Donate to the Palestine's children, safe the people of Gaza.  >>>Donate Link...... Your contribution will help to save the life of Gaza people, who trapped in war conflict & urgently needed food, water, health care and more.

Differences Between Naproxen vs Ketoprofen

Comparison Table: Naproxen vs Ketoprofen

Category Naproxen Ketoprofen
1. Drug Class NSAID (Nonsteroidal Anti-inflammatory Drug) NSAID (Nonsteroidal Anti-inflammatory Drug)
2. Mechanism of Action Inhibits COX-1 and COX-2, reducing prostaglandin synthesis Same mechanism – inhibits COX-1 and COX-2
3. Common Brand Names Aleve, Naprosyn Orudis, Oruvail, Ketoflam
4. Available Forms Tablet, capsule, suspension, delayed-release, extended-release Capsule, extended-release, topical gel, injection
5. Half-Life Long (12–17 hours) – allows twice daily dosing Shorter (2–4 hours) – may require more frequent dosing
6. Typical Dosing Frequency Every 8–12 hours Every 6–8 hours
7. Onset of Action Slower onset Faster onset
8. Pain Relief Potency Moderate to high Moderate to high (comparable to naproxen)
9. Anti-inflammatory Power Strong Strong
10. Common Indications Arthritis, menstrual pain, tendonitis, fever, muscle aches Arthritis, pain, menstrual cramps, post-surgical pain
11. Contraindications GI bleeding, severe heart/kidney/liver disease, NSAID allergy Same as naproxen
12. Typical Adult Dose 250–500 mg every 12 hours (max 1500 mg/day) 25–50 mg every 6–8 hours (max 300 mg/day)
13. GI Side Effects Gastric irritation, ulcer, nausea Slightly more irritating to GI tract than naproxen
14. Cardiovascular Risk Moderate (less than some NSAIDs like diclofenac) Slightly higher cardiovascular risk compared to naproxen
15. Renal Impact May reduce kidney function with long-term use Similar renal effects
16. Topical Option No Yes (topical gels/sprays available)
17. Use in Pregnancy Avoid in 3rd trimester Avoid in 3rd trimester
18. COX-2 Selectivity Non-selective Non-selective
19. Drug Interactions Anticoagulants, antihypertensives, lithium Same interactions
20. Cost and Availability Widely available and generally cheaper Less widely available, may be more expensive

✅ Indications (Both)

  • Osteoarthritis

  • Rheumatoid arthritis

  • Ankylosing spondylitis

  • Musculoskeletal pain

  • Menstrual cramps (dysmenorrhea)

  • Postoperative pain

  • Fever (off-label)


❌ Contraindications (Both)

  • Hypersensitivity to NSAIDs

  • History of asthma or urticaria with NSAID use

  • Active peptic ulcer or GI bleeding

  • Severe heart failure

  • Late-stage pregnancy (3rd trimester)

  • Severe liver or kidney disease


💊 Typical Dosage (Adults)

Drug Immediate-Release Extended-Release
Naproxen 250–500 mg every 12 hours (Max: 1500 mg/day) 750–1000 mg once daily
Ketoprofen 25–50 mg every 6–8 hours (Max: 300 mg/day) 200 mg once daily (Max: 200 mg/day)

⚠️ Warning Signs (Both)

Seek medical attention if you experience:

  • Black or bloody stools (GI bleeding)

  • Chest pain, shortness of breath (heart attack)

  • Swelling, rapid weight gain (kidney issues)

  • Severe abdominal pain

  • Skin rash or blisters (Stevens-Johnson Syndrome)

  • Yellowing of the skin or eyes (liver damage)

  • High blood pressure or headaches

  • Ringing in the ears or hearing changes


🆚 Which One is Best and Safer?

Criteria Better Choice Reason
Convenience Naproxen Longer half-life = less frequent dosing
GI Tolerability Naproxen Slightly less gastric irritation
Topical Use Option Ketoprofen Available as gel/patch – reduces systemic side effects
Cost & Access Naproxen Widely available, lower cost
Rapid Pain Relief Ketoprofen Faster onset

To Get Daily Health Newsletter

We don’t spam! Read our privacy policy for more info.

Download Mobile Apps
Follow us on Social Media
© 2012 - 2025; All rights reserved by authors. Powered by Mediarx International LTD, a subsidiary company of Rx Foundation.
RxHarun
Logo