Etodolac; Uses, Dosage, Side effects, Interactions

Last updated: February 7, 2026Reviewed date: February 7, 2026Reading time: 9 min read
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Etodolac is a nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in the treatment of osteoarthritis; rheumatoid arthritis; ankylosing SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE). Etodolac is a pyranocarboxylic acid and non-steroidal anti-inflammatory drug...

For severe symptoms, danger signs, pregnancy, child illness, or sudden worsening, seek urgent medical care.

বাংলা রোগী নোট এখনো যোগ করা হয়নি। পোস্ট এডিটরে “RX Bangla Patient Mode” বক্স থেকে সহজ বাংলা সারাংশ যোগ করুন।

এই তথ্য শিক্ষা ও সচেতনতার জন্য। এটি ডাক্তারি পরীক্ষা, রোগ নির্ণয় বা প্রেসক্রিপশনের বিকল্প নয়।

Article Summary

Etodolac is a nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in the treatment of osteoarthritis; rheumatoid arthritis; ankylosing SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE). Etodolac is a pyranocarboxylic acid and non-steroidal anti-inflammatory drug (NSAID) with antipyretic and analgesic activities. Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which...

Key Takeaways

  • This article explains Mechanism of Action of Etodolac  in simple medical language.
  • This article explains Indications of Etodolac  in simple medical language.
  • This article explains Contra-Indications of Etodolac  in simple medical language.
  • This article explains Dosage of Etodolac  in simple medical language.
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Emergency safety firstUrgent warning signs are highlighted below.

Seek urgent medical care if you notice

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  • Severe symptoms, breathing difficulty, fainting, confusion, or rapidly worsening illness.
  • New weakness, severe pain, high fever, or symptoms after a serious injury.
  • Any symptom that feels urgent, unusual, or unsafe for the patient.
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Emergency now

Use emergency care for severe, sudden, rapidly worsening, or life-threatening symptoms.

2

See a doctor

Book a professional medical evaluation if symptoms persist, worsen, recur often, affect daily activities, or occur in a high-risk patient.

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Use this article to understand possible causes, tests, treatment options, prevention, and questions to ask your clinician.

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Start here Choose the right pathway for symptoms, reports, medicines, or urgent warning signs. Disease article roadmap Read this topic step by step: meaning, symptoms, warning signs, diagnosis, treatment, prevention, and follow-up. Treatment planner Prepare questions about treatment choices, benefits, risks, side effects, and follow-up. Family & caregiver guide Organize symptoms, reports, medicines, questions, and follow-up safely. Nutrition & diet guide Prepare food, hydration, supplement, and medicine-timing questions safely. Prevention guide Organize risk factors, protective habits, screening, and warning signs. Recovery guide Prepare a safe plan for activity, rehabilitation, warning signs, and follow-up.
Etodolac is a nonsteroidal infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation, pain, or swelling. সহজ বাংলা: প্রদাহ/ফোলা/ব্যথা কমায়।" data-rx-term="anti-inflammatory" data-rx-definition="Anti-inflammatory means reducing inflammation, pain, or swelling. সহজ বাংলা: প্রদাহ/ফোলা/ব্যথা কমায়।">anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in the treatment of stiffness. সহজ বাংলা: বয়স/ক্ষয়ের কারণে জয়েন্টের ব্যথা।" data-rx-term="osteoarthritis" data-rx-definition="Osteoarthritis is wear-and-tear joint disease causing pain and stiffness. সহজ বাংলা: বয়স/ক্ষয়ের কারণে জয়েন্টের ব্যথা।">osteoarthritis; arthritis: Rheumatoid arthritis is an autoimmune joint disease causing inflammation, pain, and swelling. সহজ বাংলা: রোগপ্রতিরোধ ব্যবস্থার ভুল আক্রমণে জয়েন্টের প্রদাহ।" data-rx-term="rheumatoid arthritis" data-rx-definition="Rheumatoid arthritis is an autoimmune joint disease causing inflammation, pain, and swelling. সহজ বাংলা: রোগপ্রতিরোধ ব্যবস্থার ভুল আক্রমণে জয়েন্টের প্রদাহ।">rheumatoid arthritis; ankylosing SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
Etodolac is a pyranocarboxylic acid and non-steroidal infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation, pain, or swelling. সহজ বাংলা: প্রদাহ/ফোলা/ব্যথা কমায়।" data-rx-term="anti-inflammatory" data-rx-definition="Anti-inflammatory means reducing inflammation, pain, or swelling. সহজ বাংলা: প্রদাহ/ফোলা/ব্যথা কমায়।">anti-inflammatory drug (NSAID) with antipyretic and analgesic activities. Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. It also inhibits platelet aggregation by blocking platelet cyclooxygenase and the subsequent formation of thromboxane A2.
Etodolac is a nonsteroidal infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation, pain, or swelling. সহজ বাংলা: প্রদাহ/ফোলা/ব্যথা কমায়।" data-rx-term="anti-inflammatory" data-rx-definition="Anti-inflammatory means reducing inflammation, pain, or swelling. সহজ বাংলা: প্রদাহ/ফোলা/ব্যথা কমায়।">anti-inflammatory drug (NSAID) that is available by prescription only and is used long-term for therapy of chronic stiffness, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।" data-rx-term="arthritis" data-rx-definition="Arthritis means joint inflammation causing pain, swelling, stiffness, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।">arthritis and short-term for acute pain. Etodolac has been linked to rare instances of clinically apparent drug-induced liver disease.

