Midostaurin – Uses, Dosage, Side Effects, Interaction

Midostaurin is an orally available small molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3) which is used as an antineoplastic agent in the treatment of acute myeloid leukemia with FLT3 mutations. Midostaurin is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver Read More >>>>

Methylnaltrexone Bromide – Uses, Dosage, Side Effects, Interaction

Methylnaltrexone is a methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity. Methylnaltrexone is a member of phenanthrenes. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, resulting in decreases in opioid-related constipation, urinary retention, and pruritis, respectively. Methylnaltrexone does not cross the blood-brain barrier and does not affect Read More >>>>

Mercaptoethanesulfonic Acid – Uses, Dosage, Side Effects

2-mercaptoethanesulfonic acid is a Cytoprotective Agent. Coenzyme M is an organosulfonic acid consisting of a sulfonic acid having a 2-mercaptoethanol group attached to sulfur. It has a role as a coenzyme. It is an organosulfonic acid and a thiol. It is a conjugate acid of a coenzyme M(1-). Coenzyme M (commonly known by its salt form, Read More >>>>

Mesna – Uses, Dosage, Side Effects, Interactions

2-mercaptoethanesulfonic acid is a Cytoprotective Agent. Coenzyme M is an organosulfonic acid consisting of a sulfonic acid having a 2-mercaptoethanol group attached to sulfur. It has a role as a coenzyme. It is an organosulfonic acid and a thiol. It is a conjugate acid of a coenzyme M(1-). Coenzyme M (commonly known by its salt form, Read More >>>>

Trametinib – Uses, Dosage, Side Effects, Interaction

Trametinib is a dual-kinase inhibitor that is used in the treatment of advanced malignant melanoma, usually in combination with dabrafenib. Trametinib therapy is associated with transient elevations in serum aminotransferase and alkaline phosphatase levels during therapy but has yet to be linked cases of clinically apparent acute liver injury. Trametinib is an orally bioavailable inhibitor Read More >>>>

Mechlorethamine – Uses, Dosage, Side Effects, Interaction

Mechlorethamine is a nitrogen mustard and antineoplastic agent that has been in clinical use for more than 60 years, given systemically in combination with other antineoplastic agents to treat Hodgkin disease, chronic leukemias, lung cancer, and polycythemia vera. Currently, however, it is used largely as a topical gel for the therapy of cutaneous T-cell lymphomas Read More >>>>

Margetuximab-cmkb – Uses, Dosage, Side Effects, Interaction

Margetuximab is an Fc-engineered human/mouse chimeric IgG1κ anti-HER2 monoclonal antibody indicated for patients with HER2-positive metastatic breast cancer. The HER2 oncoprotein, the product of the human ERBB2/mouse neu genes, is a member of the HER family of receptor tyrosine kinases that includes the epidermal growth factor receptor (EGFR). Of the various subtypes of breast cancer, HER2-positive breast cancer Read More >>>>

Futibatinib – Uses, Dosage, Side Effects, Interaction

Futibatinib is an FGF receptor 2 kinase inhibitor that is used in the treatment of unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma. Futibatinib is associated with transient and usually mild elevations in serum aminotransferase during therapy but has not been convincingly linked to cases of clinically apparent liver injury. Futibatinib is an orally bioavailable inhibitor Read More >>>>

Olaparib – Uses, Dosage, Side Effects, Interactions

Olaparib is a small molecule inhibitor of poly ADP-ribose polymerase and is used as an antineoplastic agent in the therapy of refractory and advanced ovarian carcinoma. Olaparib therapy is associated with a low rate of transient elevations in serum aminotransferase during therapy and has not been linked to instances of clinically apparent liver injury. Olaparib is Read More >>>>

Lutetium Lu 177 Dotatate – Uses, Dosage, Side Effects, Interaction

Lutetium Lu 177 Dotatate is a radio-conjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope lutetium Lu 177, with potential imaging and antineoplastic activities. Lutetium Lu 177 dotatate binds to somatostatin receptors (SSTRs), with high affinity to type 2 Read More >>>>

Luspatercept-aamt – Uses, Dosage, Side Effects, Interaction

Luspatercept is an erythroid maturation agent used to treat anemia secondary to beta-thalassemia in patients requiring regular red blood cell transfusions. Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1.[rx,rx] It was first approved for use in the United Read More >>>>

Lurbinectedin – Uses, Dosage, Side Effects, Interaction

Lurbinectedin is an antineoplastic alkylating agent and synthetic derivative of trabectedin that is used to treat refractory, metastatic small-cell lung cancer. Lurbinectedin therapy is associated with a high rate of transient serum enzyme elevations during treatment and with occasional instances of clinically apparent liver injury with jaundice. Lurbinectedin is a synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid Read More >>>>