Cefpirome; Uses, Contra indications, Dosage, Side effects, Interaction Cefpirome is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefpirome binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Cefpirome is a fourth-generation cephalosporin. Trade names include Cefrom, Keiten, Broach, Cefir. Cefpirome is considered highly active against Gram-negative bacteria, including Pseudomonas aeruginosa, and Gram-positive bacteria. It is marketed under the brand name of CEFROM by Sanofi Aventis group India. Mechanism of action of Cefpirome Cefpirome is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefpirome binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Dosage Not available in the U.S.A 1-4 g IV q12hr Renal Impairment CrCl 20-50 mL/min: 1-2 g load, 0.5-1 g IV BID CrCl 5-20 mL/min: 1-2 g load, 0.5-1 g IV qDay CrCl <5 mL/min 0.25-0.5 g qDay Other Information Inject or infuse over 30 minutes Other Indications & Uses of Cefpirome Anaerobic cocci, Bacteroides spp., Enterobacter spp., E. coli, H. influenzae, Klebsiella spp., M. catarrhalis, M. morganii, Providencia rettgeri, Pseudomonas spp., Serratia spp., S. aureus, S. pneumoniae, S. pyogenes You Might Also Read Sertraline; Uses, Side Effects, Interactions, PregnancyDrug Interactions Monitor Closely (14) bazedoxifene/conjugated estrogens conjugated estrogens digoxin estradiol estrogens conjugated synthetic estropipate flucloxacillin mestranol mycophenolate pivmecillinam probenecid sodium picosulfate/magnesium oxide/anhydrous citric acid temocillin ticarcillin Minor (65) aceclofenac acemetacin acyclovir aminohippurate sodium aspirin aspirin rectal aspirin/citric acid/sodium bicarbonate aztreonam balsalazide bendroflumethiazide biotin bupropion cefadroxil cefamandole cefdinir ceftizoxime celecoxib chloramphenicol chlorothiazide chlorpropamide chlorthalidone choline magnesium trisalicylate cyclopenthiazide diclofenac diflunisal etodolac etoricoxib fenbufen fenoprofen flurbiprofen furosemide ganciclovir hydrochlorothiazide ibuprofen indapamide indomethacin ketoprofen ketorolac ketorolac intranasal lornoxicam meclofenamate mefenamic acid meloxicam mesalamine methyclothiazide metolazone nabumetone naproxen niacin oxaprozin pantothenic acid parecoxib piroxicam pyridoxine pyridoxine (antidote) rose hips salicylates (non-asa) salsalate sulfasalazine sulindac thiamine tolfenamic acid tolmetin ………………………………….data or information not available Reference ChemIDplus https://chem.nlm.nih.gov/chemidplus/sid/0084957299 https://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp EPA DSStox https://comptox.epa.gov/dashboard/dsstoxdb/results?search=DTXSID2048244 Human Metabolome Database (HMDB) http://www.hmdb.ca/metabolites/HMDB0041852 FDA/SPL Indexing Data https://www.fda.gov/ForIndustry/DataStandards/SubstanceRegistrationSystem-UniqueIngredientIdentifierUNII/ NCIt https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C79563 WHO ATC https://www.whocc.no/atc/ https://www.whocc.no/atc_ddd_index/ Wikipedia https://www.wikidata.org/wiki/Q27274566 https://en.wikipedia.org/wiki/Cefpirom PubChem https://pubchem.ncbi.nlm.nih.gov MeSH https://www.ncbi.nlm.nih.gov/mesh/67038950 http://www.nlm.nih.gov/mesh/meshhome.html https://www.ncbi.nlm.nih.gov/mesh/6800090