Aceclofenac Contraindications, Warning, Pregnancy Aceclofenac Contraindications/ Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies Aceclofenac potently inhibits the cyclooxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. It is orally administered for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Aceclofenac belongs to BCS Class II as it possesses poor aqueous solubility. It displays high permeability to penetrate into synovial joints wherein patients with osteoarthritis and related conditions, the loss of articular cartilage in the area causes joint pain, tenderness, stiffness, crepitus, and local inflammation. Aceclofenac belongs to the class of non-steroidal anti-inflammatory preparations for topical use. Used in the treatment of joint and muscular pains due to it muscle relaxing action. Indications of Aceclofenac Aceclofenac tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions, and symptoms Indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Muscles stiffness in spinal Muscles stiffness in muscle diseases Muscles stiffness in the joint diseases Lumbago Low back pain PLID Frozen shoulder Ankylosing spondylitis Pain caused by nonarticular rheumatism Muscles stiffness in nerve diseases Rheumatoid arthritis Osteoarthritis Cervical spondylosis Periarthritis of scapulohumeral Ischiadynia a backache Teething Aceclofenac Contraindications Hypersensitivity to Aceclofenac Tablet is a contraindication. In addition, Aceclofenac Tablet should not be used if you have the following conditions Active peptic ulcer Acute rhinitis Allergic to thiocolchicoside Asthma Breastfeeding Pregnant Urticaria Concurrent peptic ulcer, or history of ulcer disease Allergy to indomethacin, aspirin, or other NSAIDs Patients with nasal polyps reacting with angioedema to other NSAIDs Children under 2 years of age (with the exception of neonates with patent ductus arteriosus) Some painkillers, including opioid pain killers; Hypnotic drugs; Psychotropic drugs; Used monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromine Epilepsy; Addiction or are recovering from addiction to another medication. History of peptic ulcer disease, Gastrointestinal bleeding, Severe pre-existing renal and liver damage Caution: pre-existing bone marrow damage (frequent blood cell counts are indicated) Caution: bleeding tendencies of unknown origin Caution: Parkinson’s disease, epilepsy, psychotic disorders (indometacin may worsen these conditions) Concurrent with potassium sparing diuretics Patients who have a patent ductus arteriosus dependent heart defect (such as transposition of the great vessels) Significant hypertension (high blood pressure) Concomitant administration of lithium salts (such as lithium carbonate) You Might Also Read Minoxidil Oral 10 mg Tablet - Uses, Dosage, Side EffectsDosage of Aceclofenac Strengths : 100 mg , 200 mg Ankylosing spondylitis 100 mg bid, in the morning and in the evening. Rheumatoid arthritis 100 mg bid, in the morning and in the evening. Osteoarthritis 100 mg bid, in the morning and in the evening. Side Effects of Aceclofenac The most common GI disorders (e.g. dyspepsia, abdominal pain, nausea, vomiting, diarrhea, flatulence, constipation,, ulcerative stomatitis, ), indigestion, Disturbances of the gut such as diarrhea, constipation, nausea, vomiting or abdominal pain. Drowsiness and lightheadedness Nausea and vomiting joint pain Nausea and vomiting Severe stomach ache Severe diarrhea Vaginal thrush Skin rash Headache Chest pain Diarrhea or loose stools Difficulty with breathing Dizziness Heartburn Muscle pain More common Abdominal or stomach pain, Chills or fever Headache, Joint or back pain Muscle aching or cramping Muscle pains or stiffness Chest pressure or squeezing pain in the chest Excessive sweating feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis sudden tingling or coldness in an arm or leg Constipation Diarrhoea Loss of muscle coordination Sleepiness or unusual drowsiness Clumsiness or unsteadiness Drowsiness Rare Anxiety change in vision seizures abnormal or fast heart rate weight loss chest pain or tightness confusion a cough Agitation arm, back, or jaw pain blurred vision chest pain or discomfort convulsions extra heartbeats, fainting blurred vision chest pain or discomfort convulsions extra heartbeats hallucinations a headache irritability lightheadedness mood or mental changes muscle pain or cramps muscle spasm or jerking of all extremities muscle pains or stiffness chest pressure or squeezing pain in the chest discomfort in arms, shoulders, neck or upper back pain or discomfort in the chest, upper stomach, or throat pale or blue lips, fingernails, or skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue