Cefpirome; Uses, Contra indications, Dosage, Side effects, Interaction

Cefpirome
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Cefpirome is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefpirome binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Cefpirome is a fourth-generation cephalosporin. Trade names include Cefrom, Keiten, Broach, Cefir. Cefpirome is considered highly active against Gram-negative bacteria, including Pseudomonas aeruginosa, and Gram-positive bacteria. It is marketed under the brand name of CEFROM by Sanofi Aventis group India.

Mechanism of action of Cefpirome

Cefpirome is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefpirome binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Dosage

Not available in the U.S.A

1-4 g IV q12hr

Renal Impairment

CrCl 20-50 mL/min: 1-2 g load, 0.5-1 g IV BID

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CrCl 5-20 mL/min: 1-2 g load, 0.5-1 g IV qDay

CrCl <5 mL/min 0.25-0.5 g qDay

Other Information

Inject or infuse over 30 minutes

Other Indications & Uses of Cefpirome

Anaerobic cocci, Bacteroides spp., Enterobacter spp., E. coli, H. influenzae, Klebsiella spp., M. catarrhalis, M. morganii, Providencia rettgeri, Pseudomonas spp., Serratia spp., S. aureus, S. pneumoniae, S. pyogenes

Drug Interactions

Monitor Closely (14)

  • bazedoxifene/conjugated estrogens
  • conjugated estrogens
  • digoxin
  • estradiol
  • estrogens conjugated synthetic
  • estropipate
  • flucloxacillin
  • mestranol
  • mycophenolate
  • pivmecillinam
  • probenecid
  • sodium picosulfate/magnesium oxide/anhydrous citric acid
  • temocillin
  • ticarcillin

Minor (65)

  • aceclofenac
  • acemetacin
  • acyclovir
  • aminohippurate sodium
  • aspirin
  • aspirin rectal
  • aspirin/citric acid/sodium bicarbonate
  • aztreonam
  • balsalazide
  • bendroflumethiazide
  • biotin
  • bupropion
  • cefadroxil
  • cefamandole
  • cefdinir
  • ceftizoxime
  • celecoxib
  • chloramphenicol
  • chlorothiazide
  • chlorpropamide
  • chlorthalidone
  • choline magnesium trisalicylate
  • cyclopenthiazide
  • diclofenac
  • diflunisal
  • etodolac
  • etoricoxib
  • fenbufen
  • fenoprofen
  • flurbiprofen
  • furosemide
  • ganciclovir
  • hydrochlorothiazide
  • ibuprofen
  • indapamide
  • indomethacin
  • ketoprofen
  • ketorolac
  • ketorolac intranasal
  • lornoxicam
  • meclofenamate
  • mefenamic acid
  • meloxicam
  • mesalamine
  • methyclothiazide
  • metolazone
  • nabumetone
  • naproxen
  • niacin
  • oxaprozin
  • pantothenic acid
  • parecoxib
  • piroxicam
  • pyridoxine
  • pyridoxine (antidote)
  • rose hips
  • salicylates (non-asa)
  • salsalate
  • sulfasalazine
  • sulindac
  • thiamine
  • tolfenamic acid
  • tolmetin
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Reference

  1. PubChem
Cefpirome

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