PLID stands for Primary Lateral intervertebral disc. It is a rare and progressive neurodegenerative disorder that affects the upper motor neurons (UMNs) in the brain and spinal cord. The UMNs control muscle movements and coordination in the body. In PLS, these neurons degenerate and die, leading to muscle weakness and stiffness, spasticity, and difficulty with coordination and balance. PLS typically begins in middle age and progresses slowly over time. There is currently no cure for PLS and treatment focuses on managing symptoms and preserving function.
Causes
The exact cause of PLID is not known, but it is believed to be caused by a combination of genetic and environmental factors. Some possible causes include:
- Genetic mutations: Some cases of PLID have been linked to mutations in the gene that codes for the enzyme superoxide dismutase 1 (SOD1), which is involved in protecting cells from damage caused by free radicals.
- Environmental factors: Exposure to toxins, such as lead and pesticides, has been suggested as a possible cause of PLID.
- Autoimmune disorders: PLID may be caused by an autoimmune disorder, where the body’s immune system mistakenly attacks healthy cells.
- Trauma: Trauma to the spinal cord or brain may also cause PLID.
Overall, the exact cause of PLID is not well understood and further research is needed to understand the underlying mechanisms of the disease.
Dr. Md. Harun Ar Rashid, MPH, MD, PhD, is a highly respected medical specialist celebrated for his exceptional clinical expertise and unwavering commitment to patient care. With advanced qualifications including MPH, MD, and PhD, he integrates cutting-edge research with a compassionate approach to medicine, ensuring that every patient receives personalized and effective treatment. His extensive training and hands-on experience enable him to diagnose complex conditions accurately and develop innovative treatment strategies tailored to individual needs. In addition to his clinical practice, Dr. Harun Ar Rashid is dedicated to medical education and research, writing and inventory creative thinking, innovative idea, critical care managementing make in his community to outreach, often participating in initiatives that promote health awareness and advance medical knowledge. His career is a testament to the high standards represented by his credentials, and he continues to contribute significantly to his field, driving improvements in both patient outcomes and healthcare practices.
