsomatropin	The metabolism of Enasidenib can be increased when combined with Lonapegsomatropin.
Loncastuximab	The serum concentration of Loncastuximab tesirine can be increased when it is combined with Enasidenib.
Loperamide	The excretion of Loperamide can be decreased when combined with Enasidenib.
Lopinavir	The metabolism of Enasidenib can be decreased when combined with Lopinavir.
Loratadine	The metabolism of Enasidenib can be decreased when combined with Loratadine.
Lorcaserin	The metabolism of Enasidenib can be decreased when combined with Lorcaserin.
Lorlatinib	The metabolism of Enasidenib can be increased when combined with Lorlatinib.
Lornoxicam	The metabolism of Lornoxicam can be decreased when combined with Enasidenib.
Lorpiprazole	The metabolism of Enasidenib can be decreased when combined with Lorpiprazole.
Losartan	The metabolism of Enasidenib can be decreased when combined with Losartan.
Lovastatin	The metabolism of Lovastatin can be decreased when combined with Enasidenib.
Luliconazole	The serum concentration of Enasidenib can be increased when it is combined with Luliconazole.
Lumacaftor	The serum concentration of Enasidenib can be decreased when it is combined with Lumacaftor.
Lumateperone	The serum concentration of Lumateperone can be decreased when it is combined with Enasidenib.
Lumefantrine	The metabolism of Enasidenib can be decreased when combined with Lumefantrine.
Lumiracoxib	The metabolism of Lumiracoxib can be decreased when combined with Enasidenib.
Lusutrombopag	Enasidenib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Lynestrenol	The metabolism of Lynestrenol can be increased when combined with Enasidenib.
Manidipine	The metabolism of Enasidenib can be decreased when combined with Manidipine.
Mannitol	The serum concentration of Mannitol can be increased when it is combined with Enasidenib.
Maprotiline	The metabolism of Enasidenib can be decreased when combined with Maprotiline.
Maribavir	Maribavir may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Mavacamten	The serum concentration of Enasidenib can be decreased when it is combined with Mavacamten.
Meclizine	The metabolism of Enasidenib can be decreased when combined with Meclizine.
Medroxyprogesteron	The metabolism of Enasidenib can be increased when combined with Medroxyprogesterone acetate.
Mefenamic acid	The metabolism of Enasidenib can be decreased when combined with Mefenamic acid.
Mefloquine	The serum concentration of Mefloquine can be increased when it is combined with Enasidenib.
Megestrol acetate	The metabolism of Megestrol acetate can be increased when combined with Enasidenib.
Melatonin	The metabolism of Melatonin can be decreased when combined with Enasidenib.
Meloxicam	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Meloxicam.
Memantine	The metabolism of Enasidenib can be decreased when combined with Memantine.
Meperidine	The metabolism of Enasidenib can be decreased when combined with Meperidine.
Mephenytoin	The metabolism of Enasidenib can be decreased when combined with Mephenytoin.
Mepivacaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Mepivacaine.
Meprednisone	The metabolism of Enasidenib can be increased when combined with Meprednisone.
Mepyramine	The metabolism of Enasidenib can be decreased when combined with Mepyramine.
Mercaptopurine	The excretion of Mercaptopurine can be decreased when combined with Enasidenib.
Mesoridazine	The metabolism of Enasidenib can be decreased when combined with Mesoridazine.
Mestranol	The metabolism of Enasidenib can be decreased when combined with Mestranol.
Metamfetamine	The metabolism of Enasidenib can be decreased when combined with Metamfetamine.
Metformin	The serum concentration of Metformin can be increased when it is combined with Enasidenib.
Methadone	The metabolism of Enasidenib can be decreased when combined with Methadone.
Methimazole	The metabolism of Enasidenib can be decreased when combined with Methimazole.
Methotrexate	The metabolism of Methotrexate can be increased when combined with Enasidenib.
Methotrimeprazine	The metabolism of Enasidenib can be decreased when combined with Methotrimeprazine.
Methoxsalen	The metabolism of Enasidenib can be decreased when combined with Methoxsalen.
Methoxy	The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Enasidenib.
Methoxyflurane	The metabolism of Enasidenib can be decreased when combined with Methoxyflurane.
Methsuximide	The metabolism of Enasidenib can be decreased when combined with Methsuximide.
Methylene blue	The metabolism of Enasidenib can be decreased when combined with Methylene blue.
Methylergometrine	The metabolism of Enasidenib can be decreased when combined with Methylergometrine.
Methylphenobarbital	The metabolism of Enasidenib can be increased when combined with Methylphenobarbital.
Methylprednisolone	The metabolism of Enasidenib can be increased when combined with Methylprednisolone.
Methylprednisone	The metabolism of Enasidenib can be decreased when combined with Methylprednisone.
Methyltestosterone	The metabolism of Enasidenib can be decreased when combined with Methyltestosterone.
Methysergide	The metabolism of Enasidenib can be decreased when combined with Methysergide.
Metoclopramide	The metabolism of Enasidenib can be decreased when combined with Metoclopramide.

