Dosage of Metadoxine – Uses, Side Effects, Warning

User Review
( votes)

Dosage of Metadoxine/Metadoxine also is known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication. Metadoxine accelerates alcohol clearance from the blood. Metadoxine is an ion pair salt of pyridoxine and pyrrolidone carboxylate (PCA). Pyridoxine (vitamin B6) is a precursor of coenzymes including pyridoxal 5’-phosphate (PLP), which accelerates the metabolic degradation of ethanol and prevents adenosine triphosphate (ATP) inactivation by acetaldehyde. Pyridoxal phosphate-dependent enzymes also play a role in the biosynthesis of four important neurotransmitters: serotonin (5-HT), epinephrine, norepinephrine, and GABA: see vitamin B6 functions. L-PGA is present in the diet and is produced endogenously by enzymatic conversion of gamma-glutamyl amino acids to L-PGA and free amino acids.

The use of metadoxine in the treatment of hepatic fibrosis is described. Metadoxine can be orally and/or parenterally administered at a dosage comprised between 50 and 1000 mg per dose, preferably between 300 and 600 mg per dose. In the in vitro study, metadoxine results effectively at lower concentrations with respect to those that are obtained in the plasma after oral administration at the doses recommended for conventional pathology.

Mechanism of Action of Metadoxine

Metadoxine is a selective antagonist of the serotonin receptor subtype 5-HT2B and displays a high affinity to the gamma-aminobutyric acid (GABA) transporter. In vitro, enzymatic assay revealed that metadoxine reduced the activity of the GABA transaminase enzyme, responsible for the degradation of GABA. Electrophysiological studies also showed that metadoxine increased inhibitory GABAergic synaptic transmission via a presynaptic effect. As it does not affect dopamine, norepinephrine or serotonin levels, metadoxine displays a novel mechanism of action as a monoamine-independent GABA modulator.[rx]

You Can Also Like   Azelaic Acid Topical - Indications, Contraindications

In animal studies, metadoxine increased the activity of acetaldehyde dehydrogenase enzyme, prevented the decrease in alcohol dehydrogenase activity in chronic ethanol-fed rats, accelerated plasma and urinary clearance of ethanol, inhibited the increase of fatty acid esters in the liver of ethanol-treated rats, prevented the formation of fatty liver in rats exposed to a dose of ethanol sufficient to induce fatty liver, increased glutathione levels in the hepatocytes of acutely and chronically alcohol-intoxicated rats, prevented glutathione depletion, lipid peroxidation damage, collagen deposition, and TNF-α secretions induced by alcohol and acetaldehyde in hepatocytes and hepatic stellate cells.

Indications of Metadoxine

  • Alcohol Intoxication – This medicine is used to treat alcohol intoxication (alcohol poisoning), a condition associated with drinking an excessive amount of alcohol within a short period of time. The symptoms of alcohol intoxication may include slurred speech, incoordination, mood and behavior changes, coma (in rare cases), confusion, memory loss, etc.
  • Fatty liver – This medicine is used to treat alcoholic fatty liver, a condition characterized by increased deposits of fat in the liver. The symptoms of a fatty liver may include weight loss, abdominal pain, a feeling of tiredness, etc.
    Read Less

Dosage of Metadoxine

  • The use of metadoxine in the treatment of hepatic fibrosis is described. Metadoxine can be orally and/or parenterally administered at a dosage comprised between 50 and 1000 mg per dose, preferably between 300 and 600 mg per dose. In the in vitro study, metadoxine results effectively at lower concentrations with respect to those that are obtained in the plasma after oral administration at the doses recommended for conventional pathology.

Acute alcohol intoxication

  • 0.5-1 g/day.
You Can Also Like   Trimethoprim; Uses, Dosage, Side Effects, Interactions

Alcoholic fatty liver;

  • Adjunct in acute and chronic liver diseases 1 g/day. IV/IM

Acute alcohol intoxication

  • 300-600 mg/day. Alcoholic fatty liver; Adjunct in acute and chronic liver diseases 300 mg/day.

Acute alcohol intoxication

  • Adult: 500-1000 mg daily.

Alcoholic fatty liver, Supportive treatment of acute and chronic liver diseases

  • Adult: 1000 mg daily.

Acute alcohol intoxication

  • Adult: 300-600 mg daily IM/IV.

Alcoholic fatty liver, Supportive treatment of acute and chronic liver diseases

  • Adult: 300 mg daily IM/IV.

Missed Dose

  • Oral Form – The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.
  • Injection – Since this medicine is administered in the hospital/clinic setting by a qualified healthcare professional, the likelihood of a missed dose is very low. If you miss a scheduled appointment for a dose of this medicine, contact your doctor for further instructions.

Overdose

  • Oral Form – Seek emergency medical treatment or contact the doctor in case of an overdose. Injection: Since this medicine is administered in the hospital/clinic setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

Side Effects of Metadoxine

Major & minor side effects for Metadoxine

Interactions of Metadoxine

  • All drugs interact differently from person to person. You should check all the possible interactions with your doctor before starting any medicine.
You Can Also Like   Nandrolone; Uses, Dosage, Side Effects, Interactions

Interaction with Alcohol

  • Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

  • Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Levodopa

  • Disease interactions

Disease

  • Information not available.
Food interactions
  • Information not available.
Lab interactions
  • Information not available. This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

Pregnancy Category of Metadoxine

  • Information not available

References

Print Friendly, PDF & Email

Sharing to Spread to the World

Leave a Reply

Your email address will not be published.