Mechanism of Action of Etodolac 

Similar to other NSAIDs, the infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation, pain, or swelling. সহজ বাংলা: প্রদাহ/ফোলা/ব্যথা কমায়।" data-rx-term="anti-inflammatory" data-rx-definition="Anti-inflammatory means reducing inflammation, pain, or swelling. সহজ বাংলা: প্রদাহ/ফোলা/ব্যথা কমায়।">anti-inflammatory effects of etodolac result from inhibition of the enzyme cyclooxygenase (COX). This decreases the synthesis of peripheral prostaglandins involved in mediating inflammation. Etodolac binds to the upper portion of the COX enzyme active site and prevents its substrate, arachidonic acid, from entering the active site. Etodolac was previously thought to be a non-selective COX inhibitor, but it is now known to be 5 – 50 times more selective for COX-2 than COX-1. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.

Indications of Etodolac 

Carefully consider the potential benefits and risks of Etodolac and other treatment options before deciding to use Etodolac. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

Contra-Indications of Etodolac 

  • Active peptic ulcer
  • Acute rhinitis
  • Allergic to thiocolchicoside
  • Asthma
  • Breastfeeding
  • Pregnant
  • Urticaria
  • Concurrent peptic ulcer, or history of ulcer disease
  • Allergy to indomethacin, aspirin, or other NSAIDs
  • Patients with nasal polyps reacting with angioedema to other NSAIDs
  • Children under 2 years of age (with the exception of neonates with patent ductus arteriosus)
  • Some painkillers, including opioid painkillers;
  • Hypnotic drugs;
  • Psychotropic drugs;
  • Used monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromine
  • Epilepsy;
  • Addiction or are recovering from addiction to another medication.
  • History of peptic ulcer disease,
  • Gastrointestinal bleeding,
  • Severe pre-existing renal and liver damage
  • Caution: pre-existing bone marrow damage (frequent blood cell counts are indicated)
  • Caution: bleeding tendencies of unknown origin
  • Caution: Parkinson’s disease, epilepsy, psychotic disorders
  • Patients who have a patent ductus arteriosus dependent heart defect (such as transposition of the great vessels)
  • Significant hypertension (high blood pressure)
  • Concomitant administration of lithium salts (such as lithium carbonate)
  • History of gastric bypass surgery

Dosage of Etodolac 

Strengths: 200 mg; 300 mg; 400 mg; 500 mg; 600 mg

Osteoarthritis

Immediate Release

  • Initial dose: 300 mg orally 2 to 3 times a day or 400 mg to 500 mg orally twice a day
  • Maintenance dose: A lower dose of 600 mg/day may suffice for long-term use
  • Maximum dose: 1000 mg/day