Metoprolol	The metabolism of Enasidenib can be decreased when combined with Metoprolol.
Metreleptin	The metabolism of Enasidenib can be increased when combined with Metreleptin.
Metronidazole	The metabolism of Enasidenib can be decreased when combined with Metronidazole.
Metyrapone	The metabolism of Enasidenib can be increased when combined with Metyrapone.
Mexiletine	The metabolism of Enasidenib can be decreased when combined with Mexiletine.
Mianserin	The metabolism of Enasidenib can be decreased when combined with Mianserin.
Miconazole	The metabolism of Enasidenib can be decreased when combined with Miconazole.
Midazolam	The serum concentration of Midazolam can be increased when it is combined with Enasidenib.
Midostaurin	The metabolism of Enasidenib can be decreased when combined with Midostaurin.
Mifepristone	The serum concentration of Enasidenib can be increased when it is combined with Mifepristone.
Migalastat	The metabolism of Migalastat can be decreased when combined with Enasidenib.
Milnacipran	The metabolism of Milnacipran can be increased when combined with Enasidenib.
Minaprine	The metabolism of Enasidenib can be decreased when combined with Minaprine.
Minoxidil	The metabolism of Minoxidil can be decreased when combined with Enasidenib.
Miocamycin	The metabolism of Enasidenib can be decreased when combined with Miocamycin.
Mirabegron	The serum concentration of Enasidenib can be increased when it is combined with Mirabegron.
Mirtazapine	The metabolism of Enasidenib can be decreased when combined with Mirtazapine.
Mitapivat	The metabolism of Enasidenib can be increased when combined with Mitapivat.
Mitotane	The metabolism of Enasidenib can be increased when combined with Mitotane.
Mitoxantrone	Enasidenib may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Mobocertinib	The serum concentration of Enasidenib can be decreased when it is combined with Mobocertinib.
Moclobemide	The metabolism of Enasidenib can be decreased when combined with Moclobemide.
Modafinil	The metabolism of Enasidenib can be increased when combined with Modafinil.
Mometasone	The metabolism of Enasidenib can be increased when combined with Mometasone furoate.
Montelukast	The metabolism of Enasidenib can be decreased when combined with Montelukast.
Morphine	The metabolism of Enasidenib can be decreased when combined with Morphine.
Mosunetuzumab	The metabolism of Enasidenib can be decreased when combined with Mosunetuzumab.
Moxifloxacin	The metabolism of Enasidenib can be decreased when combined with Moxifloxacin.
Mycophenolate	The metabolism of Enasidenib can be decreased when combined with Mycophenolate mofetil.
Mycophenolic acid	The metabolism of Mycophenolic acid can be decreased when combined with Enasidenib.
Nabilone	The metabolism of Nabilone can be decreased when combined with Enasidenib.
Nabumetone	The metabolism of Nabumetone can be decreased when combined with Enasidenib.
Nadolol	The metabolism of Enasidenib can be decreased when combined with Nadolol.
Nafcillin	The metabolism of Enasidenib can be increased when combined with Nafcillin.
Nalidixic acid	The metabolism of Enasidenib can be decreased when combined with Nalidixic acid.
Naloxegol	The serum concentration of Naloxegol can be increased when it is combined with Enasidenib.
Naloxone	The metabolism of Enasidenib can be decreased when combined with Naloxone.
Naltrexone	The metabolism of Naltrexone can be decreased when combined with Enasidenib.
Naproxen	The metabolism of Enasidenib can be decreased when combined with Naproxen.
Nateglinide	The metabolism of Enasidenib can be decreased when combined with Nateglinide.
Nebivolol	The metabolism of Enasidenib can be decreased when combined with Nebivolol.
Nefazodone	The metabolism of Enasidenib can be decreased when combined with Nefazodone.
Nelfinavir	The metabolism of Enasidenib can be decreased when combined with Nelfinavir.
Neratinib	The metabolism of Neratinib can be increased when combined with Enasidenib.
Netupitant	The metabolism of Enasidenib can be decreased when combined with Netupitant.
Nevirapine	The metabolism of Enasidenib can be decreased when combined with Nevirapine.
Niacin	The metabolism of Enasidenib can be decreased when combined with Niacin.
Nicardipine	The metabolism of Enasidenib can be decreased when combined with Nicardipine.
Nicergoline	The metabolism of Enasidenib can be decreased when combined with Nicergoline.
Niclosamide	The metabolism of Enasidenib can be decreased when combined with Niclosamide.
Nicotine	The metabolism of Enasidenib can be decreased when combined with Nicotine.
Nifedipine	The metabolism of Enasidenib can be decreased when combined with Nifedipine.
Nilotinib	The metabolism of Enasidenib can be decreased when combined with Nilotinib.
Nilutamide	The metabolism of Enasidenib can be decreased when combined with Nilutamide.
Nilvadipine	The metabolism of Enasidenib can be decreased when combined with Nilvadipine.
Nintedanib	The metabolism of Enasidenib can be decreased when combined with Nintedanib.
Nitrofurantoin	Enasidenib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Nomegestrol	The metabolism of Nomegestrol can be increased when combined with Enasidenib.
Nomegestrol	The metabolism of Nomegestrol acetate can be increased when combined with Enasidenib.
Norelgestromin	The metabolism of Norelgestromin can be increased when combined with Enasidenib.
Norepinephrine	The serum concentration of Norepinephrine can be increased when it is combined with Enasidenib.
Norethisterone	The metabolism of Enasidenib can be decreased when combined with Norethisterone.
Norethynodrel	The metabolism of Norethynodrel can be increased when combined with Enasidenib.
Norfloxacin	The metabolism of Enasidenib can be decreased when combined with Norfloxacin.
Norgestimate	The metabolism of Enasidenib can be increased when combined with Norgestimate.
Norgestrel	The metabolism of Norgestrel can be increased when combined with Enasidenib.
Nortriptyline	The serum concentration of Nortriptyline can be increased when it is combined with Enasidenib.
Noscapine	The metabolism of Enasidenib can be decreased when combined with Noscapine.
Novobiocin	Novobiocin may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Obeticholic acid	The risk or severity of adverse effects can be increased when Obeticholic acid is combined with Enasidenib.
Octreotide	The serum concentration of Enasidenib can be increased when it is combined with Octreotide.
Olanzapine	The metabolism of Enasidenib can be decreased when combined with Olanzapine.
Olaparib	The metabolism of Olaparib can be increased when combined with Enasidenib.
Oliceridine	The serum concentration of Oliceridine can be decreased when it is combined with Enasidenib.
Olodaterol	The metabolism of Enasidenib can be decreased when combined with Olodaterol.
Omadacycline	The serum concentration of Omadacycline can be increased when it is combined with Enasidenib.
Ombitasvir	The metabolism of Enasidenib can be decreased when combined with Ombitasvir.
Omeprazole	The metabolism of Enasidenib can be increased when combined with Omeprazole.
Ondansetron	The metabolism of Enasidenib can be decreased when combined with Ondansetron.
Opium	The metabolism of Enasidenib can be decreased when combined with Opium.
Oritavancin	The metabolism of Enasidenib can be increased when combined with Oritavancin.
Orphenadrine	The metabolism of Enasidenib can be decreased when combined with Orphenadrine.
Oseltamivir	The excretion of Oseltamivir can be decreased when combined with Enasidenib.
Osilodrostat	The serum concentration of Enasidenib can be increased when it is combined with Osilodrostat.
Osimertinib	The serum concentration of Enasidenib can be decreased when it is combined with Osimertinib.
Ospemifene	The metabolism of Enasidenib can be decreased when combined with Ospemifene.
Oteseconazole	The serum concentration of Enasidenib can be increased when it is combined with Oteseconazole.
Ouabain	The excretion of Ouabain can be decreased when combined with Enasidenib.
Oxaliplatin	The serum concentration of Oxaliplatin can be increased when it is combined with Enasidenib.
Oxamniquine	The metabolism of Enasidenib can be decreased when combined with Oxamniquine.
Oxandrolone	The metabolism of Enasidenib can be decreased when combined with Oxandrolone.
Oxcarbazepine	The metabolism of Enasidenib can be increased when combined with Oxcarbazepine.
Oxetacaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Oxetacaine.
Oxprenolol	The metabolism of Enasidenib can be decreased when combined with Oxprenolol.
Oxtriphylline	The metabolism of Oxtriphylline can be decreased when combined with Enasidenib.
Oxybuprocaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Oxybuprocaine.
Oxybutynin	The metabolism of Enasidenib can be decreased when combined with Oxybutynin.
Oxycodone	The metabolism of Enasidenib can be decreased when combined with Oxycodone.
Oxymorphone	The metabolism of Enasidenib can be decreased when combined with Oxymorphone.
Oxytetracycline	The excretion of Oxytetracycline can be decreased when combined with Enasidenib.

