Ketoprofen; Uses, Dosage, Side Effects, Interactions

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Ketoprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofeninhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of ibuprofen. Ketoprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic properties. Ketoprofen has pharmacologic actions similar to those of other prototypical NSAIDs, which inhibit prostaglandin synthesis. Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and alleviate moderate pain.

Mechanism of action of Ketoprofen

The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cyclooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever, and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

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Indications of Ketoprofen

Contra-Indications of Ketoprofen

Dosages of Ketoprofen

Strengths: 12.5 mg; 25 mg; 50 mg; 75 mg;  100 mg; 150 mg; 200 mg;


  • Adults—At first, 75 milligrams (mg) three times a day or 50 mg four times a day. Your doctor may increase your dose, if necessary, up to a total of 300 mg a day.
  • Children—Use and dose must be determined by your doctor.

Mild to moderate pain or menstrual cramps

  • Adults—25 to 50 mg every six to eight hours as needed. Some people may need to take as much as 75 mg every six to eight hours. Doses larger than 75 mg are not likely to give better relief.

Osteoarthritis and rheumatoid arthritis

  • For oral dosage form (extended-release capsules):
  • Adults—200 mg once a day, in the morning or evening. Take the medicine at the same time every day.


  • Immediate Release: 25 mg to 50 mg orally every 6 to 8 hours as needed
  • Maximum dose: 300 mg/day

Side Effects of Ketoprofen

The common

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More common

Less common


Drug Interactions of Ketoprofen 

Ketoprofen may interact with following drugs, supplements & may change the efficacy of drugs

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Pregnancy & Lactation of Ketoprofen 

FDA  Pregnancy Category C


This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.


This medication should not be used by women who are breast-feeding




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