unusual drowsiness, dullness, or feeling of sluggishness You Might Also Read Indomethacin; Uses, Dosage, Side Effects, InteractionsDrug Interactions of Aceclofenac Aceclofenac may interact with following drugs, supplements & may change the efficacy of drugs antacids (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide) bisphosphonates (e.g., alendronate, etidronate, risedronate, zoledronic acid) antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone) angiotensin-converting enzyme inhibitors (ACEIs; e.g., captopril, enalapril, ramipril) angiotensin receptor blockers (ARBs; e.g., candesartan, irbesartan, losartan) beta-adrenergic blockers (e.g., metoprolol, atenolol) baclofen barbiturates (e.g., butalbital, phenobarbital) benzodiazepines (e.g., alprazolam, diazepam, lorazepam) calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil) celecoxib cilostazol “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole) clopidogrel corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone) cyclosporine diuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene) 5-ASA medications (e.g, sulfasalazine) glucosamine haloperidol heparin methotrexate multivitamins other non-steroidal anti-inflammatory medications (NSAIDs;e.g., diclofenac, ibuprofen, ketorolac, naproxen) Omega-3 fatty acids phenytoin phenobarbital pentoxifylline quinolone antibiotics (e.g., ciprofloxacin, ofloxacin) selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline) serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., duloxetine, venlafaxine) tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine) warferin Other NSAIDs: Concomitant therapy with aspirin or other NSAIDs may increase the frequency of adverse reactions, including the risk of GI bleeding. Pregnancy& Lactation of Aceclofenac FDA Pregnancy Category C Pregnancy There is no information on the secretion of aceclofenac in breast milk. The use of aceclofenac should, therefore, be avoided during lactation unless the potential benefits to the mother outweigh the possible risks to the children. During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the fetus to cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension); renal dysfunction, which may progress to renal failure with oligo-hydramnios; You Might Also Read Propylthiouracil - Uses, Dosage, Side Effects, Interactionsthe mother and the neonate, at the end of pregnancy, to possible prolongation of bleeding time, an anti-aggregating effect which may occur even at very low doses. inhibition of uterine contractions resulting in delayed or prolonged labor. Consequently, aceclofenac is contraindicated during the third trimester of pregnancy Lactation There is no information on the secretion of aceclofenac to breast milk; there was, however, no notable transfer of radiolabelled aceclofenac to the milk of lactating rats. The use of aceclofenac should, therefore, be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus. References DrugBank http://www.drugbank.ca/drugs/DB06736 http://www.drugbank.ca/drugs/DB06736#targets http://www.drugbank.ca/drugs/DB06736#enzymes ChemIDplus https://chem.nlm.nih.gov/chemidplus/sid/0089796996 https://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp EPA DSStox https://comptox.epa.gov/dashboard/dsstoxdb/results?search=DTXSID7045522 ClinicalTrials.gov https://clinicaltrials.gov/ FDA/SPL Indexing Data https://www.fda.gov/ForIndustry/DataStandards/SubstanceRegistrationSystem-UniqueIngredientIdentifierUNII/ European Chemicals Agency (ECHA) https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/174574 MassBank of North America (MoNA) http://mona.fiehnlab.ucdavis.edu/spectra/browse?inchikey=MNIPYSSQXLZQLJ-UHFFFAOYSA-N SpectraBase https://spectrabase.com/compound/CGxLUfFIi3b#C9PfHXXAtaV https://spectrabase.com/compound/CGxLUfFIi3b#L2wjxBQy29M https://spectrabase.com/compound/CGxLUfFIi3b#3oUKgJVvGXA Springer Nature . Read more … The Cambridge Structural Database http://www.ccdc.cam.ac.uk/pages/Home.aspx WHO ATC https://www.whocc.no/atc/ https://www.whocc.no/atc_ddd_index/ Wikipedia https://en.wikipedia.org/wiki/Aceclofenac https://pubchem.ncbi.nlm.nih.gov MeSH https://www.ncbi.nlm.nih.gov/mesh/67056498 http://www.nlm.nih.gov/mesh/meshhome.html https://www.ncbi.nlm.nih.gov/mesh/68000894 ChEBI http://www.ebi.ac.uk/chebi/userManualForward.do#ChEBI%20Ontology https://www.pediatriconcall.com/drugs/aceclofenac/957 https://www.drugs.com/international/aceclofenac.html KEGG http://www.genome.jp/kegg-bin/get_htext?br08303.keg http://www.genome.jp/kegg-bin/get_htext?br08310.keg WIPO http://www.wipo.int/classifications/ipc/ ChEMBL https://www.ebi.ac.uk/chembl/target/browser https://www.ncbi.nlm.nih.gov/projects/linkout Show More