Ozanimod	Enasidenib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Paclitaxel	The metabolism of Enasidenib can be increased when combined with Paclitaxel.
Pacritinib	The serum concentration of Enasidenib can be increased when it is combined with Pacritinib.
Palbociclib	The metabolism of Palbociclib can be increased when combined with Enasidenib.
Paliperidone	The metabolism of Enasidenib can be decreased when combined with Paliperidone.
Palonosetron	The metabolism of Enasidenib can be decreased when combined with Palonosetron.
Panobinostat	The metabolism of Enasidenib can be decreased when combined with Panobinostat.
Pantoprazole	Pantoprazole may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Paramethadione	The metabolism of Enasidenib can be decreased when combined with Paramethadione.
Parecoxib	The metabolism of Parecoxib can be decreased when combined with Enasidenib.
Paritaprevir	The metabolism of Enasidenib can be decreased when combined with Paritaprevir.
Paroxetine	The metabolism of Enasidenib can be decreased when combined with Paroxetine.
Pasireotide	The metabolism of Enasidenib can be decreased when combined with Pasireotide.
Pazopanib	The serum concentration of Pazopanib can be increased when it is combined with Enasidenib.
Pefloxacin	The metabolism of Enasidenib can be decreased when combined with Pefloxacin.
Peginesatide	The risk or severity of Thrombosis can be increased when Peginesatide is combined with Enasidenib.
Peginterferon	The metabolism of Enasidenib can be decreased when combined with Peginterferon alfa-2a.
Peginterferon	The serum concentration of Enasidenib can be increased when it is combined with Peginterferon alfa-2b.
Pemetrexed	Enasidenib may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Penbutolol	The metabolism of Enasidenib can be decreased when combined with Penbutolol.
Penciclovir	The metabolism of Penciclovir can be decreased when combined with Enasidenib.
Penicillamine	The excretion of Penicillamine can be decreased when combined with Enasidenib.
Pentamidine	The metabolism of Enasidenib can be decreased when combined with Pentamidine.
Pentobarbital	The metabolism of Enasidenib can be increased when combined with Pentobarbital.
Pentoxifylline	The metabolism of Pentoxifylline can be decreased when combined with Enasidenib.
Perampanel	The metabolism of Perampanel can be increased when combined with Enasidenib.
Perhexiline	The metabolism of Enasidenib can be decreased when combined with Perhexiline.
Perphenazine	The metabolism of Enasidenib can be decreased when combined with Perphenazine.
Pexidartinib	The metabolism of Pexidartinib can be increased when combined with Enasidenib.
Phenformin	The metabolism of Enasidenib can be decreased when combined with Phenformin.
Phenobarbital	The metabolism of Enasidenib can be increased when combined with Phenobarbital.
Phenol	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Phenol.
Phenprocoumon	The metabolism of Phenprocoumon can be increased when combined with Enasidenib.
Phenylbutazone	The metabolism of Enasidenib can be increased when combined with Phenylbutazone.
Phenylbutyric acid	The metabolism of Enasidenib can be decreased when combined with Phenylbutyric acid.
Phenylephrine	The metabolism of Enasidenib can be increased when combined with Phenylephrine.
Phenytoin	The metabolism of Enasidenib can be increased when combined with Phenytoin.
Pibrentasvir	The metabolism of Enasidenib can be decreased when combined with Pibrentasvir.
Pimavanserin	The metabolism of Enasidenib can be decreased when combined with Pimavanserin.
Pimozide	The metabolism of Pimozide can be increased when combined with Enasidenib.
Pindolol	The metabolism of Enasidenib can be decreased when combined with Pindolol.
Pioglitazone	The metabolism of Enasidenib can be decreased when combined with Pioglitazone.
Piperacillin	The excretion of Piperacillin can be decreased when combined with Enasidenib.
Piperaquine	The metabolism of Enasidenib can be decreased when combined with Piperaquine.
Piperazine	The metabolism of Enasidenib can be decreased when combined with Piperazine.
Pipotiazine	The metabolism of Enasidenib can be decreased when combined with Pipotiazine.
Pirfenidone	The metabolism of Enasidenib can be decreased when combined with Pirfenidone.
Piroxicam	The metabolism of Enasidenib can be decreased when combined with Piroxicam.
Pitavastatin	The metabolism of Enasidenib can be decreased when combined with Pitavastatin.
Pitolisant	The serum concentration of Enasidenib can be decreased when it is combined with Pitolisant.
Polythiazide	The excretion of Polythiazide can be decreased when combined with Enasidenib.
Pomalidomide	The serum concentration of Pomalidomide can be increased when it is combined with Enasidenib.
Ponatinib	The metabolism of Ponatinib can be increased when combined with Enasidenib.
Ponesimod	The metabolism of Ponesimod can be decreased when combined with Enasidenib.
Posaconazole	The metabolism of Enasidenib can be decreased when combined with Posaconazole.
Practolol	The metabolism of Enasidenib can be decreased when combined with Practolol.
Pralatrexate	Enasidenib may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Pralsetinib	The serum concentration of Pralsetinib can be increased when it is combined with Enasidenib.
Pramipexole	The serum concentration of Pramipexole can be increased when it is combined with Enasidenib.
Pramocaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Pramocaine.
Prasugrel	The metabolism of Enasidenib can be decreased when combined with Prasugrel.
Pravastatin	The excretion of Pravastatin can be decreased when combined with Enasidenib.
Praziquantel	The metabolism of Praziquantel can be decreased when combined with Enasidenib.
Prazosin	Enasidenib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Prednisolone	The metabolism of Enasidenib can be increased when combined with Prednisolone.
Prednisolone acetate	The metabolism of Enasidenib can be increased when combined with Prednisolone acetate.
Prednisolone	The metabolism of Enasidenib can be increased when combined with Prednisolone phosphate.
Prednisone acetate	The metabolism of Enasidenib can be increased when combined with Prednisone acetate.
Pretomanid	The metabolism of Enasidenib can be decreased when combined with Pretomanid.
Prilocaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Prilocaine.
Primaquine	The metabolism of Enasidenib can be decreased when combined with Primaquine.
Primidone	The metabolism of Enasidenib can be increased when combined with Primidone.
Probenecid	The metabolism of Enasidenib can be increased when combined with Probenecid.
Procainamide	The metabolism of Procainamide can be decreased when combined with Enasidenib.
Procaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Procaine.
Prochlorperazine	The metabolism of Enasidenib can be decreased when combined with Prochlorperazine.
Progesterone	The metabolism of Enasidenib can be decreased when combined with Progesterone.
Proguanil	The metabolism of Enasidenib can be decreased when combined with Proguanil.
Promazine	The metabolism of Enasidenib can be decreased when combined with Promazine.
Promethazine	The metabolism of Enasidenib can be decreased when combined with Promethazine.
Propafenone	The metabolism of Enasidenib can be decreased when combined with Propafenone.
Proparacaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Proparacaine.
Propofol	The metabolism of Enasidenib can be decreased when combined with Propofol.
Propoxycaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Propoxycaine.
Propranolol	The serum concentration of Propranolol can be increased when it is combined with Enasidenib.
Prucalopride	The serum concentration of Prucalopride can be increased when it is combined with Enasidenib.
Pyrimethamine	The metabolism of Enasidenib can be decreased when combined with Pyrimethamine.
Quazepam	The metabolism of Enasidenib can be decreased when combined with Quazepam.
Quetiapine	The metabolism of Enasidenib can be decreased when combined with Quetiapine.
Quinapril	The excretion of Quinapril can be decreased when combined with Enasidenib.
Quinidine	The serum concentration of Quinidine can be increased when it is combined with Enasidenib.
Quinine	The metabolism of Enasidenib can be decreased when combined with Quinine.
Quinupristin	The metabolism of Enasidenib can be decreased when combined with Quinupristin.
Rabeprazole	Rabeprazole may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Raloxifene	The metabolism of Enasidenib can be decreased when combined with Raloxifene.
Raltegravir	The metabolism of Raltegravir can be decreased when combined with Enasidenib.
Ramelteon	The metabolism of Ramelteon can be decreased when combined with Enasidenib.
Ranitidine	The metabolism of Enasidenib can be decreased when combined with Ranitidine.
Ranolazine	The metabolism of Ranolazine can be increased when combined with Enasidenib.
Rasagiline	The metabolism of Rasagiline can be decreased when combined with Enasidenib.