Extended Release

  • 400 mg to 1000 mg orally once a days

Rheumatoid Arthritis

Immediate Release

  • Initial dose: 300 mg orally 2 to 3 times a day or 400 mg to 500 mg orally twice a da
  • Maintenance dose: A lower dose of 600 mg/day may suffice for long-term use
  • Maximum dose: 1000 mg/day

Extended Release

  • 400 mg to 1000 mg orally once a day

Pediatric Juvenile Rheumatoid Arthritis

Extended Release>6 to 16 years

  • 20 to 30 kg: 400 mg orally once a day
  • 31 to 45 kg: 600 mg orally once a day
  • 40 to 60 kg: 480 mg orally once a day
  • Greater than 60 kg: 1000 mg orally once a day
  • 17 to 18 years: 400 mg to 1000 mg orally once a day

Side Effects of Etodolac 

The most common

  • GI disorders (e.g. dyspepsia, abdominal pain, nausea, vomiting, diarrhea, flatulence, constipation,ulcerative stomatitis, ), indigestion,
  • Disturbances of the gut such as diarrhea, constipation, nausea, vomiting or abdominal pain.
  • Drowsiness and lightheadedness
  • Nausea and vomiting
  • joint pain
  • Nausea and vomiting
  • Severe stomach ache
  • Severe diarrhea
  • Vaginal thrush
  • Skin rash
  • Headache
  • Chest pain
  • Diarrhea or loose stools
  • Difficulty with breathing
  • Dizziness
  • Heartburn
  • Muscle pain

More common

  • Abdominal or stomach pain,
  • Chills or fever
  • A headache,
  • Joint or back pain
  • Muscle aching or cramping
  • Muscle pains or stiffness
  • Chest pressure or squeezing pain in the chest
  • Excessive sweating
  • feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis
  • sudden tingling or coldness in an arm or leg
  • Constipation
  • Diarrhoea
  • Loss of muscle coordination
  • Sleepiness or unusual drowsiness
  • Clumsiness or unsteadiness
  • Drowsiness

Rare

  • Anxiety
  • change in vision
  • seizures
  • abnormal or fast heart rate
  • weight loss
  • chest pain or tightness
  • confusion
  • a cough
  • Agitation
  • arm, back, or jaw pain
  • blurred vision
  • chest pain or discomfort
  • convulsions
  • extra heartbeats, fainting
  • blurred vision
  • chest pain or discomfort
  • convulsions
  • extra heartbeats
  • hallucinations
  • a headache
  • irritability
  • lightheadedness
  • mood or mental changes
  • muscle pain or cramps
  • muscle spasm or jerking of all extremities
  • muscle pains or stiffness
  • chest pressure or squeezing pain in the chest
  • discomfort in arms, shoulders, neck or upper back
  • pain or discomfort in the chest, upper stomach, or throat
  • pale or blue lips, fingernails, or skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • unusual drowsiness, dullness, or feeling of sluggishness

Drug Interactions of Etodolac 

Etodolac may interact with following drugs, supplements & may change the efficacy of drugs

  • antacids (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)
  • bisphosphonates (e.g., alendronate, etidronate,  risedronate, zoledronic acid)
  • antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
  • angiotensin-converting enzyme inhibitors (ACEIs; e.g., captopril, enalapril, ramipril)
  • angiotensin receptor blockers (ARBs; e.g., candesartan, irbesartan, losartan)
  • beta-adrenergic blockers (e.g., metoprolol, atenolol)
  • baclofen
  • barbiturates (e.g., butalbital, phenobarbital)
  • benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • celecoxib
  • cilostazol
  • “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
  • clopidogrel
  • corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)
  • cyclosporine
  • diuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene)
  • 5-ASA medications (e.g, sulfasalazine)
  • glucosamine
  • haloperidol
  • heparin
  • methotrexate
  • multivitamins
  • other non-steroidal anti-inflammatory medications (NSAIDs;e.g., diclofenac, ibuprofen, ketorolac, naproxen)
  • Omega-3 fatty acids
  • phenytoin
  • phenobarbital
  • pentoxifylline
  • quinolone antibiotics (e.g., ciprofloxacin, ofloxacin)
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine,fluoxetine, paroxetine, sertraline)
  • serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., duloxetine, venlafaxine)
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • warferin

Other NSAIDs: Concomitant therapy with aspirin or other NSAIDs may increase the frequency of adverse reactions, including the risk of GI bleeding.

