Primary Lateral Intervertebral Disc

PLID stands for Primary Lateral intervertebral disc. It is a rare and progressive neurodegenerative disorder that affects the upper motor neurons (UMNs) in the brain and spinal cord. The UMNs control muscle movements and coordination in the body. In PLS, these neurons degenerate and die, leading to muscle weakness and stiffness, spasticity, and difficulty with coordination and balance. PLS typically begins in middle age and progresses slowly over time. There is currently no cure for PLS and treatment focuses on managing symptoms and preserving function.


The exact cause of PLID is not known, but it is believed to be caused by a combination of genetic and environmental factors. Some possible causes include:

  • Genetic mutations: Some cases of PLID have been linked to mutations in the gene that codes for the enzyme superoxide dismutase 1 (SOD1), which is involved in protecting cells from damage caused by free radicals.
  • Environmental factors: Exposure to toxins, such as lead and pesticides, has been suggested as a possible cause of PLID.
  • Autoimmune disorders: PLID may be caused by an autoimmune disorder, where the body’s immune system mistakenly attacks healthy cells.
  • Trauma: Trauma to the spinal cord or brain may also cause PLID.

Overall, the exact cause of PLID is not well understood and further research is needed to understand the underlying mechanisms of the disease.