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Reboxetine	The metabolism of Enasidenib can be decreased when combined with Reboxetine.
Regorafenib	The serum concentration of Regorafenib can be increased when it is combined with Enasidenib.
Relebactam	The excretion of Relebactam can be decreased when combined with Enasidenib.
Relugolix	The serum concentration of Relugolix can be increased when it is combined with Enasidenib.
Remdesivir	The metabolism of Enasidenib can be decreased when combined with Remdesivir.
Remoxipride	The metabolism of Enasidenib can be decreased when combined with Remoxipride.
Repaglinide	The metabolism of Enasidenib can be decreased when combined with Repaglinide.
Reserpine	The serum concentration of Reserpine can be increased when it is combined with Enasidenib.
Retapamulin	The metabolism of Retapamulin can be decreased when combined with Enasidenib.
Revefenacin	Enasidenib may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Ribociclib	The metabolism of Enasidenib can be decreased when combined with Ribociclib.
Rifabutin	The metabolism of Enasidenib can be increased when combined with Rifabutin.
Rifampicin	The metabolism of Enasidenib can be increased when combined with Rifampicin.
Rifamycin	The metabolism of Enasidenib can be increased when combined with Rifamycin.
Rifapentine	The metabolism of Enasidenib can be increased when combined with Rifapentine.
Rifaximin	The serum concentration of Rifaximin can be increased when it is combined with Enasidenib.
Rilonacept	The metabolism of Enasidenib can be increased when combined with Rilonacept.
Rilpivirine	The serum concentration of Rilpivirine can be decreased when it is combined with Enasidenib.
Riluzole	Enasidenib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Rimegepant	The metabolism of Rimegepant can be increased when combined with Enasidenib.
Riociguat	The metabolism of Enasidenib can be decreased when combined with Riociguat.
Ripretinib	Enasidenib may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Risperidone	The metabolism of Enasidenib can be decreased when combined with Risperidone.
Ritonavir	The serum concentration of Enasidenib can be increased when it is combined with Ritonavir.
Rivaroxaban	Enasidenib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Rofecoxib	The metabolism of Enasidenib can be increased when combined with Rofecoxib.
Roflumilast	The serum concentration of Roflumilast can be increased when it is combined with Enasidenib.
Rolapitant	The metabolism of Enasidenib can be decreased when combined with Rolapitant.
Romidepsin	The serum concentration of Romidepsin can be increased when it is combined with Enasidenib.
Ropeginterferon	The metabolism of Enasidenib can be decreased when combined with Ropeginterferon alfa-2b.
Ropinirole	The risk or severity of adverse effects can be increased when Enasidenib is combined with Ropinirole.
Ropivacaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Ropivacaine.
Rosiglitazone	The metabolism of Enasidenib can be decreased when combined with Rosiglitazone.
Rosoxacin	The metabolism of Enasidenib can be decreased when combined with Rosoxacin.
Rosuvastatin	The metabolism of Enasidenib can be decreased when combined with Rosuvastatin.
Rotigotine	The metabolism of Enasidenib can be decreased when combined with Rotigotine.
Roxadustat	The serum concentration of Enasidenib can be increased when it is combined with Roxadustat.
Roxithromycin	The metabolism of Enasidenib can be decreased when combined with Roxithromycin.
Rucaparib	The metabolism of Enasidenib can be decreased when combined with Rucaparib.
Rufinamide	The metabolism of Enasidenib can be increased when combined with Rufinamide.
Rupatadine	The metabolism of Enasidenib can be decreased when combined with Rupatadine.
Ruxolitinib	The metabolism of Ruxolitinib can be increased when combined with Enasidenib.
Sacituzumab	The serum concentration of Sacituzumab govitecan can be increased when it is combined with Enasidenib.
Safinamide	Safinamide may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Salicylic acid	The metabolism of Salicylic acid can be decreased when combined with Enasidenib.
Salmeterol	The metabolism of Enasidenib can be decreased when combined with Salmeterol.
Saquinavir	The metabolism of Enasidenib can be decreased when combined with Saquinavir.
Sarilumab	The metabolism of Enasidenib can be increased when combined with Sarilumab.
Satralizumab	The serum concentration of Enasidenib can be decreased when it is combined with Satralizumab.
Saxagliptin	The excretion of Saxagliptin can be decreased when combined with Enasidenib.
Secobarbital	The metabolism of Enasidenib can be increased when combined with Secobarbital.
Secukinumab	The metabolism of Enasidenib can be increased when combined with Secukinumab.
Segesterone	The metabolism of Segesterone acetate can be increased when combined with Enasidenib.
Selegiline	The metabolism of Enasidenib can be decreased when combined with Selegiline.
Selexipag	The metabolism of Enasidenib can be decreased when combined with Selexipag.
Selpercatinib	The serum concentration of Selpercatinib can be decreased when it is combined with Enasidenib.
Selumetinib	The metabolism of Enasidenib can be decreased when combined with Selumetinib.
Sertindole	The metabolism of Enasidenib can be decreased when combined with Sertindole.
Sertraline	The metabolism of Enasidenib can be decreased when combined with Sertraline.
Sevoflurane	The metabolism of Enasidenib can be decreased when combined with Sevoflurane.
Sildenafil	The metabolism of Enasidenib can be decreased when combined with Sildenafil.
Silodosin	The excretion of Silodosin can be decreased when combined with Enasidenib.
Siltuximab	The metabolism of Enasidenib can be increased when combined with Siltuximab.
Simeprevir	The metabolism of Enasidenib can be decreased when combined with Simeprevir.
Simvastatin	The metabolism of Enasidenib can be decreased when combined with Simvastatin.
Sincalide	The excretion of Sincalide can be decreased when combined with Enasidenib.
Siponimod	The metabolism of Siponimod can be increased when combined with Enasidenib.
Sirolimus	The serum concentration of Sirolimus can be increased when it is combined with Enasidenib.
Sitagliptin	The metabolism of Enasidenib can be decreased when combined with Sitagliptin.
Sitaxentan	The metabolism of Enasidenib can be decreased when combined with Sitaxentan.
Sodium	The metabolism of Enasidenib can be decreased when combined with Sodium aurothiomalate.
Sofosbuvir	Enasidenib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Solifenacin	The metabolism of Enasidenib can be decreased when combined with Solifenacin.
Solriamfetol	The serum concentration of Solriamfetol can be increased when it is combined with Enasidenib.
Somapacitan	The metabolism of Enasidenib can be increased when combined with Somapacitan.
Somatostatin	The metabolism of Enasidenib can be decreased when combined with Somatostatin.
Somatotropin	The metabolism of Enasidenib can be increased when combined with Somatotropin.
Somatrem	The metabolism of Enasidenib can be increased when combined with Somatrem.
Somatrogon	The metabolism of Enasidenib can be increased when combined with Somatrogon.
Sonidegib	The metabolism of Sonidegib can be increased when combined with Enasidenib.
Sorafenib	The metabolism of Sorafenib can be increased when combined with Enasidenib.
Sotagliflozin	Sotagliflozin may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Sotalol	The metabolism of Sotalol can be decreased when combined with Enasidenib.
Sotorasib	The serum concentration of Enasidenib can be decreased when it is combined with Sotorasib.
Spironolactone	The metabolism of Enasidenib can be decreased when combined with Spironolactone.
St. John’s Wort	The metabolism of Enasidenib can be increased when combined with St. John’s Wort.
Stavudine	The excretion of Stavudine can be decreased when combined with Enasidenib.
Stiripentol	The metabolism of Enasidenib can be decreased when combined with Stiripentol.
Succinic acid	The excretion of Succinic acid can be decreased when combined with Enasidenib.
Sulfadiazine	The metabolism of Enasidenib can be decreased when combined with Sulfadiazine.
Sulfamethizole	The metabolism of Enasidenib can be decreased when combined with Sulfamethizole.
Sulfamethoxazole	The metabolism of Enasidenib can be decreased when combined with Sulfamethoxazole.
Sulfaphenazole	The metabolism of Enasidenib can be decreased when combined with Sulfaphenazole.
Sulfapyridine	The metabolism of Enasidenib can be decreased when combined with Sulfapyridine.
Sulfasalazine	Sulfasalazine may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Sulfinpyrazone	The metabolism of Enasidenib can be increased when combined with Sulfinpyrazone.
Sulfisoxazole	The metabolism of Enasidenib can be decreased when combined with Sulfisoxazole.
Sumatriptan	Enasidenib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Sunitinib	The metabolism of Sunitinib can be increased when combined with Enasidenib.
Suvorexant	The metabolism of Enasidenib can be decreased when combined with Suvorexant.