Pregnancy & Lactation of Etodolac 

FDA Pregnancy Category C

Pregnancy

It is unknown whether etodolac is excreted into breast milk. According to the manufacturer, because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing babies from etodolac. The safety of using this medication during pregnancy has not been established. Using this medication during pregnancy is not recommended. If you become pregnant while taking this medication, contact your doctor immediately

Lactation

It is not known if etodolac passes into breast milk. If you are a breastfeeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding.

Important information

Etodolac can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Etodolac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using etodolac, especially in older adults.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to etodolac (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen. Do not drink alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding caused by etodolac. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medicine can make your skin more sensitive to sunlight and sunburn may result.

References

Etodolac; Uses, Dosage, Side effects, Interactions

Doctor visit helper

Prepare before seeing a doctor

A simple rural-patient checklist to help you explain symptoms clearly, ask better questions, and avoid unsafe self-treatment.

Safety note: This is not a prescription or diagnosis. For severe symptoms, pregnancy danger signs, children with serious illness, chest pain, breathing difficulty, stroke-like weakness, or major injury, seek urgent care.

Which doctor may help?

Start with a registered doctor or the nearest qualified health center.

What to tell the doctor

  • Write when the problem started and how it changed.
  • Bring old prescriptions, investigation reports, and current medicines.
  • Write allergies, pregnancy status, diabetes, kidney/liver disease, and major past illnesses.
  • Bring one family member if the patient is weak, elderly, confused, or a child.

Questions to ask

  • What is the most likely cause of my symptoms?
  • Which danger signs mean I should go to hospital quickly?
  • Which tests are necessary now, and which can wait?
  • How should I take medicines safely and what side effects should I watch for?
  • When should I come for follow-up?

Tests to discuss

  • Vital signs: temperature, pulse, blood pressure, oxygen saturation
  • Basic physical examination by a clinician
  • CBC, urine test, blood sugar, or imaging only when clinically needed

Avoid these mistakes

  • Do not use antibiotics, steroid tablets/injections, or strong painkillers without proper medical advice.
  • Do not hide pregnancy, kidney disease, ulcer, allergy, or blood thinner use.
  • Do not delay emergency care when danger signs are present.

Medicine safety and first-aid guide

This section is for patient education only. It does not replace a doctor, pharmacist, or emergency care.

Safe first steps

  • Avoid heavy lifting, sudden bending, and prolonged bed rest.
  • Use comfortable posture and gentle movement as tolerated.
  • Discuss physiotherapy, X-ray, or MRI only when clinically needed.

OTC medicine safety

  • For mild back pain, pain-relief medicine may be discussed with a doctor or pharmacist.
  • Avoid repeated painkiller use if you have kidney disease, stomach ulcer, uncontrolled blood pressure, or are taking blood thinners.

Avoid these mistakes

  • Do not start antibiotics without a proper medical decision.
  • Do not use steroid tablets or injections casually for quick relief.
  • Do not delay emergency care because of home remedies.

Get urgent help if

  • Back pain with leg weakness, numbness around private area, loss of urine/stool control, fever, cancer history, or major injury needs urgent care.
Medicine names, dose, and timing must be decided by a qualified clinician or pharmacist after checking age, pregnancy, allergy, other diseases, and current medicines.

For rural patients and family caregivers

Patient health record and symptom diary

Write your symptoms, medicines already taken, test results, and questions before visiting a doctor. This note stays on your device unless you print or copy it.

