Eletriptan; Uses, Dosage, Side Effects, Interactions

Eletriptan
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Eletriptan is a Serotonin-1b and Serotonin-1d Receptor Agonist. The mechanism of action of eletriptan is as a Serotonin 1b Receptor Agonist, and Serotonin 1d Receptor Agonist. Eletriptan is only found in individuals that have used or taken this drug. Two theories have been proposed to explain the efficacy of 5-HT receptor agonists in a migraine. One theory suggests that activation of 5-HT1 receptors located on intracranial blood vessels, including those on the arteriovenous anastomoses, leads to vasoconstriction, which is correlated with the relief of a migraine headache. The other hypothesis suggests that activation of 5-HT1 receptors on sensory nerve endings in the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.

Mechanism of action of Eletriptan

Eletriptan binds with high affinity to 5-HT1B, 5-HT1D and 5-HT1F receptors, has ma oddest affinity for 5-HT1A, 5-HT1E, 5-HT2B and 5-HT7 receptors, and little or no affinity for 5-HT2A, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A and 5-HT6 receptors. Eletriptan has no significant affinity or pharmacological activity at adrenergic alpha1, alpha2, or beta; dopaminergic D1 or D2; muscarinic; or opioid receptors. Eletriptan has no significant affinity or pharmacological activity at adrenergic alpha1, alpha2, or beta; dopaminergic D1 or D2; muscarinic; or opioid receptors. Two theories have been proposed to explain the efficacy of 5-HT receptor agonists in a migraine. One theory suggests that activation of 5-HT1 receptors located on intracranial blood vessels, including those on the arteriovenous anastomoses, leads to vasoconstriction, which is correlated with the relief of a migraine headache. The other hypothesis suggests that activation of 5-HT1 receptors on sensory nerve endings in the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.

Indications of Eletriptan

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Contra-Indications of Eletriptan

Do not take almotriptan within 24 hours before or after using another migraine headache medicine

Dosage of Eletriptan

Strengths: 20 mg; 40 mg

Migraine

Use only after a clear diagnosis of a migraine has been established

  • Initial dose: 20 mg or 40 mg orally, once
  • Provided there has been some response to the first dose, a second dose may be administered at least 2 hours later if migraine returns or symptoms recur.
  • Maximum dose: 80 mg in a 24-hour period

Side Effects of Eletriptan

The most common

More common

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Rare

Drug Interactions of Eletriptan

Eletriptan may interact with the following drug, suppliments, & may change the efficacy of the drug

Pregnancy Category of Eletriptan

FDA Pregnancy Category C

Pregnancy

This medication should not be taken during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

It is not known if almotriptan passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.T he safety and effectiveness of using this medication have not been established for children less than 12 years of age. Its use by people in this age group is not recommended.

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