Tacrine	The metabolism of Tacrine can be decreased when combined with Enasidenib.
Tacrolimus	The serum concentration of Tacrolimus can be increased when it is combined with Enasidenib.
Tafamidis	The serum concentration of Enasidenib can be increased when it is combined with Tafamidis.
Tafenoquine	The metabolism of Enasidenib can be decreased when combined with Tafenoquine.
Talazoparib	The serum concentration of Talazoparib can be increased when it is combined with Enasidenib.
Tamoxifen	The metabolism of Enasidenib can be increased when combined with Tamoxifen.
Tamsulosin	The metabolism of Enasidenib can be decreased when combined with Tamsulosin.
Tasimelteon	The metabolism of Enasidenib can be decreased when combined with Tasimelteon.
Taurocholic acid	The excretion of Taurocholic acid can be decreased when combined with Enasidenib.
Tazarotene	The metabolism of Enasidenib can be decreased when combined with Tazarotene.
Tazemetostat	The metabolism of Enasidenib can be decreased when combined with Tazemetostat.
Tazobactam	The excretion of Tazobactam can be decreased when combined with Enasidenib.
Technetium	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Enasidenib.
Technetium	The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Enasidenib.
Tecovirimat	The metabolism of Enasidenib can be increased when combined with Tecovirimat.
Tegafur	The metabolism of Tegafur can be decreased when combined with Enasidenib.
Tegaserod	The metabolism of Enasidenib can be decreased when combined with Tegaserod.
Telaprevir	The metabolism of Enasidenib can be decreased when combined with Telaprevir.
Telithromycin	The metabolism of Enasidenib can be decreased when combined with Telithromycin.
Telmisartan	Telmisartan may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Telotristat ethyl	The serum concentration of Enasidenib can be decreased when it is combined with Telotristat ethyl.
Temsirolimus	The serum concentration of Temsirolimus can be increased when it is combined with Enasidenib.
Teniposide	The metabolism of Teniposide can be increased when combined with Enasidenib.
Tenofovir	The serum concentration of Tenofovir alafenamide can be increased when it is combined with Enasidenib.
Tenofovir	The excretion of Tenofovir disoproxil can be decreased when combined with Enasidenib.
Tenoxicam	The metabolism of Tenoxicam can be decreased when combined with Enasidenib.
Tepotinib	The serum concentration of Tepotinib can be increased when it is combined with Enasidenib.
Terbinafine	The metabolism of Enasidenib can be decreased when combined with Terbinafine.
Terfenadine	The metabolism of Enasidenib can be decreased when combined with Terfenadine.
Teriflunomide	The serum concentration of Enasidenib can be decreased when it is combined with Teriflunomide.
Testosterone	The metabolism of Enasidenib can be increased when combined with Testosterone.
Testosterone	The metabolism of Enasidenib can be decreased when combined with Testosterone cypionate.
Testosterone	The metabolism of Enasidenib can be decreased when combined with Testosterone enanthate.
Testosterone	The metabolism of Enasidenib can be increased when combined with Testosterone propionate.
Tetrabenazine	The metabolism of Enasidenib can be decreased when combined with Tetrabenazine.
Tetracaine	The risk or severity of methemoglobinemia can be increased when Enasidenib is combined with Tetracaine.
Tetracycline	The metabolism of Enasidenib can be decreased when combined with Tetracycline.
Tezacaftor	The serum concentration of Tezacaftor can be increased when it is combined with Enasidenib.
Thalidomide	The metabolism of Thalidomide can be decreased when combined with Enasidenib.
Theophylline	The metabolism of Theophylline can be increased when combined with Enasidenib.
Thiabendazole	The metabolism of Enasidenib can be decreased when combined with Thiabendazole.
Thiamylal	The metabolism of Enasidenib can be increased when combined with Thiamylal.
Thiopental	The metabolism of Thiopental can be decreased when combined with Enasidenib.
Thioridazine	The metabolism of Enasidenib can be decreased when combined with Thioridazine.
Thiosulfuric acid	The metabolism of Enasidenib can be increased when combined with Thiosulfuric acid.
Thiotepa	The metabolism of Thiotepa can be increased when combined with Enasidenib.
Thiothixene	The metabolism of Thiothixene can be decreased when combined with Enasidenib.
Tiagabine	The metabolism of Tiagabine can be decreased when combined with Enasidenib.
Ticagrelor	The metabolism of Enasidenib can be decreased when combined with Ticagrelor.
Ticlopidine	The metabolism of Enasidenib can be decreased when combined with Ticlopidine.