Doctor to discuss: Orthopedic / spine specialist, physical medicine doctor, or qualified clinician
Tests to discuss with doctor
  • Neurological examination for leg power, sensation, reflexes, and straight leg raise
  • X-ray only if injury, deformity, long-lasting pain, or doctor suspects bone problem
  • MRI discussion if severe nerve symptoms, weakness, bladder/bowel problem, or persistent symptoms
Questions to ask
  • What is the most likely cause of my symptoms?
  • Which warning signs mean I should go to emergency care?
  • Which tests are really needed now?
  • Which medicines are safe for my age, pregnancy status, allergy, kidney/liver/stomach condition, and current medicines?
  • Is physiotherapy, posture correction, or activity modification needed?

Emergency warning signs such as chest pain, severe breathing difficulty, sudden weakness, confusion, severe dehydration, major injury, or loss of bladder/bowel control need urgent medical care. Do not wait for online information.

Safe pathway to proper treatment

Care roadmap for: Etodolac; Uses, Dosage, Side effects, Interactions

Use this simple roadmap to understand the next safe steps. It is educational and does not replace examination by a doctor.

Go to emergency care if you notice:
  • Severe or rapidly worsening symptoms
  • Breathing difficulty, chest pain, fainting, confusion, severe weakness, major injury, or severe dehydration
Doctor / service to discuss: Qualified healthcare provider; specialist depends on symptoms and examination.
  1. Step 1

    Check danger signs first

    If danger signs are present, seek emergency care and do not wait for online information.

  2. Step 2

    Record the symptom story

    Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.

  3. Step 3

    Visit a qualified clinician

    A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.

  4. Step 4

    Do only useful tests

    Do tests after clinical assessment. Avoid unnecessary tests, random antibiotics, or repeated medicines without diagnosis.

  5. Step 5

    Follow up and return early if worse

    If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips
  • Take a written symptom diary and all previous prescriptions/test reports.
  • Do not hide medicines already taken, even herbal or over-the-counter medicines.
  • Ask which warning signs mean urgent referral to hospital.

This roadmap is for education. A real diagnosis and treatment plan requires history, examination, and clinical judgment.

RX Patient Help

Ask a health question safely

Write your symptom story. A health professional or site editor can review it before any answer is prepared. This box is not for emergency care.

Emergency first: Severe chest pain, breathing trouble, unconsciousness, stroke signs, severe injury, heavy bleeding, or rapidly worsening symptoms need urgent local medical care now.

Frequently Asked Questions

Is this article a replacement for a doctor?

No. It is educational content only. Patients should consult a qualified clinician for diagnosis and treatment.

When should I seek urgent care?

Seek urgent care for severe symptoms, rapidly worsening condition, breathing difficulty, severe pain, neurological changes, or any emergency warning sign.

References

Add references, clinical guidelines, textbooks, journal articles, or trusted medical sources here. You can edit this area from the RX Article Professional Blocks panel.

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  7. Autism Facial Port Wine Stain Syndrome

    Autism-facial port-wine stain syndrome describes a very rare pattern seen in a handful of children: a unilateral facial port-wine stain (a flat, maroon-to-purple birthmark caused by...

    September 29, 2025 • Health (A - Z)
  8. Intellectual Developmental Disorder due to AUTS2 Deficiency

    Intellectual developmental disorder due to AUTS2 deficiency is a rare genetic neurodevelopmental condition. It happens when one copy of the AUTS2 gene does not work properly....

    September 29, 2025 • Health (A - Z)
  9. Autism Spectrum Disorder due to AUTS2 Deficiency

    Autism spectrum disorder due to AUTS2 deficiency is a rare, genetic neurodevelopmental condition caused by harmful changes (variants) in the AUTS2 gene. The gene helps control...

    September 29, 2025 • Health (A - Z)
  10. Ancylostomiasis (Hookworm Infection)

    Ancylostomiasis is the medical name for hookworm infection? in humans. Tiny worm larvae living in contaminated soil can enter your body (usually through bare feet). They...

    September 17, 2025 • Health (A - Z)