Timolol	The metabolism of Timolol can be decreased when combined with Enasidenib.
Tiotropium	The metabolism of Enasidenib can be decreased when combined with Tiotropium.
Tipiracil	The excretion of Tipiracil can be decreased when combined with Enasidenib.
Tipranavir	The metabolism of Enasidenib can be decreased when combined with Tipranavir.
Tivozanib	The metabolism of Tivozanib can be increased when combined with Enasidenib.
Tizanidine	The metabolism of Tizanidine can be decreased when combined with Enasidenib.
Tocainide	The metabolism of Enasidenib can be decreased when combined with Tocainide.
Tocilizumab	The metabolism of Enasidenib can be increased when combined with Tocilizumab.
Tofacitinib	The metabolism of Tofacitinib can be decreased when combined with Enasidenib.
Tolazamide	The metabolism of Tolazamide can be decreased when combined with Enasidenib.
Tolbutamide	The metabolism of Enasidenib can be decreased when combined with Tolbutamide.
Tolterodine	The metabolism of Enasidenib can be decreased when combined with Tolterodine.
Tolvaptan	The serum concentration of Tolvaptan can be increased when it is combined with Enasidenib.
Topiramate	The metabolism of Enasidenib can be increased when combined with Topiramate.
Topotecan	The serum concentration of Topotecan can be increased when it is combined with Enasidenib.
Torasemide	The metabolism of Enasidenib can be decreased when combined with Torasemide.
Toremifene	The serum concentration of Toremifene can be increased when it is combined with Enasidenib.
Trabectedin	The metabolism of Trabectedin can be increased when combined with Enasidenib.
Tramadol	The metabolism of Tramadol can be decreased when combined with Enasidenib.
Trametinib	The metabolism of Enasidenib can be decreased when combined with Trametinib.
Tranylcypromine	The metabolism of Enasidenib can be decreased when combined with Tranylcypromine.
Trastuzumab	The serum concentration of Trastuzumab emtansine can be increased when it is combined with Enasidenib.
Trazodone	The metabolism of Enasidenib can be decreased when combined with Trazodone.
Treprostinil	The metabolism of Enasidenib can be decreased when combined with Treprostinil.
Tretinoin	The metabolism of Enasidenib can be decreased when combined with Tretinoin.
Triamcinolone	The metabolism of Enasidenib can be increased when combined with Triamcinolone.
Triamterene	The metabolism of Triamterene can be decreased when combined with Enasidenib.
Triclabendazole	The metabolism of Enasidenib can be decreased when combined with Triclabendazole.
Trifluoperazine	The metabolism of Trifluoperazine can be decreased when combined with Enasidenib.
Trifluridine	The excretion of Trifluridine can be decreased when combined with Enasidenib.
Trilaciclib	The metabolism of Enasidenib can be increased when combined with Trilaciclib.
Trimethadione	The metabolism of Enasidenib can be decreased when combined with Trimethadione.
Trimethoprim	The metabolism of Enasidenib can be decreased when combined with Trimethoprim.
Trimipramine	The serum concentration of Trimipramine can be increased when it is combined with Enasidenib.
Tripelennamine	The metabolism of Enasidenib can be decreased when combined with Tripelennamine.
Troglitazone	The metabolism of Enasidenib can be increased when combined with Troglitazone.
Troleandomycin	The metabolism of Enasidenib can be decreased when combined with Troleandomycin.
Trospium	The metabolism of Enasidenib can be decreased when combined with Trospium.
Trovafloxacin	The metabolism of Enasidenib can be decreased when combined with Trovafloxacin.
Tucatinib	The metabolism of Tucatinib can be decreased when combined with Enasidenib.
Ubrogepant	The serum concentration of Ubrogepant can be increased when it is combined with Enasidenib.
Ulipristal	The metabolism of Ulipristal can be increased when combined with Enasidenib.
Umeclidinium	The metabolism of Enasidenib can be decreased when combined with Umeclidinium.
Valaciclovir	The excretion of Valaciclovir can be decreased when combined with Enasidenib.
Valbenazine	The metabolism of Enasidenib can be decreased when combined with Valbenazine.
Valdecoxib	The metabolism of Enasidenib can be decreased when combined with Valdecoxib.
Valproic acid	The metabolism of Enasidenib can be decreased when combined with Valproic acid.
Valsartan	The metabolism of Enasidenib can be decreased when combined with Valsartan.
Vandetanib	The metabolism of Vandetanib can be increased when combined with Enasidenib.
Vardenafil	The metabolism of Vardenafil can be decreased when combined with Enasidenib.

Drug-Food Interactions

Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of enasidenib; however, CYP3A4 is one of many enzymes involved in enasidenib metabolism.
Exercise caution with St. John’s Wort. This herb induces CYP3A4 metabolism, which may reduce the serum concentration of enasidenib; however, CYP3A4 is one of many enzymes involved in enasidenib metabolism.
Take it at the same time every day.
Take it with a full glass of water.
Take it with or without food.

Pregnancy And Lactation

US FDA pregnancy category Not Assigned:

Pregnancy

Based on animal embryo-fetal toxicity studies, IDHIFA can cause fetal harm when administered to a pregnant woman. There are no available data on IDHIFA use in pregnant women to inform a drug-associated risk of major birth defects and miscarriage. In animal embryo-fetal toxicity studies, oral administration of enasidenib to pregnant rats and rabbits during organogenesis was associated with embryo-fetal mortality and alterations to growth starting at 0.1 times the steady-state clinical exposure based on the AUC at the recommended human dose (see Data). If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, advise the patient of the potential risk to a fetus. Adverse outcomes in pregnancy occur regardless of the health of the mother or the use of medications. The background risk of major birth defects and miscarriage for the indicated population is unknown. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2%-4% and 15%-20%, respectively.

Lactation

No information is available on the clinical use of enasidenib during breastfeeding. Because enasidenib is 98.5% bound to plasma proteins and its active metabolite is 96.6% bound to plasma proteins, the amount in milk is likely to be low. However, the half-life of enasidenib is 137 hours and it might accumulate in the infant. The manufacturer recommends that breastfeeding be discontinued during enasidenib therapy and for at least 2 months after the end of therapy.

How should this medicine be used?

Enasidenib comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take enasidenib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take enasidenib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole with a cup (8 ounces [240 mL]) of water; do not split, chew, or crush them.

If you vomit after taking a dose of enasidenib, take another dose as soon as possible on the same day.

Your doctor may temporarily or permanently stop your treatment, decrease your dose of enasidenib, or treat you with other medications depending on the side effects that you experience. Be sure to talk to your doctor about how you are feeling during your treatment. Do not stop taking enasidenib without talking to your doctor.

What special precautions should I follow?

Before taking enasidenib,

tell your doctor and pharmacist if you are allergic to enasidenib, any other medications, or any of the ingredients in enasidenib tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you are pregnant, plan to become pregnant, or plan to father a child. You should not become pregnant while you are taking enasidenib. You will need to have a negative pregnancy test before you begin taking this medication. Use effective birth control during your treatment with enasidenib and for one month after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control during your treatment and for one month after your final dose. Enasidenib may decrease the effectiveness of certain oral contraceptives so talk to your doctor about birth control methods that will work for you. If you or your partner become pregnant while taking enasidenib, call your doctor.
tell your doctor if you are breastfeeding. You should not breastfeed while you are enasidenib and for one month after your final dose.
you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking enasidenib.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209606s000lbl.pdf
https://www.fda.gov/drugs/resources-information-approved-drugs/fda-granted-regular-approval-enasidenib-treatment-relapsed-or-refractory-aml
https://pubchem.ncbi.nlm.nih.gov/compound/Enasidenib
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CAS Common Chemistry

https://creativecommons.org/licenses/by-nc/4.0/

https://commonchemistry.cas.org/detail?cas_rn=1446502-11-9
ChemIDplus

LICENSE

https://www.nlm.nih.gov/copyright.html

Enasidenib [USAN:INN]

https://chem.nlm.nih.gov/chemidplus/sid/1446502119

AG 221

https://chem.nlm.nih.gov/chemidplus/sid/1802003093

ChemIDplus Chemical Information Classification

https://chem.nlm.nih.gov/chemidplus/
DrugBank

https://www.drugbank.ca/legal/terms_of_use

Enasidenib

https://www.drugbank.ca/drugs/DB13874
EPA DSSTox

LICENSE

https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources

Enasidenib

https://comptox.epa.gov/dashboard/DTXSID801027942

CompTox Chemicals Dashboard Chemical Lists

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FDA Global Substance Registration System (GSRS)

https://www.fda.gov/about-fda/about-website/website-policies#linking

ENASIDENIB

https://gsrs.ncats.nih.gov/ginas/app/beta/substances/3T1SS4E7AG
ChEBI

Enasidenib

http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:145374

ChEBI Ontology

http://www.ebi.ac.uk/chebi/userManualForward.do#ChEBI%20Ontology
FDA Pharm Classes

https://www.fda.gov/about-fda/about-website/website-policies#linking

ENASIDENIB

https://dailymed.nlm.nih.gov/dailymed/browse-drug-classes.cfm

FDA Pharmacological Classification

https://www.fda.gov/ForIndustry/DataStandards/StructuredProductLabeling/ucm162549.htm
LiverTox

LICENSE

https://www.nlm.nih.gov/copyright.html

Enasidenib

https://www.ncbi.nlm.nih.gov/books/n/livertox/Enasidenib/
NCI Thesaurus (NCIt)

https://www.cancer.gov/policies/copyright-reuse

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NCI Thesaurus Tree

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ClinicalTrials.gov

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http://www.dgidb.org/downloads

ENASIDENIB

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enasidenib

https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8960

Guide to Pharmacology Target Classification

https://www.guidetopharmacology.org/targets.jsp
Therapeutic Target Database (TTD)

AG-221

http://idrblab.net/ttd/data/drug/details/D0K7FT
European Medicines Agency (EMA)

https://www.ema.europa.eu/en/about-us/legal-notice

Enasidenib (P/0293/2017)

https://www.ema.europa.eu/en/medicines/human/paediatric-investigation-plans/emea-001798-pip02-16
Drugs and Lactation Database (LactMed)

LICENSE

https://www.nlm.nih.gov/copyright.html

Enasidenib

https://www.ncbi.nlm.nih.gov/books/NBK500925/
EU Clinical Trials Register

https://www.clinicaltrialsregister.eu/
FDA Orange Book

https://www.fda.gov/about-fda/about-website/website-policies#linking

https://www.fda.gov/drugs/drug-approvals-and-databases/approved-drug-products-therapeutic-equivalence-evaluations-orange-book
FDA Medication Guides

https://www.fda.gov/about-fda/about-website/website-policies#linking

Idhifa

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=medguide.page
Human Metabolome Database (HMDB)

http://www.hmdb.ca/citing

Enasidenib

http://www.hmdb.ca/metabolites/HMDB0251786
NLM RxNorm Terminology

https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.html

enasidenib

https://rxnav.nlm.nih.gov/id/rxnorm/1940332
Protein Data Bank in Europe (PDBe)

http://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/69Q
RCSB Protein Data Bank (RCSB PDB)

https://www.rcsb.org/pages/policies

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Springer Nature

https://pubchem.ncbi.nlm.nih.gov/substance/?source=15745&sourceid=33061531-801899220
Thieme Chemistry.

https://creativecommons.org/licenses/by-nc-nd/4.0/

https://pubchem.ncbi.nlm.nih.gov/substance/?source=22163&sourceid=33061531-801899220
WHO Anatomical Therapeutic Chemical (ATC) Classification

https://www.whocc.no/copyright_disclaimer/

https://www.whocc.no/atc/

ATC Code

https://www.whocc.no/atc_ddd_index/
Wikidata

LICENSE

CCZero

https://creativecommons.org/publicdomain/zero/1.0/

Enasidenib

https://www.wikidata.org/wiki/Q27077182
PubChem

https://pubchem.ncbi.nlm.nih.gov

PFAS and Fluorinated Compounds in PubChem

https://gitlab.lcsb.uni.lu/eci/pubchem-docs/-/raw/main/pfas-tree/PFAS_Tree.pdf?inline=false
Medical Subject Headings (MeSH)

https://www.nlm.nih.gov/copyright.html

enasidenib

https://www.ncbi.nlm.nih.gov/mesh/2011767

MeSH Tree

http://www.nlm.nih.gov/mesh/meshhome.html
KEGG

https://www.kegg.jp/kegg/legal.html

Anatomical Therapeutic Chemical (ATC) classification

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Target-based classification of drugs

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ChEMBL

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ChEMBL Protein Target Tree

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NORMAN Suspect List Exchange

https://creativecommons.org/licenses/by/4.0/

NORMAN Suspect List Exchange Classification

https://www.norman-network.com/nds/SLE/
National Drug Code (NDC) Directory

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FDA Drug Type and Pharmacologic Classification

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PATENTSCOPE (WIPO)

SID 393443194

https://pubchem.ncbi.nlm.nih.gov/substance/393443194